Blood Compatibility and Protein Adsorption Characteristics of Sol-Gel Derived Titania

2000 ◽  
Vol 192-195 ◽  
pp. 889-892 ◽  
Author(s):  
S. Takashima ◽  
S. Takemoto ◽  
Kanji Tsuru ◽  
Satoshi Hayakawa ◽  
Akiyoshi Osaka
Keyword(s):  
Protein Adsorption ◽  
Blood Compatibility ◽  
Sol Gel ◽  
Adsorption Characteristics

scholarly journals Surface Chemistry, Crystal Structure, Size and Topography Role in the Albumin Adsorption Process on TiO2 Anatase Crystallographic Faces and Its 3D-Nanocrystal: A Molecular Dynamics Study

Coatings ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 420
Author(s):  
Giuseppina Raffaini
Keyword(s):  
Crystal Structure ◽  
Molecular Dynamics ◽  
Surface Chemistry ◽  
Protein Adsorption ◽  
Adsorption Process ◽  
Sol Gel ◽  
Interaction Strength ◽  
Theoretical Work ◽  
Blood Protein ◽  
Tio2 Anatase

TiO2 is widely used in biomaterial implants. The topography, chemical and structural properties of titania surfaces are an important aspect to study. The size of TiO2 nanoparticles synthetized by sol–gel method can influence the responses in the biological environment, and by using appropriate heat treatments different contents of different polymorphs can be formed. Protein adsorption is a crucial step for the biological responses, involving, in particular, albumin, the most abundant blood protein. In this theoretical work, using molecular mechanics and molecular dynamics methods, the adsorption process of an albumin subdomain is reported both onto specific different crystallographic faces of TiO2 anatase and also on its ideal three-dimensional nanosized crystal, using the simulation protocol proposed in my previous theoretical studies about the adsorption process on hydrophobic ordered graphene-like or hydrophilic amorphous polymeric surfaces. The different surface chemistry of anatase crystalline faces and the nanocrystal topography influence the adsorption process, in particular the interaction strength and protein fragment conformation, then its biological activity. This theoretical study can be a useful tool to better understand how the surface chemistry, crystal structure, size and topography play a key role in protein adsorption process onto anatase surface so widely used as biomaterial.

Selective protein adsorption and blood compatibility of hydroxy-carbonate apatites

2004 ◽  
Vol 69A (3) ◽  
pp. 544-551 ◽  
Author(s):  
Shinji Takemoto ◽  
Yuko Kusudo ◽  
Kanji Tsuru ◽  
Satoshi Hayakawa ◽  
Akiyoshi Osaka ◽  
...  
Keyword(s):  
Protein Adsorption ◽  
Blood Compatibility ◽  
Hydroxy Carbonate

scholarly journals The effect of strontium incorporation into sol-gel biomaterials on their protein adsorption and cell interactions

2019 ◽  
Vol 174 ◽  
pp. 9-16 ◽  
Author(s):  
F. Romero-Gavilán ◽  
N. Araújo-Gomes ◽  
I. García-Arnáez ◽  
C. Martínez-Ramos ◽  
F. Elortza ◽  
...  
Keyword(s):  
Protein Adsorption ◽  
Sol Gel ◽  
Cell Interactions ◽  
Strontium Incorporation

scholarly journals The blood compatibility challenge. Part 2: Protein adsorption phenomena governing blood reactivity

2019 ◽  
Vol 94 ◽  
pp. 11-24 ◽  
Author(s):  
John L. Brash ◽  
Thomas A. Horbett ◽  
Robert A. Latour ◽  
Pentti Tengvall
Keyword(s):  
Protein Adsorption ◽  
Blood Compatibility ◽  
Adsorption Phenomena

Blood compatibility of surfaces with superlow protein adsorption

Biomaterials ◽  
2008 ◽  
Vol 29 (32) ◽  
pp. 4285-4291 ◽  
Author(s):  
Zheng Zhang ◽  
Min Zhang ◽  
Shengfu Chen ◽  
Thomas A. Horbett ◽  
Buddy D. Ratner ◽  
...  
Keyword(s):  
Protein Adsorption ◽  
Blood Compatibility

Fabrication and Properties of Hydroxyapatite-Ti Network Composites

2008 ◽  
Vol 41-42 ◽  
pp. 41-48 ◽  
Author(s):  
Zhi Meng Xiu ◽  
Yi Liu ◽  
Ji Guang Li ◽  
Di Huo ◽  
Xiao Dong Li ◽  
...  
Keyword(s):  
Bending Strength ◽  
Blood Compatibility ◽  
Sol Gel ◽  
Material System ◽  
Mechanical Mixing ◽  
Reinforcement Structure ◽  
Relative Growth Rates ◽  
3D Network ◽  
Tih2 Powder ◽  
Mixing Method

Hydroxyapatite (HA) powder was synthesized by a sol-gel method with Ca(OH)2 and H3PO4 as reactants. The HA granules were then coated with TiH2 powder using a mechanical mixing method. The HA-TiH2 material system produced HA-Ti composites after hot-pressing at 1050°C. The HA-Ti composites are mainly composed of HA and Ti, with small amounts of Ca2P2O7 and Ca3(PO4)2 phases. Fracture toughness and bending strength are 2.4 MPa·m1/2 and 54.3 MPa, respectively for the HA-20vol%Ti composite, higher than those of the pure HA ceramic. The improvement in properties is because of the unique 3D network structure of Ti, which is an ideal reinforcement structure for the weak and brittle HA. According to ISO/TR 7405-1984, hemolysis test was performed to evaluate the blood compatibility of the material. The results show that the hemolysis rate of the HA-20vol%Ti composite is 0.56%. Relative growth rates (RGR) of L-929 cells soaked after 6 days in the HA-20vol%Ti group, pure Ti group, black group and pure Pb group were 132%, 100%, 90% and 6% respectively, while the level of cytotoxicity was grade 0 in HA-Ti composite group. These results imply that the HA-20vol%Ti composite has good biocompatibility and bioactivity.

Protein adsorption characteristics of calcium hydroxyapatites modified with pyrophosphoric acids

2007 ◽  
Vol 58 (2) ◽  
pp. 98-104 ◽  
Author(s):  
Kazuhiko Kandori ◽  
Shintaro Tsuyama ◽  
Hidekazu Tanaka ◽  
Tatsuo Ishikawa
Keyword(s):  
Protein Adsorption ◽  
Adsorption Characteristics
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