Development of Nifedipine Amorphous Solid Dispersion Composed of Surface-Active Agents

2021 ◽  
Vol 901 ◽  
pp. 35-39
Author(s):  
Sukannika Tubtimsri ◽  
Yotsanan Weerapol
Keyword(s):  
Surface Active Agent ◽  
Active Agent ◽  
Amorphous Solid ◽  
Drug Dissolution ◽  
Amorphous Solid Dispersion ◽  
Polysorbate 80 ◽  
X Ray ◽  
Surface Active Agents ◽  
Surface Active ◽  
Methacrylate Copolymer

The amorphous solid dispersions (ASDs) containing amino methacrylate copolymer and surface-active agents were prepared to improve the nifedipine (NDP) dissolution. The different types of surface-active agent i.e., polysorbates 80, sodium lauryl sulfate (SLS) and polyethylene glycol (PEG) 400 were used. In order to evaluate the ASDs formulation,powder X-ray diffractometry and thermal analysis to characterize NDP crystallinity in ASDs and the dissolution study of NDP have been performed to compare the dissolution profiles. The ASDs were kept for 6 months to investigate the stability. In the X-ray diffraction pattern, no peak was observed in all samples of ASDs. No peak was found in sample of all ASDs from the thermograms. These results suggest that the drug may be molecularly dispersed in matrix of amino methacrylate copolymer. The drug dissolution at 120 min, from ASDs without surface-active agent and NDP powder were 58.31% and 17.95%, respectively. The dissolved NDP from ASDs composed of SLS, polysorbate 80 and PEG400 were 96.25%, 88.86% and 75.32%, respectively. These results may occur due to the reduction of surface tension, the addition of the low amount of high efficiency of surface-active agent e.g., SLS (compared with PEG400 and polysorbate 80) provided the higher NDP dissolution. The content analysis of NDP in selected ASDs was studied at the end of 3 and 6 months, the NDP content remained unchanged after storage.

scholarly journals THE PATHOGENESIS OF HYPERLIPEMIA INDUCED BY MEANS OF SURFACE-ACTIVE AGENTS

1956 ◽  
Vol 104 (1) ◽  
pp. 1-13 ◽  
Author(s):  
Robert L. Hirsch ◽  
Aaron Kellner
Keyword(s):  
Surface Active Agent ◽  
Active Agent ◽  
Subcutaneous Injections ◽  
Surface Active Agents ◽  
Triton Wr 1339 ◽  
Surface Active

Mice rendered hyperlipemic by means of intravenous or subcutaneous injections of triton WR 1339 were found to have an increase in the total amount of cholesterol in their bodies. This observation indicates that the injected surface-active agent affects the metabolism of cholesterol and brings about hyperlipemia by augmenting the synthesis of lipides, or by interfering with their degradation or excretion, or by some combination of these factors. The implications of the findings for the pathogenesis of the hyperlipemia induced by triton are discussed further in the accompanying paper (16).

Drug-Loaded Pectin Microparticles Prepared by Emulsion-Solvent Evaporation

2012 ◽  
Vol 506 ◽  
pp. 282-285 ◽  
Author(s):  
Pornsak Sriamornsak ◽  
S. Konthong ◽  
K. Burapapadh ◽  
Srisagul Sungthongjeen
Keyword(s):  
Crystalline State ◽  
Amorphous Solid ◽  
Solvent Evaporation ◽  
Drug Dissolution ◽  
Amorphous Solid Dispersion ◽  
Degree Of Esterification ◽  
X Ray ◽  
Evaporation Technique ◽  
Model Drug ◽  
High Degree

The aim of this study was to develop the pectin-based microparticles by emulsion-solvent evaporation technique. The effects of concentration and type of pectin and addition of glutaraldehyde on size, size distribution, drug crystalline state and drug dissolution from microparticles were investigated. The results showed that a model drug, indomethacin, could be encapsulated in microparticles. Higher molecular weight of pectin caused a larger in size of microparticles than the lower one. A high degree of esterification is preferred to stabilize the pectin microparticles. The powder x-ray diffractograms showed that all microparticles led to amorphous products while their physical mixture still showed the crystalline state of drug. Drug dissolution from the microparticles containing indomethacin and pectin was increased, resulting from the formation of an amorphous solid dispersion. Addition of glutaraldehyde, however, resulted in slower drug dissolution, compared to the formulations without glutaraldehyde or drug alone.

Impacts of Surface-Active Agents on the Crystal Structure of Nano Manganese Oxide

2013 ◽  
Vol 798-799 ◽  
pp. 125-129
Author(s):  
Fu Yun Li ◽  
Jing Wang ◽  
Ying Yang Qin ◽  
Li Zhen Yang
Keyword(s):  
Crystal Structure ◽  
Manganese Oxide ◽  
Hydrothermal Method ◽  
Manganese Oxides ◽  
Surface Active Agent ◽  
Active Agent ◽  
Tween 80 ◽  
Surface Active Agents ◽  
Surface Active ◽  
Addition Amount

The nano manganese oxides were prepared with the hydrothermal method by adding surface-active agent. The influence of the type and addition amount of surface-active agent on the preparation of nano manganese oxides was studied. The products were characterized with XRD. Experimental results show that MnOOH is obtained at 180°C with the addition of N,N,N-trimethyl-1-dodecanaminium bromide, and Mn3O4is obtained at 180 °C with OP Emulsifier or Tween-80 added. Different addition amount of surface-active agent would have diverse effects on the purity of products.

scholarly journals Solubility Enhancement of Simvastatin through Surfactant Addition for Development of Hydrophobic Drug-Loaded Gelatin Hydrogel

2019 ◽  
Vol 19 (4) ◽  
pp. 920
Author(s):  
Niswati Fathmah Rosyida ◽  
Pinandi Sri Pudyani ◽  
Akhmad Kharis Nugroho ◽  
Ika Dewi Ana ◽  
Teguh Ariyanto
Keyword(s):  
Surface Active Agent ◽  
Active Agent ◽  
Polysorbate 80 ◽  
Hydrophobic Drug ◽  
Solubility Study ◽  
Gelatin Hydrogel ◽  
Hydrogel Microparticles ◽  
Varied Temperature ◽  
Surface Active ◽  
Uv Visible

This study aims to synthesize simvastatin hydrogel as drug delivery system with surfactant addition for improving solubility of simvastatin. Surfactants used in the study were the zwitterionic amino acid of arginine and nonionic surface-active agent of polysorbate 80. The solubility study was conducted by pouring of an excess mass of simvastatin into the solution of a surfactant in a conical flask. The sample was shaken up to 72 h in a mechanical water bath shaker at a varied temperature of 25, 40, and 50 °C. The amount of drug dissolved in solution was analyzed by UV/Visible spectrophotometer at 238 nm. The results showed that the simvastatin solubility is profoundly influenced by the surfactant type, surfactant concentration, and temperature. Polysorbate 80 exhibited as a better surfactant than arginine and an enhancement up to 1400 times, in respect of without any addition of a surfactant, was observed. Based on the solubility study, simvastatin-loaded gelatin hydrogel composite was formulated and the characterization (FTIR and SEM) showed the successful impregnation. The hydrogel microparticles of featured swelling indexes in the range of 2–6 for every patch and presented a sustained release profile.

Research on Optimal Formula of Dustfall Agent to Remove Blasting Smoke

2012 ◽  
Vol 534 ◽  
pp. 298-303
Author(s):  
Wei Niu ◽  
Zhong An Jiang ◽  
Ju Shi Chen
Keyword(s):  
Surface Active Agent ◽  
Sodium Dodecyl ◽  
Active Agent ◽  
Base Material ◽  
Sodium Dodecyl Benzene Sulfonate ◽  
Base Materials ◽  
Surface Active Agents ◽  
Optimal Surface ◽  
Dodecyl Benzene Sulfonate ◽  
Surface Active

In order to reduce dust produced during the blasting, effective measures according to smoke components and properties are required to be taken. The experiment adopted a number of base materials and surface-active agents to reduce the dust in smoke. Besides, corresponding additives were adopted to reduce poisonous and harmful gases during the blasting. Experiments focused on wettability and surface tension, using contrast experiment to determine optimal base material and surface-active agent, and also studied the influence of additives on their performance. The experimental results suggested that： sodium chloride was the optimal base material, sodium dodecyl benzene sulfonate was the optimal surface-active agent, and copper sulphate and ammonium chloride as additives had almost no influence on performance of surface-active agent and base material. Therefore, adding this dustfall agent to the water bag during the blasting can effectively reduce the concentration of smoke.

The Preparation of Fe3O4 Magnetic Nanometer Particle by Co-Precipitation Method

2012 ◽  
Vol 271-272 ◽  
pp. 320-323
Author(s):  
Xiao Chun Ma ◽  
Lei Hao Cui ◽  
Guang Fei Xu
Keyword(s):  
Electron Microscopy ◽  
Surface Active Agent ◽  
Active Agent ◽  
Precipitation Method ◽  
X Ray Diffraction ◽  
X Ray ◽  
Transmission Electron ◽  
Surface Active ◽  
Co Precipitation ◽  
Nanometer Particle

In this paper, the Fe3O4 magnetic nanometer particle was prepared by co-precipitation method. At the same time, the samples were characterized by X-ray diffraction (XRD) and transmission electron microscopy (TEM). The results show that the surface active agent (PEG4000) can be good for the dispersion performance of Fe3O4 magnetic nanometer particle; and the temperature of 80°C is the appropriate drying temperature to prepare the Fe3O4 magnetic nanometer particle.

Wind-generated waves in thin liquid films with soluble contaminant

1971 ◽  
Vol 45 (3) ◽  
pp. 527-544 ◽  
Author(s):  
F. I. P. Smith ◽  
Alex D. D. Craik
Keyword(s):  
Surface Active Agent ◽  
Active Agent ◽  
Theoretical Work ◽  
Liquid Films ◽  
Stream Flows ◽  
Surface Active Agents ◽  
Air Stream ◽  
Surface Active ◽  
The Stability

Craik (1968) has previously examined the stability of horizontal liquid films when an air stream flows over the liquid surface and when the surface is contaminated by an insoluble surface-active agent. The present theoretical work extends this investigation to examine the role of soluble surface-active agents for cases where the liquid Reynolds number is small. This role is found to be a rather complex one which, under suitable conditions, may be either stabilizing or destabilizing.Related experimental work is described which yields results in qualitative agreement with the theoretical analysis.

The Influence of Different Kinds of Surfactants on Rheology in Polymer/Surfactant Complex Flooding

2013 ◽  
Vol 437 ◽  
pp. 1089-1092
Author(s):  
Wei Lin Cui ◽  
Wu Ju Xu ◽  
Ling Jian Song
Keyword(s):  
Binary System ◽  
Enhanced Recovery ◽  
Surface Active Agent ◽  
Active Agent ◽  
Ionic Surfactant ◽  
Sweep Efficiency ◽  
Surface Active Agents ◽  
Linear Viscoelastic ◽  
Surface Active ◽  
Polymer Surfactant

Because of alkaline declining the sweep efficiency, causing scale formation problem in the reservoir and the well bottom and the tubular pipes, so polymer/surfactant compound flooding technology is the emphasis in the research of enhanced recovery. So the articles study the regulation of different kinds of surface active agents at different temperature by MARS Rheometer. The testing result showed that the variation of viscocity under the interaction between the surface active agent and association polymer according to “three stage” model .The linear viscoelastic region of stress decrease when different surface active agents are put into polymer liquor, and the higher frequency, the better elasticity of polymer liquor. The hydrophobic association between the surface active agents and polymer decrease with a higher temperature, but the ionic surfactant is aggravate. The systematic study of binary system rheology can contribute to correctly understand and apply binary system.

scholarly journals Influence of decyl glucoside on the electrodeposition of tin

2006 ◽  
Vol 71 (6) ◽  
pp. 661-668 ◽  
Author(s):  
Mohamed Charrouf ◽  
Said Bakkali ◽  
Mohammed Cherkaoui ◽  
Mahassin Amrani
Keyword(s):  
Surface Active Agent ◽  
Active Agent ◽  
Point Of View ◽  
X Ray Diffraction ◽  
X Ray ◽  
Deposition Kinetics ◽  
Structural Modifications ◽  
Surface Active ◽  
Acidic Sulphate

The aim of the present study was to improve an electrochemical deposition bath for tin coating an acidic sulphate medium by addition of decyl glucoside. The effects of this additve on the deposition kinetics were examined by electrochemical methods, namely voltammetry and galvanostatic tin-layer formation, while scanning electron microscopy and X-ray diffraction analysis allowed the determination of the morphological and structural modifications resulting from the addition of this new surface active agent. The presence of the examined additive induced an increase of the activation energy and of the overvoltage of the reduction of stannous ions. From the morphological point of view, a marked decrease in the grain size of the deposit was achieved in the presence of the additive. The preferential crystal growth axes was also changed from Sn (200) without additive to Sn (112) with the additive.

scholarly journals Ir-Ni based mono and bimetallic nanocrystals: synthesis, characterization and effect of cationic, anionic, and non-ionic stabilizers

2021 ◽  
pp. 209-220
Author(s):  
Anjali Goel ◽  
Shikha Shikha ◽  
Shivani Shivani ◽  
Sudha Tomar
Keyword(s):  
Reduction Method ◽  
Size Range ◽  
Surface Active Agent ◽  
Active Agent ◽  
Spherical Shape ◽  
Particle Size Range ◽  
Surface Active Agents ◽  
Bimetallic Nanocrystals ◽  
Surface Active ◽  
Cationic And Anionic Surfactants

Nickel based bimetallic nanocrystals, iridium-nickel play an imperative role in catalysis, electrocatalysis, and magnetic applications. In the present work Ir-Ni bimetallic nanoalloys were synthesized by modified polyol reduction method with different cationic, anionic, and non-ionic surface active agents like CTAB, SDS, TSC, and PVP. The non-ionic surface active agent PVP produced a better effect on nanoparticle size than cationic and anionic surfactants. The synthesized bimetallic nanocrystals were characterized by UV-Vis, XRD, FTIR, FESEM, and HRTEM techniques. XRD and FTIR verify the nature of synthesized bimetallic nanocrystals and the interaction between stabilizers and nanoparticles. HRTEM studies reveal that the PVP stabilized Ir-Ni (3:1) and Ir-Ni (1:1) bimetallic nanocrystals are small in size and less dispersed. Particle size range of these nanoparticles is from (1.77-2.36) nm. FESEM images show that nanoparticles are in quasi spherical shape. EDX analysis indicates that the resultant particles are core shell structure with Ni core and Ir shell.

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