scholarly journals Antineutrophil Cytoplasmic Antibodies Negative Microscopic Polyangiitis With Initial Pulmonary Manifestation

2020 ◽  
Vol 27 (3) ◽  
pp. 203-208
Author(s):  
Jeong Seon Lee ◽  
Min Su Oh ◽  
Jin-Haeng Chung ◽  
Soyoung Lee ◽  
Ji-Won Kwon
Keyword(s):  
Microscopic Polyangiitis ◽  
Antineutrophil Cytoplasmic Antibodies ◽  
Pulmonary Manifestation

scholarly journals Asbestos and Probable Microscopic Polyangiitis

2004 ◽  
Vol 11 (5) ◽  
pp. 359-362 ◽  
Author(s):  
George S Rashed Philteos ◽  
Kelly Coverett ◽  
Rajni Chibbar ◽  
Heather A Ward ◽  
Donald W Cockcroft
Keyword(s):  
Autoimmune Diseases ◽  
Lung Diseases ◽  
Microscopic Polyangiitis ◽  
Present Report ◽  
Vascular Diseases ◽  
Antineutrophil Cytoplasmic Antibody ◽  
Antineutrophil Cytoplasmic Antibodies ◽  
Collagen Vascular Diseases ◽  
Immunological Mechanisms ◽  
Pulmonary Asbestosis

Several inorganic dust lung diseases (pneumoconioses) are associated with autoimmune diseases. Although autoimmune serological abnormalities are common in asbestosis, clinical autoimmune/collagen vascular diseases are not commonly reported. A case of pulmonary asbestosis complicated by perinuclear-antineutrophil cytoplasmic antibody (myeloperoxidase) positive probable microscopic polyangiitis (glomerulonephritis, pericarditis, alveolitis, multineuritis multiplex) is described and the possible immunological mechanisms whereby asbestosis fibres might be relevant in induction of antineutrophil cytoplasmic antibodies are reviewed in the present report.

scholarly journals Clinical Characteristics and Outcome of ANCA-Associated Vasculitis; Experience of A Single Reference Vasculitis Center

Acta Medica ◽  
2020 ◽  
Vol 51 (4) ◽  
pp. 22-32
Author(s):  
İlim Irmak ◽  
Silam Bas ◽  
Maide Gözde Inam ◽  
Fatih Tekin ◽  
Berkay Yesilyurt ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Clinical Characteristics ◽  
Granulomatosis With Polyangiitis ◽  
Microscopic Polyangiitis ◽  
Demographic Data ◽  
Pulmonary Involvement ◽  
Antineutrophil Cytoplasmic Antibodies ◽  
Eosinophilic Granulomatosis With Polyangiitis ◽  
Proteinase 3 ◽  
Thoracic Computed Tomography

Objective: The aim of the study is to describe the clinical characteristics of Antineutrophil cytoplasmic antibodies-associated vasculitis and to analyze the parameters affecting the outcome. Materials and Methods: The study is a retrospective cohort study. Totally 130 patients with Antineutrophil cytoplasmic antibodies-associated vasculitis (18 years and over) who were followed up between October 2014 and October 2019 were analyzed. Demographic data, laboratory values, clinical course, thorax computed tomography findings and treatment approaches were noted from the charts of patients. Patients were divided into two groups as those with pulmonary involvement and non-pulmonary involvement. Results: We retrospectively reviewed the medical records of 130 patients with Antineutrophil cytoplasmic antibodies-associated vasculitis; 111 with granulomatosis with polyangiitis, 15 with microscopic polyangiitis, 1 with eosinophilic granulomatosis with polyangiitis, and 3 with other types of vasculitis. The ratio of having the abnormality in thoracic computed tomography was 72.2%. There were 84 cases with pulmonary involvement and 46 cases with non-pulmonary involvement. The frequency of microscopic polyangiitis was significantly higher (p=0.034) in non-pulmonary involvement cases. There were 67 cases with proteinase 3 Antineutrophil cytoplasmic antibodies and 39 cases with myeloperoxidase Antineutrophil cytoplasmic antibodies positivity. Most of the cases with proteinase 3 Antineutrophil cytoplasmic antibodies positivity were classified as granulomatosis with polyangiitis, this was statistically significant. Recovery was referenced for the outcome. Any of the variables were found statistically significant effective on outcome. Conclusions: Cases with pulmonary involvement were more than the cases without pulmonary involvement in our study. microscopic polyangiitis was significantly higher in non- pulmonary involvement cases. We studied on a large group, and these significant findings may have important implications for the investigation, pathogenesis, and treatment of Antineutrophil cytoplasmic antibodies-associated vasculitis.

scholarly journals Silicosis, then microscopic polyangiitis-antineutrophil cytoplasmic antibodies-associated vasculitis may be work-related disease in patients with silicosis

2017 ◽  
Vol 18 (5) ◽  
pp. 288-290 ◽  
Author(s):  
Yoshito Nishimura ◽  
Tomohiro Tsuda ◽  
Shinichi Nishina ◽  
Akiyoshi Omoto ◽  
Mahito Misawa ◽  
...  
Keyword(s):  
Microscopic Polyangiitis ◽  
Antineutrophil Cytoplasmic Antibodies ◽  
Work Related ◽  
Related Disease

scholarly journals Microscopic Polyangiitis Accompanied by Pleuritis as the only Pulmonary Manifestation of Occupational Silica Exposure

2010 ◽  
Vol 49 (10) ◽  
pp. 925-929 ◽  
Author(s):  
Hideki Shibuya ◽  
Hiroko Sano ◽  
Kou Osamura ◽  
Kosei Kujime ◽  
Kei Hara ◽  
...  
Keyword(s):  
Microscopic Polyangiitis ◽  
Silica Exposure ◽  
Pulmonary Manifestation

scholarly journals HLA-DR in Brazilian Patients with Polyarteritis Nodosa (PAN) and Microscopic Polyangiitis (MPA)

2009 ◽  
Vol 26 (3) ◽  
pp. 105-109 ◽  
Author(s):  
Alzírton de Lira Freire ◽  
Roseneide Aparecida Conde ◽  
Manoel Barros Bertolo ◽  
Lílian Teresa Lavras Costallat ◽  
Maurício Levy-Neto ◽  
...  
Keyword(s):  
Polyarteritis Nodosa ◽  
Microscopic Polyangiitis ◽  
Systemic Vasculitis ◽  
Severe Disease ◽  
Consensus Conference ◽  
Antineutrophil Cytoplasmic Antibodies ◽  
Eular Recommendations ◽  
American College Of Rheumatology ◽  
Hla Dr ◽  
Caucasian Patients

The aim of this study was to evaluate the frequency and clinical associations of HLA-DR alleles in Brazilian Caucasian patients with polyarteritis nodosa (PAN) or microscopic polyangiitis (MPA). We evaluated 29 Caucasian patients with vasculitis classified as PAN or MPA according to the American College of Rheumatology (ACR) 1990 Criteria, Chapel Hill Consensus Conference (CHCC) nomenclature for vasculitis and EULAR recommendations for conducting clinical studies in systemic vasculitis. HLA-DR alleles were typed using polymerase chain reaction-amplified DNA, hybridized with sequence-specific low resolution primers. DNA obtained from 59 Caucasian healthy blood donors were used as control. In order to evaluate if a specific HLA may have influence on the clinical profile of those diseases, we also divided the patients according to Birmingham vasculitis score (BVAS) and Five-Factors Score (FFS) at the time of diagnosis. Increased frequency of HLA-DRB1*16 (p= 0.023) and DRB4*01 (p= 0.048) was found in patients with higher disease activity at the time of diagnosis (BVAS ≥ 22). Patients with less severe disease (FFS = 0) had a higher frequency of HLA-DRB1*03 (p= 0.011). Patients with gastrointestinal tract involvement had significantly increased frequency of HLA-DRB1*11 or B1*12 (p= 0.046), B1*13 (p= 0.021) and B3 (p= 0.008). In contrast, patients with renal disease, had higher frequency of DRB1*15 or DRB1*16 (p= 0.035) and B5 (p= 0.035). In the subgroup of patients with MPA, increased frequency of HLA-DRB1*15 was found in patients with BVAS ≥ 22 (p= 0.038) and FFS ≥ 1 (p= 0.039) suggesting that this allele is associated with more aggressive disease. Antineutrophil cytoplasmic antibodies (ANCA) negative MPA patients had significantly increased frequency of HLA-DRB1*11 or DRB1*12 when compared to ANCA positive patients (p= 0.023). Our results suggest that HLA-DR alleles may influence PAN and MPA clinical expression and outcome and that in MPA they participate in the mechanisms involved in the development to ANCA.

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