scholarly journals Electroconvulsive therapy hasn’t negative effects on short-term memory function, as assessed using a bedside hand-held device

2017 ◽  
Vol 9 (1) ◽  
Author(s):  
Helge H.O. Müller ◽  
Mareen Reike ◽  
Simon Grosse-Holz ◽  
Mareike Röther ◽  
Caroline Lücke ◽  
...  
Keyword(s):  
Cognitive Performance ◽  
Electroconvulsive Therapy ◽  
Short Term Memory ◽  
Memory Function ◽  
Memory Deficits ◽  
Treatment Resistant ◽  
Negative Effects ◽  
Short Term ◽  
Term Memory ◽  
Digital Measurements

Electroconvulsive therapy (ECT) is effective in the treatment of treatment-resistant major depression. The fear of cognitive impairment after ECT often deters patients from choosing this treatment option. There is little reliable information regarding the effects of ECT on overall cognitive performance, while short-term memory deficits are well known but not easy to measure within clinical routines. In this pilot study, we examined ECT recipients’ pre- and posttreatment performances on a digital ascending number tapping test. We found that cognitive performance measures exhibited good reproducibility in individual patients and that ECT did not significantly alter cognitive performance up to 2 hours after this therapy was applied. Our results can help patients and physicians make decisions regarding the administration of ECT. Digital measurements are recommended, especially when screening for the most common side effects on cognitive performance and short-term memory.

scholarly journals Electroconvulsive therapy hasn't negative effects on short-term memory function, as assessed using a bedside hand-held device

2017 ◽  
Vol 9 (1) ◽  
pp. 30-35 ◽  
Author(s):  
Helge H.O. Müller ◽  
Mareen Reike ◽  
Simon Grosse-Holz ◽  
Mareike Röther ◽  
Caroline Lücke ◽  
...  
Keyword(s):  
Cognitive Performance ◽  
Electroconvulsive Therapy ◽  
Short Term Memory ◽  
Memory Function ◽  
Memory Deficits ◽  
Treatment Resistant ◽  
Negative Effects ◽  
Short Term ◽  
Term Memory ◽  
Digital Measurements

Electroconvulsive therapy (ECT) is effective in the treatment of treatment-resistant major depression. The fear of cognitive impairment after ECT often deters patients from choosing this treatment option. There is little reliable information regarding the effects of ECT on overall cognitive performance, while short-term memory deficits are well known but not easy to measure within clinical routines. In this pilot study, we examined ECT recipients' pre- and post-treatment performances on a digital ascending number tapping test. We found that cognitive performance measures exhibited good reproducibility in individual patients and that ECT did not significantly alter cognitive performance up to 2 hours after this therapy was applied. Our results can help patients and physicians make decisions regarding the administration of ECT. Digital measurements are recommended, especially when screening for the most common side effects on cognitive performance and short-term memory.

Effectiveness of humor on short term memory function in age matched elderly and diabetic subjects vs. control group

2013 ◽  
Author(s):  
Gurinder S. Bains ◽  
Lee Berk ◽  
Noha Daher ◽  
Pooja Deshpande ◽  
Everett Lohman ◽  
...  
Keyword(s):  
Short Term Memory ◽  
Memory Function ◽  
Control Group ◽  
Short Term ◽  
Term Memory

scholarly journals Higher Handgrip Strength Is Linked to Better Cognitive Performance in Chinese Adults with Hypertension

2021 ◽  
Vol 11 (8) ◽  
pp. 985
Author(s):  
Shenghua Lu ◽  
Fabian Herold ◽  
Yanjie Zhang ◽  
Yuruo Lei ◽  
Arthur F. Kramer ◽  
...  
Keyword(s):  
Cognitive Performance ◽  
Short Term Memory ◽  
Handgrip Strength ◽  
Adult Health ◽  
Linear Regression Models ◽  
Chinese Adults ◽  
Short Term ◽  
Term Memory ◽  
Using Data ◽  
The Relationship

Objective: There is growing evidence that in adults, higher levels of handgrip strength (HGS) are linked to better cognitive performance. However, the relationship between HGS and cognitive performance has not been sufficiently investigated in special cohorts, such as individuals with hypertension who have an intrinsically higher risk of cognitive decline. Thus, the purpose of this study was to examine the relationship between HGS and cognitive performance in adults with hypertension using data from the Global Ageing and Adult Health Survey (SAGE). Methods: A total of 4486 Chinese adults with hypertension from the SAGE were included in this study. Absolute handgrip strength (aHGS in kilograms) was measured using a handheld electronic dynamometer, and cognitive performance was assessed in the domains of short-term memory, delayed memory, and language ability. Multiple linear regression models were fitted to examine the association between relative handgrip strength (rHGS; aHGS divided by body mass index) and measures of cognitive performance. Results: Overall, higher levels of rHGS were associated with higher scores in short-term memory (β = 0.20) and language (β = 0.63) compared with the lowest tertiles of rHGS. In male participants, higher HGS was associated with higher scores in short-term memory (β = 0.31), language (β = 0.64), and delayed memory (β = 0.22). There were no associations between rHGS and cognitive performance measures in females. Conclusion: We observed that a higher level of rHGS was associated with better cognitive performance among hypertensive male individuals. Further studies are needed to investigate the neurobiological mechanisms, including sex-specific differences driving the relationship between measures of HGS and cognitive performance in individuals with hypertension.

scholarly journals Explaining semantic short-term memory deficits: Evidence for the critical role of semantic control

2011 ◽  
Vol 49 (3) ◽  
pp. 368-381 ◽  
Author(s):  
Paul Hoffman ◽  
Elizabeth Jefferies ◽  
Matthew A. Lambon Ralph
Keyword(s):  
Short Term Memory ◽  
Critical Role ◽  
Memory Deficits ◽  
Short Term ◽  
Term Memory

scholarly journals Effects of Dehydration and Rehydration on Cognitive Performance and Mood among Male College Students in Cangzhou, China: A Self-Controlled Trial

2019 ◽  
Vol 16 (11) ◽  
pp. 1891 ◽  
Author(s):  
Na Zhang ◽  
Song M. Du ◽  
Jian F. Zhang ◽  
Guan S. Ma
Keyword(s):  
Cognitive Performance ◽  
Test Scores ◽  
Short Term Memory ◽  
Digit Span ◽  
Error Rates ◽  
Digit Symbol ◽  
Short Term ◽  
Mental Work ◽  
Term Memory ◽  
Baseline Test

Water accounts for 75% of brain mass. Associations may exist between hydration and cognitive performance. The objective of this study was to investigate the effects of dehydration and rehydration on cognitive performance and mood. In this self-control trial, 12 men were recruited from a medical college in Cangzhou, China. After 12 h of overnight fasting, the participants took baseline tests at 8:00 AM on day 2. First morning urine and blood osmolality were analyzed to determine hydration state. Height, weight, and blood pressure were measured following standardized procedures. A visual analog scale for the subjective sensation of thirst was applied, and a profile of mood states questionnaire was applied. Tests were conducted for cognitive performance, including a test of digit span forward and backward, digit-symbol substitutions, dose-work, and stroop effects. Participants were required not to drink water for 36 h but were given three meals on day 3. On day 4, the same indexes were tested as a baseline test. At 8:30 AM, participants drank 1500 mL of purified water over 15 min. After a 1 h interval, the same measurements were performed. Compared with baseline test results, during the dehydration test, participants had lower scores of vigor (11.9 vs. 8.8, %, p = 0.007) and esteem-related affect (8.2 vs. 5.7, %, p = 0.006), lower total scores of digit span (14.3 vs. 13.3, %, p = 0.004), and higher error rates for dose-work (0.01 vs. 0.16, %, p = 0.005). Compared with the dehydration test scores, rehydration test scores showed that fatigue (4.3 vs. 2.1, %, p = 0.005) and total mood disturbance (TMD) (99.0 vs. 90.2, %, p = 0.008) improved, and scores of forward, backward, and total digit span increased (7.7 vs. 8.6, p = 0.014; 5.7 vs. 1.2, p = 0.019; 13.3 vs. 15.4, p = 0.001). Increases were also noted in correct number of digit symbol substitutions, reading speed, and mental work ability (70.8 vs. 75.4, p < 0.001; 339.3 vs. 486.4, n/min, p < 0.001; 356.1 vs. 450.2, p < 0.001), and reaction time decreased (30.2 vs. 28.7, s, p = 0.002). As a conclusion, dehydration had negative effects on vigor, esteem-related affect, short-term memory, and attention. Rehydration after water supplementation alleviated fatigue and improved TMD, short-term memory, attention, and reaction.

Acute Exercise and Sustained Attention on Memory Function

2020 ◽  
Vol 44 (3) ◽  
pp. 326-332
Author(s):  
Audreaiona Waters ◽  
Liye Zou ◽  
Myungjin Jung ◽  
Qian Yu ◽  
Jingyuan Lin ◽  
...  
Keyword(s):  
Neural Networks ◽  
Sustained Attention ◽  
Acute Exercise ◽  
Short Term Memory ◽  
Memory Function ◽  
Long Term Memory ◽  
Short Term ◽  
Attention Task ◽  
Term Memory

Objective: Sustained attention is critical for various activities of daily living, including engaging in health-enhancing behaviors and inhibition of health compromising behaviors. Sustained attention activates neural networks involved in episodic memory function, a critical cognition for healthy living. Acute exercise has been shown to activate these same neural networks. Thus, it is plausible that engaging in a sustained attention task and engaging in a bout of acute exercise may have an additive effect in enhancing memory function, which was the purpose of this experiment. Methods: 23 young adults (Mage = 20.7 years) completed 2 visits, with each visit occurring approximately 24 hours apart, in a counterbalanced order, including: (1) acute exercise with sustained attention, and (2) sustained attention only. Memory was assessed using a word-list paradigm and included a short- and long-term memory assessment. Sustained attention was induced via a sustained attention to response task (SART). Acute exercise involved a 15-minute bout of moderate-intensity exercise. Results: Short-term memory performance was significantly greater than long-term memory, Mdiff = 1.86, p < .001, and short-term memory for Exercise with Sustained Attention was significantly greater than short-term memory for Sustained Attention Only, Mdiff = 1.50, p = .01. Conclusion: Engaging in an acute bout of exercise before a sustained attention task additively influenced short-term memory function.

scholarly journals Increasing cerebral blood flow improves cognition into late stages in Alzheimer’s disease mice

2019 ◽  
Vol 40 (7) ◽  
pp. 1441-1452 ◽  
Author(s):  
Oliver Bracko ◽  
Brendah N Njiru ◽  
Madisen Swallow ◽  
Muhammad Ali ◽  
Mohammad Haft-Javaherian ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Short Term Memory ◽  
Memory Function ◽  
Neutrophil Adhesion ◽  
Short Term ◽  
Term Memory ◽  
Model Of Alzheimer’S Disease

Alzheimer’s disease is associated with a 20–30% reduction in cerebral blood flow. In the APP/PS1 mouse model of Alzheimer’s disease, inhibiting neutrophil adhesion using an antibody against the neutrophil specific protein Ly6G was recently shown to drive rapid improvements in cerebral blood flow that was accompanied by an improvement in performance on short-term memory tasks. Here, in a longitudinal aging study, we assessed how far into disease development a single injection of anti-Ly6G treatment can acutely improve short-term memory function. We found that APP/PS1 mice as old as 15–16 months had improved performance on the object replacement and Y-maze tests of spatial and working short-term memory, measured at one day after anti-Ly6G treatment. APP/PS1 mice at 17–18 months of age or older did not show acute improvements in cognitive performance, although we did find that capillary stalls were still reduced and cerebral blood flow was still increased by 17% in 21–22-months-old APP/PS1 mice given anti-Ly6G antibody. These data add to the growing body of evidence suggesting that cerebral blood flow reductions are an important contributing factor to the cognitive dysfunction associated with neurodegenerative disease. Thus, interfering with neutrophil adhesion could be a new therapeutic approach for Alzheimer’s disease.

scholarly journals Selective memory and behavioral alterations after ambient ultrafine particulate matter exposure in aged 3xTgAD Alzheimer’s disease mice

2019 ◽  
Vol 16 (1) ◽  
Author(s):  
Katrina Jew ◽  
Denise Herr ◽  
Candace Wong ◽  
Andrea Kennell ◽  
Keith Morris-Schaffer ◽  
...  
Keyword(s):  
Locomotor Activity ◽  
Learning And Memory ◽  
Spatial Learning ◽  
Short Term Memory ◽  
Memory Deficits ◽  
Olfactory Discrimination ◽  
Spatial Learning And Memory ◽  
Short Term ◽  
Term Memory ◽  
Appetitive Motivation

Abstract Background A growing body of epidemiological literature indicates that particulate matter (PM) air pollution exposure is associated with elevated Alzheimer’s disease (AD) risk and may exacerbate AD-related cognitive decline. Of concern is exposure to the ultrafine PM (UFP) fraction (≤100 nm), which deposits efficiently throughout the respiratory tract, has higher rates of translocation to secondary organs, like brain, and may induce inflammatory changes. We, therefore, hypothesize that exposure to UFPs will exacerbate cognitive deficits in a mouse model of AD. The present study assessed alterations in learning and memory behaviors in aged (12.5 months) male 3xTgAD and non-transgenic mice following a 2-week exposure (4-h/day, 4 days/week) to concentrated ambient UFPs using the Harvard ultrafine concentrated ambient particle system (HUCAPS) or filtered air. Beginning one month following exposure, locomotor activity, spatial learning and memory, short-term recognition memory, appetitive motivation, and olfactory discrimination were assessed. Results No effects on locomotor activity were found following HUCAPS exposure (number concentration, 1 × 104–4.7 × 105 particles/cm3; mass concentration, 29–132 μg/m3). HUCAPS-exposed mice, independent of AD background, showed a significantly decreased spatial learning, mediated through reference memory deficits, as well as short-term memory deficits in novel object recognition testing. AD mice displayed diminished spatial working memory, potentially a result of olfactory deficits, and short-term memory. AD background modulated HUCAPS-induced changes on appetitive motivation and olfactory discrimination, specifically enhancing olfactory discrimination in NTg mice. Modeling variation in appetitive motivation as a covariate in spatial learning and memory, however, did not support the conclusion that differences in motivation significantly underlie changes in spatial learning and memory. Conclusions A short-term inhalation exposure of aged mice to ambient UFPs at human-relevant concentrations resulted in protracted (testing spanning 1–6.5 months post-exposure) adverse effects on multiple memory domains (reference and short-term memory) independent of AD background. Impairments in learning and memory were present when accounting for potential covariates like motivational changes and locomotor activity. These results highlight the need for further research into the potential mechanisms underlying the cognitive effects of UFP exposure in adulthood.

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