scholarly journals Comparison of saccadic reaction time between normal and glaucoma using an eye movement perimeter

2014 ◽  
Vol 62 (1) ◽  
pp. 55 ◽  
Author(s):  
Ronnie George ◽  
Jvan der Steen ◽  
Deepmala Mazumdar ◽  
JJM Pel ◽  
Manish Panday ◽  
...  
2019 ◽  
Vol 8 (4) ◽  
pp. 13 ◽  
Author(s):  
Deepmala Mazumdar ◽  
Najiya S. Kadavath Meethal ◽  
Manish Panday ◽  
Rashima Asokan ◽  
Gijs Thepass ◽  
...  

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Deepmala Mazumdar ◽  
Najiya S. Kadavath Meethal ◽  
Ronnie George ◽  
Johan J. M. Pel

AbstractIn eye movement perimetry (EMP), the saccadic reaction time (SRT) to ‘seen’ visual stimuli are delayed in glaucoma. Evaluating SRT behaviour in hemi-field sectors could refine its clinical implication. The development phase included 60 controls retrospectively and for the test cohort in evaluation phase, another 30 healthy subjects and 30 glaucoma patients were recruited prospectively. The SRTs were used to calculate the normative limits within 5 predefined hemi-field sectors. Scores were assigned to probabilities for SRT at the level of 5%, 2.5% 1% and 0.5%. Per sector pair, a probability score limit (PSL) was calculated at each of the four levels and were compared with the scores obtained from the test cohort. The classification accuracy ‘normal versus abnormal’ was assessed for PSL in EMP and compared with glaucoma hemi-field test in standard automated perimetry. We found no statistically significant differences in SRTs between the mirror sectors in healthy subjects. The PSL at 2.5% had moderate classification accuracy with a specificity of 77% and sensitivity 70%. This could be suggestive of an SRT delay in the overall visual field in glaucoma.


2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Susanne Hopf ◽  
Caroline Nowak ◽  
Julia B. Hennermann ◽  
Irene Schmidtmann ◽  
Norbert Pfeiffer ◽  
...  

2020 ◽  
Vol 14 ◽  
Author(s):  
Shimpei Yamagishi ◽  
Shigeto Furukawa

It is often assumed that the reaction time of a saccade toward visual and/or auditory stimuli reflects the sensitivities of our oculomotor-orienting system to stimulus saliency. Endogenous factors, as well as stimulus-related factors, would also affect the saccadic reaction time (SRT). However, it was not clear how these factors interact and to what extent visual and auditory-targeting saccades are accounted for by common mechanisms. The present study examined the effect of, and the interaction between, stimulus saliency and audiovisual spatial congruency on the SRT for visual- and for auditory-target conditions. We also analyzed pre-target pupil size to examine the relationship between saccade preparation and pupil size. Pupil size is considered to reflect arousal states coupling with locus-coeruleus (LC) activity during a cognitive task. The main findings were that (1) the pattern of the examined effects on the SRT varied between visual- and auditory-auditory target conditions, (2) the effect of stimulus saliency was significant for the visual-target condition, but not significant for the auditory-target condition, (3) Pupil velocity, not absolute pupil size, was sensitive to task set (i.e., visual-targeting saccade vs. auditory-targeting saccade), and (4) there was a significant correlation between the pre-saccade absolute pupil size and the SRTs for the visual-target condition but not for the auditory-target condition. The discrepancy between target modalities for the effect of pupil velocity and between the absolute pupil size and pupil velocity for the correlation with SRT may imply that the pupil effect for the visual-target condition was caused by a modality-specific link between pupil size modulation and the SC rather than by the LC-NE (locus coeruleus-norepinephrine) system. These results support the idea that different threshold mechanisms in the SC may be involved in the initiation of saccades toward visual and auditory targets.


2013 ◽  
Vol 90 (3) ◽  
pp. 347-353
Author(s):  
Walter Machado-Pinheiro ◽  
Aydamari Faria ◽  
Filipe Braga ◽  
Pedro Guerra ◽  
Pandelis Perakakis ◽  
...  

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