scholarly journals Accelerating peripheral nerve regeneration using electrical stimulation of selected power spectral densities

2022 ◽  
Vol 17 (4) ◽  
pp. 781
Author(s):  
VincentC.-F. Chen ◽  
Wei-Ming Yu ◽  
MadelynA McCullen
2011 ◽  
Vol 29 (2) ◽  
pp. 88-93 ◽  
Author(s):  
Motohiro Inoue ◽  
Yasukazu Katsumi ◽  
Megumi Itoi ◽  
Tatsuya Hojo ◽  
Miwa Nakajima ◽  
...  

Neurosurgery ◽  
2009 ◽  
Vol 65 (suppl_4) ◽  
pp. A132-A144 ◽  
Author(s):  
Tessa Gordon ◽  
K. Ming Chan ◽  
Olawale A.R. Sulaiman ◽  
Esther Udina ◽  
Nasim Amirjani ◽  
...  

Abstract OBJECTIVE Injured peripheral nerves regenerate at very slow rates. Therefore, proximal injury sites such as the brachial plexus still present major challenges, and the outcomes of conventional treatments remain poor. This is in part attributable to a progressive decline in the Schwann cells' ability to provide a supportive milieu for the growth cone to extend and to find the appropriate target. These challenges are compounded by the often considerable delay of regeneration across the site of nerve laceration. Recently, low-frequency electrical stimulation (as brief as an hour) has shown promise, as it significantly accelerated regeneration in animal models through speeding of axon growth across the injury site. METHODS To test whether this might be a useful clinical tool, we carried out a randomized controlled trial in patients who had experienced substantial axonal loss in the median nerve owing to severe compression in the carpal tunnel. To further elucidate the potential mechanisms, we applied rolipram, a cyclic adenosine monophosphate agonist, to rats after axotomy of the femoral nerve. RESULTS We demonstrated that effects similar to those observed in animal studies could also be attained in humans. The mechanisms of action of electrical stimulation likely operate through up-regulation of neurotrophic factors and cyclic adenosine monophosphate. Indeed, the application of rolipram significantly accelerated nerve regeneration. CONCLUSION With new mechanistic insights into the influencing factors of peripheral nerve regeneration, the novel treatments described above could form part of an armament of synergistic therapies that could make a meaningful difference to patients with peripheral nerve injuries.


2018 ◽  
Vol 302 ◽  
pp. 75-84 ◽  
Author(s):  
J.L.B. Senger ◽  
V.M.K. Verge ◽  
H.S.J. Macandili ◽  
J.L. Olson ◽  
K.M. Chan ◽  
...  

2012 ◽  
Vol 39 (6) ◽  
pp. 540-547 ◽  
Author(s):  
Peng-Cheng ZHAO ◽  
Yong-Gang LV ◽  
Yang ZOU ◽  
Xiao-Mei ZHANG ◽  
Guo-Bao CHEN ◽  
...  

2021 ◽  
Author(s):  
Moataz Dowaidar

In the U.S., peripheral nerve injuries (PNI) harm about 22 million people. The most frequent causes and types of PNI vary by demography (civilians vs. military, geography/country). After crush injuries, functional recovery is better than after transections, and better after distal injuries than proximal ones. Despite advancements in microsurgical treatments, severe PNIs remain connected to slow recovery. This review highlights new peripheral nerve regeneration approaches (e.g. electrical stimulation, cell therapies), which may lead to a shift in PNI therapeutic paradigms in conjunction with neurotrophic agents and breakthroughs in bioscaffold engineering. It also examines how synthetic neural scaffolds can aid with peripheral nerve recovery, as well as the next generation of biomimetic neural scaffolding that can aid in tissue regeneration. Neurotrophic factor-enriched neural scaffolds, stem cell treatments, and electrical stimulation have shown promising preclinical and even clinical results. The future of peripheral nerve regeneration is bright, since a combination of the aforementioned treatments may have a synergistic impact on nerve regeneration and functional recovery in patients with PNI. Stem cell technology is improving and evolving, and it has been explored through a number of methods in preclinical research for peripheral nerve regeneration. Electrical stimulation is another interesting potential treatment for PNI that may be used to stimulate axon regeneration.


2012 ◽  
Vol 72 (1) ◽  
pp. 199-205 ◽  
Author(s):  
Chun-Hsu Yao ◽  
Ruey-Lin Chang ◽  
Shih-Liang Chang ◽  
Chin-Chuan Tsai ◽  
Fuu-Jen Tsai ◽  
...  

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