scholarly journals Protective Role of Angiotensin II Type 1 Receptor Blocker on Short Time Effect of Oleic Acid Induced Lung and Kidney Injury

2021 ◽  
Vol 12 (1) ◽  
pp. 4
Author(s):  
Mehdi Nematbakhsh ◽  
Ardeshir Talebi ◽  
Fatemeh Emami ◽  
Reza Biranvand ◽  
Zahra Moosavi ◽  
...  
2008 ◽  
Vol 10 (3) ◽  
pp. 201-207 ◽  
Author(s):  
Gregory P. Vyssoulis ◽  
Eva A. Karpanou ◽  
Stella-Maria G. Kyvelou ◽  
Dionysios N. Adamopoulos ◽  
George C. Antonakoudis ◽  
...  

2020 ◽  
Vol 88 (12) ◽  
pp. 2081-2089
Author(s):  
ALAA I. ALI, M.D.; DOAA A. ABDEL MOETY, M.D. ◽  
EBTESAM M. IBRAHIM, M.D.; MAHMOUD M.A. ABULMEATY, M.D.

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pp. 1-8
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Saeed Aali ◽  
Borzoo Khaledifar ◽  
Gordon A. Ferns ◽  
Majid Khazaei ◽  
...  

<b><i>Background:</i></b> Post-surgical adhesion bands (PSABs) are a common complication after abdominal or pelvic surgeries for different reasons like cancer treatment. Despite improvements in surgical techniques and the administration of drugs or the use of physical barriers, there has only been limited improvement in the frequency of postoperative adhesions. Complications of PSAB are pain, infertility, intestinal obstruction, and increased mortality. The most important molecular mechanisms for the development of PSAB are inflammatory response, oxidative stress, and overexpression of pro-fibrotic molecules such as transforming growth factor β. However, questions remain about the pathogenesis of this problem, for example, the causes for individual differences or why certain tissue sites are more prone to post-surgical adhesions. <b><i>Summary:</i></b> Addressing the pathological causes of PSAB, the potential role of local angiotensin II/angiotensin II type 1 receptors (AngII/AT1R), may help to prevent this problem. <b><i>Key Message:</i></b> The objective of this article was to explore the role of the AngII/AT1R axis potential to induce PSAB and the therapeutic potential of angiotensin receptor blockers in the prevention and treatment of PSAB.


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