scholarly journals HPTLC and RP-HPTLC Method Development and Validation for the Estimation of Felodipine in Bulk and Pharmaceutical Formulation

2018 ◽  
Vol 9 (11) ◽  
Author(s):  
Jain PS ◽  
Ansari NA ◽  
Surana SJ
2013 ◽  
Vol 25 (7) ◽  
pp. 3827-3830
Author(s):  
Avinash G. Darshana A. Patil ◽  
Aqsa Y. Ansari ◽  
Swapneel P. Koli ◽  
Darshana A. Patil

2011 ◽  
Vol 8 (3) ◽  
pp. 1444-1450 ◽  
Author(s):  
K. Ashok Kumar ◽  
S. Ramachandra Shetty ◽  
Laxmi Narasu

A simple, precise and accurate high-performance thin-layer chromatographic method has been established for the determination of rutin in the stem extract ofHibiscus micranthusLinn. A flavonoid fraction of methanolic extract of the stem powder was used for the experimental work. Separation was performed on silica gel 60 F254HPTLC plates withn-butanol: acetic acid: water: ammonia 3:1:1:1(v/v), as mobile phase. The determination was carried out using the densitometric absorbance mode at 286 nm. Rutin response was linear over the range 50–400 ng/μL. The concentration of rutin in the flavanoidal fraction was found to be 9.93%. The HPTLC method was evaluated in terms of sensitivity, accuracy, precision and reproducibility.


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