scholarly journals Heat shock protein 20 promotes sirtuin 1-dependent cell proliferation in induced pluripotent stem cells

2021 ◽  
Vol 13 (6) ◽  
pp. 659-669
Author(s):  
Mujib Ullah ◽  
Nicole Pek Min Qian ◽  
Gustavo Yannarelli ◽  
Asma Akbar
Keyword(s):  
Stem Cells ◽  
Cell Proliferation ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Sirtuin 1 ◽  
Heat Shock Protein 20 ◽  
Dependent Cell ◽  
Induced Pluripotent

scholarly journals MicroRNA-199a induces differentiation of induced pluripotent stem cells into endothelial cells by targeting sirtuin 1

2015 ◽  
Vol 12 (3) ◽  
pp. 3711-3717 ◽  
Author(s):  
ZHOUBIN LI ◽  
ANDRIANA MARGARITI ◽  
YUTAO WU ◽  
FENG YANG ◽  
JIAN HU ◽  
...  
Keyword(s):  
Stem Cells ◽  
Endothelial Cells ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Sirtuin 1 ◽  
Induced Pluripotent

scholarly journals Brain-derived neurotrophic factor increases cell number of neural progenitor cells derived from human induced pluripotent stem cells

PeerJ ◽  
2021 ◽  
Vol 9 ◽  
pp. e11388
Author(s):  
Panetha Pansri ◽  
Phetcharat Phanthong ◽  
Nopparat Suthprasertporn ◽  
Yindee Kitiyanant ◽  
Alisa Tubsuwan ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cell Proliferation ◽  
Induced Pluripotent Stem Cells ◽  
Progenitor Cells ◽  
Pluripotent Stem Cells ◽  
Neurotrophic Factor ◽  
Neural Progenitor Cells ◽  
Cell Number ◽  
Induced Pluripotent

Background Several pieces of evidence from in vitro studies showed that brain-derived neurotrophic factor (BDNF) promotes proliferation and differentiation of neural stem/progenitor cells (NSCs) into neurons. Moreover, the JAK2 pathway was proposed to be associated with mouse NSC proliferation. BDNF could activate the STAT-3 pathway and induce proliferation in mouse NSCs. However, its effects on proliferation are not fully understood and JAK/STAT pathway was proposed to play a role in this activity. Methods In the present study, the effects of BDNF on cell proliferation and neurite outgrowth of Alzheimer’s disease (AD) induced pluripotent stem cells (iPSCs)-derived human neural progenitor cells (hNPCs) were examined. Moreover, a specific signal transduction pathway important in cell proliferation was investigated using a JAK2 inhibitor (AG490) to clarify the role of that pathway. Results The proliferative effect of BDNF was remarkably observed as an increase in Ki-67 positive cells. The cell number of hNPCs was significantly increased after BDNF treatment represented by cellular metabolic activity of the cells measured by MTT assay. This noticeable effect was statistically shown at 20 ng/ml of BDNF treatment. BDNF, however, did not promote neurite outgrowth but increased neuronal cell number. It was found that AG490 suppressed hNPCs proliferation. However, this inhibitor partially decreased BDNF-induced hNPCs proliferation. These results demonstrated the potential role of BDNF for the amelioration of AD through the increase of AD-derived hNPCs number.

Directed differentiation of mouse-induced pluripotent stem cells generates dopaminergic nerve

2010 ◽  
Vol 34 (8) ◽  
pp. S36-S36
Author(s):  
Ping Duan ◽  
Xuelin Ren ◽  
Wenhai Yan ◽  
Xuefei Han ◽  
Xu Yan ◽  
...  
Keyword(s):  
Stem Cells ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Directed Differentiation ◽  
Induced Pluripotent

Derivation and Characterization of human Induced Pluripotent Stem Cells

Acta Naturae ◽  
2009 ◽  
Vol 1 (2) ◽  
pp. 91-92 ◽  
Author(s):  
M V Shutova ◽  
A N Bogomazova ◽  
M A Lagarkova ◽  
S L Kiselev
Keyword(s):  
Stem Cells ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Induced Pluripotent
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