scholarly journals Ocular Dirofilariasis Case in Thailand Confirmed by Molecular Analysis to Be Caused by Dirofilaria immitis

Author(s):  
Yuwadee Somsap ◽  
Patcharaporn Boonroumkaew ◽  
Attawit Somsap ◽  
Rutchanee Rodpai ◽  
Lakkhana Sadaow ◽  
...  

A rare ocular dirofilariasis case along with the clinical characteristics, treatment, and outcome is reported. A whitish roundworm (10.6 cm long and 0.5 mm width) emerged from the pterygium, a triangular tissue growth on the cornea of the eye, of a male patient. The worm had a rounded anterior part, mouth without lips, smooth cuticular surface, and short rounded posterior tail with spicules: these features suggested that it was a male Dirofilaria sp. Molecular identification confirmed that the worm belonged to Dirofilaria immitis. This is the first molecular confirmation that D. immitis is a causative agent of ocular dirofilariasis in Thailand: dirofilariasis is a newly emerging zoonotic disease. Physicians should be alert to zoonotic filarial worms and knowledgeable about treatment of this disease.

2020 ◽  
Author(s):  
Dalin Feng ◽  
Mingshuai Wang ◽  
Xiaodong Zhang ◽  
Jianwen Wang

Abstract Background The objective of this study is to discuss clinical characteristics and treatments of hereditary leiomyomatosis renal cell carcinoma on the basis of 2 cases and to review recent literature, in order to present medical advances. Methods A 29-year old male patient came to our hospital because of a huge tumour on the right kidney. Enhanced CT showed that the tumour was about 15.5*10.5 cm, and was considered to be malignant. Another case was a 38-year old female patient. She complained was found to have a right kidney tumour in a routine physical examination. Enhanced CT showed an early-stage tumour of about 4.3*3.7 cm on the lower pole of the right kidney. The male patient underwent open radical nephrectomy and the female patient underwent laparoscopic radical nephrectomy and extensive retroperitoneal lymph node dissection. The two patients underwent genetic testing and were diagnosed as having hereditary leiomyomatosis with renal cell carcinoma. Results The postoperative pathology in both patients revealed type 2 papillary renal cell carcinoma but with different prognosis. The male patient suffered multiple metastasis 10 months post-operation. The metastatic tumour of the abdominal wall was resected to confirm recurrence and hereditary leiomyomatosis renal cell carcinoma was diagnosed by the genetic test. While the female patient had a specific family history and uterine leiomyomas, the genetic test helped us to identify hereditary leiomyomatosis renal cell carcinoma pre-operation. Because of the early diagnosis and timely treatment, the female patient was considered to have a good prognosis. Conclusion Hereditary leiomyomatosis renal cell carcinoma is a rare hereditary disease resulting from FH gene mutation. There are currently no effective treatments.Our cases demonstrate that hereditary leiomyomatosis renal cell carcinoma is a very aggressive disease. Early screening and surveillance are recommended for patients with a family history or who are at risk of hereditary leiomyomatosis renal cell carcinoma. Surgical and palliative therapy still play an important role in clinical treatment.


2010 ◽  
Vol 59 (3) ◽  
pp. 407-413 ◽  
Author(s):  
Hideo Hasegawa ◽  
Hiroshi Sato ◽  
Shiho Fujita ◽  
Pierre Philippe Mbehang Nguema ◽  
Kenichi Nobusue ◽  
...  

2018 ◽  
Vol 293 (48) ◽  
pp. 18636-18645 ◽  
Author(s):  
Mebratu A. Bitew ◽  
Chen Ai Khoo ◽  
Nitika Neha ◽  
David P. De Souza ◽  
Dedreia Tull ◽  
...  

2010 ◽  
Vol 28 (15_suppl) ◽  
pp. 1510-1510
Author(s):  
M. M. Patnaik ◽  
S. Khambatta ◽  
S. I. Robinson ◽  
R. L. Richardson ◽  
M. P. Goetz

2000 ◽  
Vol 118 (4) ◽  
pp. A368 ◽  
Author(s):  
Eduardo Maurino ◽  
Alejandra Cherniasky ◽  
Sonia I Niveloni ◽  
Nahuel Fittipaldi ◽  
Ana Cabanne ◽  
...  

2010 ◽  
Vol 72 (5) ◽  
pp. 454-459 ◽  
Author(s):  
Z.-Y. Zhang ◽  
X.-D. Zhao ◽  
L.-P. Jiang ◽  
E.-M. Liu ◽  
M. Wang ◽  
...  

2012 ◽  
Vol 75 (12) ◽  
pp. 2219-2222 ◽  
Author(s):  
AGATA BANCERZ-KISIEL ◽  
ANNA SZCZERBA-TUREK ◽  
KAROLINA LIPCZYŃSKA ◽  
TOMASZ STENZEL ◽  
WOJCIECH SZWEDA

Yersinia enterocolitica is the causative agent of yersiniosis in different animal species and in humans. Food contaminated with Y. enterocolitica is the main source of infection for humans, and swine plays a major role in the transmission of the disease. There are a limited number of reports of the prevalence of Y. enterocolitica in wild animals and birds. This study characterized virulence markers associated with Y. enterocolitica isolates recovered from mallards and pheasants. Y. enterocolitica strains were isolated from 5 (11.11%) of 45 mallards originating from a cold culture (peptone, sorbitol, and bile salts medium) belonging to biotype 1A. Serotyping showed that three of these five serotypes represented serotype O:8, one belonged to serotype O:5, and one did not agglutinate with any of the sera and was classified as nonidentified. Molecular analysis for virulence markers detected the ystB gene, which encodes an enterotoxin, in five isolates. Y. enterocolitica was not detected in any of the 16 examined pheasants.


Author(s):  
Alice Latinne ◽  
Ben Hu ◽  
Kevin J. Olival ◽  
Guangjian Zhu ◽  
Libiao Zhang ◽  
...  

AbstractBats are presumed reservoirs of diverse coronaviruses (CoVs) including progenitors of Severe Acute Respiratory Syndrome (SARS)-CoV and SARS-CoV-2, the causative agent of COVID-19. However, the evolution and diversification of these coronaviruses remains poorly understood. We used a Bayesian statistical framework and sequence data from all known bat-CoVs (including 630 novel CoV sequences) to study their macroevolution, cross-species transmission, and dispersal in China. We find that host-switching was more frequent and across more distantly related host taxa in alpha-than beta-CoVs, and more highly constrained by phylogenetic distance for beta-CoVs. We show that inter-family and -genus switching is most common in Rhinolophidae and the genus Rhinolophus. Our analyses identify the host taxa and geographic regions that define hotspots of CoV evolutionary diversity in China that could help target bat-CoV discovery for proactive zoonotic disease surveillance. Finally, we present a phylogenetic analysis suggesting a likely origin for SARS-CoV-2 in Rhinolophus spp. bats.


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