Prevalence of Salmonella in Chinese Food Commodities: A meta-analysis

2021 ◽  
Author(s):  
Song Miao ◽  
Li Liu ◽  
Zheng Fu
Keyword(s):  
Prevalence Rate ◽  
Meta Analysis ◽  
Meat Products ◽  
Food Type ◽  
Retail Stores ◽  
Raw Meat ◽  
Geographical Regions ◽  
Significant Difference ◽  
Subgroup Analyses ◽  
Food Commodities

The objective of the present study was to analyze the prevalence of Salmonella in multiple food commodities in China by performing a meta-analysis. Accordingly, we screened studies that examined the prevalence of Salmonella in PubMed, Embase, and Web of Science databases. Methodological quality assessment and heterogeneity analyses were performed for included studies. The prevalence rate with the 95% confidence interval (95% CI) was selected as the effect size. Subgroup analyses for each food type were conducted and then stratified by regions, food-chain processing points, and seasons. In total, 49 studies were included in the meta-analysis, among them, 8 (16.3%) studies were deemed “High risk”, 13 (26.5%) studies were “Unclear risk”, and 28 (57.2%) studies were “Low risk”. The overall prevalence rate of Salmonella was 20.0 (95%CI: 15.9-24.4)%. The prevalence rate of Salmonella in raw meat products was 23.6 (95%CI: 19.8-27.6)%, which was higher than that in aquatic products (13.7 [95%CI: 3.1-29.9]%), milk products (0.9 [95%CI: 0.0-3.9]%), frozen convenience foods (6.5 [95%CI: 4.4-8.9]%), ready-to-eat foods (2.0 [95%CI: 1.1-3.2]%), vegetables and fruits (0.9 [95%CI: 0.0-5.2]%), and shell eggs (4.2 [95%CI: 3.0-5.7]%). Subgroup analyses revealed that prevalence rates of Salmonella in raw meat products from abattoirs (26.3 [95%CI: 17.4-36.3]%) and retail stores (30.0 [95%CI: 24.6-35.8]%) were higher than those determined from farms (10.2 [95%CI: 7.0-13.9)%; P < 0.05); however, no significant difference was observed in the prevalence of Salmonella stratified by different geographical regions or seasons (P > 0.05). Based on these findings, high levels of Salmonella contamination could be detected in raw meat products in China, and the prevalence rate of Salmonella in raw meat products from abattoirs and retail stores was high.

scholarly journals Regional and chronological differences in prevalences of olfactory and gustatory dysfunction in coronavirus disease (COVID-19): a systemic review and meta-analysis

2020 ◽  
Author(s):  
Jeong-Whun Kim ◽  
Seung Cheol Han ◽  
Hyung Dong Jo ◽  
Sung-Woo Cho ◽  
Jin Youp Kim
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Random Effect ◽  
Random Effect Model ◽  
Olfactory Dysfunction ◽  
Systemic Review ◽  
Effect Model ◽  
Geographical Regions ◽  
Significant Difference ◽  
Subgroup Analyses

Abstract Olfactory and gustatory dysfunction are frequently reported in patients with coronavirus disease (COVID-19). However, the reported prevalence of olfactory and/or gustatory dysfunction varies widely, and the reason for the inter-study differences is unclear. Hence, in this meta-analysis, we performed subgroup analyses to investigate the factors that contribute to the inter-study variability in the prevalence of olfactory and gustatory dysfunction. Out of 943 citations, we included 55 eligible studies with 13,527 patients with COVID-19 for a systematic review. The overall pooled prevalences of olfactory and gustatory dysfunction were 51.4% and 47.5%, respectively, in the random-effect model. In subgroup analyses, the prevalences of olfactory and gustatory dysfunction were significantly different among four geographical regions (both P < 0.001, respectively). Although the prevalences of olfactory and gustatory dysfunction did not significantly differ according to the time of enrollment, the subgroup analyses including only studies from the same geographical region (Europe) revealed a significant difference in olfactory dysfunction according to the time of enrollment. The regional and chronological differences in the prevalences of olfactory and gustatory dysfunctions partly explain the wide inter-study variability.

scholarly journals Characterization of the Complete Nucleotide Sequences of mcr-1-Encoding Plasmids From Enterobacterales Isolates in Retailed Raw Meat Products From the Czech Republic

2021 ◽  
Vol 11 ◽  
Author(s):  
Marketa Zelendova ◽  
Costas C. Papagiannitsis ◽  
Adam Valcek ◽  
Matej Medvecky ◽  
Ibrahim Bitar ◽  
...  
Keyword(s):  
Meat Products ◽  
Study Data ◽  
Sequence Type ◽  
Sequence Database ◽  
The Czech Republic ◽  
Raw Meat ◽  
Geographical Regions ◽  
Antimicrobial Resistance Genes ◽  
Retail Meat

The aim of our study was to determine complete nucleotide sequence of mcr-1-carrying plasmids from Enterobacterales isolates recovered from domestic and imported raw retailed meat and compare them with plasmids available at the GenBank sequence database. A set of 16 plasmids originating from Escherichia coli (n = 13), Klebsiella pneumoniae (n = 2), and Citrobacter braakii (n = 1) were analyzed. In our previous study, data from whole genome sequencing showed that mcr-1 gene was located on plasmids of different incompatibility groups (IncHI2, IncI2, and IncX4). The IncI2 (n = 3) and IncX4 (n = 8) plasmids harbored mcr-1.1 gene only, whereas IncHI2 sequence type 4 plasmids (n = 5) carried large multidrug resistance (MDR) regions. MDR regions of IncHI2 plasmids included additional antimicrobial resistance genes conferring resistance to β-lactams (blaTEM−1), aminoglycosides [aadA1, aadA2, and aph(6)-Id], macrolides [mef (B)], tetracycline (tetA, tetR), and sulphonamides (sul1, sul2, and sul3). Likewise, IncHI2 plasmids carried several insertion sequences including IS1, IS3, IS26, IS1326, and ISApl1. In conclusion, our findings confirmed the involvement of IncX4, IncI2, and IncHI2 plasmids in the dissemination of mcr-1.1 gene in several environmental niches, as in samples of retail meat originating from different geographical regions. In contrast to IncX4 and IncI2, IncHI2 plasmids were more diverse and carried additional genes for resistance to heavy metals and multiple antimicrobials.

scholarly journals Tryptophan Catabolites in Bipolar Disorder: A Meta-Analysis

2021 ◽  
Vol 12 ◽  
Author(s):  
Kaat Hebbrecht ◽  
Katrien Skorobogatov ◽  
Erik J. Giltay ◽  
Violette Coppens ◽  
Livia De Picker ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Cerebrospinal Fluid ◽  
Methodological Quality ◽  
Meta Analysis ◽  
Random Effect ◽  
Healthy Controls ◽  
Significant Difference ◽  
Subgroup Analyses ◽  
Tryptophan Catabolites

ObjectiveTryptophan catabolites (TRYCATs) are implicated in the pathophysiology of mood disorders by mediating immune-inflammation and neurodegenerative processes. We performed a meta-analysis of TRYCAT levels in bipolar disorder (BD) patients compared to healthy controls.MethodsA systematic literature search in seven electronic databases (PubMed, Embase, Web of Science, Cochrane, Emcare, PsycINFO, Academic Search Premier) was conducted on TRYCAT levels in cerebrospinal fluid or peripheral blood according to the PRISMA statement. A minimum of three studies per TRYCAT was required for inclusion. Standardized mean differences (SMD) were computed using random effect models. Subgroup analyses were performed for BD patients in a different mood state (depressed, manic). The methodological quality of the studies was rated using the modified Newcastle-Ottawa Quality assessment Scale.ResultsTwenty-one eligible studies were identified. Peripheral levels of tryptophan (SMD = -0.44; p &lt; 0.001), kynurenine (SMD = - 0.3; p = 0.001) and kynurenic acid (SMD = -.45; p = &lt; 0.001) were lower in BD patients versus healthy controls. In the only three eligible studies investigating TRP in cerebrospinal fluid, tryptophan was not significantly different between BD and healthy controls. The methodological quality of the studies was moderate. Subgroup analyses revealed no significant difference in TRP and KYN values between manic and depressed BD patients, but these results were based on a limited number of studies.ConclusionThe TRYCAT pathway appears to be downregulated in BD patients. There is a need for more and high-quality studies of peripheral and central TRYCAT levels, preferably using longitudinal designs.

scholarly journals COVID-19 gender difference pattern in Iranian population, compared to the global pattern; a systematic review and meta-analysis

2021 ◽  
Author(s):  
misagh rajabinejad ◽  
Hossein Asgarian-Omran
Keyword(s):  
Gender Differences ◽  
General Population ◽  
Meta Analysis ◽  
Iranian Population ◽  
Detection Methods ◽  
Antibody Isotype ◽  
Global Pattern ◽  
Men And Women ◽  
Significant Difference ◽  
Subgroup Analyses

The coronavirus disease 2019 (COVID-19) pandemic has highlighted Sex-related immune responses. In this review, gender differences in seroprevalence, severity, mortality, and recovery in the Iranian population were systematically compared to the COVID-19 global pattern. This compressive meta-analysis was conducted on studies published up to April 1, 2021, examining seroprevalence in the general population as well as disease outcomes in hospitalized patients. Data were analyzed based on gender to determine differences between men and women in COVID-19. The PubMed, Scopus, Google Scholar, WOS, medRxiv, and bioRxiv were searched. The odds ratio (OR) was calculated based on the random-effects model, with a corresponding 95% confidence interval (CI), according to the number of participants reported in papers. Subgroup analyses were performed according to the age, antibody isotype, and detection assay. Overall, 61 studies with 225799 males and 237017 females were eligible for meta-analysis. Seroprevalence was 1.13 times higher (95% CI: 1.03, 1.24), mortality was 1.45 times higher (95% CI: 1.19, 1.77), and severity was up to 1.37 times higher (95% CI: 1.13, 1.67) in males than those of females in the general population across the globe. Mortality was higher in Iranian patients up to 26% in men (95% CI: 1.20, 1.33), but no significant difference was observed between disease severity and serum prevalence between men and women. Besides, the rate of recovery was 29% (global pattern) and 21% (Iran pattern) lower in males than in females. The results of subgroup analyses for seroprevalence were not significant for the age, antibody isotype, and detection methods. The results of our meta-analyses showed that the patient mortality and recovery patterns are similar in Iran and other countries in the context of gender differences, and the disease is more fatal in men.

Chemoradiation versus chemotherapy after D2 gastrectomy: A meta-analysis including randomized and real-world trials.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e16590-e16590
Author(s):  
Chai Hong Rim ◽  
In-soo Shin ◽  
Hye yoon Lee ◽  
Sunmin Park
Keyword(s):  
Recurrence Rate ◽  
Real World ◽  
Randomized Clinical Trials ◽  
Meta Analysis ◽  
Disease Free Survival ◽  
Pooled Analysis ◽  
R0 Resection ◽  
D2 Gastrectomy ◽  
Significant Difference ◽  
Subgroup Analyses

e16590 Background: The ARTIST trial failed to achieve positive result regarding benefit of chemoradiation (CRT) after D2 gastrectomy. In most of clinical guidelines and practices, postoperative CRT has been recommended only for those with R1 resection or lesser extent surgery than D2. Our study is to evaluate oncologic benefit of CRT after D2 gastrectomy, integrating data from randomized clinical trials (RCTs) and real-world studies so far. Methods: Systematic searches for Medline and Embase were performed for controlled trials comparing CRT and chemotherapy (CT) arms after D2 gastrectomy with R0 resection, for gastric cancer. Subgroup analyses were performed including RCTs, and balanced studies without significant difference regarding major clinical indicators. Primary endpoint was disease free survival (DFS), and secondary endpoints included overall survival (OS), locoregional recurrence rate (LRR), distant recurrence rate (DRR), and grade ≥3 complications. Results: A total of 13 studies, comprised of 6 RCTs and 7 non-RCTs, involving 2,603 patients were included. DFS benefit was found in overall pooled analysis [odds ratio (OR): 1.264, p = 0.053, I2= 37.5%], and more evident in subgroup analyses using RCTs (OR: 1.440, p = 0.006, I2= ~0%) and balanced studies (OR: 1.417, p < 0.001, I2= ~0%). OS benefit was not significant. LRR reduction was noted in overall pooled analysis (OR: 0.559, p = 0.012, I2 = 46.1%), and clearer in the subgroup analyses with RCTs (OR: 0.495, p < 0.001, I2= ~0%) and balanced studies (OR 0.472, p < 0.001, I2= 9.2%). Pooled LRR rates were 11.3% (95% confidence interval: 7.5-16.8) and 18.1% (13.1-24.4) in CRT and CT arms. DRR was lower in CRT arms (OR: 0.768, p = 0.023, I2= ~0.0%), but the difference was less significant in subgroup analyses. A grade 5 complication was found in each of the two arms among all studies. Comparison of complications varies and will be shown descriptively in the manuscript. Conclusions: Benefit of DFS and LRR with CRT after D2 gastrectomy was well shown in the present study. Identifying subgroup population mostly benefitable from CRT might yield positive results regarding OS and DRR in future studies.

scholarly journals Intra-Articular versus Subacromial Corticosteroid Injection for the Treatment of Adhesive Capsulitis: A Meta-Analysis and Systematic Review

2019 ◽  
Vol 2019 ◽  
pp. 1-12 ◽  
Author(s):  
Xiaoke Shang ◽  
Zhong Zhang ◽  
Xuelin Pan ◽  
Jian Li ◽  
Qi Li
Keyword(s):  
Internal Rotation ◽  
Adverse Reactions ◽  
Corticosteroid Injection ◽  
Meta Analysis ◽  
Adhesive Capsulitis ◽  
Risk Of Bias ◽  
Secondary Outcome ◽  
Significant Difference ◽  
Subgroup Analyses ◽  
Corticosteroid Injections

Background. Adhesive capsulitis is one of the most well-known causes of pain and stiffness of the shoulder. Corticosteroid injections have been used for many years. However, it is still controversial where corticosteroid should be injected, whether subacromial or intra-articular. Objective. The objective of this meta-analysis was to compare the effects of intra-articular (IA) and subacromial (SA) corticosteroid injections for the treatment of adhesive capsulitis. Materials and Methods. Four foreign databases and two Chinese databases were searched for RCTs and quasi-RCTs involving the comparison of IA and SA corticosteroid injection for the treatment of adhesive capsulitis. The Cochrane risk of bias tool and PEDro score were used to evaluate the quality of the studies. The primary clinical outcomes including VAS, Constant score, ASES score, and ROM were collected. The secondary outcome of corticosteroid-related adverse reactions was also compared between the two groups. The results were evaluated and compared at five time points. Subgroup analyses were performed to further explore the differences between groups. Results. Eight RCTs and one quasi-RCT, involving 512 participants, were identified and included in this meta-analysis. All studies were of low risk of bias and medium-high quality with the PEDro score ≥5 points. The pooled effect showed that there was no significant difference in the primary outcomes between IA injection and SA injection, with an exception of VAS at 2-3 weeks (P=0.02) and ROM of internal rotation at 8–12 weeks (P=0.02). According to the results of subgroup analyses, the differences of VAS and ROM of internal rotation did not last beyond the 2-3-week time period. Additionally, SA injection had the advantage of avoiding adverse reactions from the corticosteroid, especially in avoiding a large fluctuation of serum blood glucose levels. Conclusions. When corticosteroid injection is used to treat adhesive capsulitis, both injection sites can be selected. However, due to the scarcity of related studies, more rigorous trials are needed to confirm the current findings.

scholarly journals Survey of Cysticercus (Bladder Worm) in Meat Sold for Consumption in Bukuru, Plateau State, Nigeria

2013 ◽  
Vol 2 ◽  
pp. 11-18
Author(s):  
P.D. Kaze ◽  
K.P. Gam
Keyword(s):  
Infection Rate ◽  
Prevalence Rate ◽  
Taenia Solium ◽  
Total Sample ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Raw Meat ◽  
Significant Difference ◽  
Plateau State ◽  
Cooked Meat

A cross – sectional study of bovine, porcine and dog cysticercosis was carried out in Bukuru Plateau State Nigeria,in 2010 using Gyel Bukuru abattoir, Fwagul and Kuru trade centre slaughtering abattoir, as study areas. Two hundred and twenty-five samples were collected at random comprising of seventy-five samples each from cattle, dog and pig respectively, where twenty-five samples were taking for raw meat, cooked meat and feaces in relation to the sex of the animals examined. The overall prevalence rate of 28 (12.44%) was recorded out of the total sample of 225. Raw meat records 10 (4.44%), cooked meat record 7 (3.11%) and feaces records 11 (4.98%) infection rate. X2 analysis show no significant difference in the prevalence rate of cysticercus in meat and cyst in feaces of the examined animals (p > 0.05). There was no record of infection in cattle, both in beef and feaces in different sexes of the cattle examined, sex specific incidence rate obtained in both studies did not differ significantly (p > 0.05). The female animal studied had the highest infection rate of 17 (60.71%).There was significant difference in tapeworms encountered with the meat and feaces examined (p < 0.05) Taenia solium had the highest infection rate of 14 (6.22 %), Dipylidium caninum had 12 (5.33%) with the least infestatioin recorded in T. hydatigena 2 (0.89%). Hence no record of T. saginata infection was encountered in the present study. However mixed infection was recorded in Dog with T. hydatigena & D. caninum.

scholarly journals Surgery at early versus late for intermittent exotropia: a Meta-analysis and systematic review

2021 ◽  
Vol 14 (4) ◽  
pp. 582-588
Author(s):  
Yi Dong ◽  
◽  
Yu-Yan Liu ◽  
Keyword(s):  
Meta Analysis ◽  
Early Surgery ◽  
Surgical Approaches ◽  
China National Knowledge Infrastructure ◽  
Intermittent Exotropia ◽  
Scientific Databases ◽  
Significant Difference ◽  
Subgroup Analyses ◽  
Long Term Follow Up

AIM: To compare the outcomes between early surgery and late surgery for intermittent exotropia (IXT) with a Meta-analysis. METHODS: Scientific databases including PubMed, Embase, Web of Science, Cochrane and China National Knowledge Infrastructure were searched prior to December 16, 2019. From this broad database search, we performed some Meta-analysis including eleven independent studies, to further evaluate the outcome(s) when comparing early versus late surgery for IXT. The boundaries between early and late surgery and the surgery methods were not inconsistent, so subgroup analyses were conducted by different boundaries of age at surgery and different surgical approaches. The pooled odds ratios (ORs) and the 95% confidence interval (CI) were estimated according to the random-effects model for high heterogeneity between studies. RESULTS: Eleven retrospective studies were included in this Meta-analysis. No significant difference between early and late surgery was observed for IXT patients (ORFirst follow-up= 0.88, 95%CI 0.53-1.44, P=0.61; ORFinal follow-up=1.48, 95%CI 0.94-2.31, P=0.09). However, sensitivity analysis performed by sequentially omitting individual studies showed that the final follow-up result was not stable. Subgroup analyses revealed that an earlier surgical procedure could lead to a better outcome in the 4-year boundary subgroup as well as the bilateral lateral rectus recession (BLR) subgroup for the final follow-up (OR4y=2.64, 95%CI 1.57-4.44, P=0.00; ORBLR=2.25, 95%CI 1.36-3.74, P=0.00). CONCLUSION: Early surgery for IXT provides a better long term follow-up outcome when patients are younger than 4 years old or choose the BLR surgical method.

scholarly journals Epidemic Trend of Dental Fluorosis in Mainland China, 1995-2020: A Systematic Review and Meta-Analysis

2021 ◽  
Author(s):  
Yuzhen Zhan ◽  
Lianjie Xiong ◽  
Zhoujie Gong ◽  
Ting Xu ◽  
Xiaonan Zhang
Keyword(s):  
Rural Areas ◽  
Urban Areas ◽  
Dental Fluorosis ◽  
Meta Analysis ◽  
Mainland China ◽  
Significant Difference ◽  
Subgroup Analyses ◽  
System Review ◽  
Epidemiological Characteristics ◽  
Comprehensive Literature Search

Abstract The aim of this system review and meta-analysis was to explore the epidemiological characteristics of dental fluorosis in mainland China from 1995 to 2020. A comprehensive literature search was conducted through PubMed, Embase, CBM, CNKI, Chinese Wan Fang database, and VIP database. Subgroup analyses were done to explore epidemic tread of dental fluorosis (gender, location, survey year and geographical distribution) with the help of relative software. Forty-one publications were included in this study. The overall prevalence was 23.6%, and the prevalence of dental fluorosis increased from 18.8% during 1995–1999 to 34.3% during 2010–2014, while it decreased to 20.5% during 2015–2019. There was no significant difference in prevalence between boys (15.7%) and girls (15.2%) (RR = 1.05, 95% CI: 1.02–1.07); and the prevalence of dental fluorosis in rural areas (14.5%) was slightly higher than those in urban areas (12.7%) (RR = 0.93, 95% CI: 0.76–1.13). The prevalence before (63.3%) and after (34.7%) water improvement showed a great benefit of fluoride reduction policy. Result of this meta-analysis provides evidence enable governments taking effective measures to control dental fluorosis.

scholarly journals Meta-Analysis of the Relationship between the APOE Gene and the Onset of Parkinson’s Disease Dementia

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
Suisui Pang ◽  
Jia Li ◽  
Yingyu Zhang ◽  
Jiajun Chen
Keyword(s):  
Risk Factors ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Risk Factor ◽  
Protective Factor ◽  
Meta Analysis ◽  
Parkinson’S Disease Dementia ◽  
Geographical Regions ◽  
Significant Difference ◽  
The Relationship

Purpose. To clarify the relationship between certain genotypes or alleles of the APOE gene and the onset risk of Parkinson’s disease dementia (PDD). Methods. The PubMed, Cochrane, Embase, CBM, CNKI, and Wanfang databases were searched to identify all case-control studies and cohort studies published before October 30, 2017, that investigated the association between the APOE gene and the onset of PDD. Manual information retrieval was also performed. All studies that met the quality requirements were included in a meta-analysis performed using RevMan 5.3 software. Results. The meta-analysis included 17 studies, with a total of 820 patients in the PDD group and 1,922 in the non-PDD group. The influence of the APOE gene on PDD onset was analyzed from three aspects: five genotypes vs. ε3/3, ε2+/ε4+ vs. ε3/3, and ε4+ vs. ε4−. The risk factors for PDD may include the genotypes ε3/4 (OR 1.47, 95% CI 1.14–1.89) and ε4/4 (OR 2.93, 95% CI 1.20–7.14). In patients with PDD, there was no significant difference in the distribution of ε2+ vs. ε3/3 (OR 1.35, 95% CI 0.97–1.87, P=0.07). The risk of PDD was 1.61 times greater in ε4+ compared with ε3/3 (OR 1.61, 95% CI 1.24–2.08, P=0.0003). As the results indicated that ε2+ did not play a role as a risk factor or a protective factor, we divided the population into ε4+ and ε4− for the meta-analysis and found that, among patients with Parkinson’s disease, the dementia risk of those with ε4+ was 1.72 times greater than that of those with ε4− (OR 1.72, 95% CI 1.41–2.10, P<0.00001). Subgroup analysis in accordance with different geographical regions revealed that ε4+ was a risk factor for PDD in people from all regions. Conclusions. Among the APOE genotypes, ε2+ is neither a risk factor nor a protective factor for PDD, while ε4+ is a risk factor for PDD. The present results are applicable to Asian, European, and American patients with Parkinson’s disease. Regarding the single APOE genotypes, ε3/4 and ε4/4 may be risk factors for PDD; however, further studies with large sample sizes are needed to verify this.

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