The Value Free Ideal of Science and non-epistemic values in regulatory toxicology

2021 ◽  
pp. 223-244
Author(s):  
Osman Çağlar Dede
Author(s):  
Heather Douglas

After describing the origins and nature of the value-free ideal for science, this chapter details three challenges to the ideal: the descriptive challenge (arising from feminist critiques of science, which led to deeper examinations of social structures in science), the boundary challenge (which questioned whether epistemic values can be distinguished from nonepistemic values), and the normative challenge (which questioned the ideal qua ideal on the basis of inductive risk and scientific responsibility). The chapter then discusses alternative ideals for values in science, including recent arguments regarding epistemic values, arguments distinguishing direct from indirect roles for values, and arguments calling for more attention to getting the values right. Finally, the chapter turns to the many ways in which values influence science and the importance of getting a richer understanding of the place of science within society in order to address the questions about the place of values in science.


2021 ◽  
pp. 019262332098325
Author(s):  
Alys E. Bradley ◽  
Maurice G. Cary ◽  
Kaori Isobe ◽  
Stuart Naylor ◽  
Stephen Drew

This Proof of Concept (POC) study was to assess whether assessment of whole slide images (WSI) of the 2 target tissues for a contemporaneous peer review can elicit concordant results to the findings generated by the Study Pathologist from the glass slides. Well-focused WSI of liver and spleen from 4 groups of mice, that had previously been diagnosed to be the target tissues by an experienced veterinary toxicologic pathologist examining glass slides, were independently reviewed by 3 veterinary pathologists with varying experience in assessment of WSIs. Diagnostic discrepancies were then reviewed by an experienced adjudicating pathologist. Assessment of microscopic findings using WSI showed concordance with the glass slides, with only slight discrepancy in severity grades noted. None of the lesions recorded by the Study pathologist were “missed” and no lesions were added by the pathologists evaluating WSIs, thus demonstrating equivalence of the WSI to glass slides for this study.


2021 ◽  
Vol 11 (2) ◽  
Author(s):  
Yin Chung Au

AbstractThis paper proposes an extended version of the interventionist account for causal inference in the practical context of biological mechanism research. This paper studies the details of biological mechanism researchers’ practices of assessing the evidential legitimacy of experimental data, arguing why quantity and variety are two important criteria for this assessment. Because of the nature of biological mechanism research, the epistemic values of these two criteria result from the independence both between the causation of data generation and the causation in question and between different interventions, not techniques. The former independence ensures that the interventions in the causation in question are not affected by the causation that is responsible for data generation. The latter independence ensures the reliability of the final mechanisms not only in the empirical but also the formal aspects. This paper first explores how the researchers use quantity to check the effectiveness of interventions, where they at the same time determine the validity of the difference-making revealed by the results of interventions. Then, this paper draws a distinction between experimental interventions and experimental techniques, so that the reliability of mechanisms, as supported by the variety of evidence, can be safely ensured in the probabilistic sense. The latter process is where the researchers establish evidence of the mechanisms connecting the events of interest. By using case studies, this paper proposes to use ‘intervention’ as the fruitful connecting point of literature between evidence and mechanisms.


1996 ◽  
Vol 24 (2) ◽  
pp. 173-178
Author(s):  
Johannes J.M. van de Sandt ◽  
Victor J. Feron

With rapidly increasing knowledge of toxicological processes, the scientific value and relevance of toxicity studies for risk assessment must be re-evaluated. In this paper, it is proposed that the rigid risk evaluation currently required should be replaced by a more flexible, case-by-case approach, in order to increase the relevance of each animal test conducted. The development of new types of toxicity studies and their application in risk evaluation are also described.


2013 ◽  
Vol 38 (6) ◽  
pp. 727-748 ◽  
Author(s):  
David Demortain

2014 ◽  
pp. 849-853
Author(s):  
Herbert Desel ◽  
Pieter Brekelmans ◽  
Ronald de Groot

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