Vitamin A Nutritional Status–Relationship to the Infection and the Antibody Response

In the present study, we investigated nutritional status and health-related factors in a multistage cluster sample of 3119 Thai urban and rural children aged 0·5–12·9 years. In a subsample, blood samples were collected for the measurement of Hb, transferrin receptor, vitamin A and vitamin D concentrations. The prevalence of stunting and underweight was higher in rural children than in urban children, whereas the wasting rate was similar in both rural and urban areas. Among children aged 3·0–5·9 years, the prevalence of overweight was significantly higher in urban areas than in rural areas and so was the obesity rate in children aged 6·0–12·9 years. Protein intakes of all age groups were relatively high in both the areas. Intakes of Ca, Fe, Zn and vitamin C were significantly higher in urban areas than in rural areas. The prevalence of anaemia in rural areas was twice as high as that in urban areas, particularly in infants and young children. However, the prevalence of Fe-deficiency anaemia was similar in both urban and rural areas. While the prevalence of vitamin A deficiency (by serum retinol cut-off < 0·7 μmol/l) seemed to be very low, vitamin A insufficiency (by serum retinol cut-off < 1·05 μmol/l) was more prevalent (29·4–31·7 %) in both the areas. The prevalence of vitamin D insufficiency ranged between 27·7 and 45·6 % among the children. The present study indicates that the double burden of malnutrition is still a major public health problem in Thailand. Further studies need to explore the associated risk factors for these nutrient deficiencies. Effective strategies and actions are needed to tackle the nutritional problems in Thai children.

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Hubungan Penerapan Perilaku Kadarzi (Keluarga Sadar Gizi) dengan Status Gizi Balita di Kabupaten Tulungagung

Amerta Nutrition ◽

10.20473/amnt.v1i4.2017.379-388 ◽

2017 ◽

Vol 1 (4) ◽

pp. 379

Author(s):

Santik Wijayanti ◽

Triska Susila Nindya

Keyword(s):

Vitamin A ◽

Nutritional Status ◽

Vitamin A Deficiency ◽

Fisher Exact Test ◽

Height Measurement ◽

Cross Sectional ◽

Exact Test ◽

Children Under Five ◽

Under Five ◽

Nutritional Status Of Children

Background: Family conscious nutrition (Kadarzi) is an Indonesia government program that aims to address the nutrition problem. The family expected to be able to independently giving the best nutrition to improve health. Each Kadarzi indicator has an important role to resolve and prevent the occurrence of utrition problem as indicator of vitamin A supplementation is used to resolve vitamin A deficiency. Nutrition problems can be seen by using nutritional status. Children under five years are age-prone to experiencenutritional problem such as underweight, stunting, and wasting. Objective: The purpose of this study was to analyze the relationship between the application of Kadarzi behavior with the nutritional status of children under five (WAZ, HAZ, and WHZ). Method: The research was an analytic obsevation research, using cross sectional design. The sample consist of 72 toddlers in Salakkembang Village, Kalidawir Subdistrict, Tulungagung Regency. The data were collected by using weight and height measurement, also Kadarzi bahavior questionnaire. The data were analyzed using Fisher Exact test. Result: The results of the study showed that there was a correlation between Kadarzi behavior with nutitional status of toddlers based on WAZ (p=0.010), and HAZ (p=0.000) but not with WHZ (p=0.368). Conclusion: The better apllication of Kadarzi behavior, the better the nutritional status of toddlers WAZ and HAZ. Mothers should apply Kadarzi behavior to prevent toddlers from nutritional problems. ABSTRAK Latar belakang: Keluarga Sadar Gizi (Kadarzi) merupakan program pemerintah Indonesia yang bertujuan mengatasi masalah gizi. Keluarga diharapkan dapat secara mandiri mewujudkan keadaan gizi yang sebaik-baiknya untuk meningkatkan kesehatan. Setiap indikator Kadarzi memiliki peran penting untuk mengatasi dan mencegah terjadinya masalah gizi seperti indikator pemberian suplemen vitamin A digunakan untuk mengatasi kekurangan vitamin A. Masalah gizi dapat dilihat salah satunya dengan menggunakan status gizi. Balita merupakan usia yang rawan mengalami masalah gizi seperti underweight, stunting, dan wasting.Tujuan: Tujuan dari penelitian ini adalah menganalisis hubungan antara penerapan perilaku Kadarzi dengan status gizi balita (BB/U, TB/U, dan BB/TB).Metode: Penelitian ini merupakan penelitian observasinol analitik, dengan desain penelitian cross sectional. Sampel terdiri dari 72 balita di Desa Salakkembang, Kecamatan Kalidawir, Kabupaten Tulungagung. Pengumpulan data menggunakan penimbangan berat badan, tinggi badan, dan kuesioner perilaku Kadarzi. Data dianalisis menggunakan Fisher Exact test. Hasil: Hasil dari penelitian menunjukkan terhadap hubungan antara perilaku Kadarzi dengan status gizi balita BB/U (p=0,010) dan TB/U (p=0,000) namun tidak dengan BB/TB (p=0,368).Kesimpulan: Semakin baik penerapan perilaku Kadarzi maka semakin baik status gizi balita BB/U dan TB/U. Ibu dan seluruh anggota keluarga seharusnya menerapkan perilaku Kadarzi agar balita terhindar dari masalah gizi.

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The early changes in retinol-binding protein and prealbumin concentrations in plasma of protein–energy malnourished children after treatment with retinol and an improved diet

British Journal Of Nutrition ◽

10.1079/bjn19800107 ◽

1980 ◽

Vol 43 (3) ◽

pp. 393-402 ◽

Cited By ~ 30

Author(s):

Suzanne Large ◽

G. Neal ◽

J. Glover ◽

O. Thanangkul ◽

R. E. Olson

Keyword(s):

Body Weight ◽

Vitamin A ◽

Nutritional Status ◽

Plasma Proteins ◽

Binding Protein ◽

Vitamin A Deficiency ◽

Plasma Concentrations ◽

Retinol Binding Protein ◽

Mean Values ◽

The Mean

1. Changes in total retinol-binding protein (RBP), the holoprotein (holoRBP) and prealbumin (PA) concentrations have been monitored in plasma of thirty protein- and vitamin A-deficient preschool children from within a few hours up to 7 weeks after treatment with retinol and a good-quality protein diet.2. The children were classified into groups according to nutritional status as having either kwashiorkor, marasmus-kwashiorkor or marasmus, and given formula diets whose protein and energy contents increased stepwise from 1 g and 105 kJ/kg body-weight respectively up to 4 g and 733 kJ/kg body-weight after 4 weeks. Retinol was administered in the forms of retinyl palmitate either orally or intramuscularly.3. PA and total RBP were determined by electroimmunoassay procedures and the holoRBP by its fluorescence after separation from other plasma proteins.4. RBP in plasma of the vitamin A-deficient child is largely denatured and incapable of binding administered retinol, which must first be taken up by the liver before native holoRBP is released. An increased pool of native apoprotein accumulates in the liver during vitamin A deficiency which is released into plasma quickly after retinol uptake to form peak concentrations of total and holoRBP approximately 3 h after dosing intramuscularly and 6 h orally.5. The accumulated pool of RBP was highest in livers from the marasmus group and lowest in those from the kwashiorkor group, reflecting their relative capacities to synthesize plasma proteins.6. The mean plasma concentrations of total and holoRBP for the various groups were minimal 24–48 h after dosing with retinol and then improved almost linearly over the following week.7. Mean plasma PA concentrations of the various groups on admission were also in order of the severity of their malnutrition. There was little or no change in this protein concentration over the first 24 h after dosing with retinol, but thereafter the mean values rose almost linearly over 2 weeks. Albumin on the other hand changed little during the first week. The results show that PA is the more sensitive measurement of protein nutritional status.

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Micronutrients and Infection with COVID-19: A Critical Mini-Review

Critical Comments in Biomedicine ◽

10.18502/ccb.v2i1.5868 ◽

2021 ◽

Author(s):

Zahra Yaghtin ◽

Richard Webb ◽

Sayyed Saeid Khayyatzadeh

Keyword(s):

Severe Acute Respiratory Syndrome ◽

Vitamin A ◽

Nutritional Status ◽

Serum Levels ◽

Global Pandemic ◽

Micronutrient Intake ◽

Severity Of The Disease ◽

The Impact ◽

The Relationship ◽

Low Serum

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has been the cause of a global pandemic. Given the impact of nutritional status upon immune function, it is crucial to understand the relationship between micronutrient intake and severity of the disease. This mini-review aimed to summarize the known associations between specific micronutrients (vitamin A, D, E, C and zinc, selenium and magnesium) and the health of coronavirus-infected patients. Low serum levels of these micronutrients are associated with the incidence and severity of SARS-CoV-2. However, further studies are needed to evaluate the outcomes of supplementation with these nutrients.

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Effect of Infection on Nutritional Status of Infants in a Cohort Study of Vitamin a in Western Kenya (P10-121-19)

Current Developments in Nutrition ◽

10.1093/cdn/nzz034.p10-121-19 ◽

2019 ◽

Vol 3 (Supplement_1) ◽

Author(s):

Frederick Grant ◽

Rose Wanjala ◽

Jan Low ◽

Carol Levin ◽

Donald Coke ◽

...

Keyword(s):

Cohort Study ◽

Iron Deficiency ◽

Vitamin A ◽

Nutritional Status ◽

Acute Phase ◽

Acute Phase Proteins ◽

Infection Prevalence ◽

Subclinical Inflammation ◽

Maternal Recall ◽

The Impact

Abstract Objectives Infection is associated with impaired nutritional status especially of infants under 5 years old. We assessed the impact of infection indicated by both the acute phase proteins (APP), C-reactive protein (CRP) and α-1-acid glycoprotein (AGP), and as reported by maternal recall on the nutritional status of infants. Methods 505 pregnant women were enrolled into a nested longitudinal cohort study of vitamin A. Data analysis was restricted to infant data at 9-months (n = 385 mother-infant dyads) postpartum. Incidence and severity of respiratory infection and diarrhea over the previous 14 days were assessed by maternal recall; information on infant/child feeding practices were also collected. Infant weight, recumbent length and heel-prick capillary blood collection were taken at 9-months postpartum. Indicators of VA status [(retinol binding protein (RBP)], iron status (Hb, ferritin) and subclinical inflammation APP, CRP and AGP, were determined. Subclinical inflammation was defined as CRP >5 mg/L and/or AGP >1 g/L. Impacts of infection on infant nutritional status were estimated with multivariable logistic regression models adjusted for clustering and differences at enrollment. Results Infection prevalence, based on elevated CRP and AGP levels, was 36.7%. For diarrhea reported symptoms, 42.4% of infants at 9-months had no indication of infection as indicated by CRP and AGP; whilst for acute respiratory reported symptoms, 42.6% had no indication of infection. There was a weak but significant positive association with infection among VA deficient (RBP <0.83 µmol/L) infants based on maternal reported symptoms but not with iron deficiency (ferritin <12 µg/L). The odds of having infection, based on raised CRP and AGP, in underweight infants was 3.7 times higher (OR: 3.7; P = 0.019). Infants with iron deficiency were less likely (OR: 0.40; P = 0.001) to have infection based on CRP and AGP, whilst infants with VA deficiency were 5 times more likely (OR: 5.06; P = 0.0001) to have infection. Conclusions Acute phase proteins are more useful in defining infection in a population compared to reported symptoms of illness. Not controlling for inflammation in a population while assessing nutritional status might result in inaccurate prevalence estimation. Funding Sources Supported by the Bill &Melinda Gates Foundation (OPP53344).

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