scholarly journals Theoretical Analysis of Coupled Modified Hindmarsh-rose Model Under Transcranial Magnetic-acoustic Electrical Stimulation

2022 ◽  
Vol 16 ◽  
pp. 610-617
Author(s):  
Liang Guo ◽  
Shuai Zhang ◽  
Jiankang Wu ◽  
Xinyu Gao ◽  
Mingkang Zhao ◽  
...  
Keyword(s):  
Nervous System ◽  
Electrical Stimulation ◽  
Modulation Frequency ◽  
Ultrasonic Waves ◽  
Neuronal Firing ◽  
Electrical Synapse ◽  
Discharge Frequency ◽  
Neural Network Modeling ◽  
Chemical Synapse ◽  
Chemical Synapses

Transcranial magnetic-acoustic electrical stimulation (TMAES) is a new technology with ultrasonic waves and a static magnetic field to generate an electric current in nerve tissues to modulate neuronal firing activities. The existing neuron models only simulate a single neuron, and there are few studies on coupled neurons models about TMAES. Most of the neurons in the cerebral cortex are not isolated but are coupled to each other. It is necessary to study the information transmission of coupled neurons. The types of neuron coupled synapses include electrical synapse and chemical synapse. A neuron model without considering chemical synapses is not comprehensive. Here, we modified the Hindmarsh-Rose (HR) model to simulate the smallest nervous system—two neurons coupled electrical synapses and chemical synapses under TMAES. And the environmental variables describing the synaptic coupling between two neurons and the nonlinearity of the nervous system are also taken into account. The firing behavior of the nervous system can be modulated by changing the intensity or the modulation frequency. The results show that within a certain range of parameters, the discharge frequency of coupled neurons could be increased by altering the modulation frequency, and intensity of stimulation, modulating the excitability of neurons, reducing the response time of chemical postsynaptic neurons, and accelerating the information transferring. Moreover, the discharge frequency of neurons was selective to stimulus parameters. These results demonstrate the possible theoretical regulatory mechanism of the neurons' firing frequency characteristics by TMAES. The study establishes the foundation for large-scale neural network modeling and can be taken as the theoretical basis for TMAES experimental and clinical application.

scholarly journals Interactions of the Giant Fibres and Motor Giant Neurones of the Hermit Crab

1987 ◽  
Vol 133 (1) ◽  
pp. 353-370
Author(s):  
W. J. HEITLER ◽  
K. FRASER
Keyword(s):  
Hermit Crab ◽  
Electrical Synapse ◽  
Chemical Synapse ◽  
Electrical Synapses ◽  
Giant Fibre ◽  
Giant Neurone ◽  
Giant Fibres ◽  
Chemical Synapses ◽  
Contralateral Motor ◽  
Recent Claim

A recent claim that the giant fibre of the hermit crab excites its contralateral motor giant neurone through a chemical rather than an electrical synapse (Stephens, 1986) was re-examined. We found that the reported increased latency (relative to the electrical ipsilateral synapse) was postsynaptic in origin, as was the increased spike ‘jitter’. There was no difference in synaptic latency between the electrical synapse and the supposed chemical one. We did not find a consistent resistance to N-ethylmaleimide (an uncoupler of electrical synapses) by the supposed chemical synapse, but the synapse was resistant to 2 mmol 1−1 cadmium, which blocks known chemical synapses in the system. Sub-threshold depolarizing current passed from the presynaptic giant fibre to the postsynaptic contralateral motor giant, and hyperpolarizing current passed antidromically. We conclude that the synapse is electrical and not chemical in nature.

Fast Detoxification of Heroin Addicts by Acupuncture and Electrical Stimulation (AES) in Combination with Naloxone

1977 ◽  
Vol 05 (03n04) ◽  
pp. 257-263 ◽  
Author(s):  
H. L. WEN
Keyword(s):  
Nervous System ◽  
Electrical Stimulation ◽  
Parasympathetic Nervous System ◽  
The Other ◽  
Abstinence Syndrome ◽  
Rehabilitation Centre ◽  
Heroin Addicts ◽  
Social Rehabilitation ◽  
Receptor Sites ◽  
Long Acting

Detoxification can be accomplished more rapidly by first "flushing" the opiates from the receptor sites. Naloxone, a short antagonist displaces opiates from the receptor sites and such displacement precipitates an abstinence syndrome. Recently, a method of using acupuncture and electrical stimulation (AES) in combination with naloxone for fast detoxification was reported. This technique was applied to 50 cases of heroin addicts. Forty-one were detoxified. There were nine failures. Of the 41 cases, 18 patients were sent to rehabilitation centres and did not experience abstinence symptoms. Six were sent out of Hong Kong where heroin is not available, and two others did not go to a rehabilitation centre but still abstained. The other 15 were presumed to be on the drug. It is advocated that AES increases endorphin and relieves abstinence syndrome, but also at the same time inhibits the autonomic nervous system, mainly the parasympathetic nervous system. The technique does not stop the craving, therefore after detoxification, the patients should be sent for psycho-social rehabilitation, or alternatively be put on long acting antagonist.

scholarly journals Effect of Low-Level Electrical Stimulation of the Arotic Root Ventricular Ganglionated Plexi on Electrical and Structural Remodling in Dogs with Heart Failure

2016 ◽  
Vol 1 (1) ◽  
Keyword(s):  
Heart Failure ◽  
Nervous System ◽  
Electrical Stimulation ◽  
Autonomic Nervous System ◽  
Aortic Root ◽  
General Argument ◽  
Low Level ◽  
Ganglionated Plexi ◽  
Atrial Enlargement ◽  
Stimulation Of

Low-level electrical stimulation (LL-ES) of aortic root ventricular ganglionated plexi (GP) was proved to be antiarrhythmic in the initiation of AF mediated by autonomic nervous system. However,it is still uncertain whether LL-ES of the ventricular GP can reverse the structural remodeling of myocardial fibrosis and atrial enlargement following heart failure by attenuating the sympathetic tone. Therefore,this review will give an general argument on this topic.

scholarly journals Synaptic polarity and sign-balance prediction using gene expression data in the Caenorhabditis elegans chemical synapse neuronal connectome network

2020 ◽  
Vol 16 (12) ◽  
pp. e1007974
Author(s):  
Bánk G. Fenyves ◽  
Gábor S. Szilágyi ◽  
Zsolt Vassy ◽  
Csaba Sőti ◽  
Peter Csermely
Keyword(s):  
Gene Expression ◽  
Caenorhabditis Elegans ◽  
Gene Expression Data ◽  
Receptor Gene ◽  
Directed Network ◽  
Chemical Synapse ◽  
Expression Data ◽  
Chemical Synapses ◽  
Theoretical Analyses ◽  
Receptor Gene Expression

Graph theoretical analyses of nervous systems usually omit the aspect of connection polarity, due to data insufficiency. The chemical synapse network of Caenorhabditis elegans is a well-reconstructed directed network, but the signs of its connections are yet to be elucidated. Here, we present the gene expression-based sign prediction of the ionotropic chemical synapse connectome of C. elegans (3,638 connections and 20,589 synapses total), incorporating available presynaptic neurotransmitter and postsynaptic receptor gene expression data for three major neurotransmitter systems. We made predictions for more than two-thirds of these chemical synapses and observed an excitatory-inhibitory (E:I) ratio close to 4:1 which was found similar to that observed in many real-world networks. Our open source tool (http://EleganSign.linkgroup.hu) is simple but efficient in predicting polarities by integrating neuronal connectome and gene expression data.

scholarly journals Design and Implementation ofReal-time Electrical Stimulation Artifact Suppression based on STM32

2021 ◽  
Vol 12 (5) ◽  
pp. 424-427
Author(s):  
Sangsoo Park, Hojun Yeom
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Electrical Stimulation ◽  
Embedded System ◽  
Muscle Contraction ◽  
Real Time ◽  
High Performance ◽  
Floating Point ◽  
Time Signal ◽  
Central Nervous System Damage

A biosignal is used as a control signal for electrical stimulation to restore weakened muscle function due to damage to the central nervous system. In patients with central nervous system damage, sufficient muscle contraction does not occur spontaneously. In this case, applying electrical stimulation can cause normal muscle contraction. However, it is necessary to remove the electrical stimulation artifact caused by the electrical stimulation. This paper describes a system design that removes electrical stimulation artifact in real time using a Cortex-M4-based STM32F processor. The STM32F is a very advantageous MCU for such DSPs, especially because it has a built-in floating point operator. Using STM32F's various high-performance peripherals (12-bit parallel ADC and 12-bit DAC, UART, Timer), an optimized embedded system was implemented.In this paper, the simulated and real-time results were compared and evaluated with the designed fir filter. In addition, the performance of the filter was evaluated through frequency analysis. As a result, it was verified that a high-performance 32-bit STM32F with floating point calculator and various peripherals is suitable for real-time signal processing

Electrical Stimulation of the Nervous System

2011 ◽  
pp. 1247-1258
Author(s):  
Stanisa Raspopovic ◽  
Marco Capogrosso ◽  
Silvestro Micera
Keyword(s):  
Nervous System ◽  
Electrical Stimulation ◽  
Stimulation Of

A New Paradigm for Neurological Lead Cyclic Testing

2006 ◽  
Author(s):  
Paul Wisnewski
Keyword(s):  
Chronic Pain ◽  
Nervous System ◽  
Electrical Stimulation ◽  
Pain Management ◽  
Standard Therapy ◽  
Cyclic Testing ◽  
New Paradigm ◽  
Stimulation Of

The feasibility of electrical stimulation of the nervous system to treat chronic pain was proven with implantation of the first device for this purpose by Norm Shealy, MD in 1967. Since then, neurological stimulation has become a standard therapy for pain management.

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