A Case Report- Management of a patient with severe trismus with bilateral recurrent pericoronitis along with chronic Oral Submucous Fibrosis- A premalignant lesion

2021 ◽  
Vol 2 (2) ◽  
pp. 45-49
Author(s):  
Nanda Ghoshal
Keyword(s):  
Oral Submucous Fibrosis ◽  
Mouth Opening ◽  
Chief Complaint ◽  
Surgical Removal ◽  
Conservative Approach ◽  
Third Molars ◽  
Open Mouth ◽  
Patient Reported ◽  
Wisdom Teeth ◽  
Submucous Fibrosis

A 37 years, the old male patient reported the chief complaint of inability to open mouth since 10-11 months and recently pain and swelling resulting from wisdom teeth of both sides limited the mouth opening severely (<9mm, less than one finger opening) that he could not take solid food properly. After partial relief and mouth opening (12mm) with antibiotic therapy, the patient was examined and diagnosed with oral submucous fibrosis (osmf) along with impacted molars on both sides. Treatment was planned with a conservative approach consisted of pharmacotherapy and physiotherapy for osmf and surgical removal of impacted third molars of both sides. Mouth opening was improved gradually (>15mm after 3 weeks, >22mm after 6 weeks,>27 mm after 9 weeks).

scholarly journals Comparative Study of Intralesional Dexamethasone Plus Hyaluronidase & Oral Colchicine in Patients with Oral Submucous Fibrosis

2018 ◽  
Vol 14 (2) ◽  
pp. 60-65
Author(s):  
Ganesh Prasad Neupane ◽  
Maya Rai ◽  
R. S. Rathore ◽  
V. K. Bhargava ◽  
A. K. Mahat ◽  
...  
Keyword(s):  
Treatment Outcomes ◽  
Oral Mucosa ◽  
Oral Submucous Fibrosis ◽  
Mouth Opening ◽  
Study Groups ◽  
T Test ◽  
Significant Difference ◽  
Intralesional Injections ◽  
Submucous Fibrosis ◽  
Larger Sample

Introduction: Oral Submucous Fibrosis (OSMF) is a precancerous condition of the oral mucosa. It is characterized by excessive production of collagen leading to inelasticity of the oral mucosa and atrophic changes of the epithelium.Aim and objective: To evaluate the efficacy of oral Colchicine in comparison to intralesional injections of Dexamethasone plus Hyaluronidase in the management of OSMF patients.Materials and Methods: Fourty patients with OSMF were randomly divided equally into two groups. 20 patients in Dexamethasone group received biweekly intralesional injections of Dexamethasone (4mg/ml) plus Hyaluronidase 1500 IU in buccal mucosa for a period of 12 weeks. Other 20 patients in Colchicine group received oral Colchicine 0.5 mg tablets twice daily for 12 weeks. Parameters taken in the study were burning sensation, and mouth opening. Descriptive statistics, paired t test and unpaired t test were used for statistical analysis.Results and Conclusions: The pre- and post-treatment differences were found to be statistically significant for both the groups (p<0.001) and for both the treatment outcomes. When the average difference of the treatment outcomes was compared between the two study groups, statistically highly significant difference was noted (p <0.001) only in mouth opening but not in burning sensation.These encouraging results should prompt further clinical trials with Colchicine on a larger sample size to broaden the therapeutic usefulness of the drug in the management of OSMF. JNGMC,  Vol. 14 No. 2 December 2016, Page: 60-65

Comparison Of Collagen-Curcumin Blend (Collaper Rtu)With Intralesional Steroid Injections in Oral Submucous Fibrosis a Randomized, Open-Label Interventional Study.

2021 ◽  
Author(s):  
Bharat Kwatra ◽  
Manya Pahwa
Keyword(s):  
Oral Submucous Fibrosis ◽  
Mouth Opening ◽  
Burning Sensation ◽  
Current Therapy ◽  
Intralesional Injection ◽  
Complete Regression ◽  
Open Label ◽  
Tongue Protrusion ◽  
Interincisal Distance ◽  
Submucous Fibrosis

Abstract Introduction: Oral Submucous Fibrosis (OSMF) is a precancerous condition characterized by limited mouth opening, burning sensation, stiffness, and blanching of the oral mucosa induced by areca nut eating. With any of the current therapy regimens, complete regression of the illness has not been accomplished in all patients. Curcumin is a yellow pigment found in curry powder that has antioxidant, anti-inflammatory, and pro-apoptotic properties. As a result, interventional research was conducted to determine the efficacy of Collaper RTu a proprietary collagen-curcumin based product in patients with OSMF.Setting and design: Forty patients with clinically and histologically confirmed Oral Submucous Fibrosis participated in a randomized open label interventional research. Method & materials: For the research, forty patients with clinically and histologically verified Oral Submucous Fibrosis were randomly assigned to one of two groups. The first group was given a weekly intralesional injection of 4 mg Dexamethasone and 1500 I.U Hyaluronidase, whereas the second was given two Collagen-Curcumin pills (Collaper Rtu 60mg Collagen with 100 mg Curcumin) every day for three months. On a weekly basis, the improvement of burning sensation, interincisal distance, and tongue protrusion was assessed.Results: From early to late stages, the burning feeling improved in both groups. Collaper Rtu was found to eliminate the burning feeling. In groups 1 and 2, the mean increase in interincisal distance was 3.13 mm and 1.25 mm, respectively. The interincisal distance improved significantly in both groups by the end of the first month. When compared to group 2, group 1's tongue protrusion recovered faster at the conclusion of the first month. Conclusion: Collaper RTu is useful and effective in lowering the burning feeling in people with early OSMF.

scholarly journals Immunohistochemical Analysis of Myofibroblasts Using α- SMA in Oral Submucous Fibrosis Turning into Malignancy- A Case Report and Review

2021 ◽  
pp. 192-198
Author(s):  
Swapan Kumar Purkait ◽  
. Abhinandan ◽  
Nimisha Priya ◽  
Sriyanshi Singh ◽  
Sneha Singh
Keyword(s):  
Case Report ◽  
Immunohistochemical Study ◽  
Oral Submucous Fibrosis ◽  
Mouth Opening ◽  
Immunohistochemical Analysis ◽  
Invasive Front ◽  
Premalignant Condition ◽  
Submucous Fibrosis ◽  
Very High ◽  
Premalignant Conditions

Oral submucous fibrosis is a premalignant condition, characterized by fibrosis in oral mucosa causing stiffness of mucosa and leading to reduced mouth opening. The malignant transformation of oral submucous fibrosis is very high among the rest of the premalignant conditions. Chronic chewing of arecanut causes production of myofibroblasts. These myofibroblasts plays an important role in neoangiogenesis as well as disintegration of the basement membrane at the tumor invasive front leading to carcinoma.  Here, we are doing an Immunohistochemical study using alpha SMA for proper microscopic visulizations of myofibroblastic activity in an OSF patient, encompassing the pathogenesis and malignant potentiality of the disease.

scholarly journals Nasolabial Flap in the Management of Oral Submucous Fibrosis

2016 ◽  
Vol 1 (1) ◽  
pp. 27-29
Author(s):  
Vaishali Jamdade ◽  
Amit LNU
Keyword(s):  
Surgical Treatment ◽  
Physical Therapy ◽  
Oral Submucous Fibrosis ◽  
Mouth Opening ◽  
Oral Carcinoma ◽  
Treatment Modalities ◽  
Nasolabial Flap ◽  
Mahatma Gandhi ◽  
Premalignant Condition ◽  
Submucous Fibrosis

ABSTRACT Oral submucous fibrosis (OSMF) is a premalignant condition associated with restricted mouth opening. Oral submucous fibrosis is poorly understood and unsatisfactorily treated disease. Serious complication is the risk of development of oral carcinoma. Different treatment modalities like medical, surgical, physical therapy or combination are used to improve the condition of the patient. Surgical treatment is usually indicated in late and irreversible stage of the disease. Successful use of nasolabial flap in the management of OSMF is presented. How to cite this article Jamdade V, Sharma S, Chitlangia P, Amit. Nasolabial Flap in the Management of Oral Submucous Fibrosis. J Mahatma Gandhi Univ Med Sci Tech 2016;1(1):27-29.

scholarly journals Vascular endothelial growth factor (VEGF) gene polymorphism in oral submucous fibrosis subjects - A preliminary study

2016 ◽  
Vol 7 (5) ◽  
pp. 10-16 ◽  
Author(s):  
Devishree V Rai ◽  
Kruthika S Guttal ◽  
Bhusan B Kulkarni ◽  
Shivaprakash Hiremath ◽  
Krishna N Burde
Keyword(s):  
Malignant Transformation ◽  
Oral Submucous Fibrosis ◽  
Mouth Opening ◽  
Control Group ◽  
Transformation Rate ◽  
Significant Finding ◽  
Vegf Gene ◽  
Oral Potentially Malignant Disorders ◽  
Male Predominance ◽  
Submucous Fibrosis

Background: Oral Submucous Fibrosis is one of the oral potentially malignant disorders presenting with progressive restriction in mouth opening. The condition having a high malignant transformation rate necessitates identification of biomarkers to be employed for early detection of malignant change. This will influence the prognosis in addition to adding better quality of life to patients.Aims and Objectives: To relate the association of VEGF -460C/T polymorphism in patients with OSMF and to compare the same among healthy subjects.Materials and Methods: Thirty patients with Oral submucous fibrosis and 20 controls free from habits and any form of lesions were included in the study. The polymorphism of VEGF gene was detected by polymerase chain reaction-based restriction analysis.Results: Sixty-four percent of the population in the study was in the age group of 21-40 yrs suggesting the prominence of disease in younger individuals with male predominance. With reference to polymorphism, 6.67% of the subjects from OSMF group showed CT polymorphism and 16.67% showed TT polymorphism. There were no statistically significant differences in the polymorphism between the study group and controls. However the frequency of T allele in the patient group 12 (20%) was greater than that in the control group 1 (2.5%), which was a significant finding. There was no association between the habits, frequency of habits, duration of quid placement, site of quid placement and style of chewing with the nature of polymorphism. Conclusion: VEGF 460C/T has the potential to be used as a prognostic marker in predicting the malignant transformation of OSMF.Asian Journal of Medical Sciences Vol.7(5) 2016 10-16

scholarly journals Hearing Efficiency in Oral Submucous Fibrosis: A Clinical Study

2020 ◽  
Author(s):  
J. S. Shah ◽  
Nutan Lunagariya
Keyword(s):  
Oral Mucosa ◽  
Conductive Hearing Loss ◽  
Oral Submucous Fibrosis ◽  
Hearing Threshold ◽  
Mouth Opening ◽  
Burning Sensation ◽  
Areca Nut ◽  
Gradual Reduction ◽  
Submucous Fibrosis ◽  
Conductive Hearing

Abstract Oral Submucous fibrosis (OSMF) is a chronic insidious disease of oral mucosa that occurs due to areca-nut chewing, consumption of chillies, autoimmunity and genetic predisposition. The disease starts with burning sensation and inability to tolerate spicy foods with gradual reduction in mouth opening due to fibrosis of the oral mucosa. The extension of fibrosis into the naso pharynx leads to reduction in hearing efficiency. As very few studies had been done to evaluate the hearing disability in OSMF patients, this study had been undertaken to prove the same. To evaluate hearing efficiency in patients with Oral Submucous Fibrosis of various grades of severity. Presentation includes 30 patients of osmf with various grades and evaluated for hearing efficacy by audiometry. Hearing threshold was compared in different grades of osmf. The present study revealed a significant association between OSMF and hearing deficit. Involvement of the palatal muscles with OSMF may decrease the patency of the Eustachian tube, leading to conductive hearing loss. Therefore, the protocol for managing OSMF patients should include ENT consultation and treatment for hearing deficit in order to increase the success rate of treatment.

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