scholarly journals Development prospects of primary education integration (on the example of exact and natural sciences)

2021 ◽  
Vol 2 (7/S) ◽  
pp. 221-225
Author(s):  
Navruza Salokhitdinova
Keyword(s):  
Primary Education ◽  
Research Work ◽  
Science Content ◽  
Science Integration ◽  
Teacher Relationships ◽  
Current State ◽  
And Function ◽  
Content Review ◽  
Meaning And Function ◽  
Student Teacher Relationships

This article discusses current state of science integration in primary education reflected in the literature and relevant sources review. In addition, integration of science content review given its meaning and function fully expresses the essence of education. The article also emphasizes importance of correctly established student - teacher relationships in the primary education process and their significant effect on education quality. The research work also puts forward the idea of designing the disciplines’ integration process on the basis of the opinion of teachers and argumentation of the result.

The Bastion of Christendom

2020 ◽  
Vol 25 (2) ◽  
pp. 281-304
Author(s):  
Orsolya Száraz
Keyword(s):  
Cultural Studies ◽  
Collective Memory ◽  
Research Group ◽  
Basic Hypothesis ◽  
And Function ◽  
The University ◽  
Meaning And Function

The Institute of Hungarian Literary and Cultural Studies at the University of Debrecen formed a research group in 2010 in order to launch the research of Hungarian realms of memory. This paper was written within the frameworks of the research group. Its basic hypothesis is that the identification of Hungary as the Bastion of Christendom is an established part of Hungarian collective memory. This paper attempts to demonstrate the changes of this realm of memory, regarding its meaning and function, from its formation up to the present day.

Fractal analysis in biology and medicine

2020 ◽  
pp. 85-92
Keyword(s):  
Fractal Analysis ◽  
A Priori ◽  
Research Work ◽  
Structure And Function ◽  
Review Article ◽  
Living Systems ◽  
Modern Biology ◽  
Additional Information ◽  
Important Additional Information ◽  
And Function

The review article discusses the possibilities of using fractal mathematical analysis to solve scientific and applied problems of modern biology and medicine. The authors show that only such an approach, related to the section of nonlinear mechanics, allows quantifying the chaotic component of the structure and function of living systems, that is a priori important additional information and expands, in particular, the possibilities of diagnostics, differential diagnosis and prediction of the course of physiological and pathological processes. A number of examples demonstrate the specific advantages of using fractal analysis for these purposes. The conclusion can be made that the expanded use of fractal analysis methods in the research work of medical and biological specialists is promising.

MDM2-p53 Interaction Inhibitors: The Current State-of-Art and Updated Patent Review (2010-Present)

2020 ◽  
Vol 14 (4) ◽  
pp. 324-369 ◽  
Author(s):  
Rafał Rusiecki ◽  
Jakub Witkowski ◽  
Joanna Jaszczewska-Adamczak
Keyword(s):  
Therapeutic Potential ◽  
Research Work ◽  
Academic Research ◽  
Tumor Suppressor P53 ◽  
Research Groups ◽  
Current State ◽  
Mouse Double Minute ◽  
Patent Review ◽  
Main Emphasis ◽  
Double Minute

Background: Mouse Double Minute 2 protein (MDM2) is a cellular regulator of p53 tumor suppressor (p53). Inhibition of the interaction between MDM2 and p53 proteins is a promising anticancer therapy. Objective: This updated patent review is an attempt to compile the research and achievements of the various researchers working on small molecule MDM2 inhibitors from 2010 to date. We provide an outlook into the future for therapy based on MDM2 inhibition by presenting an overview of the most relevant patents which have recently appeared in the literature. Methods: Literature and recent patents focusing on the anticancer potential of MDM2-p53 interaction inhibitors and its applications have been analyzed. We put the main emphasis on the most perspective compounds which are or were examined in clinical trials. Results: Literature data indicated that MDM2 inhibitors are therapeutically effective in specific types of cancer or non-cancer diseases. A great number of patents and research work around new MDM2- p53 interaction inhibitors, possible combinations, new indications, clinical regimens in previous years prove that this targeted therapy is in the scope of interest for many business and academic research groups. Conclusion: Novel MDM2 inhibitors thanks to higher potency and better ADME properties have shown effectiveness in preclinical and clinical development however the final improvement of therapeutic potential for MDM2 inhibitors might depend on the useful combination therapy and exploring new cancer and non-cancer indications.

Demonstrative Nouns of INI and AINI in Muna Language

2016 ◽  
Vol 2 (3) ◽  
pp. 1
Author(s):  
La Ode Sidu ◽  
La Ino ◽  
Nirmalasari
Keyword(s):  
A Minor ◽  
And Function ◽  
Meaning And Function ◽  
Reading Book ◽  
Descriptive Qualitative

The article titled “Demonstrative Nouns of ini and aini in Muna Language.” The purpose of this article is to analyze the form, meaning, and function of ini and aini in Muna language. The method used is descriptive qualitative with distributional technique. This method is used to describe and analyze the form, meaning, and function of ini and aini. The results of the analysis found that the form of ini is a base or monomorpheme, while the form of aini is a derivative or polymorpheme which consists of morpheme a- and morpheme aini. In construction of phrase, clause, or sentence generally have the same meaning, namely ‘this’. For instance, O lambu ini damasoe and lambu aini damasoe the meaning is ‘The house will be sold.’ However, when it’s examined more closely, both forms of demonstrative ini and aini in distributional are not interchangeable. For instance, *O lambu aini damasoe dan *Lambu ini damasoe. Both of constructions are ungrammatical caused by form ini has a meaning ‘this’, while form aini means ‘which this’. The bound morpheme a- in aini has a function as a noun marker which pointed in article ini called relative noun marker. Thus, demonstrative aini can stand alone as a minor sentence in the answer sentence, e.g., Question: Hamai bokuku kabasa? ‘Where is my reading book?’ Answer: Aini! ‘This’ < (Here is it!). Demonstrative aini when substituted with ini, the construction became ungrammatical, e.g., Question: Hamai bokuku kabasa? ‘Where is my reading book?’ Answer: *ini. Hereafter, the form ini cannot be formed in more complexes, whereas the form aini can be formed again with another bound morpheme, such as: ainihakanau ‘This is me’, ainihako ‘This is you’, ainihakoomu ‘These are you’, ainihae ‘This is he’, ainihada ‘These are they’, and ainihakasami ‘These are we’.

The Art of Love Poetry

2018 ◽  
Author(s):  
Erik Gray
Keyword(s):  
Popular Culture ◽  
Cultural History ◽  
Literary Tradition ◽  
Love Poetry ◽  
Erotic Love ◽  
Wide Range ◽  
History Of ◽  
And Function ◽  
Meaning And Function ◽  
Comprehensive History

Love begets poetry; poetry begets love. These two propositions have seemed evident to thinkers and poets across the Western literary tradition. Plato writes that “anyone that love touches instantly becomes a poet.” And even today, when poetry has largely disappeared from the mainstream of popular culture, it retains its romantic associations. But why should this be so—what are the connections between poetry and erotic love that lead us to associate them so strongly with one another? An examination of different theories of both love and poetry across the centuries reveals that the connection between them is not merely an accident of cultural history—the result of our having grown up hearing, or hearing about, love poetry—but something more intrinsic. Even as definitions of them have changed, the two phenomena have consistently been described in parallel terms. Love is characterized by paradox. Above all, it is both necessarily public, because interpersonal, and intensely private; hence it both requires expression and resists it. In poetry, especially lyric poetry, which features its own characteristic paradoxes and silences, love finds a natural outlet. This study considers both the theories and the love poems themselves, bringing together a wide range of examples from different eras in order to examine the major structures that love and poetry share. It does not aim to be a comprehensive history of Western love poetry, but an investigation into the meaning and function of recurrent tropes, forms, and images employed by poets to express and describe erotic love.

The Oxford Handbook of the Auditory Brainstem

2018 ◽  
Keyword(s):  
Current Knowledge ◽  
Auditory Pathway ◽  
Auditory Brainstem ◽  
Auditory Midbrain ◽  
Current State ◽  
Neuronal Mechanisms ◽  
Maladaptive Plasticity ◽  
And Function ◽  
Auditory Field

The Oxford Handbook of the Auditory Brainstem provides an in-depth reference to the organization and function of ascending and descending auditory pathways in the mammalian brainstem. Individual chapters are organized along the auditory pathway, beginning with the cochlea and ending with the auditory midbrain. Each chapter provides an introduction to the respective area and summarizes our current knowledge before discussing the disputes and challenges that the field currently faces.The handbook emphasizes the numerous forms of plasticity that are increasingly observed in many areas of the auditory brainstem. Several chapters focus on neuronal modulation of function and plasticity on the synaptic, neuronal, and circuit level, especially during development, aging, and following peripheral hearing loss. In addition, the book addresses the role of trauma-induced maladaptive plasticity with respect to its contribution in generating central hearing dysfunction, such as hyperacusis and tinnitus.The book is intended for students and postdoctoral fellows starting in the auditory field and for researchers of related fields who wish to get an authoritative and up-to-date summary of the current state of auditory brainstem research. For clinical practitioners in audiology, otolaryngology, and neurology, the book is a valuable resource of information about the neuronal mechanisms that are currently discussed as major candidates for the generation of central hearing dysfunction.

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