scholarly journals Review on the Systemic Damage and Biochemical Alterations Associated with COVID-19 Infection

2021 ◽  
Vol 1 (8) ◽  
pp. 34-57
Author(s):  
Yiglet Mebrat
Keyword(s):  
Biochemical Parameters ◽  
Total Bilirubin ◽  
Severe Disease ◽  
Systemic Infection ◽  
Cytokine Storm ◽  
Biochemical Alterations ◽  
The People ◽  
Daily Report ◽  
The World ◽  
Hematological Manifestations

According to the WHO daily report, the world lost 4.3 million peoples and more than 203 million of the people were infected by the epidemic till August 10, 2021. Coronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) is a respiratory disease and it is a systemic infection with cardiovascular, pulmonary, gastrointestinal, neurological, and hematological manifestations, leading to death. Many biomarkers reflecting the main pathophysiological characteristics of the disease have been associated with the risk of developing severe disease. Biochemical changes like leukocytosis, neutrophilia, lymphopenia, cytokine storm, decreased albumin, increase in ALT, total bilirubin, LDH, and procalcitonin levels are significant predictors of ICU admitted COVID-19 patients. So, monitoring of biochemical parameters in COVID-19 patients is critical for assessing disease severity and progression as well as monitoring therapeutic intervention.

scholarly journals Alterations in Various Biochemical Parameters Among Covid-19 Patients: An Observational Retrospective Analysis

2021 ◽  
Vol 14 (4) ◽  
pp. 1648-1659
Author(s):  
Arul Senghor K. Aravaanan
Keyword(s):  
Biochemical Parameters ◽  
Distress Syndrome ◽  
Total Bilirubin ◽  
Ferritin Level ◽  
Respiratory Illness ◽  
Biochemical Alterations ◽  
Indirect Bilirubin ◽  
Assessment And Monitoring ◽  
Novel Coronavirus ◽  
Study Participants

Novel coronavirus causing the pandemic infectious disease termed as COVID-19 is characterized by respiratory illness which may lead on to acute respiratory distress syndrome. Ferritin is a key mediator of immune dysregulation leading on to cytokine storm. Alterations in various biochemical parameters have been widely reported in COVID-19. Early identification of effective biomarkers to assess the severity of this disease is essential. Our study was aimed to evaluate the variations in the routinely analysed biochemical parameters and their association with ferritin levels among COVID patients. The study participants consisted of 270 members among which 149 were COVID positive and 121 were negative. Analysis of the routine biochemical parameters as well as ferritin level were carried out. Among the 149 positive cases, 84 (56.4%) were mild positive with ferritin levels <500ng/ml and 65 (43.6%) were severe positive with ferritin levels >500ng/ml. We reported significant increase in serum ferritin levels in severe positive samples (1449.84 ± 249.47) compared to mild positive samples (230.04 ± 17.41). We observed increased levels of total bilirubin in 12.7%, direct bilirubin in 16.8%, indirect bilirubin in 8.7%, AST in 65.8%, ALT in 44.3%, ALP in 9.4%, GGT in 51.7%, urea in 18.4%, creatinine in 14.3%, BUN in 18.4% and decreased levels of total protein and albumin in 23.5% positive patients compared to negative patients. Ferritin and its associated biochemical parameters act as predictors of COVID severity. These biochemical alterations suggest the significance of early risk assessment and monitoring of COVID patients.

The Platelet Role in Severe and Fatal Forms of COVID-19.

2021 ◽  
Vol 21 ◽  
Author(s):  
Edgar L. Esparza-Ibarra ◽  
Jorge L. Ayala-Luján ◽  
Brenda Mendoza-Almanza ◽  
Irma González-Curiel ◽  
Susana Godina-González ◽  
...  
Keyword(s):  
World Health Organization ◽  
Causes Of Death ◽  
Distress Syndrome ◽  
Severe Disease ◽  
World Health ◽  
Cytokine Storm ◽  
The World ◽  
Critical Patients ◽  
Health Organization ◽  
Coagulation Dysfunction

: On December 31, 2019, the World Health Organization received a report of several pneumonia cases in Wuhan, China. The causative agent was later confirmed as Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Since then, the SARS-CoV-2 virus has spread throughout the world, giving rise in 2020 to the 2019 coronavirus (COVID-19) pandemic, which, according to the world map of the World Health Organization, has, until May 18, 2021, infected 163,312,429 people and caused 3,386,825 deaths throughout the world. Most critical patients progress rapidly to acute respiratory distress syndrome (ARDS) and, in underlying form, to septic shock, irreversible metabolic acidosis, blood coagulation dysfunction, or hemostatic and thrombotic anomalies have been reported as the leading causes of death due to COVID-19. The main findings in severe and fatal COVID-19 patients make it clear that platelets play a crucial role in developing severe disease cases. Platelets are the enucleated cells responsible for hemostasis and thrombi formation; thus, platelet hyperreactivity induced by pro-inflammatory microenvironments contributes to the "cytokine storm" that characterizes the more aggressive course of COVID- 19.

Biochemical biomarkers alterations in Coronavirus Disease 2019 (COVID-19)

Diagnosis ◽  
2020 ◽  
Vol 7 (4) ◽  
pp. 365-372 ◽  
Author(s):  
Marcello Ciaccio ◽  
Luisa Agnello
Keyword(s):  
Early Stage ◽  
Severe Disease ◽  
Inflammatory Biomarkers ◽  
Cytokine Storm ◽  
C Reactive Protein ◽  
Biochemical Biomarkers ◽  
Biochemical Characteristics ◽  
Biochemical Alterations ◽  
Reactive Protein ◽  
Increased Risk

AbstractCoronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a respiratory disease, which can evolve into multi-organ failure (MOF), leading to death. Several biochemical alterations have been described in COVID-19 patients. To date, many biomarkers reflecting the main pathophysiological characteristics of the disease have been identified and associated with the risk of developing severe disease. Lymphopenia represents the hallmark of the disease, and it can be detected since the early stage of infection. Increased levels of several inflammatory biomarkers, including c-reactive protein, have been found in COVID-19 patients and associated with an increased risk of severe disease, which is characterised by the so-called “cytokine storm”. Also, the increase of cardiac and liver dysfunction biomarkers has been associated with poor outcome. In this review, we provide an overview of the main biochemical characteristics of COVID-19 and the associated biomarkers alterations.

Identification of maize mosaic virus by immunoelectron microscopy

1986 ◽  
Vol 44 ◽  
pp. 240-241
Author(s):  
O. E. Bradfute
Keyword(s):  
Zea Mays ◽  
Mosaic Virus ◽  
Immunoelectron Microscopy ◽  
Severe Disease ◽  
Maize Mosaic Virus ◽  
The World ◽  
Plant Rhabdovirus

Maize mosaic virus (MMV) causes a severe disease of Zea mays in many tropical and subtropical regions of the world, including the southern U.S. (1-3). Fig. 1 shows internal cross striations of helical nucleoprotein and bounding membrane with surface projections typical of many plant rhabdovirus particles including MMV (3). Immunoelectron microscopy (IEM) was investigated as a method for identifying MMV. Antiserum to MMV was supplied by Ramon Lastra (Instituto Venezolano de Investigaciones Cientificas, Caracas, Venezuela).

Universal Values and Muslim Democracy

2020 ◽  
Vol 9 (1) ◽  
pp. 1-7
Author(s):  
Anwar Ibrahim
Keyword(s):  
New York ◽  
Muslim World ◽  
World Today ◽  
The People ◽  
The World ◽  
Universal Values ◽  
Human Desire ◽  
Dignified Life

This study deals with Universal Values and Muslim Democracy. This essay draws upon speeches that he gave at the New York Democ- racy Forum in December 2005 and the Assembly of the World Movement for Democracy in Istanbul in April 2006. The emergence of Muslim democracies is something significant and worthy of our attention. Yet with the clear exceptions of Indonesia and Turkey, the Muslim world today is a place where autocracies and dictatorships of various shades and degrees continue their parasitic hold on the people, gnawing away at their newfound freedoms. It concludes that the human desire to be free and to lead a dignified life is universal. So is the abhorrence of despotism and oppression. These are passions that motivate not only Muslims but people from all civilizations.

Peacebuilding requirements in post-conflict societies

2020 ◽  
pp. 249
Author(s):  
Zyad Samir Al-Dabagh
Keyword(s):  
Major Obstacle ◽  
Normal Life ◽  
Post Conflict ◽  
The People ◽  
The World

The process of building peace and laying its foundations within the societies of the world, especially those newly emerging from the stage of conflict, are among the important and indispensable matters. Without peace, opportunities diminish in obtaining the essentials of a safe and normal life, and without peace, societies cannot It works and advances towards a better future. However, peacebuilding operations in many societies emerging from conflict or those in which they live may face a set of challenges and obstacles that constitute a major obstacle to them, which necessitates searching for the best ways and means by which these obstacles can be addressed in order to build a real and effective peace that is reflected Positively on the people of those societies.

Covid-19 – rumours and facts in media

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 171-174
Author(s):  
Tarare Toshida ◽  
Chaple Jagruti
Keyword(s):  
Social Media ◽  
Preventive Measures ◽  
Vital Role ◽  
The Other ◽  
Sources Of Information ◽  
Other Hand ◽  
Corona Virus ◽  
The People ◽  
The World

The covid-19 resulted in broad range of spread throughout the world in which India has also became a prey of it and in this situation the means of media is extensively inϑluencing the mentality of the people. Media always played a role of loop between society and sources of information. In this epidemic also media is playing a vital role in shaping the reaction in ϑirst place for both good and ill by providing important facts regarding symptoms of Corona virus, preventive measures against the virus and also how to deal with any suspect of disease to overcome covid-19. On the other hand, there are endless people who spread endless rumours overs social media and are adversely affecting life of people but we always count on media because they provide us with valuable answers to our questions, facts and everything in need. Media always remains on top of the line when it comes to stop the out spread of rumours which are surely dangerous kind of information for society. So on our side we should react fairly and maturely to handle the situation to keep it in the favour of humanity and help government not only to ϑight this pandemic but also the info emic.

The relevance of dietetic approach of Ayurveda from the perspective of COVID-19 pandemic

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 748-752
Author(s):  
Swapnali Khabade ◽  
Bharat Rathi ◽  
Renu Rathi
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Healthy Person ◽  
World Health ◽  
Physical And Mental Health ◽  
Leading Role ◽  
Global Pandemic ◽  
The People ◽  
The World ◽  
Health Organization ◽  
The Individual

A novel, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causes severe acute respiratory syndrome and spread globally from Wuhan, China. In March 2020 the World Health Organization declared the SARS-Cov-2 virus as a COVID- 19, a global pandemic. This pandemic happened to be followed by some restrictions, and specially lockdown playing the leading role for the people to get disassociated with their personal and social schedules. And now the food is the most necessary thing to take care of. It seems the new challenge for the individual is self-isolation to maintain themselves on the health basis and fight against the pandemic situation by boosting their immunity. Food organised by proper diet may maintain the physical and mental health of the individual. Ayurveda aims to promote and preserve the health, strength and the longevity of the healthy person and to cure the disease by properly channelling with and without Ahara. In Ayurveda, diet (Ahara) is considered as one of the critical pillars of life, and Langhana plays an important role too. This article will review the relevance of dietetic approach described in Ayurveda with and without food (Asthavidhi visheshaytana & Lanhgan) during COVID-19 like a pandemic.

Awareness about Covid 19 Pandemic and its Social Impacts on Normal Human Lifestyle Among Chennai Population

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 659-666
Author(s):  
Anu Iswarya Jaisankar ◽  
Raghu Nandhakumar ◽  
Ezhilarasan D
Keyword(s):  
Psychological Stress ◽  
Economic Burden ◽  
Economic Impacts ◽  
Functional Limitations ◽  
Social Impacts ◽  
Biological Processes ◽  
The People ◽  
The World ◽  
Normal Human

Covid 19 pandemic is a terrible ongoing pandemic that has spread worldwide. Covid 19 Pandemic has infected more than 188 countries and territories across the globe. The basic biological processes and functional limitations that govern the development and survival of the particular behaviors of the virus continue to be elucidated. On that note, Prevention is the only cure. The World is facing a great economic turmoil. People suffer from Psychological stress and Economic burden combined. Here assessing the Psychological, Physical, Social, Financial and Economic impacts of the Pandemic on the people becomes really very important in analysing the mindset of the people and in evaluating the significance of implemented changes and in implementing new changes. The current study aims at analysing the various impacts of Covid 19 on the people residing at the Greater Chennai corporation circle.

Role of Self Help Groups A Study with Specific Reference to Vellore District

GIS Business ◽  
2019 ◽  
Vol 14 (6) ◽  
pp. 243-252
Author(s):  
Dr. M.A. Bilal Ahmed ◽  
Dr. S. Thameemul Ansari
Keyword(s):  
Leadership Role ◽  
Three Dimensions ◽  
Specific Reference ◽  
Government Organizations ◽  
Research Article ◽  
Self Help ◽  
The People ◽  
The World ◽  
Self Help Groups

SHG is a movement which came to being in the early 1969. Prof. Muhammed Younus, a great economist of Bangladesh took initiative in setting up Self Help Groups and these SHGs were gradually spread all over the world. This social movement unites the people hailing from poor background. Those who are joining this group feel socially and economically responsible to one another. In India, there are some likeminded bodies and stakeholders of some government organizations play pivotal role towards the formation of SHG In this research article, role of SHGs in Vellore district is studies under the three dimensions of Cognitive role, leadership role and role towards entrepreneurship.

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