scholarly journals Study on the production of Reference Material (RM) for Vitamin B1, B2, B6 in health supplements

Author(s):  
Hang Nguyen Thi ◽  
Phuong Thao Le Thi ◽  
Huu Cuong Dang ◽  
Huyen Trang Luu Thi ◽  
Hong Hao Le Thi ◽  
...  

Vitamins are essential nutrients commonly found in food products in general and health supplements in particular. In order to accurately evaluate product quality, laboratories need to use reference material in analysis, proficiency assessment, method validation and ensure the validity of the results. The use of reference materials plays an important role in the quality control of test results and is a mandatory requirement for laboratories wishing to demonstrate appropriate competence as required by ISO/IEC 17025:2017. The need to provide reference materials for laboratories is huge. However, at present, there are very few domestic organizations that can produce reference materials, while the cost of buying reference materials from reputable firms in the world is expensive. In this study, we introduced the procedure and production reference materials for the analysis of B-group vitamins (B1, B2, B6). These reference materials were evaluated for homogeneity and stability in 322 days. The certified values are consistent with the concentrations of substances present in normal samples in practice. The measurement uncertainty ranges from 14.5 - 23.3 %. The reference materials can be used for internal quality control for domestic laboratories and is also a premise for further research on standard samples with different matrix and analytical criteria.

1998 ◽  
Vol 6 (A) ◽  
pp. A53-A61
Author(s):  
Judit Budai ◽  
Judit Fükó

The Chemical Section of OMH1,2 embarked on the preparation of a series of wheat samples as Certified Reference Materials (CRMs) in 1992. The certification processes were carried out according to the recommendations of ISO. Since then we have developed a series of flour samples as well. The investigations of the long-term stability and the application of wheat and flour CRMs are continuous. Wheat is one of the most widely grown crops in Hungary and it is one of the major determining factors of the economy. Its uniform and objective qualification is of great importance. There are well-equipped laboratories available with sufficient experience but, as the proficiency testing regularly showed, certified samples need to be used to achieve exact and uniform measuring results.


2019 ◽  
Vol 22 ◽  
Author(s):  
Carla de Oliveira Rosas ◽  
Janaína Marques Rodrigues ◽  
Marcus Henrique Campino de la Cruz ◽  
Silvia Maria dos Reis Lopes ◽  
Aline da Silva Soares Souto ◽  
...  

Abstract Reference materials are crucial for laboratory quality assurance. They are widely used for the internal quality control of analytical tests, in the validation of methodologies and as test items in proficiency tests. Microbiological reference materials are represented mainly by reference strains, whose use in laboratory internal quality control is unquestionable and recommended by several microbiological manuals. In Brazil, the practice of producing microbiological reference materials has advanced in recent years in the development of specific materials for proficiency testing. However, the same did not occur with the establishment of reference strains due to a lack of incentive policies, maintaining the country dependant on the use of international reference strains. This article aims to emphasize the importance of the use of microbiological reference materials in laboratory quality control and discuss the need for the development of such materials in Brazil. The paper presents a brief explanation of microbiological reference materials and points out questions concerning the country’s dependence on the acquisition of international biological materials. It also describes quality standards related to the production of these materials and the situation of culture collections and Brazilian reference laboratories that supply reference strains. The study also mentions practical recommendations on the subcultures of reference strains.


2015 ◽  
Vol 17 (2) ◽  
pp. 131-137
Author(s):  
Willy Cahya Nugraha ◽  
Yohanes Susanto Ridwan

Lead is widely knows as one of the harmful pollutants for humans. Contaminated fishery built by lead may endanger the consumption body. Therefore, contamination monitoring for the fishery products is necessary to be conducted. To ensure the validity of data, Oyster Tissue 1566b certified reference material was used as Internal Quality Control. Marlin fish powder and certified reference materials were analyzed with the same method, personnel, duration or time, equipment and environmental conditions. As the results, it was found that the lead contained in CRM was 0.306 mg.kg-1 with 11.9 % rsd, which is within range of lead content in  the certificate. The method was applied for Marlin Fish. Lead content obtained in this study (1.821 mg.kg-1 with 11.06 % rsd) can be reported with high level of confidence.Keywords: Lead, Certified Reference Materials, Marlin fish


1973 ◽  
Vol 19 (1) ◽  
pp. 62-66 ◽  
Author(s):  
Ronald H Laessig ◽  
Thomas H Schwartz ◽  
Toni A Paskey

Abstract A state-wide cooperative quality-control program for automated multichannel analytical systems is described. The survey benefits participating laboratories by providing, through regular comparison, a means of improving interlaboratory precision. A common lot of reference material used for a large group of similar multichannel analyzers is shown to significantly improve their precision. The study delineates components of interlaboratory variation resulting from the inconsistency of the reference materials and from the inherent precision of the analyzers. Errors in the assay values of commercial controls and reference sera, as well as problems of homogeneity in these products, are documented. These errors make some form of regular interlaboratory comparison an essential element of a total quality-control program


2019 ◽  
Vol 63 (9) ◽  
pp. 1061-1069
Author(s):  
Yvonne Giesen ◽  
Franziska Nürnberger ◽  
Krista Gusbeth ◽  
Ann-Kathrin Mühlberg ◽  
Nils Lamm ◽  
...  

Abstract Quality control is crucially important in the arena of chemical analysis. Reference materials are essential for calibration and quality control processes, and for verification of the accuracy and reliability of the analytical results obtained. Owing to the complexity of their manufacture, reference materials for chemical agents occurring at workplaces are expensive and available only on a limited scale and for a small number of substances. Therefore, their cost-effective and fast production is an important aim. The Institute for Occupational Health and Safety (IFA) of the German Social Accident Insurance (DGUV) currently pursues different strategies for the production of reference materials. One strategy entails the use of a piezoelectric micro-dispensing system for non-contact spiking of extremely small quantities of substances with high reproducibility. The dispensing system is coupled to a semi-automated assembly unit for loading high numbers of samples. It is used for spiking phosphoric and sulphuric acid onto quartz fibre filters. Comparison of the results obtained on different days shows higher variability than results observed on the same day. However, after daily adjustment of the number of droplets to the current droplet volume, highly reproducible series with an adequate number of samples (>500) could be realized. The results of the internal quality control were verified in an interlaboratory comparison. Furthermore, storage stability was investigated systematically over a period of 2 years. The samples produced are suitable for use as reference materials for both inorganic acids.


2019 ◽  
Vol 37 (3) ◽  
pp. 273
Author(s):  
Armando Guerrero Peña ◽  
Aarón Jarquín Sánchez ◽  
Jorge D. Etchevers Barra ◽  
Irma J. González Acuña ◽  
Lorena Del Carmen Hernández Nataren ◽  
...  

The Mexican regulation NMX-EC-17025-IMNC-2006, establishes that laboratories must have quality control procedures to monitor the validity of tests and calibrations, such monitoring must be planned and reviewed with: a) the regular use of certif ied reference materials or internal quality control of secondary references; b) participation in inter-laboratory comparisons or a prof iciency testing program; c) the repetition of tests or calibrations using the same method or different methods; d) the repetition of the test or the calibration of determined objects; e) the correlation of results for different characteristics of a reference material certif ied by MRC. The quality evaluation of results from the eight laboratories of the Laboratory Network for Analysis, Use, Conservation and Management of Soil (REDLABS) included the elements of sections a), b), c), and d) in order to verify the hypothesis that laboratories emit repeatable, reproducible and unbiased results. In our study, elemental analyzers of different brands were used to measure the total carbon of soil. A certif ied reference material was included in the Inter-comparison Practice. Repeatability and reproducibility of the carbon analyzes were evaluated with samples from the inter-comparison practice; the precision of analyzes from each laboratory was qualif ied with MRC. The results obtained indicate that the laboratories show repeatability in their analyzes with no statistical differences, i.e. reproducibility is detected by inter-comparison. The data issued by the laboratories were unbiased according to their evaluation with certif ied reference material.


2020 ◽  
Vol 108 (2) ◽  
pp. 99-103 ◽  
Author(s):  
Santiago Hurtado-Bermúdez ◽  
José Luis Mas

AbstractCertified reference materials (CRM) are being widely used for quality control assurance in environmental analysis. For certain CRM, the analytes and/or the range of concentrations are not be available or certified at all. The Joint Research Centre – Institute for Reference Materials and Measurements (JRC-IRMM) of the European Commission has issued a CRM of Wild Berries (IRMM-426) in order to validate radionuclide measurement methods for activity concentrations of the natural radionuclide 40K and the anthropogenic nuclides 90Sr and 137Cs, but not for 210Po. The aim of the work was to determine low-level activity concentration of 210Po in these wild berries. The activity concentration of 210Po was assessed by α-particle spectroscopy after dissolution of the sample by wet digestion and chemical isolation of Po by extraction chromatography. According to the time elapsed since sample collection, the results here shown can be useful not only for ultra low-level analysis of 210Po but also for 210Pb in the reference material.


2021 ◽  
pp. 39-47
Author(s):  
F.N. Karachevtsev ◽  
◽  
S.G. Eroshkin ◽  
I.V. Mostayev ◽  
M.V. Akinina ◽  
...  

A technology for the manufacture and production of reference material (CRM) of the composition of magnesium alloys of the VML20 and VMD16 grades has been developed. In FSUE «VNIIOFI» tests of CRM material were carried out in order to approve their type, as well as metrological examination. Conclusions were drawn up on checking the results of CRM testing for the composition of the indicated alloys and certificates of type approval of reference materials were issued. CRM sets of the approved type of state standard samples of high-strength magnesium alloys of VML20 and VMD16 grades have a relative error of the certified values of the mass fraction of elements in the range from 0.5 to 5% (by weight) no more than 5% rel.


1985 ◽  
Vol 31 (2) ◽  
pp. 261-263 ◽  
Author(s):  
A Hainline ◽  
P Hill ◽  
L Garbaczewski ◽  
C Winn

Abstract A special standardization and quality assurance program, similar to that created for the Lipid Research Clinics Program (LRC), was developed for the American Health Foundation Laboratory by the Centers for Disease Control (CDC) to assure the quality of lipid measurements in the U.S. Air Force Health Evaluation and Risk Tabulation (HEART) Program. This study was designed to test the feasibility of reducing the incidence of heart disease in active-duty U.S. Air Force personnel through life-study intervention. During the 18-month study, CDC provided serum calibrators and reference materials for internal control and an external surveillance program for measurements of total cholesterol (TC) and high-density-lipoprotein cholesterol (HDLC). The Laboratory, using an automated enzymic method to measure cholesterol, achieved an overall goal for accuracy of less than 2% error (av systematic error, -30.6 mg/L) for TC, as measured on nine reference pools for which values were assigned by CDC. The average bias of measurements of HDLC with heparin-manganese to separate the lipoproteins in five CDC reference pools was -4.6 mg/L. Bias was estimated relative to the values assigned to the reference materials by the CDC reference methods for TC and HDLC. The average CV for TC was 0.89%, for HDLC 2.66%. Accuracy of cholesterol measurements can be assured over time with a standardization and quality-assurance program that incorporates accurately labeled reference materials for calibration, internal quality control, and external surveillance.


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