scholarly journals Clinical Benefit of Chemotherapy for Small-Cell Lung Cancer Patients with Extremely Poor Performance Status (PS)

2018 ◽  
Vol 26 (1) ◽  
pp. 1-6
Author(s):  
Ou Yamaguchi ◽  
Hiroshi Kagamu ◽  
Atsuto Mouri ◽  
Ayako Shiono ◽  
Harue Utsugi ◽  
...  
2020 ◽  
Vol 130 ◽  
pp. 155-167 ◽  
Author(s):  
Francesco Facchinetti ◽  
Giulia Mazzaschi ◽  
Fausto Barbieri ◽  
Francesco Passiglia ◽  
Francesca Mazzoni ◽  
...  

2012 ◽  
Vol 20 (11) ◽  
pp. 2721-2727 ◽  
Author(s):  
Clarissa Seródio Baldotto ◽  
Eduardo Henrique Cronemberger ◽  
Paulo de Biasi ◽  
Mauro Zamboni ◽  
Aureliano Sousa ◽  
...  

Cancers ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1995
Author(s):  
Nagio Takigawa ◽  
Nobuaki Ochi ◽  
Nozomu Nakagawa ◽  
Yasunari Nagasaki ◽  
Masataka Taoka ◽  
...  

Lung cancer patients ≥75 years represent nearly 40% of all lung cancer patients and continue to increase. If elderly patients have a good performance status and adequate organ function, they can be treated the same as non-elderly patients. However, few comparative studies limited to elderly patients (≥75 years) have been conducted. We review the evidence on using immune check inhibitors for the treatment of elderly patients (≥75 years old) with advanced non-small cell lung cancer. Prospective randomized or non-randomized, retrospective, registrational, insurance-based, and community-based studies have shown that elderly (≥75 years) and non-elderly patients are similarly treated with immune check inhibitors effectively and safely. However, such analyses have not shown that immune check inhibitors are significantly more effective than chemotherapy alone. In addition, patient selection might be critically performed to administer immune check inhibitors in the elderly because they are more likely to have a poor performance status with comorbidities, which lead to little benefit, even in non-elderly patients. There is a need for more evidence showing the benefit of immune check inhibitors in non-small cell lung cancer patients ≥75 years.


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