scholarly journals Clinical Outcomes of Salivary Gland Tumor Surgery: A 10-year-chart View

2021 ◽  
Vol 12 (1) ◽  
pp. 11-14
Author(s):  
Sanjeev Mohanty ◽  
Vinoth Manimaran ◽  
Tejasvi Vemuru ◽  
Shiva Priya
Keyword(s):  
Salivary Gland ◽  
Submandibular Gland ◽  
Clinical Outcomes ◽  
Malignant Tumors ◽  
Histopathological Examination ◽  
Salivary Gland Tumor ◽  
Salivary Gland Tumors ◽  
Tumor Surgery ◽  
Gland Tumor ◽  
Parotid Tumors

ABSTRACT Background Salivary gland tumors constitute about 3% of all head and neck tumors. We present a series of 104 cases of various salivary gland pathologies and the various modalities of surgeries done between January 2007 and July 2017. Materials and methods Total 104 patients with salivary gland tumors were included in this study, of which 76 patients had parotid tumors and 28 were submandibular gland tumors. The presence or absence of coexisting salivary gland stones, involvement or noninvolvement of ducts were all considered. Preoperatively, patients underwent fine needle aspiration cytology (FNAC) and imaging studies along with routine blood investigations. Results All patients underwent surgery and subsequent histopathological examination (HPE). The preoperative FNAC and postoperative HPE were not correlating in 6.5% of parotid tumors and in 3.5% of submandibular gland tumor. Anomalies in the fasciovenous planes were seen in 3% of the patients, which caused intraoperative difficulties. Postoperatively, five patients had salivary leak and three patients had neuropraxia, which was managed conservatively and the patients recovered subsequently between 3 months and 6 months postoperatively. Conclusion Surgery for salivary gland tumors has its own threats due to the close proximity of nerve, vessels, and ducts. Postoperative complications like nerve palsy is seen more common in malignant tumors in both parotid and submandibular gland tumors. A proper methodical assessment and awareness of the various anatomical anomalies intraoperatively may give good surgical outcomes in surgeries of salivary gland tumors. In our study, various anomalies were encountered and dealt appropriately. How to cite this article Vemuru T, Mohanty S, Manimaran V, et al. Clinical Outcomes of Salivary Gland Tumor Surgery: A 10-year-chart View. Int J Head Neck Surg 2021;12(1):11–14.

scholarly journals Primary Salivary Gland Tumors- A two years study at Nobel Medical College

2019 ◽  
Vol 2 (2) ◽  
pp. 234-238
Author(s):  
Niraj Nepal ◽  
Prabesh Kumar Choudhary ◽  
Manish Kumar Das ◽  
Meenakshi Basnet ◽  
Sagar Paudel
Keyword(s):  
Salivary Gland ◽  
Pleomorphic Adenoma ◽  
Mucoepidermoid Carcinoma ◽  
Malignant Tumors ◽  
Age Groups ◽  
Salivary Gland Tumor ◽  
Salivary Gland Tumors ◽  
Parotid Glands ◽  
Gland Tumor ◽  
Medical College

Introduction: Salivary gland tumors are a heterogeneous group of neoplasms that are relatively rare but represent a wide variety of both benign and malignant histopathologic subtypes. The aim of this study was to find out the histopathological distribution of primary salivary gland tumors and correlate fine needle aspiration cytology reports with histological findings.Materials and Methods: A total of 83 patients attending the otorhinolaryngology department with salivary gland tumors were enrolled in our study. The histopathological findings were reported and correlated with cytological findings.Results: The mean age of the patient with salivary tumors was 43.11 ± 13.02 years. Out of 83 cases, 3 (3.6%) patients were diagnosed as inflammatory lesions, 64 (77.1%) patients had benign salivary gland tumors and 16 (19.3%) of patients had malignant salivary glands tumors in histopathology. The sensitivity and specificity of FNAC in this series for detecting salivary gland malignancy were 68.8% and 98.5% respectively with an overall diagnostic accuracy of 92.8%. The most common salivary gland tumor was found to be pleomorphic adenoma (56.6%) and the most common malignant salivary gland tumor was found to be mucoepidermoid carcinoma (19.3%). The comparison of the incidence of salivary gland tumors in various age groups showed a statisticallysignificant difference (p=0.009).  Conclusions: Benign salivary tumors are more common than malignant tumors with the most common occurrence in parotid glands. Pleomorphic adenoma is the most common benign tumor whereas; mucoepidermoid carcinoma is the most common malignant tumor in patients visiting Nobel medical college.

scholarly journals 2021 Update on Diagnostic Markers and Translocation in Salivary Gland Tumors

2021 ◽  
Vol 22 (13) ◽  
pp. 6771
Author(s):  
Malin Tordis Meyer ◽  
Christoph Watermann ◽  
Thomas Dreyer ◽  
Süleyman Ergün ◽  
Srikanth Karnati
Keyword(s):  
Salivary Gland ◽  
Malignant Tumors ◽  
Salivary Gland Tumor ◽  
Incidence Rates ◽  
Salivary Gland Tumors ◽  
Gland Tumor ◽  
Adenoid Cystic ◽  
Recent Developments ◽  
Tumor Entity ◽  
Low Incidence

Salivary gland tumors are a rare tumor entity within malignant tumors of all tissues. The most common are malignant mucoepidermoid carcinoma, adenoid cystic carcinoma, and acinic cell carcinoma. Pleomorphic adenoma is the most recurrent form of benign salivary gland tumor. Due to their low incidence rates and complex histological patterns, they are difficult to diagnose accurately. Malignant tumors of the salivary glands are challenging in terms of differentiation because of their variability in histochemistry and translocations. Therefore, the primary goal of the study was to review the current literature to identify the recent developments in histochemical diagnostics and translocations for differentiating salivary gland tumors.

CLINICOPATHOLOGICAL STUDY ON RARE MALIGNANT TUMORS OF PAROTID GLAND AND COMPREHENSIVE REVIEW ON NEWER ENTITIES OF SALIVARY GLAND TUMORS

2021 ◽  
pp. 35-40
Author(s):  
Veena B Ganga ◽  
Krishnappa Krishnappa
Keyword(s):  
Salivary Gland ◽  
Malignant Tumors ◽  
Treatment Strategies ◽  
Salivary Gland Tumors ◽  
Term Survival ◽  
Comprehensive Review ◽  
Parotid Tumors ◽  
Time Period ◽  
Classi Cation

Salivary gland tumors are a heterogeneous group of tumors in the head and neck; most of the malignant tumors have a poor prognosis and limited long-term survival. The recent 2017 WHO classication had made few changes in the sub-categorization and modied some terms. More studies are underway in the eld of molecular level changes and responses to targeted therapies in these tumors. These researches have shown some resemblance in the behavior of salivary gland and breast carcinomas, leading to a new line of thinking in terms of hormonal therapy. This study outlines 14 cases of rare parotid tumors reported in our institute during the time period of 2018 to 2020 and a comprehensive review on salivary gland tumors, newer entities added, and newer treatment strategies.

scholarly journals Pattern of distribution of different salivary gland tumors; a retrospective study in NICRH, Dhaka

2016 ◽  
Vol 15 (1) ◽  
pp. 95-98
Author(s):  
Afroza Khanam ◽  
Gulshan Akhter ◽  
Md. Abdur Rahman
Keyword(s):  
Salivary Gland ◽  
Retrospective Study ◽  
Parotid Gland ◽  
Minor Salivary Gland ◽  
Salivary Gland Tumor ◽  
Salivary Gland Tumors ◽  
Major Salivary Gland ◽  
Gland Tumor ◽  
Minor Salivary Gland Tumors ◽  
Malignant Salivary Gland Tumors

Background: Salivary gland tumors are rare, generally benign and affect both major and minor salivary glands.Objective: To find out the pattern of distribution of different benign and malignant salivary gland epithelial tumors and their relation to age and sex in a tertiary care center in Bangladesh.Methodology: This is a retrospective study. Details of epithelial salivary gland tumors were obtained from department of ENT, National institute of cancer & research hospital (NICRH), Dhaka, Bangladesh from the period January 2009 to December 2012 (3 years).Result: A total number of 261 cases presenting with both benign and malignant salivary gland tumors were analyzed according to gender, age and histopathological findings. There were 130 (49.84%) males and 131 (50.19%) females with the male female ration of 1: 0.99. Age of study population ranged from 10 to 70 years with the mean age 40.78. Percentage of benign salivary gland tumors was 73.94% and malignant salivary gland tumor 26.05%. Among major salivary gland tumors, no sublingual tumors were found and parotid gland tumors were the commonest. Whereas, among minor salivary gland tumors palatal minor salivary tumors were common.Conclusion: Parotid gland was the most common site of origin of both benign and malignant salivary gland tumors. Histopathologically, pleomorphic adenoma was the most common benign salivary gland tumor and mucoepidermoid carcinoma was the most frequent malignant neoplasm. Adenoid cystic carcinoma was common minor salivary gland tumor.Bangladesh Journal of Medical Science Vol.15(1) 2016 p.90-94

The value of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in salivary gland tumors.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e17592-e17592
Author(s):  
Idris Yucel ◽  
Ozgur Kemal ◽  
Yasemin Kemal ◽  
Ayse Bel ◽  
Ugur Yildirim ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Malignant Tumors ◽  
Hematological Parameters ◽  
Salivary Gland Tumor ◽  
Salivary Gland Tumors ◽  
Neutrophil To Lymphocyte Ratio ◽  
Platelet To Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Inflammatory Parameters ◽  
Tumor Group

e17592 Background: Salivary gland tumors are rare, comprising only 6 to 8 percent of head and neck neoplasms. Most of them are benign and commonly occur in the parotid gland. In the last decade elevated hematological inflammatory parameters like neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) were identified as predictive and prognostic factors in various malignancies. The aim of this study was to evaluate the differences of preoperative of NLR and PLR levels in benign and malignant causes of salivary gland tumors. Methods: This retrospective study was made of a total of 133 patients with salivary gland tumors (age range: 17-89 years; 68 male and 65 female) who were treated between January 2006 and May 2016. Preoperative counts and levels of hematological parameters were obtained from the recorded computerized database in benign and malignant tumors. Results: NLR and PLR levels were significantly higher in the malignant salivary gland tumor group than the benign group( NLR: 0.66±1.3 vs 0.59±0.31 p=0.001, PLR: 160.3±85.7 vs 124.6±44.1 p=0.014). Conclusions: The results of the current study revealed the potential predicitve role of NLR and PLR in patients with salivary gland tumors. These cheap and easily available blood count parameters could be useful biomarkers in the future; but further investigations are needed to confirm our findings. [Table: see text]

scholarly journals New Developments in Salivary Gland Pathology: Clinically Useful Ancillary Testing and New Potentially Targetable Molecular Alterations

2017 ◽  
Vol 141 (3) ◽  
pp. 381-395 ◽  
Author(s):  
Christopher C. Griffith ◽  
Alessandra C. Schmitt ◽  
James L. Little ◽  
Kelly R. Magliocca
Keyword(s):  
Salivary Gland ◽  
In Situ Hybridization ◽  
Fluorescence In Situ Hybridization ◽  
Salivary Gland Tumor ◽  
Molecular Techniques ◽  
Salivary Gland Tumors ◽  
Gland Tumor ◽  
Molecular Alterations ◽  
Tumor Pathology

Accurate diagnosis of salivary gland tumors can be challenging because of the many diagnostic entities, the sometimes extensive morphologic overlap, and the rarity of most tumor types. Ancillary testing is beginning to ameliorate some of these challenges through access to newer immunohistochemical stains and fluorescence in situ hybridization probes, which can limit differential diagnostic considerations in some cases. These ancillary testing strategies are especially useful in small biopsy samples, including aspiration cytology. Molecular techniques are also expanding our understanding of salivary gland tumor pathology and are helping to identify potential targets that may improve treatment for some of these tumors. Here, we summarize the clinical use of new immunohistochemical markers in our practice and review the current understanding of chromosomal rearrangements in salivary gland tumor pathology, emphasizing the prospects for exploiting molecular alterations in salivary gland tumors for diagnosis and targeted therapy. We find that immunohistochemistry and fluorescence in situ hybridization are powerful tools toward the diagnosis of salivary gland tumors, especially when used in a systematic manner based on morphologic differential-diagnostic considerations. As new targeted therapies emerge, it will become increasingly vital to incorporate appropriate molecular testing into the pathologic evaluation of salivary gland cancers.

scholarly journals Upregulation of Serum Vascular Endothelial Growth Factor in Patients with Salivary Gland Tumor

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Azadeh Andisheh Tadbir ◽  
Bijan Khademi ◽  
Mahyar Malekzadeh ◽  
Maryam Mardani ◽  
Bahar Khademi
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Salivary Gland ◽  
Growth Factor ◽  
Malignant Tumors ◽  
Salivary Gland Tumor ◽  
Benign Tumors ◽  
Vascular Endothelial ◽  
Healthy Controls ◽  
Gland Tumor ◽  
Endothelial Growth Factor

Neoangiogenesis is essential for tumor development, invasion, and dissemination. The most potent of the cytokines associated with angiogenesis is vascular endothelial growth factor (VEGF). The aim of the present study was to determine VEGF serum level in patients with salivary gland tumor. Using an ELISA kit, the circulating levels of VEGF in sera from 58 patients with salivary gland tumor and 30 healthy controls were assessed. Mean VEGF levels in sera of patients with salivary gland tumors (574.9 ± 414.3) were significantly higher than those in controls (263.9 ± 310.0) (P=0.009). Within the salivary gland tumor group, mean serum VEGF concentration in malignant tumors (n=27) was 727.3 ± 441.8 pg/mL, and that in benign tumors (n=31) was 442.2 ± 343.3 pg/mL. Mean serum VEGF concentration was significantly higher in malignant tumors than in benign tumors (P=0.008) and was higher in benign tumors than in controls (P=0.03). The data in the present study clearly show that VEGF level was consistently upregulated in benign and malignant tumors in comparison to healthy controls. However, the role of VEGF as a prognostic factor in salivary gland tumor and its application in antiangiogenic therapy require further clinical research.

scholarly journals Histopathological Pattern of Salivary Gland Tumors

2014 ◽  
Vol 4 (7) ◽  
pp. 520-524 ◽  
Author(s):  
S Shrestha ◽  
GK Pandey ◽  
CB Pun ◽  
R Bhatta ◽  
R Shahi
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Pleomorphic Adenoma ◽  
Malignant Tumor ◽  
Mucoepidermoid Carcinoma ◽  
Salivary Gland Tumor ◽  
Salivary Gland Tumors ◽  
Carcinoma Ex Pleomorphic Adenoma ◽  
Common Site ◽  
Gland Tumor

Background: The tumors of the salivary glands are uncommon head and neck neoplasms. The aim of this study was to evaluate the relative frequencies, types, site distribution and the histopathological features of salivary gland tumors. Materials and Methods: This was a retrospective study of 176 cases of salivary gland tumors collected from medical record section and department of pathology at B.P.Koirala Memorial Cancer Hospital from Jan. 2005 to Dec. 2010. Tumors were analyzed based on demographics, anatomic location and histopathological type. Results: Out of 176 cases, 66 (37.5 %) were benign and 110 (62.5 %) were malignant with M:F ratio of 1.7:1. The mean age observed was 44.76 years with age range of 12 to 75 years. Pleomorphic adenoma was found to be the commonest benign tumor (72.7 %), followed by Warthin tumor (15.1%), monomorphic adenoma (3.0 %) and basal cell adenoma (3.0 %). The mucoepidermoid carcinoma was the most common malignant tumor (38.1 %), followed by adenoid cystic carcinoma (25.4%), acinic cell carcinoma (10.9%), adenocarcinoma NOS (6.3%), carcinoma ex pleomorphic adenoma (5.4%) and unclassified malignant tumor (4.5 %). Parotid was the most common site for the location of tumors (70.4%) followed by submandibular (19.3%) and minor salivary glands (10.2 %). Conclusion: Pleomorphic adenoma was the commonest salivary gland tumor observed in both sexes. Mucoepidermoid carcinoma was the most common malignant salivary gland tumor. The parotid gland was the most common site of origin in both benign and malignant tumors. DOI: http://dx.doi.org/10.3126/jpn.v4i7.10291 Journal of Pathology of Nepal (2014) Vol. 4, 520-524

Principles of Salivary Gland Tumor Surgery

2015 ◽  
pp. 59-59
Author(s):  
Krishnakumar Thankappan ◽  
Mahamaya Singh ◽  
Subramania Iyer
Keyword(s):  
Salivary Gland ◽  
Salivary Gland Tumor ◽  
Tumor Surgery ◽  
Gland Tumor

R411 – FISH of Salivary Tumors to Enhance Diagnostic Accuracy

2008 ◽  
Vol 139 (2_suppl) ◽  
pp. P180-P181
Author(s):  
Tania L Kraai ◽  
Garth T Olson ◽  
Therese J Bocklage ◽  
Hozier John
Keyword(s):  
Salivary Gland ◽  
Diagnostic Accuracy ◽  
Malignant Tumors ◽  
Salivary Gland Tumor ◽  
Needle Aspiration ◽  
Salivary Gland Tumors ◽  
Fish Analysis ◽  
Malignant Group ◽  
Cost Efficient ◽  
Multiple Samples

Problem Fine needle aspiration biopsy (FNAB) is used to triage patients with salivary tumors. Distinguishing benign from malignant is difficult on cytology features and immunohistochemistry alone, leading sometimes to an incorrect surgical resection. Therefore, we evaluated whether fluorescent in situ hybridization (FISH) could be performed routinely on salivary gland tumor FNAB's, potentially to improve diagnostic accuracy. Methods Pathology files from our institution were searched for patients with salivary gland tumors. We collected data on 74 tumors: 25 benign (18 pleomorphic adenoma and 7 Warthin's tumors) and 49 malignant (miscellaneous including adenoid cystic carcinoma, mucoepidermoid carcinoma and acinic cell carcinoma, among others). Clinical presentation, staging, and follow-up information were obtained. Representative tumor blocks were disaggregated, converted to nuclear preps, and analyzed for aneuploidies of chromosomes 3, 7, 9, 11, and 19 using FISH. A novel technique creating a CMA (cytology microarray) enabled testing of multiple samples on one glass slide. Signal quantitation was performed using a Metasystems instrument. Shrunken centroid analysis was used to test for significant differences in the benign versus malignant group. Results Six tumors exhibited trisomies (8 percent); those few were exclusively limited to the malignant tumors. The tumor preps yielded adequate cellularity in 90% percent, and the CMA technique was time and cost efficient. Conclusion In a large number of salivary gland tumors, we found that chromosome copy number abnormalities do not occur with high enough frequency to enhance diagnostic accuracy. When trisomy occurs, it more likely is associated with malignancy. Significance Polyploidy seen on FISH analysis of the FNA of salivary tumors does not enhance diagnostic accuracy.

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