Clinical and Hormonal Profile of Polycystic Ovary Syndrome

2009 ◽  
Vol 1 (2) ◽  
pp. 22-25
Author(s):  
Ferdousi Begum
Keyword(s):  
Menstrual Cycle ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Serum Insulin ◽  
Pcos Patient ◽  
Serum Prolactin ◽  
Transvaginal Sonography ◽  
Ovary Syndrome ◽  
Cross Sectional ◽  
Hormonal Profile

ABSTRACT Objectives The objectives of the study were to find out the clinical features, biochemical and hormonal profile of patients with polycystic ovary syndrome (PCOS) in Bangladesh. Material and Methods A case control and cross-sectional study was undertaken among 78 PCOS patients attending infertility clinic and 33 controls at BIRDEM Hospital, Dhaka. Inclusion criteria for cases were oligo/amenorrhea, transvaginal sonography suggesting PCO and/ or features of hyperandrogenemia with exclusion of other causes. Controls were women with regular menstrual cycle. Results Age and height of cases and controls were similar. BMI >25 was 67% among cases and 19% among controls (P<0.001); waist hip ratio >0.8 was 64% among cases and 29% among controls (P<0.001). Mean BMI of cases was 28.2 + 4.5 and that of cases was 21.05 + 4.1; mean fasting glucose among cases was 5.93 + 1.08 and among controls was 4.4 + 1.11 mmol/L (P<0.01); mean fasting serum insulin level was 32.15+ 12.13 among cases was 11.32 +10.02 ìU/ml among controls(P<.001); insulin resistance (fasting HOMA-IR>6.8) was 42.32% in cases and 12% in control (P<.001). Patients with PCOS had following clinical and biochemical parameters: oligomenorrhea- 74%, amenorrhea- 26%, mean Ferriman-Galaway score -19.89 + 5.06. At day 3 of menstrual cycle meanserum LH was 12.79+7.1 mmol/L, serum FSH was 5.23 + 2.5 miu/ml and serum prolactin was 415.15+180.5 mmol/L; 30% had biochemical hyperandrogenemia. Conclusions PCOS patient in Bangladesh are usually overweight, hirsute (grade I and II), hyperandrogenemic, insulin resitant and have altered LH to FSH ratio.

scholarly journals A COMPARATIVE STUDY OF INSULIN RESISTANCE IN PATIENTS OF POLYCYSTIC OVARY SYNDROME

2021 ◽  
Vol 71 (5) ◽  
pp. 1746-50
Author(s):  
Amena Arif ◽  
Palvasha Waheed ◽  
Robina Anees ◽  
Amir Rashid ◽  
Saleem Ahmed Khan
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovary Syndrome ◽  
Comparative Study ◽  
Polycystic Ovary ◽  
Serum Insulin ◽  
Insulin Level ◽  
Normal Weight ◽  
Ovary Syndrome ◽  
Cross Sectional ◽  
Control Subjects

Objective: To assess the relationship between obesity and insulin resistance in polycystic ovary syndrome affected women. Study Design: Cross sectional comparative study. Place and Duration of Study: Multidisciplinary Lab-I of Department of Biochemistry, Army Medical College, Rawalpindi, in collaboration with Pakistan Naval Ship Hafeez Hospital, Islamabad from Feb 2018 to Jan 2019. Methodology: One hundred and five selected females (puberty till 25 years of age) were divided into three groups of 35 each. Blood samples were collected an overnight fast (from 8-11 AM). Serum level of insulin was measured and insulin resistance was calculated based on HOMA-IR. Results: HOMA-IR concentrations correlated directly with Basal Metabolic Index, fasting plasma glucose and serum insulin levels. Mean serum insulin level was also elevated in patients with polycystic ovary syndrome (normal weight & overweight) as compared to control subjects (7.4 ± 1.2 mIU/L & 9.1 ± 0.8 mIU/L vs 6.3 ± 1.1 mIU/L; p as 0.003). The insulin resistance was slightly higher in patients with polycystic ovary syndrome as compared to the control subjects (1.4 ± 0.3 & 1.7 ± 0.2 vs. 1.1 ± 0.3; p<0.001). Conclusion: HOMA-IR levels are positively associated with BMI, the intensity of peripheral insulin resistance in polycystic ovary syndrome-affected females, indicating that normal weight, and overweight patients with polycystic ovary syndrome have tendency towards insulin resistance.

scholarly journals Prevalence of Polycystic Ovary Syndrome Awareness Among Female Medical Students

2020 ◽  
Vol 3 ◽  
pp. e10
Author(s):  
Hamyel Tahir ◽  
◽  
Amna Hassan ◽  
Qudsia Umaira Khan ◽  
Farida Hafeez ◽  
...  
Keyword(s):  
Medical Students ◽  
Menstrual Cycle ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Follicular Development ◽  
World Health ◽  
Ethical Review ◽  
Ovary Syndrome ◽  
Cross Sectional ◽  
Health Organization

Background: Polycystic ovary syndrome is one of the most common causes of infertility in woman, affecting 4-18% of reproductive aged women worldwide. It is characterized by hormonal imbalance leading to reproductive, metabolic and psychological dysfunction. It is a multi-organ syndrome affecting both female gonads and the pituitary gland. Polycystic ovary syndrome is idiopathic in occurrence. However, recent studies suggest that it can be caused by inherent abnormalities of ovarian steroidogenesis, follicular development, excessive gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH), and reduced follicle stimulating hormone (FSH) secretion. Objectives: To evaluate the knowledge and level of awareness of female students about polycystic ovary syndrome. To determine the prevalence of the symptoms of polycystic ovary syndrome. Methods: A cross sectional type of quantitative study was conducted following the approval from the Ethical Review Committee. The study was carried out on a sample of medical students, with a calculated sample size of 278 individuals according to the World Health Organization (WHO) formula. A questionnaire-based survey was implemented. Results: The most important question was regarding the awareness of polycystic ovary syndrome and to our interest 74.5% of the participants were aware of the disease. 42.2% of the participants gained knowledge of the disease from social media and the internet. The diagnosed cases of polycystic ovary syndrome in the sample was 11.2%, among which 41.9 % are receiving the treatment. Conclusion: The majority of the female medical students (74.5%) were aware of polycystic ovary syndrome in female medical students. 33.8% of the participants had a normal menstrual cycle of 28 days. A noticeable percentage of students had polycystic ovary syndrome and were under treatment. Our study can be further used to determine relations between polycystic ovary syndrome and a variety of factors, such as the duration of menstrual cycle, body mass index (BMI) or symptoms of this syndrome, such as the weight gain and acne.

scholarly journals Frequency of Hyperprolactinemia in PCOS and its Association with Female Infertility

2019 ◽  
Vol 33 (4) ◽  
pp. 1-5
Author(s):  
Anam Rehman
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Pearson Correlation ◽  
Cross Sectional Study ◽  
Female Infertility ◽  
Health Concern ◽  
Serum Prolactin ◽  
Sectional Study ◽  
Ovary Syndrome ◽  
Cross Sectional

Introduction: Infertility is a critical health concern partially due to intricacy in its causes and striving for its prevention, diagnosis and treatment. Various researches have documented a close linkage between polycystic ovary syndrome and hyperprolactinemia. Aims & Objectives: This study was aimed to determine the frequency of hyperprolactinemia in PCOS and its association with infertility in PCOS subjects. Place and duration of study: It was a cross sectional study, conducted during April 2017 and September 2017 at Aziz Fatimah Hospital, Faisalabad, Pakistan. Material & Methods: It was a cross sectional study which was conducted at Aziz Fatimah Hospital, Faisalabad, Pakistan from April to September 2017. This study comprised of 88 female subjects of 17-35 years old who included PCOS subjects and age matched controls. Hyperprolactinemia was assessed by the measurement of serum prolactin levels which were measured by chemiluminescence immunoassay technique (CLIA). SPSS version 22 was used for the statistical analysis of the data. Results: Out of total 88 female participants, 61.4% of polycystic ovary syndrome subjects had hyperprolactinemia as compared to this 36.4% of controls had hyperprolactinemia. Pearson correlation also revealed significant positive association of hyperprolactinemia with infertility. Conclusion: Hyperprolactinemia was frequently seen in polycystic ovary syndrome females as well as raised BMI was also found. Raised prolactin levels are strongly associated with female infertility. Key words: Hyperprolactinemia, Infertilty, Polycystic Ovary Syndrome.

scholarly journals Manifestations of Polycystic Ovary Syndrome are Similar Regardless of the Degree of Menstrual Cycle Variation

2022 ◽  
Vol 6 (1) ◽  
pp. 96
Author(s):  
Begum Moriom Zamila ◽  
Hurjahan Banu ◽  
Md Shahed Morshed ◽  
Sukanti Shah ◽  
Afroza Begum ◽  
...  
Keyword(s):  
Menstrual Cycle ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Cross Sectional Study ◽  
Control Group ◽  
Menstrual Irregularity ◽  
Glycerol Phosphate ◽  
Ovary Syndrome ◽  
Cross Sectional ◽  
Regular Cycle

Background: Menstrual irregularities may predict over adverse consequences in polycystic ovary syndrome (PCOS).Objective: To observe the relation of variants of menstrual cycles with clinical and biochemical features of PCOS.Methods: This cross-sectional study encompassed 200 PCOS women diagnosed by Rotterdam criteria and 120 age-matched healthy controls. Subgroups were classified according to menstrual cycle length as: polymenorrheic (<21 days), eumenorrheic (21-35 days), oligomenorrheic (36 days-3 months) and amenorrheic (>3 months). Glucose was measured by glucose oxidase, lipid by glycerol phosphate dehydrogenenase-peroxidase and all hormones by chemiluminescent immuno-assay method.Results: Around 86% of PCOS patients had menstrual irregularity, among which 75% had oligomenorrhea followed by amenorrhea (9%) and polymenorrhea (2%). All the subgroups of PCOS patients (polymenorrhea excluded from further analyses) had significantly poor metabolic manifestations than the control namely insulin resistance (IR), impaired glycaemic status, general and central obesity, metabolic syndrome and dyslipidaemia. Acanthosis nigricans (AN), hyperandrogenemia (HA) and IR had significant predictive association with PCOS patients with both irregular [OR (95% CI)- AN: 21.994 (6.427, 75.267), p<0.001; HA: 27.735 (8.672, 88.704), p<0.001; IR: 7.268 (2.647, 19.954), p<0.001] and regular cycle [AN: 16.449 (3.830, 70.643), p<0.001; HA: 24.635 (6.349, 95.590), p<0.001; IR: 6.071 (1.658, 22.234), p=0.006] in reference to control group. None of the variables had significant predictive associations with irregular cycle in reference to regular cycle in patients with PCOS.Conclusion: Oligomenorrhea was the most common variant of menstrual irregularity in PCOS patients. All menstrual variants including eumenorrhea had similar manifestations in PCOS women, but poorer than controls.International Journal of Human and Health Sciences Vol. 06 No. 01 January’22 Page: 96-103

scholarly journals Sexuality in women with polycystic ovary syndrome: a pilot study

2010 ◽  
Vol 8 (4) ◽  
pp. 397-403 ◽  
Author(s):  
Jucilene Sales da Paixão Silva ◽  
Angela Maggio da Fonseca ◽  
Vicente Renato Bagnoli ◽  
Ana Lucia Cavalcanti ◽  
José Maria Soares Jr ◽  
...  
Keyword(s):  
Sexual Behavior ◽  
Menstrual Cycle ◽  
Polycystic Ovary Syndrome ◽  
Sexual Satisfaction ◽  
Sexual Partner ◽  
Polycystic Ovary ◽  
Clinical Aspects ◽  
Clinical Parameters ◽  
Ovary Syndrome ◽  
Cross Sectional

ABSTRACT Objective: The objective of this study was to evaluate the sexual behavior of women with polycystic ovary syndrome and the relationship between sexual behavior and the clinical parameters related to this syndrome (obesity, hirsutism and menstrual irregularities). Methods: A cross-sectional study was carried out involving 48 women with polycystic ovary syndrome. The evaluation was based on the complaints reported by the women with particular emphasis on sexual satisfaction, the presence of a sexual partner, phases of the sexual response cycle (desire, arousal, orgasm and resolution phases), sexual frequency, practice of masturbation, evaluation of less usual sexual habits, degree of intimacy and the quality of communication in the women's involvement with their sexual partner. The variables of sexual behavior (sexual satisfaction, masturbation, sexual fantasies, frequency of desire, arousal and orgasm) were compared with three clinical parameters: menstrual cycle, hirsutism and body mass index (BMI). Results: The sexual initiation, ways of expressing sexuality, communication and intimacy with partner and sexual satisfaction were not influenced by the clinical aspects of the syndrome. With respect to association of polycystic ovary syndrome clinical parameters with sexual behavior, a statistically significant correlation was found with the menstrual cycle. Conclusion: The absence of menstruation affected sexual interest in activities not involving the partner, thus increasing the frequency of masturbation.

Vitamin D Levels in Women with Polycystic Ovary Syndrome

KnE Medicine ◽  
2016 ◽  
Vol 1 (1) ◽  
Author(s):  
Elida Sidabutar
Keyword(s):  
Vitamin D ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Cross Sectional Study ◽  
Pcos Patient ◽  
Reproductive Age ◽  
Obese Women ◽  
Ovary Syndrome ◽  
Cross Sectional ◽  
Vitamin D Levels

<p><strong>INTRODUCTION</strong>: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. There is some evidence suggested that vitamin D played a role in the incidence of PCOS. Previous research has found vitamin D deficiency in the pathogenesis of PCOS and cohort studies showing the relationship of obesity with decreased levels of 25-hydroxy vitamin D. Therefore, we aim to conduct a study on vitamin D levels in women with polycystic ovary syndrome.</p><p><strong>OBJECTIVE</strong>: To determine the difference of the levels of vitamin D in women with and without polycystic ovary syndrome.</p><p><strong>METHODS</strong>: This study is a comparative analytical study on two unpaired population by using cross-sectional study design. The study was conducted in Halim Fertility Clinic Medan starting in November 2014 through April 2015. Blood samples were taken from 23 women PCOS and 23 non-PCOS women. Further data were tabulated and analyzed.</p><p><strong>RESULTS</strong>: Vitamin D levels are lower in women with PCOS compared to controls. In the PCOS group, the levels of vitamin D were lower in obese women. Vitamin D levels were also lower in PCOS women with WHR&gt; 0.85.</p><strong>CONCLUSION</strong>: This study showed a significant lower level of vitamin D in PCOS patient.

scholarly journals Clinical, Biochemical and Hormonal Profile of Polycystic Ovary Syndrome

2018 ◽  
Vol 3 (2) ◽  
pp. 94-98
Author(s):  
Khairun Nahar ◽  
Gazi Mahfuza ◽  
Shirin Akhter Begum ◽  
Khodeza Khatun ◽  
Md Rafiqul Islam
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Serum Testosterone ◽  
Type Ii Diabetes Mellitus ◽  
Mean Value ◽  
Total Testosterone ◽  
Ovary Syndrome ◽  
Cross Sectional ◽  
Hormonal Profile ◽  
Increased Risk

Background: The polycystic ovary syndrome is a heterogenous condition, the pathophysiology of which is multifactorial. It is considered as a systemic and metabolic disorder like hyperglycemia and insulin resistance with increased risk of type II diabetes mellitus and cardiovascular diseases.Objective: The purpose of the present study was to analyze the clinical, biochemical and hormonal profile of patients PCOS and to find out correlations among them.Methodology: This cross-sectional observational study was done including 100 diagnosed cases of PCOS attending the GOPD, BSMMU Hospital. This study was done to analyze the clinical, biochemical and hormonal characteristics of PCOS patients and to observe the correlations among them.Result: The mean age of study populations was 22.7± 6.9 years and more than half of them were overweight or obese. Menstrual abnormality like oligomenorrhoea and secondary amenorrhoea was found in 95% cases and 5% were eumenorrhic. Prevalence of hirsutism and subfertility was 69% and 50% respectively. More than half (52%) of cases had LH/FSH ratio >2 which is taken to be significant. About one-third (30%) of cases had total testosterone level above the reference range with a mean value of serum testosterone 71.4±27.9 ng/dL.Conclusion: Significant positive correlation was found among increased BMI, increased LH/FSH ratio, serum testosterone and serum TSH level. Further studies are needed to corroborate our findings and to find out the clinical, biochemical and endocrinological characteristics of our women of PCOS.Journal of National Institute of Neurosciences Bangladesh, 2017;3(2): 94-98

scholarly journals Evaluation of hyperprolactinemia risk factors in infertile women referred to Yazd Infertility Center: A cross-sectional study

2022 ◽  
pp. 1085-1090
Author(s):  
Elahe Dehghan ◽  
Nasim Namiranian ◽  
Akram Ghadiri-Anari ◽  
Seid Kazem Razavi Ratki ◽  
Reyhaneh Azizi
Keyword(s):  
Pituitary Adenoma ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Cross Sectional Study ◽  
Serum Prolactin ◽  
Sectional Study ◽  
Ovary Syndrome ◽  
Cross Sectional ◽  
Infertile Women ◽  
The Mean

Background: Hyperprolactinemia is one of the most common causes of infertility in women. The prevalence of pituitary tumors is 25-30% among infertile participants with hyperprolactinemia. Objective: The aim of this study was to describe the causes of hyperprolactinemia in infertile women referred to Yazd Infertility Center. Materials and Methods: This cross-sectional study was conducted with 182 infertile women with hyperprolactinemia who were referred to Yazd Infertility Center from February 2018 to October 2019. Serum prolactin was assessed by the human prolactin ELISA kit according to the Padtan Gostar Isar protocol. The age, duration of infertility, causes of hyperprolactinemia, and type of infertility treatment were noted. The MRI findings were added. Results: The mean age of participants was 28.9 ± 0.36 yr and the prolactin level was 76 ± 8.97 ng/ml. The etiology of hyperprolactinemia among the study participants was 35 participants (19.2%) with pituitary adenoma, 47 participants (25.8%) with polycystic ovary syndrome, 14 participants (7.7%) with pituitary adenoma and polycystic ovary syndrome, and 86 participants (47.3%) with idiopathic hyperprolactinemia. The results of this study showed that there was no statistically significant difference between the mean prolactin levels in participants with different causes of hyperprolactinemia (p = 0.31). Conclusion: Idiopathic hyperprolactinemia and polycystic ovary syndrome are the most common reasons for hyperprolactinemia. Key words: Hyperprolactinemia, Infertility, PCOS.

scholarly journals Is polycystic ovary syndrome appropriately diagnosed by obstetricians and gynaecologists across China: a nationwide survey

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Deng Yan ◽  
Wang Yan-Fang ◽  
Zhu Shi-Yang ◽  
Ma Rui-Lin ◽  
Ding Xue-Song ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Diagnostic Criteria ◽  
Polycystic Ovary ◽  
Final Analysis ◽  
Nationwide Survey ◽  
Care Quality ◽  
Cross Sectional Survey ◽  
Ovary Syndrome ◽  
Cross Sectional ◽  
Rotterdam Criteria

Abstract Background To describe the diagnostic criteria used and their application accuracy in the practice of polycystic ovary syndrome (PCOS) caring among obstetricians and gynaecologists across China. Methods This was an Online cross-sectional survey of Obstetricians and gynecologists involved in PCOS caring conducted via the largest continuing education platform of obstetrics and gynecology across China from September 2019 to November 2019. Results A total of 2,328 respondents were eligible for the final analysis. Of these, 94.5 % were general obstetricians and gynaecologists (Ge-ObGyn), and 5.5 % were reproductive endocrinologists (Re-ObGyn). Overall, the most frequently used criteria were the Androgen Excess and Polycystic Ovary Syndrome Society (AE-PCOS) criteria (48.2 %), followed by the Rotterdam criteria (35.7 %) and NIH criteria (12.1 %). Of the respondents, 31.3 % used their diagnostic criteria in their clinical practice. More respondents who chose the Rotterdam criteria could accurately apply the diagnostic criteria than those who chose the AE-PCOS criteria (41.2 % vs. 32.1 %, P < 0.001). Compared with Ge-ObGyn, Re-ObGyn were less likely to use the AE-PCOS criteria (adjusted odds ratio, 0.513; 95 % CI, 0.328–0.802; P < 0.05) and 1.492 times more likely to accurately use their criteria (95 % CI, 1.014–2.196; P < 0.05). Conclusions Less than one-third of obstetricians and gynaecologists across China could accurately use the diagnostic criteria they choose to diagnose PCOS. There is an urgent need to train obstetricians and gynaecologists on PCOS diagnosis in an effort to improve the medical care quality of patients with PCOS.

scholarly journals Effects of probiotic and synbiotic supplementation on insulin resistance in women with polycystic ovary syndrome: a meta-analysis

2021 ◽  
Vol 49 (7) ◽  
pp. 030006052110317
Author(s):  
Chenyun Miao ◽  
Qingge Guo ◽  
Xiaojie Fang ◽  
Yun Chen ◽  
Ying Zhao ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovary Syndrome ◽  
Confidence Interval ◽  
Polycystic Ovary ◽  
Serum Insulin ◽  
Meta Analysis ◽  
Mean Difference ◽  
Model Assessment ◽  
Ovary Syndrome ◽  
Synbiotic Supplementation

Objective This meta-analysis evaluated the effect of probiotics and synbiotics on insulin resistance in patients with polycystic ovary syndrome (PCOS). Methods A systematic search was performed to identify all relevant publications listed on the electronic databases (PubMed®, Web of Science, Embase® and China National Knowledge Infrastructure) between inception and 30 October 2020. All statistical analyses were performed on randomized controlled trials (RCTs) using RevMan version 5.3 software provided by the Cochrane Collaboration. Results A total of 486 patients from seven RCTs were included in the meta-analysis. Probiotic and synbiotic supplementation appeared to improve levels of homeostatic model assessment of insulin resistance (mean difference = –0.37; 95% confidence interval –0.69, –0.05) and serum insulin (standardized mean difference = –0.66; 95% confidence interval –1.19, –0.12). The results failed to show any influence of probiotic and synbiotic supplementation on body mass index, waist circumference, hip circumference and fasting blood sugar. Conclusions Probiotics and synbiotics appear to have a partially beneficial effect on indices of insulin resistance in patients with PCOS.

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