scholarly journals Occurrence of Insulin Resistance with Recurrent Pregnancy Loss of Unknown Etiology in North Indian Hospital-based Women Population: A Pilot Study

2021 ◽  
Vol 13 (1) ◽  
pp. 15-17
Author(s):  
Manju Puri ◽  
Harpreet Singh ◽  
Binita Goswami ◽  
Anubhuti Chitkara ◽  
Jayashree Bhattacharjee
Keyword(s):  
Insulin Resistance ◽  
Pilot Study ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Unknown Etiology

The association of insulin resistance and recurrent pregnancy loss.

2001 ◽  
Vol 76 (3) ◽  
pp. S158
Author(s):  
L.J Barker ◽  
R.W Ke ◽  
G.S Ghazeeri ◽  
W.H Kutteh
Keyword(s):  
Insulin Resistance ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss

scholarly journals Triglyceride Induced Metabolic Inflammation: Potential Connection of Insulin Resistance and Recurrent Pregnancy Loss

2021 ◽  
Vol 12 ◽  
Author(s):  
Yongjie Liu ◽  
Mengyang Du ◽  
Yuexin Gan ◽  
Shihua Bao ◽  
Liping Feng ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Lymphocyte Subsets ◽  
Clinical Chemistry ◽  
Venous Blood ◽  
Multiple Logistic Regression Analysis ◽  
Oral Glucose ◽  
Significant Positive Association ◽  
Color Flow

The underlying correlative mechanisms between Insulin resistance (IR) and recurrent pregnancy loss (RPL) in patients without polycystic ovarian syndrome (PCOS) remain inconclusive. To investigate the association between triglyceride (TG) levels, lymphocyte subsets, and IR in RPL patients without PCOS and obesity. Eighty-nine subjects with an unexplained RPL, independent of PCOS/obesity were enrolled in this study. A 75-g oral glucose tolerance test was performed on each subject with plasma tested for glucose and insulin. The fasting venous blood of all subjects was collected for routine clinical chemistry analysis. Lymphocyte subsets were analyzed by four-color flow cytometry. As a result, TG levels were significantly elevated in RPL patients with IR compared to those without IR. Pearson linear correlation model and receiver operating characteristic (ROC) curve analyses revealed a significant positive association between TG and HOMA-IR index value. In multiple logistic regression analysis, TG was significantly associated with the risk of hyperinsulinemia and increased CD3+CD4+/CD3+CD8+ ratio which was significantly negatively correlated with disposition index (DI30) and DI120, indicators for insulin sensitivity. In addition, DI30 and DI120 were significantly decreased in the higher CD3+CD4+/CD3+CD8+ group. Our findings showed that the elevated TG and altered immune responses in RPL patients with IR are independent of PCOS and obesity, and could be used as an indicator of IR in RPL patients. These results contribute to the understanding of the pathophysiology of IR in RPL for potential prevention and therapeutic targets.

Paternal and maternal carriage of the annexin A5 M2 haplotype are equal risk factors for recurrent pregnancy loss: a pilot study

2012 ◽  
Vol 98 (2) ◽  
pp. 383-388 ◽  
Author(s):  
Nina Rogenhofer ◽  
Laura Engels ◽  
Nadja Bogdanova ◽  
Frank Tüttelmann ◽  
Arseni Markoff ◽  
...  
Keyword(s):  
Risk Factors ◽  
Pilot Study ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Annexin A5

scholarly journals Recurrent Pregnancy Loss in Polycystic Ovary Syndrome: Role of Hyperhomocysteinemia and Insulin Resistance

PLoS ONE ◽  
2013 ◽  
Vol 8 (5) ◽  
pp. e64446 ◽  
Author(s):  
Pratip Chakraborty ◽  
S. K. Goswami ◽  
Shweta Rajani ◽  
Sunita Sharma ◽  
Syed N. Kabir ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovary Syndrome ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Polycystic Ovary ◽  
Ovary Syndrome

scholarly journals The C20068T gene variant in the 3` end of the prothrombin gene and recurrent pregnancy loss: A pilot study

Genetika ◽  
2015 ◽  
Vol 47 (2) ◽  
pp. 469-476 ◽  
Author(s):  
Iva Pruner ◽  
Valentina Djordjevic ◽  
Maja Gvozdenov ◽  
Branko Tomic ◽  
Mirjana Kovac ◽  
...  
Keyword(s):  
Risk Factors ◽  
Pilot Study ◽  
Health Problem ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Reproductive Age ◽  
Gene Variant ◽  
Women Of Reproductive Age ◽  
Prothrombin Gene

Recurrent pregnancy loss (RPL) is a health problem affecting up to 5% of women of reproductive age. Several thrombophilic risk factors might contribute to RPL.To investigate relationship between a novel C20068T gene variant in the 3` end of prothrombin gene and RPL, we tested 153 women with RPL and 111 controls for the presence of this gene variant. In patients, we have detected four heterozygous (2.61%) and no homozygous carriers. In controls, no carriers were detected. Our results indicate higher prevalence of C20068T gene variant in women with RPL but this difference was not statistically significant. However, in patients who suffered 5 or more RPL, frequency of C20068T gene variant was significantly increased compared to controls (12.5% vs. 0%, P=0.02). This is the first study which points out a possible role of C20068T gene variant in etiology of RPL, but larger studies should be carried out to confirm our findings.

scholarly journals Relationship of insulin resistance with recurrent pregnancy loss

2017 ◽  
Vol 6 (4) ◽  
pp. 1312 ◽  
Author(s):  
Asifa Ali Wani ◽  
Irfan Gul ◽  
Farhat Jabeen ◽  
Shiveta Kaul ◽  
Farhat Ali Lone ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Fasting Glucose ◽  
Histopathological Examination ◽  
Control Group ◽  
Study Group ◽  
Fasting Insulin ◽  
Significant Difference ◽  
Mean Glucose

Background: The recurrent pregnancy loss (RPL) is defined as two and more failed pregnancies as documented by ultrasound and histopathological examination and suggested some assessment after each loss with a thorough evaluation after three or more losses. RPL is one of the most frustrating and difficult areas in reproductive medicine because the aetiology is often unknown and there are few evidence based diagnostic and treatment strategies.Methods: 150 Non pregnant females were taken as both cases and controls in the study. All the pregnancy losses were documented by ultrasound or histological examination after uterine curettage. The control group consisted of women with no RPL with at least one live birth. These two groups were matched on the basis of age and BMI. All the women underwent following examinations, viz. Hysterosalpingography, karyotype of both partners, serum TSH, FT4, prolactin and antibodies for APLA. In addition blood sample were taken for fasting serum glucose and serum insulin level later insulin resistance was calculate using three parameters Fasting insulin > 20IU/ml. Diagnostic of Insulin Resistance. (2) Fasting glucose / Fasting insulin. A ratio of < 4.5 being diagnostic of insulin resistance. (3) HOMA IR.        FG (mg/dl) x FPI (IU/ml) FG (mmol/l) x FPI (IU/ml)------------------------------------ OR -----------------------------------                                             405 22.5Where 1 mmol/l = 18mg/dl, A value of > 4.5 being diagnostic of insulin resistance.Results: 150 patients were enrolled in this study among which 75 were selected as cases and 75 as controls after fulfilling inclusion and exclusion criteria with mean age cases group was28.4+2.37 years and 29.1+2.70 years in control group mean miscarriage rate in study group was 3.17+83 and control group with 0.35+0.48 with statistically significant difference. Mean fasting glucose (96.5+ 7.86) mg/dl, Fasting Insulin (14.1±5.91) IU/ml. Mean Glucose Insulin ratio (8.1±3.39), HOMA-IR (3.4 ±1.51) in the study group and in control group mean fasting glucose was (87.1+11.49) mg/dl, Fasting Insulin (6.9 ± 4.99) IU/ml. Mean Glucose Insulin ratio (17.8 ±11.44), HOMA-IR (1.5 ±1.27) respectively with statistically significant difference.Conclusions: In women with recurrent pregnancy loss fasting insulin and insulin resistance are higher than those in women without spontaneous abortion. The most sensitive parameter for calculating insulin resistance was found to be fasting insulin followed by HOMA – IR and followed by fasting glucose/fasting insulin ratio. It is therefore important to recommend a fasting insulin and fasting glucose level while evaluating a case of recurrent pregnancy loss to assess for insulin resistance.

scholarly journals High Fasting Insulin Levels and Insulin Resistance May Be Linked to Idiopathic Recurrent Pregnancy Loss: A Case-Control Study

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Corina-Alina Ispasoiu ◽  
Radu Chicea ◽  
Florin Vasile Stamatian ◽  
Florin Ispasoiu
Keyword(s):  
Insulin Resistance ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Case Control Study ◽  
Fasting Glucose ◽  
Case Control ◽  
Control Group ◽  
Case Group ◽  
Fasting Insulin ◽  
Control Study

Objective. Patients with more than two spontaneous pregnancy losses are diagnosed with recurrent pregnancy loss. The aim of this study was to evaluate the IR (insulin resistance) in patients with idiopathic recurrent pregnancy loss.Material and Method. A single center, case control study was performed on one hundred eighteen women divided into case group (with at least two pregnancy losses, earlier than 20 weeks of gestation, and negative for the recurrent pregnancy loss testing) and control group (with at least one live birth, no pregnancy loss). FG (fasting glucose) and FI (fasting insulin) were determined for all patients. IR was evaluated by HOMA-IR index.Results. There were not significant differences between the mean age and BMI in cases and controls (P>0.05). Fasting glucose was significantly higher in the control group (85.6 versus 79.8P<0.01), but fasting insulin (15.24 versus 12.83,P<0.001) and HOMA-IR (2.98 versus 2.69,P<0.05) were significantly higher in the case group.Conclusion. In women with idiopathic recurrent pregnancy loss FI and IR are higher than those in women without spontaneous abortion.

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