scholarly journals FATORES DE IMPACTO NA RESERVA OVARIANA E FERTILIDADE EM PACIENTES COM ENDOMETRIOSE

2021 ◽  
Author(s):  
Thaís de Almeida Silva Ferreira ◽  
Gabriela Halpern
Keyword(s):  
Fertility Preservation ◽  
Ovarian Reserve ◽  
Female Fertility ◽  
Vitamina D

Introdução: Endometriose é uma afecção inflamatória na qual o conteúdo endometrial acomete sítios além da cavidade uterina como ovários e órgãos pélvicos. É uma doença comum, crônica, heterogênea e pode ter a infertilidade como um dos seus sintomas, tendo implicações importantes na reserva ovariana, diminuindo as taxas de fertilização, implantação e gravidez. Objetivos: Fazer uma revisão bibliográfica sobre os fatores que relacionam a endometriose com os impactos na reserva ovariana e fertilidade feminina em relação ao número e qualidade de oócitos e embriões, em taxas de sucesso em tratamentos de fertilização in vitro e nos fatores de risco modificáveis como tabagismo, uso de álcool, níveis de vitamina D e indicação cirúrgica para excisão da endometriose. Material e Métodos: Foram reunidos 100 trabalhos científicos inseridos nas bases de dados do PubMed, Scielo e Google Acadêmico. As palavras-chaves utilizadas foram “endometriosis”, “endometriosis management” “ovarian reserve”, “fertility preservation”, “fertility impact”, “female fertility”, “laparoscopy” em inglês e português, utilizando os termos de busca booleanos "AND" e "OR" para mesclar os assuntos. Apenas revisões de literatura e revisões sistemáticas publicadas entre os anos 2000 e 2021, nos idiomas inglês e português (PT/BR), foram consideradas. Resultados: A qualidade oocitária é impactada pela presença da endometriose, a reserva ovariana é menor em portadoras de endometriomas do que em endometriose peritoneal, as taxas de sucesso em fertilização in vitro e a qualidade dos embriões gerados são dependentes da idade materna e as taxas de implantação, gravidez e nascidos-vivos são similares a outros grupos em tratamentos assistidos por outras causas de infertilidade. A laparoscopia para a remoção da endometriose é danosa à reserva ovariana e deve ser indicada quando há outros sintomas além da infertilidade. Mulheres com indicação cirúrgica podem se beneficiar da vitrificação de oócitos previamente à excisão endometriótica. Níveis insuficientes de vitamina D estão relacionados a maiores taxas de infertilidade associada à endometriose, os dados sobre uso de álcool são inconclusivos. Tabagismo não tem ação comprovada sobre a manifestação da endometriose. Conclusão: A endometriose tem impacto sobre a fertilidade feminina e seu manejo deve ser individualizado de acordo com os sintomas apresentados e o desejo reprodutivo da mulher.

Female fertility preservation strategies: cryopreservation and ovarian tissuein vitroculture, current state of the art and future perspectives

Zygote ◽  
2016 ◽  
Vol 24 (5) ◽  
pp. 635-653 ◽  
Author(s):  
M.A. Filatov ◽  
Y.V. Khramova ◽  
M.V. Kiseleva ◽  
I.V. Malinova ◽  
E.V. Komarova ◽  
...  
Keyword(s):  
Fertility Preservation ◽  
State Of The Art ◽  
Ovarian Tissue ◽  
Female Fertility ◽  
Ovarian Tissue Cryopreservation ◽  
Future Perspectives ◽  
Current State ◽  
Female Fertility Preservation ◽  
Tissue Cryopreservation

SummaryIn the present review, the main strategies of female fertility preservation are covered. Procedures of fertility preservation are necessary for women who suffer from diseases whose treatment requires the use of aggressive therapies, such as chemotherapy and radiotherapy. These kinds of therapy negatively influence the health of gametes and their progenitors. The most commonly used method of female fertility preservation is ovarian tissue cryopreservation, followed by the retransplantation of thawed tissue. Another approach to female fertility preservation that has been actively developed lately is the ovarian tissuein vitroculture. The principal methods, advantages and drawbacks of these two strategies are discussed in this article.

scholarly journals A Warning Call for Fertility Preservation Methods for Women Undergoing Gonadotoxic Cancer Treatment

Medicina ◽  
2021 ◽  
Vol 57 (12) ◽  
pp. 1340
Author(s):  
Claudia Mehedintu ◽  
Francesca Frincu ◽  
Andreea Carp-Veliscu ◽  
Ramona Barac ◽  
Dumitru-Cristinel Badiu ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Fertility Preservation ◽  
Ovarian Reserve ◽  
Negative Impact ◽  
Future Fertility ◽  
Negative Effect ◽  
The One

Malignant hematological conditions have recognized an increased incidence and require aggressive treatments. Targeted chemotherapy, accompanied or not by radiotherapy, raises the chance of defeating the disease, yet cancer protocols often associate long-term gonadal consequences, for instance, diminished or damaged ovarian reserve. The negative effect is directly proportional to the types, doses, time of administration of chemotherapy, and irradiation. Additionally, follicle damage depends on characteristics of the disease and patient, such as age, concomitant diseases, previous gynecological conditions, and ovarian reserve. Patients should be adequately informed when proceeding to gonadotoxic therapies; hence, fertility preservation should be eventually regarded as a first-intention procedure. This procedure is most beneficial when performed before the onset of cancer treatment, with the recommendation for embryos or oocytes’ cryopreservation. If not feasible or acceptable, several options can be available during or after the cancer treatment. Although not approved by medical practice, promising results after in vitro studies increase the chances of future patients to protect their fertility. This review aims to emphasize the mechanism of action and impact of chemotherapy, especially the one proven to be gonadotoxic, upon ovarian reserve and future fertility. Reduced fertility or infertility, as long-term consequences of chemotherapy and, particularly, following bone marrow transplantation, is often associated with a negative impact of recovery, social and personal life, as well as highly decreased quality of life.

Reproduction and ovarian ageing

2005 ◽  
Vol 11 (4) ◽  
pp. 126-131 ◽  
Author(s):  
Alexander Swanton ◽  
Tim Child
Keyword(s):  
Fertility Preservation ◽  
Premature Ovarian Failure ◽  
Ovarian Reserve ◽  
Ovarian Function ◽  
Reproductive Potential ◽  
Ovarian Failure ◽  
Female Fertility ◽  
Fertility Rates ◽  
Rate Of Decline

Female fertility rates are inherently linked to a woman's age, which is in turn related to ovarian function. Reproductive potential declines gradually until 37–38 years of age, from when the rate of decline hastens. Approximately 1% of women suffer from premature ovarian ageing, and many may not have completed their families. This paper reviews the physiology and fertility consequences of ovarian ageing, premature ovarian failure, measures of ovarian reserve and methods of fertility preservation.

Bovine in vitro reproduction models can contribute to the development of (female) fertility preservation strategies

2015 ◽  
Vol 84 (4) ◽  
pp. 477-489 ◽  
Author(s):  
An Langbeen ◽  
Hannelore F.M. De porte ◽  
Esther Bartholomeus ◽  
Jo L.M.R. Leroy ◽  
Peter E.J. Bols
Keyword(s):  
Fertility Preservation ◽  
Female Fertility ◽  
Female Fertility Preservation

scholarly journals THE CURRENT STATE OF THE PROBLEM OF FEMALE FERTILITY IN CANCER AND A DECREASE IN OVARIAN RESERVE

2019 ◽  
Vol 5 (2) ◽  
pp. 18-33
Author(s):  
A. A. Shmidt ◽  
O. N. Kharkevich ◽  
L. I. Kalyuzhnaya
Keyword(s):  
Ovarian Reserve ◽  
In Vitro Maturation ◽  
Ovarian Tissue ◽  
The Body ◽  
Female Fertility ◽  
Primordial Follicles ◽  
Advantages And Disadvantages ◽  
Current State ◽  
Number Of Patients

Analysis of the current state of the problem of preserving female fertility in cancer and reducing ovarian reserve revealed that there are currently several proven methods for young women — cryopreservation of embryos, oocytes and ovarian tissue, each of which has its own advantages and disadvantages. The promising technologies are cryopreservation of oocytes after in vitro maturation, as well as cryopreservation of embryos derived from oocytes, which were matured in vitro. In vitro maturation of immature oocytes aspirated from primordial follicles allows for the production of many mature oocytes without ovarian stimulation, which makes this technology a potentially effective strategy for preserving fertility. However, the best results can be achieved by combining several methods that must be determined individually in each specific case. Although there was no negative effect of cancer on the results of treatment of oncological obesity in the next generation, long-term observations and studies with a large number of patients are needed. The goal of helping with oncological infertility is not only the preservation of fertility, but the creation of a nationwide system of care for oncological diseases in which interdisciplinary coordination will allow all cancer patients to receive multidisciplinary assistance. The organization and standardization of the treatment of oncological symptoms and the development of modern technologies for preserving the reserve of female fertility outside the body are the urgent tasks of national health care in our country.

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