scholarly journals COMPARISON OF MONTHLY PULSE OF ORAL AZITHROMYCIN WITH DAILY DOXYCYCLINE IN THE TREATMENT OF MODERATE ACNE VULGARIS

2021 ◽  
Vol 71 (Suppl-1) ◽  
pp. S268-72
Author(s):  
Muhammad Mudassir ◽  
Ali Amar ◽  
Naeem Raza ◽  
Ayesha Khokhar ◽  
Adeel Siddiqui ◽  
...  
Keyword(s):  
Acne Vulgaris ◽  
Severity Index ◽  
Post Treatment ◽  
Military Hospital ◽  
Dermatology Department ◽  
Oral Doxycycline ◽  
Group A ◽  
Pre Treatment ◽  
Group B ◽  
Oral Azithromycin

Objective: To compare oral Azithromycin with oral Doxycycline in treatment of moderate Acne Vulgaris. Study design: Randomized control trial Place and duration of the study: Dermatology Department , Pak Emirates Military Hospital, Rawalpindi from 1st August 2017 till 31st January 2018. Materials and methods: A total of 92 patients with moderate Acne were selected from Dermatology outpatient department (OPD) Pak Emirates Military Hospital Rawalpindi, after written informed consent. Patients were randomly allocated to one of the two treatment groups: Group A and Group B by lottery method. Patients in group A were given oral Azithromycin 500 mg daily for four consecutive days each month for 03 months and patients in group B were given oral Doxycycline 100 mg daily for 03 months. Patients were reviewed monthly for 03 months and Acne Severity Index (ASI) was recorded at baseline, at one month and three months. The primary outcome measured was more than 50% decrease from baseline in ASI within 3 months of treatment, using Global Acne Grading System (GAGS). Results: Mean age of patients in group A was 21.80 + 4.64 years whereas mean age of patients in group B was 21.61 + 4.48 years. In group A mean pre-treatment ASI was 24.83 + 3.15 and mean post-treatment ASI was 10.15 + 1.7. In group B mean pre-treatment ASI was 25.30 ± 2.96 and mean post-treatment ASI was 9.86 + 1.58. Conclusion: Azithromycin is comparable to Doxycycline in terms of mean change in ASI, in the treatment of moderate Acne Vulgaris.

scholarly journals Comparison of efficacy and safety of oral azithromycin and oral doxycycline in acne vulgaris

2019 ◽  
Vol 8 (5) ◽  
pp. 913
Author(s):  
Marya Ahsan ◽  
Rahul Ranjan ◽  
Shalini Chandra ◽  
Kumar Mayank
Keyword(s):  
Adverse Effects ◽  
Acne Vulgaris ◽  
Optimal Dose ◽  
Chronic Inflammatory Disease ◽  
P Value ◽  
Severe Acne ◽  
Oral Doxycycline ◽  
Group A ◽  
Group B ◽  
Oral Azithromycin

Background: Acne vulgaris is a chronic inflammatory disease of the pilosebaceous unit with considerable psychosocial impact. Oral azithromycin or oral doxycycline can be used for the management of moderate and severe acne vulgaris. However, there is no consensus on which antibiotic is superior and the optimal dose for management.Methods: A prospective randomized interventional study was carried out among 120 patients of moderate to severe acne vulgaris. The patients were randomized into group A and B. While group A was prescribed oral azithromycin 500 mg three times a week, group B was given oral doxycycline 100 mg daily for 12 weeks. Topical clindamycin twice daily application was also given. Global Acne Grading Scale (GAGS) score was recorded at baseline and at 2nd, 4th, 8th and 12th weeks.Results: GAGS score at baseline in azithromycin (n = 53) and doxycycline (n = 55) group was 31.98±4.49 and 30.63±3.78 respectively (p value >0.05). 83.91±6.83% (p <0.001) and 81.87±6.75% (p <0.001) improvement was seen in azithromycin group and doxycycline group after 12 weeks of treatment. However, there was no difference in the GAGS score between the groups at any follow-up (p value >0.05). 15.09% patients in azithromycin group and 20% patients in doxycycline group reported adverse effects. The most commonly reported adverse effect was diarrhoea. All adverse effects were of ‘mild’ category and causality assessment was ‘possible’.Conclusions: Oral azithromycin is equally efficacious but safer alternative to oral doxycycline for the management of acne vulgaris.

scholarly journals TREATMENT OF VERTIGO- WITH & WITHOUT ANXIOLYTIC DRUG (ALPRAZOLAM 0.25MG)

2021 ◽  
Vol 71 (Suppl-3) ◽  
pp. S445-47
Author(s):  
Muhammad Waqas Ayub ◽  
Syed Muhammad Asad Shabbir Bukhari ◽  
Mohsin Raza ◽  
Asma Waqas ◽  
Beenish Hassan Khan ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Treatment Outcome ◽  
Comparative Study ◽  
Conventional Treatment ◽  
Post Treatment ◽  
Beck Anxiety Inventory ◽  
Military Hospital ◽  
Trial Group ◽  
Group A ◽  
Group B

Objective: To compare the effect of using the tablet Alprazolam 0.25mg in the treatment outcome of vertigo related anxiety by beck anxiety inventory. Study Design: Comparative study. Place and Duration of Study: Combined Military Hospital Okara Cantt, Sep 2018 to Jun 2020. Methodology: A total of 384 patients were included in the study. They were randomly assigned to group A and B by randomized clinical trial. Group A was given tablet alprazolam 0.25 mg along with the conventional treatment of vertigo and group B was given the treatment of vertigo only and no anxiolytic was added. Their pre & post treatment (after 2 weeks) anxiety level using Beck anxiety inventory was scored. Results: There was a significant improvement in group A patient’s vertigo effects after treatment with alprazolam. Also, it was observed that group A patients responded significant improvement in anxiety score as compared to Group B patients 02 weeks post treatment. Conclusion: Antianxiety treatment should be added in all cases with the conventional treatment of vertigo to reduce the vertigo associated anxiety of the patients.

scholarly journals Comparing the efficacy of intense pulsed light combined with oral azithromycin versus oral azithromycin alone in the treatment of moderate to severe papulopustular acne vulgaris

2021 ◽  
Vol 42 (6) ◽  
pp. 621-626
Author(s):  
Niloofar Afshari ◽  
Mehdi Amirnia ◽  
Davod Ahmadi ◽  
Saeed Kashefi ◽  
Vahideh Aghamohammadi
Keyword(s):  
Complete Remission ◽  
Therapeutic Option ◽  
Acne Vulgaris ◽  
Intense Pulsed Light ◽  
Pulsed Light ◽  
Field Methods ◽  
Severe Acne ◽  
Group A ◽  
Group B ◽  
Oral Azithromycin

Background: Rising follicular keratin secretion, increasing sebum production, and Propionibacterium acnes are among the main etiology of acne vulgaris formation. Antibiotics are the predominant conventional treatment of acne. Antibiotic resistance is the main problem in the ordinary treatments of acne. Therefore, newer treatments are necessary. Intense pulsed light (IPL) is a novel therapeutic option with rapid application in this field. Methods: Patients referred to us were randomized into two groups: group A (cases) and group B (controls). In addition to conventional antibiotic therapy, IPL was prescribed to group A while azithromycin alone was prescribed to group B. IPL treatment was performed weekly for five weeks and the patients were followed for three months. Declining inflammatory lesions count after the intervention was considered the remission scale. Results: In group A, moderate, partial, and complete remission occurred in 4, 9, and 7 patients, respectively. In group B, moderate, partial, and complete remission occurred in 10, 7, and 3 patients, respectively. Statistically, the remission difference was meaningful between the two groups. Conclusion: IPL with conventional antibiotics is an effective treatment choice in moderate to severe acne vulgaris but also is a more accelerating agent in treatment versus antibiotics alone.

A Comparison of Acupuncture with Advice and Exercises on the Symptomatic Treatment of Osteoarthritis of the Hip – a Randomised Controlled Trial

2001 ◽  
Vol 19 (1) ◽  
pp. 19-26 ◽  
Author(s):  
Roisin Haslam
Keyword(s):  
Controlled Trial ◽  
Randomised Trial ◽  
Symptomatic Treatment ◽  
Post Treatment ◽  
Control Group ◽  
Group A ◽  
Pre Treatment ◽  
Group B ◽  
Randomised Controlled

Acupuncture is becoming a common technique within the physiotherapy profession as a treatment modality for pain relief; however, few randomised controlled trials have been undertaken to assess the effectiveness of acupuncture, particularly in the treatment of osteoarthritis (OA) of the hip. Therefore, a randomised trial to compare the effectiveness of acupuncture with advice and exercises on the symptomatic treatment of OA of the hip was carried out. Thirty-two patients awaiting a total hip arthroplasty were randomly allocated to either the experimental group, (A), to have six sessions of acupuncture each lasting up to 25 minutes, or the control group, (B), to be given advice and exercises for their hip over a six week period. Group A consisted of three men and 13 women, and group B consisted of four men and eight women. The average age in group A was 66 years and in group B it was 68 years. Patients were assessed for pain and functional ability, using a modified version of the WOMAC questionnaire, pre-treatment, immediately post-treatment and at eight weeks post-treatment. The pre-treatment WOMAC scores in the two groups were similar (p=0.85). There was a significant improvement in group A (decrease in WOMAC score) immediately post-treatment (p=0.002) and this was maintained at the eight-week follow-up (p=0.03). There were no significant changes in group B. When the changes in WOMAC scores were compared between groups, a significantly greater improvement was found between pre-treatment and immediately post-treatment in group A, compared with group B (p=0.02). The changes between pre-treatment and the eight-week follow-up also showed a significant improvement in group A compared with group B (p=0.03). In conclusion, this trial supports the hypothesis that acupuncture is more effective than advice and exercises in the symptomatic treatment of OA of the hip.

scholarly journals Comparison of Effects of Low Level Laser and Ultrasound Therapy in Plantar Fasciitis

2020 ◽  
Vol 5 (11) ◽  
pp. 510-515
Author(s):  
Fatima Mehmood ◽  
Dr. Aiesha Malik ◽  
Muhammad Zeeshan
Keyword(s):  
Plantar Fasciitis ◽  
Post Treatment ◽  
P Value ◽  
Ultrasound Therapy ◽  
Low Level ◽  
Low Level Laser ◽  
Level Laser ◽  
Group A ◽  
Pre Treatment ◽  
Group B

Plantar Fasciitis is among the major causes of heel pain. Mechanical stress of plantar aponeurosis usually causes inflammation thus result in problem with weight bearing and difficulty in walking. Pain often exacerbates and may stick at for months with unremitting activity, limiting the activities of daily living and the functional status. The objective of the study was to compare the effects of low level laser and ultrasound therapy in patients for pain and their functional status presents with plantar fasciitis. This study was a Quasi-experimental trial and conducted at Physical therapy Center for Arthritis & Rehabilitation Excellence (PT CARE), Gulberg III Lahore. The study completed in the time duration of six months (Aug 2019 – Jan 2020). Consecutive sampling technique was used to collect the data. A sample size of `total 28 patients were taken in this study; patients were divided into two groups. Conventional Physiotherapy protocol was given to both groups as baseline treatment. (Group A patients were treated with low level laser protocol whereas Group B was treated with ultrasound therapy protocol). Functional Foot Index (FFI) score was used to ask some questions related to patients symptoms and daily activities and to measure the intensity of pain Numeric Pain Rating Scale (NPRS) was used. All participants of the study filled the FFI & NPRS score and Numeric pain rating scale on day 1 in first cycle as pretreatment values and at the end of 5th session and 10th session as first and second cycles as post treatment values respectively. Data was analyzed on SPSS 21.The means of pre-treatment NPRS in group A was 7.78 and in group B means of pre-treatment NPRS was 7.35 with p value <0.05. Means difference of NPRS for group A was 4.07 and in group B the post treatment-1 means difference 4.85 with p value <0.05. Means of post treatment-2 in group A was 1.71 and in group B was 2.64 with p value <0.05. While means of pre-treatment in group A for FFI was 77.66 in group A and group B was 73.35 with p value <0.05. Means of post treatment-1 for group A for FFI was 54.50 and for group B 58.27 with p value <0.05. And means of post treatment-2 in FFI for group-A was 28.22 and for group B was 35.88 with p values <0.05. Low Level Laser Therapy is more effective than Ultrasound Therapy in reducing pain and improving functions in patients with plantar fasciitis and vice versa.

scholarly journals Effects Of Remote Myofascial Release Of Sub-Occipital Region In Asymptomatic Individuals With Hamstrings Tightness

2021 ◽  
Vol 4 (2) ◽  
Author(s):  
Irfan Ahmad ◽  
Tabassum Manzoor ◽  
Saima Riaz ◽  
Muhammad Zeeshan ◽  
Mehboob Ali ◽  
...  
Keyword(s):  
Knee Extension ◽  
Post Treatment ◽  
Occipital Region ◽  
Static Stretching ◽  
Asymptomatic Individual ◽  
Myofascial Release ◽  
Group A ◽  
Pre Treatment ◽  
Group B ◽  
Stretching Exercises

The purpose of this study was to research the effect of performing Remote myofascial release of sub occipital region in asymptomatic individual with hamstring tightness. Keeping these muscles loose is important. If muscles have tightened up then muscles are working at less than 100 % of capacity and performance will be down as a result. Objective: The objective of this study was to find out the effect of performing Remote myofascial release of sub occipital region in asymptomatic individual with hamstring tightness. Methods: The study was a Quasi experimental trial and was conducted in Physiotherapy center for arthritis. 64participant in this research & divided into 2 Groups. (Group A was   treated with static Stretching exercises of hamstrings and Group B was treated with remote Myofascial release of sub occipital region and static Stretching exercises). For analysis we were used Knee Extension angle and Sit to reach test at baseline and after 2 weeks of treatment in both groups. Data analysis was done by SPSS. Results: p value of within the group comparison for  knee extension angle and Sit to reach test score was significant i.e. <0.001.Mayofascial Release of sub occipital region and static stretch give us best result.IN group A Pre-treatment knee extension angle was 14.68 & post treatment 10.87 with mean difference 3.81 P <0.01.In Group B pre-treatment knee extension angle 14.78.& post-treatment   knee extension angle 13.75 with mean difference 11.03 & p<0.001 which concludes that remote myofascial release of sub-occipital region improve the flexibility of hamstring tightness. Conclusion: The current study concludes that myofascial release of sub occipital region along with static stretching and static stretching alone, both are effective in improving flexibility in patients with hamstring tightness. However, myofascial release of sub occipital region along with static stretching is more effective than static stretching alone.

scholarly journals A COMPARISON OF EFFICACY OF INTRADERMAL TRANEXAMIC ACID WITH TOPICAL 20% AZELAIC ACID IN THE TREATMENT OF MELASMA

2021 ◽  
Vol 71 (2) ◽  
pp. 494-97
Author(s):  
Sayyida Komal ◽  
Asher Ahmed Mashhood ◽  
Muhammad Farooq ◽  
Nida Qayyum
Keyword(s):  
Tranexamic Acid ◽  
Azelaic Acid ◽  
Poor Response ◽  
Severity Index ◽  
Index Score ◽  
Military Hospital ◽  
Severity Index Score ◽  
Group A ◽  
The Mean ◽  
Group B

Objective: To compare the efficacy of Intradermal Tranexamic acid and topical 20% Azelaic acid cream in the treatment of melasma. Study Design: Comparative prospective study. Place and Duration of Study: Dermatology department, Combined Military Hospital Peshawar, from Sep 2018 to Mar 2019. Methodology: A total of 116 female patients, at the outpatient department of dermatology at Combined Military Hospital Peshawar, were randomly assigned into two groups; group A (intradermal tranexamic acid) and group B (topical azelaic acid) by lottery method. Patients in group A received intradermal injection, while the participants of group B received topical azelaic acid only, fortnightly for 6 weeks. Melasma area severity index score was calculated for each patient in both groups at the start and at the end of the treatment. Results: The mean Melasma area severity index score in group A (intradermal tranexamic acid) before and at 6 weeks of treatment was 7.10 ± 2.94 and 5.27 ± 2.44, respectively. The mean Melasma area severity index score in group B (topical azelaic acid) before and at 6 weeks of treatment was 7.56 ± 2.57 and 5.76 ± 2.89, respectively. Efficacy of intradermal tranexamic acid, as poor response, good response and excellent response was 27.6%, 41.4% and 31% respectively. While, efficacy of topical azelaic acid group as poor response, good response and excellent response was 62.1%, 20.7% and 17.2% respectively. The difference was statistically significant, (p=0.001). Conclusion: It can be concluded that intradermal tranexamic acid is more effective as compared to topical 20% azelaic acid in..................

scholarly journals Comparison of nasal douching with isotonic saline versus Ringer lactate in chronic rhinosinusitis: a randomized controlled trial

2020 ◽  
Vol 6 (6) ◽  
pp. 1064
Author(s):  
K. Paventhan ◽  
Pradeep Krishna R. ◽  
Ramya Shree C.
Keyword(s):  
Chronic Rhinosinusitis ◽  
Controlled Trial ◽  
Isotonic Saline ◽  
Post Treatment ◽  
Ringer Lactate ◽  
Treatment Data ◽  
Group A ◽  
Pre Treatment ◽  
Group B ◽  
Lactate Solution

<p class="abstract"><strong>Background:</strong> Nasal douching is a best effective and simple treatment procedure for chronic rhinosinusitis. This study compares the efficacy of nasal douching with isotonic saline solution versus ringer lactate solution in patients suffering from chronic rhinosinusitis.</p><p class="abstract"><strong>Methods:</strong> This randomized control trial was conducted among the patients with chronic rhinosinusitis who were attending the outpatient department of Otorhinolaryngology in Chettinad Hospital and Research Institute, Chennai, during the study period from June 2019 to December 2019. After randomization group A and B includes thirty cases of chronic rhinosinusitis each and they received nasal douching with saline and Ringer lactate two times a day for a period of three weeks and assessed using sino-nasal outcome test (SNOT) 20 during pre-treatment and post treatment. Data was entered in Microsoft excel and data analysis was done using SPSS version 17.  </p><p class="abstract"><strong>Results:</strong> On assessing the overall SNOT 20 mean score, in both group A and group B, there was statistically significant improvement post treatment score when compare to pre-treatment scores. But the differences in improvement between the two groups were not found to be significant.</p><p class="abstract"><strong>Conclusions:</strong> Though isotonic saline and ringer lactate solution showed significant improvement after treatment both these are same with respect to efficacy in the treatment of douching for chronic rhinosinusitis with no difference in outcome.</p><p class="abstract"> </p>

scholarly journals Effect of Cupping Therapy versus Continuous Aerobic Exercise on Lipid Proϑile in Hypertensive Men

2020 ◽  
Vol 11 (4) ◽  
pp. 6537-6542
Author(s):  
Aya M. Mahmoud ◽  
Karim A. Fathy ◽  
Ahmed Y. Ali
Keyword(s):  
Blood Pressure ◽  
Aerobic Exercise ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Cupping Therapy ◽  
Post Treatment ◽  
Exercise Effect ◽  
Group A ◽  
Pre Treatment ◽  
Group B

Blood pressure and lipid profile are strongly linked to function, particularly in patients with hypertension disease (HTN). That study was aimed to differentiate between the cupping therapy and continuous aerobic exercise effect on lipid profile in hypertensive men. Thirty volunteers male patient with primary hypertension selected from outpatients Desouk general hospital. Their age ranged between 40-50 years, they were divided into two equal groups: group (A) attended a program of cupping therapy one time per month for three months and group (B) attended a program of continuous aerobic exercise on a treadmill for 30 minutes, two times per week for three months. Analysis of the results revealed that there was a major decrease in blood pressure (systole and diastole) and lipid profile (Triglyceride LDL, and Total Cholesterol) and increase in HDL during the cupping therapy closely same continuous aerobic exercise. A major decrease post treatment compared with that pre-treatment (p > 0.05) in both groups, but there was no major difference between both groups (A, B) in pre-treatment and also post treatment (p > 0.05). Both cupping therapy, as well as continuous aerobic exercises, showed a significant decrease in blood pressure and lipid profile (Total Cholesterol, Triglyceride and LDL) and a significant increase in HDL post-treatment compared with that pre-treatment.

scholarly journals PRETREATMENT WITH LIGNOCAINE

2010 ◽  
Vol 17 (04) ◽  
pp. 633-637
Author(s):  
MOBEEN IKRAM ◽  
MUHAMMAD ISHAQUE ◽  
NAVEED MASOOD
Keyword(s):  
Normal Saline ◽  
Military Hospital ◽  
Double Blind Study ◽  
Double Blind ◽  
Pain On Injection ◽  
Experienced Pain ◽  
Group A ◽  
Pre Treatment ◽  
Group B ◽  
Induction Of Anaesthesia

Objective: To assess the frequency of pain and withdrawal movements after injection of rocuronium and effects of pre-treatment with lignocaine. Study Design: Double blind study. Duration of Study: This study was of six months duration and was carried out from March 2004 to September 2004. Setting: Combined Military Hospital Kharian. Patients and Methods: One hundred and twenty unpremedicated patients with ASA grade I and II, aged between 18-60 years and of both sexes were enrolled in the study. Patients were randomly divided into two groups of 60 patients each. After induction of anaesthesia with thiopentone, patients in group A received 3 ml of lignocaine plain while those in group B, received 3 ml of normal saline as pre-treatment before injection of rocuronium. Their effects on pain on injection and withdrawalmovements of the arm were studied. Results: Out of total of 120 patients, only 17 patients (14%) developed withdrawal movements of the arm or wrist. In Group A, who received lignocaine plain before rocuronium injection, only 3 patients out of 60 patients had withdrawal movements while in Group B, who received normal saline as pre-treatment fourteen out of 60 patients developed withdrawal movements of the arm or wrist. Only one patient belonging to Group B experienced pain. Conclusions: Pretreatment with lignocaine plain greatly reduces the chances of withdrawal movements and pain on injection of rocuronium.

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