scholarly journals ОКСИДАЗИ L-АМІНОКИСЛОТ: ОДЕРЖАННЯ, ВЛАСТИВОСТІ ТА ПЕРСПЕКТИВИ ВИКОРИСТАННЯ

InterConf ◽  
2021 ◽  
pp. 228-237
Author(s):  
Галина Гайда
Keyword(s):  
Amanita Phalloides

Проаналізовано наукову літературу за проблемою оксидаз L-амінокислот стосовно джерел їхнього накопичення, методів одержання, моніторингу каталітичної активності, характеристик ферментів та перспектив їхнього використання. Розроблено скринінгові кольорові експрес-тести виявлення L-аргініноксидази (ArgО), запропоновано схему очищення ArgО з шапинкового гриба Amanita phalloides. Препарати АргО виділено в аналітичних кількостях, вивчено деякі властивості ферменту, а саме, умови зберігання та субстратну специфічність.

Intravenous rifampicin use in the management of amanita phalloides toxicity

2021 ◽  
pp. 1-4
Author(s):  
Rona Zuker-Herman ◽  
Roger Tong ◽  
Anselm Wong
Keyword(s):  
Amanita Phalloides

scholarly journals Acute Liver Failure Caused byAmanita phalloidesPoisoning

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Luca Santi ◽  
Caterina Maggioli ◽  
Marianna Mastroroberto ◽  
Manuel Tufoni ◽  
Lucia Napoli ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Rna Polymerase Ii ◽  
Gastrointestinal Symptoms ◽  
Amanita Phalloides ◽  
Prognostic Indicators ◽  
Mushroom Poisoning ◽  
Lag Phase ◽  
Kidney Involvement

Mushroom poisoning is a relatively rare cause of acute liver failure (ALF). The present paper analyzes the pathogenesis, clinical features, prognostic indicators, and therapeutic strategies of ALF secondary to ingestion ofAmanita phalloides, which represents the most common and deadly cause of mushroom poisoning. Liver damage fromAmanita phalloidesis related to the amanitins, powerful toxins that inhibit RNA polymerase II resulting in a deficient protein synthesis and cell necrosis. After an asymptomatic lag phase, the clinical picture is characterized by gastrointestinal symptoms, followed by the liver and kidney involvement. Amatoxin poisoning may progress into ALF and eventually death if liver transplantation is not performed. The mortality rate afterAmanita phalloidespoisoning ranges from 10 to 20%. The management of amatoxin poisoning consists of preliminary medical care, supportive measures, detoxification therapies, and orthotopic liver transplantation. The clinical efficacy of any modality of treatment is difficult to demonstrate since randomized, controlled clinical trials have not been reported. The use of extracorporeal liver assist devices as well as auxiliary liver transplantation may represent additional therapeutic options.

scholarly journals A breakthrough on Amanita phalloides poisoning: an effective antidotal effect by polymyxin B

2015 ◽  
Vol 89 (12) ◽  
pp. 2305-2323 ◽  
Author(s):  
Juliana Garcia ◽  
Vera Marisa Costa ◽  
Alexandra T. P. Carvalho ◽  
Ricardo Silvestre ◽  
José Alberto Duarte ◽  
...  
Keyword(s):  
Polymyxin B ◽  
Amanita Phalloides

scholarly journals Amanita phalloides poisoning and treatment with silibinin in the Australian Capital Territory and New South Wales

2013 ◽  
Vol 198 (1) ◽  
pp. 43-47 ◽  
Author(s):  
Darren M Roberts ◽  
Michael J Hall ◽  
Morna M Falkland ◽  
Simone I Strasser ◽  
Nick A Buckley
Keyword(s):  
New South ◽  
New South Wales ◽  
Amanita Phalloides ◽  
Australian Capital Territory ◽  
Australian Capital ◽  
South Wales

Curative potencies of penicillin in experimental amanita phalloides poisoning

1971 ◽  
Vol 2 (3) ◽  
pp. 138-141 ◽  
Author(s):  
G. L. Floersheim ◽  
J. Schneeberger ◽  
K. Bucher
Keyword(s):  
Amanita Phalloides

scholarly journals Fulminant Liver Failure Due to Amanita Phalloides Toxicity Treated with Emergent Liver Transplantation

2015 ◽  
Vol 12 (3) ◽  
Author(s):  
Funda Gok ◽  
Ahmet Topal ◽  
Gülçin Hacibeyoglu ◽  
Atilla Erol ◽  
Murat Biyik ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Liver Failure ◽  
Amanita Phalloides ◽  
Fulminant Liver Failure
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