scholarly journals COMPARATIVE ANALYSIS OF SURFACE ELECTROMYOGRAPHY DATA IN PATIENTS WITH CHRONIC DAILY HEADACHE AFTER BOTULOTOXIN INJECTION TYPE A AND STANDARD MEDICAL THERAPY

InterConf ◽  
2021 ◽  
pp. 377-386
Author(s):  
Anna Prokhorova
Keyword(s):  
Medical Therapy ◽  
Chronic Daily Headache ◽  
Surface Electromyography ◽  
Type A ◽  
Surface Emg ◽  
Standard Medical Therapy ◽  
Group I ◽  
Significant Difference ◽  
Before And After ◽  
Daily Headache

Goal. The aim of the study was to compare the results of surface electromyography after injection of Botulinum toxin type A and standard medical therapy. Material and methods. The study encompassed 62 participants with chronic daily headaches (CDH). Group I included 26 patients with chronic migraine (15 treated with BTX-A injection and 11 treated with standard medical therapy), whilst, Group II comprised of 36 patients with chronic tension type headache (20 treated with BTX-A injection and 16 treated with standard medical therapy) with an average age of 32.1 ± 10.3 (M ± SD) years. Before and after therapy, clinical questionnaires, instrumental data, and headache episode characteristics were collected from all patients. To examine the differences between BTX - A injection and standard medical therapy, we measured muscle activity with surface EMG in patients with chronic daily headache before and after 3 months of treatment. On days when the patients had no headache attacks, the surface EMG was measured. Results. After treatment, surface electromyography data revealed a statistically significant difference in outcomes between the patients who received BTX-A injection and those who received standard medical therapy. Before treatment on surface EMG, all patients with chronic daily headache had high amplitude and velocity in the muscles under study, and there was no statistically significant difference between these groups, where p => 0.05. In this study, it was discovered that there was no statistically significant difference in pericranial and neck muscles dysfunction (before treatment between patients receiving BTX-A injection and standard medical therapy in Group I, patients with CM 95% CI -0.9087 - 0.4887; t = -0.607, df = 40, p = 0.5470 and Group II, patients with CTTH 95 % CI -0.5756 - 0.4356, t = -0.27, After treatment, there was a statistically significant difference between groups treated by BTX- A injection and standard medical therapy, with CM 95% CI 0.3258 - 1.4142, t = 3.231, df = 40, p = 0.0025 and CTTH 95 % CI 0.1020 - 1.1780, t = 2.381, df = 58, p = 0.0206, where p = <0.05. Conclusion. The obtained results testify the effectiveness of BTX-A injections compared to standard medical therapy in patients with CDH.

scholarly journals Binocular responses and vertical strabismus

2007 ◽  
Vol 64 (2) ◽  
pp. 109-115 ◽  
Author(s):  
Dusica Risovic ◽  
Lidija Petrovic ◽  
Natalija Kosanovic-Jakovic ◽  
Katarina Misailovic ◽  
Branislav Stankovic ◽  
...  
Keyword(s):  
Binocular Vision ◽  
Oblique Muscle ◽  
Common Pattern ◽  
Inferior Oblique Muscle ◽  
Group I ◽  
Significant Difference ◽  
Before And After ◽  
Group Ii ◽  
Sensory Tests ◽  
Dissociated Vertical Deviation

Background/Aim. Elevation in adduction is the most common pattern of vertical strabismus, and it is mostly treated with surgery. The results of weaking of inferior oblique muscle are very changeable. The aim of this study was to evaluate binocular vision using sensory tests before and one and six months after the surgery. Methods. A total of 79 children were divided in two groups: the first, with inferior oblique muscle of overaction (n = 52), and the second with dissociated vertical deviation (DVD), and primary inferior oblique muscle overaction (n = 27). We tested them by polaroid mirror test (PMT), Worth test at distance and near, fusion amplitudes on sinoptofore, Lang I stereo test and Wirt-Titmus stereo test. We examined our patients before and two times after the surgery for vertical strabismus. Results. Foveal suppression in the group I was found in 60.5% of the patients before, and in 56.4% after the surgery. In group II Foveal suppression was detected in 64.7% of the patients before, but in 55.6% 6 months after the surgery with PMT. Worth test revealed suppression in 23.5% of the patients before, and in 40.7% after the vertical muscle surgery. Parafoveal fussion persisted in about 1/3 of the patients before the surgery, and their amplitudes were a little larger after the surgery in the group I patients. Lang I stereo test was negative in 53.9% before and 51.9% after the surgery in the group I, and in 48.2% of the patients before and after the surgery in the group II patients. Wirt-Titmus stereo test was negative in 74.5% of the patients before and in 72.9% after the surgery in the group I, but in the group II it was negative in 70.8% before and in 68.0% of the patients 6 months after the surgery. Conclusion. Binocular responses were found after surgery in 65.7% of the patients the group I and in 55.6% patients the group II. There was no significant difference between these two groups, but binocular responses were more often in the patients of the group I.

scholarly journals THE COMPARISON OF DEEP NECK FLEXOR STRENGTHENING EXERICISE WITH MCKENZIE NECK EXERCISE FOR NECK POSTURE CORRECTION ON STUDENTS WITH FORWARD HEAD POSTURE AT SMA N 1 SEMARAPURA

2018 ◽  
Vol 6 (1) ◽  
pp. 23
Author(s):  
Gede Eka Juli Prasana ◽  
I Nyoman Adiputra ◽  
I Made Krisna Dinata
Keyword(s):  
Exercise Intervention ◽  
Hypothesis Test ◽  
Test Group ◽  
Forward Head Posture ◽  
Head Posture ◽  
Group I ◽  
Strengthening Exercise ◽  
Significant Difference ◽  
Before And After ◽  
Group Ii

This study aims to compare deep neck flexor strengthening exercise intervention with mckenzie neck exercise to correct the neck posture of student with forward head posture. Using experimental design with Pre-Test and Post-Test Group Design involves a sample of 24 people divided into 2 groups. Group I was given deep neck flexor strengthening exercise intervention and Group II was given mckenzie neck exercise intervention. Hypothesis Test using paired sample t-test obtained result p = 0.592 with average difference in Group I 7.58 ± 4.39 whereas Group II got difference mean 8.5 ± 3.84. These results showed no significant difference in craniovertebral angle elevation before and after intervention in both groups. Keywords : forward head posture, craniovertebrae angle, deep neck flexor strengthening exercise, mckenzie neckexercise,

scholarly journals Different Bleeding Patterns with the Use of Levonorgestrel Intrauterine System: Are They Associated with Changes in Uterine Artery Blood Flow?

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Carlo Bastianelli ◽  
Manuela Farris ◽  
Stefania Rapiti ◽  
Roberta Bruno Vecchio ◽  
Giuseppe Benagiano
Keyword(s):  
Blood Flow ◽  
Uterine Artery ◽  
Endometrial Thickness ◽  
Power Doppler ◽  
Artery Blood Flow ◽  
Group Iii ◽  
Group I ◽  
Significant Difference ◽  
Before And After ◽  
Group Ii

Objective. Evaluate if different bleeding patterns associated with the use of the levonorgestrel intrauterine system (LNG-IUS) are associated with different uterine and endometrial vascularization patterns, as evidenced by ultrasound power Doppler analysis.Methodology. A longitudinal study, with each subject acting as its own control was conducted between January 2010 and December 2012. Healthy volunteers with a history of heavy but cyclic and regular menstrual cycles were enrolled in the study. Ultrasonographic examination was performed before and after six months of LNG-IUS placement: uterine volume, endometrial thickness, and subendometrial and myometrial Doppler blood flow patterns have been evaluated.Results. A total of 32 women were enrolled out of 186 initially screened. At six months of follow-up, all subjects showed a reduction in menstrual blood loss; for analysis, they were retrospectively divided into 3 groups: normal cycling women (Group I), amenorrheic women (Group II), and women with prolonged bleedings (Group III). Intergroup analysis documented a statistically significant difference in endometrial thickness among the three groups; in addition, mean pulsatility index (PI) and resistance index (RI) in the spiral arteries were significantly lower in Group I and Group III compared to Group II. This difference persisted also when comparing—within subjects of Group III—mean PI and RI mean values before and after insertion.Conclusions. The LNG-IUS not only altered endometrial thickness, but—in women with prolonged bleedings—also significantly changed uterine artery blood flow. Further studies are needed to confirm these results and enable gynecologists to properly counsel women, improving initial continuation rates.

Glutamate and Nitric Oxide Pathway in Chronic Daily Headache: Evidence From Cerebrospinal Fluid

Cephalalgia ◽  
2003 ◽  
Vol 23 (3) ◽  
pp. 166-174 ◽  
Author(s):  
V Gallai ◽  
A Alberti ◽  
B Gallai ◽  
F Coppola ◽  
A Floridi ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Chronic Daily Headache ◽  
Central Sensitization ◽  
Receptor Activation ◽  
Guanosine Monophosphate ◽  
Peripheral Sensitization ◽  
No Production ◽  
Neurokinin A ◽  
Significant Difference ◽  
Daily Headache

A central sensitization has been advocated to explain chronic daily headache (CDH) due to sustained peripheral sensitization of algogenic structures responsible for sustained trigeminovascular system activation. Several mechanisms have been suggested to underlie central sensitization, but have been poorly investigated in CDH. They involve N-methyl-D-aspartate (NMDA) receptor activation and nitric oxide (NO) production and supersensitivity and increased and maintained production of sensory neuropeptides. The present study supports the above pathogenic mechanisms demonstrating a significant increase in glutamate and nitrite levels in the CSF of CDH patients, without a significant difference between patients without and those with analgesic overuse headache ( P < 0.0001 and P < 0.002). The increase in CSF nitrites was accompanied by a significant rise in the CSF values of cyclic guanosine monophosphate (cGMP) in patients in comparison with controls ( P < 0.0001). A statistically significant correlation emerged between visual analogic scale (VAS) values and glutamate, nitrites and cGMP. Although substance P (SP) and calcitonin gene-related peptide (CGRP), and to a lesser extent neurokinin A, were significantly increased in CSF compared with control subjects, their values did not correlate with glutamate, nitrites and cGMP levels in CSF in the patient group. The present study confirms the involvement of glutamate-NO-cGMP-mediated events underlying chronic head pain that could be the target of a new therapeutic approach which should be investigated.

scholarly journals Botulinum toxin type a for the treatment of spasticity in children with cerebral palsy

2007 ◽  
Vol 64 (8) ◽  
pp. 513-518 ◽  
Author(s):  
Lidija Dimitrijevic ◽  
Ivona Stankovic ◽  
Vesna Zivkovic ◽  
Aleksandra Mikov ◽  
Hristina Colovic ◽  
...  
Keyword(s):  
Botulinum Toxin ◽  
Range Of Motion ◽  
Botulinum Toxin Type A ◽  
Type A ◽  
Botulinum Toxin Type ◽  
Group I ◽  
Active Range Of Motion ◽  
Significant Difference ◽  
Motor Outcome ◽  
Group Ii

Background/Aim. Cerebral palsy (CP) is the most common physical disability in childhood. Children have problems with motor functions as a result of limbs spasticity, which leads to severe contractures and limbs deformity. There is a growing interest in the therapeutic role of botulinum toxin type A (BTA) in CP. The aim of this study was to examine the effects of BTA on spasticity, active range of motion and functional motor outcomes in children with CP. Methods. This study included 42 children of both sexes, aged 2?6 years, with spastic CP, divided into two groups: group I (21 child) treated with BTA and physical therapy, and group II (21 child) treated with physical therapy only. The following parameters were analyzed: spasticity; active range of motion of the hip, knee and ankle, and functional motor outcome. These parameters measurements were carried out four times in both groups: before the treatment, three, eight and 16 weeks after the beginning of the treatment. The obtained results were statistically processed and compared. Results. There was no evidence of any significant difference between the groups before the treatment. After eight weeks there was a remarkable difference concerning spasticity reducing on behalf of the group I (group I - 0.76?0.51 vs. II group - 2.17?0.64; p < 0.0001). There was statistically significant difference concerning active range of motion increasing on behalf of the group I (hip abduction: group I - 44.37?1.130 vs. group II - 32.61?8,070, p < 0,01; knee extension: group I - 0,77?1.820 vs. II group - 14.99?7.610, p < 0.01; dorsiflexion of the foot: group I - 11.50?6.080 vs. group II - 8.98?7.850, p < 0,01). A statistically significant difference was found after 16 weeks in functional motor outcome as well, on behalf of the group I: functional motor abilities level in the group I was 1.86 vs. 2.71 in the group II, p < 0.05. Conclusion. Botulinum toxin type A application leads to an important spasticity decreasing, active range of motion increasing, as well as to functional abilities in children with CP. .

scholarly journals Hook plate with or without coracoclavicular ligament augmentation in the treatment of acute acromioclavicular separation

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Chung-Ting Liu ◽  
Ten-Fang Yang
Keyword(s):  
Plate Fixation ◽  
Functional Results ◽  
Hook Plate ◽  
Group I ◽  
Ligament Augmentation ◽  
Significant Difference ◽  
Before And After ◽  
Acromioclavicular Separation ◽  
Group Ii ◽  
Type V

Abstract Background Acromioclavicular (AC) separation can be treated with the use of a hook plate. Some studies have reported that coracoclavicular (CC) ligament augmentation is necessary to reduce the complications of hook plate fixation, whereas others recommend hook plate fixation alone without augmentation. The aim of this study was to compare the results and complications between these two groups. Methods This was an observational case-control study. Patients with acute (less than 2 weeks) Rockwood type V AC separation were treated with a hook plate at our hospital. A total of 105 cases received hook plate fixation with CC ligament augmentation (group I), and 112 cases received hook plate fixation without augmentation (group II). Constant-Murley scores were used to evaluate the function before and after implant removal, and radiographs were taken to evaluate the complications. The results and complications were compared between groups. Results Before removal, the Constant-Murley score was significantly higher in group I (mean, 50.1) than in group II (mean, 42.6) (p = 0.004); however, there was no significant difference between groups at 3 and 6 months after removal. The incidence of significant acromion osteolysis was higher in group II (65/112) than in group I (25/105). Before removal, the patients with significant acromion osteolysis had worse Constant-Murley scores than those of the patients without osteolysis in both groups. The incidence of peri-implant fracture of the hook plate was higher in group II (8/112) than in group I (1/105). Conclusion The patients without CC ligament augmentation had worse functional results before hook plate removal, a higher incidence of radiographic acromion osteolysis, and a higher incidence of peri-implant fractures than those patients with CC ligament augmentation. Therefore, CC ligament augmentation is highly recommended to improve short-term outcomes and decrease complications for Rockwood type V AC separation treated by hook plate.

scholarly journals KOMBINASI MCKENZIE EXERCISE DAN ULTRASOUND LEBIH BAIK DARIPADA MYOFASCIAL RELEASE DAN ULTRASOUND UNTUK MEMPERBAIKI DISABILITAS PADA MECHANICAL NECK PAIN

2017 ◽  
Author(s):  
Jasmine Kartiko Pertiwi ◽  
Ketut Tirtayasa ◽  
Sugijanto ◽  
J. Alex. Pangkahila ◽  
I Made Muliarta ◽  
...  
Keyword(s):  
Neck Pain ◽  
Soft Tissues ◽  
Joint Space ◽  
T Test ◽  
Mean Difference ◽  
Myofascial Release ◽  
Group I ◽  
Significant Difference ◽  
Before And After ◽  
Quasi Experimental

Introdaction: Patients with mechanic neck pain a population that often found overstretches it is caused by occurred between the two bones in the neck on the ligaments and soft tissues located around, static resulting in hipomibilitas the joint space and joint play movement, resulting in the emergence of provocation on the part of the occipital region on Cervical stressor resulting in excess tissue around the contractile and non-contractile. Purpose: This study the application of ultrasound and McKenzie exercise and myofacial release ultrasound in reducing disability in mechanical neck pain, Methods: This research method is a quasi experimental research with Pre and Post Test Two Group Design. The samples were divided into two treatment groups consisting of McKenzie exercice and ultrasounds were 20 participants with myofascial release and ultrasound with 19 participants, a total of 39 participants. Result: Differences between the mean decrease in neck with NDI disability before and after the application of each group were tested by t-test related, the results obtained mean between the groups before treatment 17,10±1,889% and after treatment 12,90±2,490% by value (p = 0.001) with a mean difference of 42% and showed the average group between before treatment 17,42±2,388% and after treatment 15,63±2,362% (p = 0.001) with a mean difference of 17,9%. The statistical test of using independent t-test showed is a significant difference between group I and group II and the result is p = 0.001 (p< 0.05). Conclusion: application of combined Mc Kenzie exercise and ultrasound better than the application of a combination of myofacial release and ultrasound in reducing disabilities in case of mechanical neck pain.

scholarly journals A prospective randomized double blind placebo controlled crossover study of fluoxetine efficacy in the prophylaxis of chronic daily headache in children and adolescents

2005 ◽  
Vol 63 (3a) ◽  
pp. 559-563 ◽  
Author(s):  
José Luiz Dias Gherpelli ◽  
Sandro Blasi Esposito
Keyword(s):  
Adverse Effects ◽  
Crossover Study ◽  
Children And Adolescents ◽  
Chronic Daily Headache ◽  
Headache Frequency ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Group I ◽  
Daily Headache ◽  
Group Ii

Thirty-two children (21 female and 11 male), between 7 and 14 years old, with chronic daily headache (CDH) were consecutively included in a prospective, randomized, double blind, placebo controlled crossover study. The patients were divided in group I (fluoxetine vs. placebo), with 17 patients and group II (placebo vs. fluoxetine), with 15 patients. After one month of baseline headache frequency recording, the patients received fluoxetine in dosages from 0.25 to 0.50 mg/kg for three months. A wash out period of one month was followed by another three months treatment period. Results showed a significant decrease in headache frequency in the study period [78% reduction in group I (p<0.025), and 45% reduction in group II (p=0.025)]. Gastrointestinal adverse effects were observed in nine patients (29%) that received fluoxetine, compared with 3 (10%), with placebo. We conclude that fluoxetine efficacy is not higher than placebo in the prophylaxis of CDH in children and adolescents.

Impact of Direct Acting Antivirals therapy on metabolic profiles and adiponectin serum level in Egyptian patients with chronic hepatitis C infection

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Mohamed Lotfy Fahmy Abd Elmeged ◽  
Sameh Mohamed Fahim Ghaly ◽  
Osama Ashraf Ahmed ◽  
Ahmed Samir Abohalima ◽  
Ahmed Samir Allam ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Lipid Profile ◽  
Chronic Hepatitis C ◽  
Adiponectin Level ◽  
Fasting Insulin ◽  
Group I ◽  
Significant Difference ◽  
Before And After ◽  
Group Ii

Abstract Background and Objectives Hepatitis C Virus (HCV) infection is a major global health challenge. Chronic hepatitis C viral infection is associated with wide metabolic disarrangements. HCV interacts with lipid metabolism leading to steatosis, causing wide adipocytokines changes and impairs glucose metabolism leading to increased prevalence of insulin resistance (IR) and type 2 diabetes. Several oral anti-HCV drugs (direct acting antivirals; DAAs) have been developed over the last several years. Now, HCV can be eliminated from the infected host within 12 weeks of DAA combination therapy. As, there is limited data on the effects of DAA therapy on metabolic profiles, lipid profile and adiponectin level. Hence, this study was carried out to evaluate the Impact of Direct Acting Antivirals therapy on metabolic profiles and adiponectin serum level in Egyptian patients with chronic hepatitis C infection. Methods This study was performed on 100 patients who have chronic infection with hepatitis C, patients were divided into two groups, Group I was 50 patients were treated with (Sofosbuvir/Daclatasvir/Ribavirin) for 3 months. Group II was 50 patients were treated with (Ombitasvir, Paritaprevir, Ritonavir/Ribavirin) for 3 months. With follow up changes were occurred in Fasting Lipid profile (total cholesterol, triglyceride, HDL and LDL), metabolic profile (fasting blood sugar, Fasting Insulin, HOMA-IR and HBA1C) and Serum adiponectin level before and after end of treatment. Results One hundred patients met inclusion criteria were reviewed, (56%) were males in group I while (46%) were males in group I, Mean age in group I was 47.4 ± 5.3 years while in group II was 43.2 ± 6.6 years, statistical analysis of data showed significant difference in the lipid profile in group I before and after treatment .As, we found significant reduction in serum triglycerides after treatment (113.2 ± 22.9 mg/dL vs 105.6 ± 23.2 mg/dL, P &lt; 0.001) and a significant elevation of serum Total Cholesterol, LDL and HDL after treatment (TC: 153.2 ± 20.1 mg/dL vs 174.1 ± 19 mg/dL, P &lt; 0.001, LDL: 74.7 ± 9.9 mg/dL vs 93.3 ± 12 mg/dL, P &lt; 0.001, HDL: 54.6 ± 10.1 mg/dL vs 57.2 ± 10.3 mg/dL, P 0.010) But in group II there was no significant difference in the lipid profile before and after treatment, Also, We found significant reduction in fasting insulin, HOMAIR and HBA1C after treatment in group I (Fasting Insulin: 11.4 ± 3.3 (uU/L)/ml vs 9.7 ± 2.2 (uU/L)/ml, P &lt; 0.001, HOMA-IR: 2.7 ± 0.9 vs 2.2 ± 0.6, P &lt; 0.001, HBA1C: 5.6 ± 0.4 vs 5.4 ± 0.3, P 0.003) But in group II there was no significant difference in fasting insulin, HOMA-IR and HBA1C before and after treatment. Also, we found that there was no significant changes in the serum adiponectin level in the both group before and after treatment. Conclusion Eradication of chronic hepatitis C viral infection with DAAs may affect the lipid and the metabolic profile of patients after the end of treatment according to the type of DAAs used in the treatment and according to the stage of the liver disease of patients. But not affect the serum Adiponectin level.

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