scholarly journals <sup>129</sup>Xe ultra-fast Z spectroscopy enables micromolar detection of biosensors on a 1 T benchtop spectrometer

2021 ◽  
Vol 2 (1) ◽  
pp. 409-420
Author(s):  
Kévin Chighine ◽  
Estelle Léonce ◽  
Céline Boutin ◽  
Hervé Desvaux ◽  
Patrick Berthault

Abstract. The availability of a benchtop nuclear magnetic resonance (NMR) spectrometer, of low cost and easily transportable, can allow detection of low quantities of biosensors, provided that hyperpolarized species are used. Here we show that the micromolar threshold can easily be reached by employing laser-polarized xenon and cage molecules reversibly hosting it. Indirect detection of caged xenon is made via chemical exchange, using ultra-fast Z spectroscopy based on spatio-temporal encoding. On this non-dedicated low-field spectrometer, several ideas are proposed to improve the signal.

2021 ◽  
Author(s):  
Kévin Chighine ◽  
Estelle Léonce ◽  
Céline Boutin ◽  
Hervé Desvaux ◽  
Patrick Berthault

Abstract. The availability of a benchtop NMR spectrometer, of low cost and easily transportable, can allow detection of low quantities of biosensors, provided that hyperpolarized species are used. Here we show that the micromolar threshold can easily be reached, by employing laser-polarized xenon and cage-molecules reversibly hosting it. Indirect detection of caged xenon is made via chemical exchange, using ultrafast Z-spectroscopy based on spatio-temporal encoding. On this non-dedicated low-field spectrometer, several ideas are proposed to improve the signal.


2021 ◽  
Vol 35 (3) ◽  
pp. 2174-2182
Author(s):  
Yongchao Zhang ◽  
Lele Liu ◽  
Daigang Wang ◽  
Pengfei Chen ◽  
Zhun Zhang ◽  
...  

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