AGE RELATED MACULAR DEGENERATION (ARMD) CLINICAL PROFILE AND MANAGEMENT

Age Related Macular Degeneration (ARMD) next to cataract is the leading cause visual loss in elderly. My study is to focus on cleanical profile of Age Related Macular Degeneration with effective Ayurveda management to increasing in average longitivity of an individual with advance in science and technology along with traditional management.In research scenario it has been demonstrated that choroidal neovascular lesion of Age Related Macular Degeneration. Account for most of severe loss of vision attributed to this condition. My study tries to give additional option and contribution of Ayurveda to patient affected with Age Related Macular Degeneration. Macula is area which correspond to centre of vision. There are two types Dry and Wet ARMD based on appearance of exudates and tiny haemorrhage in the macular area . in wet AMD treatment of Raktpitta should be followed. Though description of macular degeneration is not described is classics . Gradual loss of vision in Timira we can assume this regenerative pathology as Prakopita Vatalakshana in Drushti Mandala . Inn proper Tarpak Kapha result in weakening of function and death of life sensing cells of macula . In dry Age Related Macular Degeneration this cells breakdown slowly and result in loss of central vision . These can be stated Kaphavata Drushtijanya Timira . In case of wet AMD abnormal blood vessels start to grow under macula and eventually bleed . This explains Raktpitta Drushti . Management of Age Related Macular Degeneration should be done on the principle of Vatavyadhi with Rasayan Chikitsa .

Download Full-text

Outer retinal tubulation formation and clinical course of advanced age-related macular degeneration

Scientific Reports ◽

10.1038/s41598-021-94310-5 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Alessandro Arrigo ◽

Emanuela Aragona ◽

Ottavia Battaglia ◽

Andrea Saladino ◽

Alessia Amato ◽

...

Keyword(s):

Macular Degeneration ◽

Müller Cells ◽

Geographic Atrophy ◽

Age Related Macular Degeneration ◽

Advanced Age ◽

Age Related ◽

Dry Amd ◽

Foveal Sparing ◽

Wet Amd

AbstractOuter retinal tubulations (ORT) are a relatively new finding characterizing outer retinal atrophy. The main aim of the present study was to describe ORT development in advanced age-related macular degeneration (AMD) and to assess its relationship with disease’s severity. Patients with advanced AMD characterized either by macular neovascularization or geographic atrophy, showing signs of outer retinal disruption or retinal pigment epithelium atrophy on structural optical coherence tomography (OCT) at the inclusion examination were prospectively recruited. All the patients underwent complete ophthalmologic evaluation, structural OCT scans and fundus autofluorescence imaging. The planned follow-up was of 3-years. Main outcome measures were ORT prevalence, mechanism of ORT formation, mean time needed for complete ORT formation, best-corrected visual acuity (BCVA), definitely decreased autofluorescence (DDAF) area, questionably decreased autofluorescence (QDAF) area, retinal layer thickness, foveal sparing, number of intravitreal injections. We also assessed the possible role of external limiting membrane (ELM) and Müller cells in ORT pathogenesis. Seventy eyes (70 patients) were included; 43 showed dry AMD evolving to geographic atrophy, while 27 displayed the features of wet AMD. Baseline BCVA was 0.5 ± 0.5 LogMAR, decreasing to 0.9 ± 0.5 LogMAR at the 3-year follow-up (p < 0.01). We detected completely formed ORT in 26/70 eyes (37%), subdivided as follows: 20 eyes (77%) wet AMD and 6 eyes (23%) dry AMD (p < 0.01). ORT took 18 ± 8 months (range 3–35 months) to develop fully. We described the steps leading to ORT development, characterized by progressive involvement of, and damage to the photoreceptors, the ELM and the RPE. Eyes displaying ORT were associated with a smaller QDAF area, less retinal layers damage and lower rate of foveal sparing than eyes free of ORT (p < 0.01). We also described pigment accumulations simulating ORT, which were detected in 16/70 eyes (23%), associated with a greater loss of foveal sparing, increased DDAF area and smaller QDAF area at the 3-year follow-up (p < 0.01). In conclusion, this study provided a description of the steps leading to ORT development in AMD. ELM and Müller cells showed a role in ORT pathogenesis. Furthermore, we described a subtype of pigment hypertrophy mimicking ORT, evaluating its clinical utility.

Download Full-text

Early predictive factors of visual loss at 1-year in neovascular age-related macular degeneration under anti–VEGF in the GEFAL study

Ophthalmology Retina ◽

10.1016/j.oret.2021.04.015 ◽

2021 ◽

Author(s):

Laurent Kodjikian ◽

Amina Rezkallah ◽

Evelyne Decullier ◽

Gilles Aulagner ◽

Laure Huot ◽

...

Keyword(s):

Macular Degeneration ◽

Predictive Factors ◽

Visual Loss ◽

Age Related Macular Degeneration ◽

Anti Vegf ◽

Age Related

Download Full-text

SCARB1 rs5888 is associated with the risk of age-related macular degeneration susceptibility and an impaired macular area

Ophthalmic Genetics ◽

10.1080/13816810.2016.1203442 ◽

2016 ◽

Vol 38 (3) ◽

pp. 233-237 ◽

Cited By ~ 2

Author(s):

Daiva Stanislovaitiene ◽

Dalia Zaliuniene ◽

Algimantas Krisciukaitis ◽

Robertas Petrolis ◽

Alina Smalinskiene ◽

...

Keyword(s):

Macular Degeneration ◽

Age Related Macular Degeneration ◽

Macular Area ◽

Age Related

Download Full-text

Therapeutic Effect of Garcinia cambogia Extract and Hydroxycitric Acid Inhibiting Hypoxia-Inducible Factor in a Murine Model of Age-Related Macular Degeneration

International Journal of Molecular Sciences ◽

10.3390/ijms20205049 ◽

2019 ◽

Vol 20 (20) ◽

pp. 5049 ◽

Cited By ~ 4

Author(s):

Ibuki ◽

Shoda ◽

Miwa ◽

Ishida ◽

Tsubota ◽

...

Keyword(s):

Macular Degeneration ◽

Hypoxia Inducible Factor ◽

Age Related Macular Degeneration ◽

Luciferase Assay ◽

Inhibitory Effects ◽

Garcinia Cambogia ◽

Food Ingredients ◽

Age Related ◽

Dry Amd ◽

Wet Amd

Background: Age-related macular degeneration (AMD) is the leading cause of blindness and can be classified into two types called atrophic AMD (dry AMD) and neovascular AMD (wet AMD). Dry AMD is characterized by cellular degeneration of the retinal pigment epithelium, choriocapillaris, and photoreceptors. Wet AMD is characterized by the invasion of abnormal vessels from the choroid. Although anti-vascular endothelial growth factor (VEGF) therapy has a potent therapeutic effect against the disease, there is a possibility of chorio-retinal atrophy and adverse systemic events due to long-term robust VEGF antagonism. We focused on hypoxia-inducible factor (HIF) regulation of VEGF transcription, and report the suppressive effects of HIF inhibition against ocular phenotypes in animal models. Many of the known HIF inhibitors are categorized as anti-cancer drugs, and their systemic side effects are cause for concern in clinical use. In this study, we explored food ingredients that have HIF inhibitory effects and verified their effects in an animal model of AMD. Methods: Food ingredients were screened using a luciferase assay. C57BL6/J mice were administered the Garcinia cambogia extract (Garcinia extract) and hydroxycitric acid (HCA). Choroidal neovascularization (CNV) was induced by laser irradiation. Results: Garcinia extract and HCA showed inhibitory effects on HIF in the luciferase assay. The laser CNV model mice showed significant reduction of CNV volume by administering Garcinia extract and HCA. Conclusions: Garcinia extract and HCA showed therapeutic effects in a murine AMD model.

Download Full-text