scholarly journals The role of dviharidradi taila locally in the managment of mukhadushika w.s.r. to Acne vulgaris –a case study

2021 ◽  
Vol 5 (04) ◽  
Author(s):  
Sneha Z. Borutkar
Keyword(s):  
Fast Food ◽  
Acne Vulgaris ◽  
Underlying Mechanism ◽  
The Body ◽  
Hormonal Changes ◽  
Common Chronic Disease ◽  
Late Night ◽  
The Face ◽  
Modern Era

Acne vulgaris  is a common chronic disease involving blockage and /or inflammation of pilo sebaceous units.  The resulting appearance can lead to anxiety, reduced self-esteem, and in extreme cases depression. It is the commonest dilemma associated with complexion and smoothness of skin .sometimes leading to major skin problems, which is characterized by macula, papulo, pustular eruption on the skin, especially on the face.  The role of diet and cigarette smoking in the condition is unclear and neither cleanliness nor exposure to sunlight appears to play a part. In both sexes, hormones called androgens appear to be part of the underlying mechanism, by causing increased production of sebum. In the Ayurvedic perspective Acne vulgaris  can be correlated with Mukhadushika . Mukhadushika is explained by Aacharya Sushruta under kshudra rogas and is considered as swatantra vyadhi in the ayurvedic literature. It is characterized by shalmali kantaka sadrusha pidika on the face. Mukhadushika is also called as Tarunya pitika. Tarunya pitika word itself says that it is pittikopatti in taurnya awastha due to some hormonal changes, up to limit it is normal but in excess, it becomes a reason for depression in a person. In Modern Era, physicians came across so many patients suffering from the disease, mukhadushika .The prevalence of mukhadushika increasing day by day due to their fast lifestyle, consumption of food, constipation,late-night sleep, fast food, cold drinks leads to an imbalance in doshas which in turn affects the body as well as mind.turns affects body as well as mind

scholarly journals The role of dviharidradi taila locally in the managment of mukhadushika w.s.r. to acne vulgaris –A case study.

2021 ◽  
Vol 5 (03) ◽  
Author(s):  
Sneha Z. Borutkar
Keyword(s):  
Acne Vulgaris ◽  
Female Gender ◽  
Underlying Mechanism ◽  
Self Esteem ◽  
Age Group ◽  
Oil Glands ◽  
Common Chronic Disease ◽  
The Face

Acne vulgaris is a common chronic disease involving blockage and /or inflammation of pilosebaceous units. Acne can presents as noninflammatory lesions, inflammatory lesions, or a mixture of both, affecting mostly the face but also the back and chest. Typical features of the condition include blackheads or whiteheads, pimples, oily skin, and possible scarring. It primarily affects skin with a relatively high number of oil glands, including the face, upper part of the chest, and back. The resulting appearance can lead to anxiety, reduced self-esteem, and in extreme cases depression. It is the commonest dilemma associated with complexion and smoothness of skin .sometimes leading to major skin problems,  which is characterized by macula, papulo, pustular eruption on the skin, especially on the face. Both male and female gender of adolescent age group are commonly affected. Genetics is the primary cause of acne in 80%of cases. The role of diet and cigarette smoking in the condition is unclear and neither cleanliness nor exposure to sunlight appears to play a part. In both sexes, hormones called androgens appear to be part of the underlying mechanism, by causing increased production of sebum. In the Ayurvedic perspective Acne Vulgaris can be correlated with Mukhadushika . Mukhadushika is explained by Aacharya Sushruta under kshudra rogas and is considered as swatantra vyadhi in the ayurvedic literature. It is characterized by shalmali kantaka sadrusha pidika on the face. Mukhadushika is also called as Tarunya pitika.

Questions on the role of biofilms for the adaptation of microorganisms to unfavorable environmental factors by the example of P. aeruginosa

2020 ◽  
Vol 99 (4) ◽  
pp. 379-383
Author(s):  
Vasily N. Afonyushkin ◽  
N. A. Donchenko ◽  
Ju. N. Kozlova ◽  
N. A. Davidova ◽  
V. Yu. Koptev ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Environmental Factors ◽  
Barrier Function ◽  
Infectious Agent ◽  
Antagonistic Activity ◽  
The Body ◽  
Main Function ◽  
Pathogenic Potential ◽  
The Face

Pseudomonas aeruginosa is a widely represented species of bacteria possessing of a pathogenic potential. This infectious agent is causing wound infections, fibrotic cystitis, fibrosing pneumonia, bacterial sepsis, etc. The microorganism is highly resistant to antiseptics, disinfectants, immune system responses of the body. The responses of a quorum sense of this kind of bacteria ensure the inclusion of many pathogenicity factors. The analysis of the scientific literature made it possible to formulate four questions concerning the role of biofilms for the adaptation of P. aeruginosa to adverse environmental factors: Is another person appears to be predominantly of a source an etiological agent or the source of P. aeruginosa infection in the environment? Does the formation of biofilms influence on the antibiotic resistance? How the antagonistic activity of microorganisms is realized in biofilm form? What is the main function of biofilms in the functioning of bacteria? A hypothesis has been put forward the effect of biofilms on the increase of antibiotic resistance of bacteria and, in particular, P. aeruginosa to be secondary in charcter. It is more likely a biofilmboth to fulfill the function of storing nutrients and provide topical competition in the face of food scarcity. In connection with the incompatibility of the molecular radii of most antibiotics and pores in biofilm, biofilm is doubtful to be capable of performing a barrier function for protecting against antibiotics. However, with respect to antibodies and immunocompetent cells, the barrier function is beyond doubt. The biofilm is more likely to fulfill the function of storing nutrients and providing topical competition in conditions of scarcity of food resources.

A concise yet informative stroll through matrix metalloproteinases and TIMPs

2000 ◽  
Vol 113 (19) ◽  
pp. 3355-3356
Author(s):  
S.D. Shapiro
Keyword(s):  
Matrix Metalloproteinases ◽  
Biological Knowledge ◽  
Late Night ◽  
Oxford University ◽  
Score Card ◽  
Tadpole Tail ◽  
The Family ◽  
Modern Era

Matrix Metalloproteinases and TIMPs by J. Frederick Woessner and Hideaki Nagase Oxford University Press (2000) pp. 223. ISBN 0–19-850268-0 35.00 Ever since Gross discovered that collagenase was responsible for resorption of the tadpole tail, there has been a small group of outstanding scientists that have dedicated their careers to the study of matrix metalloproteinases (MMPs). The family of MMPs has now grown to over 20, and they have been implicated in multiple biological processes drawing the attention of scientists of many disciplines. Two leaders in the field who have ushered in the modern era of MMP biology are Fred Woessner and Hideake Nagase and they share their expertise in Matrix Metalloproteinases and TIMPs. In a concise, yet thorough manner, these authors provide the basic biochemical and biological basis for the study of MMPs. This information, laced with a strong sense of historical perspective, is conveyed in the same interesting manner in which they educated this reviewer and many others over late night scotch at MMP Gordon Conferences. For the interested novice, one will come away no longer needing a score card to keep track of MMP-1 through MMP-22 (perhaps more by now). One will understand which cells produce which MMPs and TIMPs in response to which stimuli. The reader will understand the multiple levels of regulation of MMP activity through gene transcription, proenzyme activation, and inhibition by TIMPs. The book is filled with readable tables depicting important concepts in classification, evolution, and substrate specificity. The authors provide extensive key references for further reading as only they can. The only area not extensively covered is the rapidly emerging in vivo function of MMPs that comes from transgenic and gene targeted mice and animal models. Perhaps this will be the sequel to this primer. As the biological role of these enzymes expands and it becomes more difficult for scientists to ignore MMPs, this book provides a meaningful and painless way to become fluent in the field. Upon completion of the text, readers will feel comfortable incorporating MMPs into their research endeavors. Hopefully this work will spark investigators to ask how these enzymes relate to one's own research interests thus broadening our general biological knowledge.

Illness, Threat and Systems of Authority in Dunhuang

Inner Asia ◽  
2005 ◽  
Vol 7 (1) ◽  
pp. 5-46
Author(s):  
Lewis Mayo
Keyword(s):  
20Th Century ◽  
The Body ◽  
Late 20Th Century ◽  
The Public ◽  
Organisational Form ◽  
Political Forces ◽  
The Face ◽  
Administrative Structures ◽  
Modern Era ◽  
Administrative Problem

AbstractThis paper analyses the relationships between illness and structures of authority in the oasis of Dunhuang in the late 20th century and during the time of the Guiyijun regime which ruled the area as an independent warlord state from the middle of the 9th to the beginning of the 11th century. Both the medieval and the modern systems for dealing with illness in Dunhuang are analysed here as part of a larger problem of threat as an inherent element in any order of authority. In this paper, illness is taken as a political and administrative problem, both in the sense that political forces are mobilised around it and in the sense that political and administrative structures give illness an organisational form. Guiyijun systems of storage and structures of governance in the political and familial realms are understood as the reference point for the strategies deployed in the face of illness ‘events’ and as explanatory frameworks closely linked to accounts of dysfunction in the internal order of the body. The late 20th century order of disease management in Dunhuang forms a counterpart to these medieval structures, despite the major differences in the forms for responding to and attacking illness in the oasis in the public health regimes of the modern era and in the medical and ceremonial practices used a millennium before.

scholarly journals The Association Between the Incidence of Acne Vulgaris and Lifestyle Factors Including Dietary Habits, Physical Activity, and Bathing Frequency

2021 ◽  
Vol 7 (3) ◽  
Author(s):  
Arezoo Bajelan ◽  
Mehdi Ghaebi ◽  
Maryam Javadi ◽  
Ameneh Barikani ◽  
Akram Beheshti ◽  
...  
Keyword(s):  
Physical Activity ◽  
Fast Food ◽  
Dietary Habits ◽  
Vegetable Consumption ◽  
Acne Vulgaris ◽  
Lifestyle Factors ◽  
Control Group ◽  
Case Group ◽  
Significant Difference

Background: Acne vulgaris is a multifactorial skin disease affecting many of the world’s population throughout their lives and can cause severe emotional distress and psychological disorders such as poor self-image, depression, and anxiety. Several underlying risk factors are known for acne development, and many, including inappropriate lifestyle, are yet to be studied. Objectives: In this study, we aimed to determine the role of lifestyle factors including dietary habits, physical activity, and bathing frequency in the incidence of acne vulgaris. Methods: The study population included 425 subjects, of whom 171 were acne patients (the case group), and 254 were non-acne patients (the control group). All participants filled out a questionnaire addressing their demographic information and some lifestyle habits. The data were analyzed by SPSS. Results: Fast food consumption was significantly higher in the case than in the control group (P = 0.008). Dairy intake and bathing frequency were significantly higher among non-acne patients than those with acne (P < 0.001 and P = 0.001, respectively). Vegetable consumption, water intake, and the number of episodes and minutes of physical activity per week were not significantly different between the two groups (P = 0.1, P = 0.4, P = 0.9, and P = 0.8, respectively). The mean weight of participants was significantly higher in the case than in the control group (P = 0.001). Conclusions: There was no significant difference in most of the studied factors between the two groups. Therefore, further studies are needed to assess the role of other underlying conditions such as genetic factors and hormonal changes in the development of acne vulgaris.

scholarly journals The Potential Role of Lithium as an Antiviral Agent against SARS-CoV-2 via Membrane Depolarization: Review and Hypothesis

2021 ◽  
Vol 89 (1) ◽  
pp. 11
Author(s):  
Abdallah Barjas Qaswal ◽  
Aiman Suleiman ◽  
Hasan Guzu ◽  
Taima’a Harb ◽  
Bashir Atiyat
Keyword(s):  
Cell Death ◽  
Immune System ◽  
Antiviral Agent ◽  
Membrane Depolarization ◽  
The Body ◽  
Pyrin Domain ◽  
The Face ◽  
Preclinical And Clinical Studies ◽  
Receptor Family

Studies on potential treatments of Coronavirus Disease 2019 (COVID-19) are important to improve the global situation in the face of the pandemic. This review proposes lithium as a potential drug to treat COVID-19. Our hypothesis states that lithium can suppress NOD-like receptor family pyrin domain containing-3 (NLRP3) inflammasome activity, inhibit cell death, and exhibit immunomodulation via membrane depolarization. Our hypothesis was formulated after finding consistent correlations between these actions and membrane depolarization induced by lithium. Eventually, lithium could serve to mitigate the NLRP3-mediated cytokine storm, which is allegedly reported to be the inciting event of a series of retrogressive events associated with mortality from COVID-19. It could also inhibit cell death and modulate the immune system to attenuate its release, clear the virus from the body, and interrupt the cycle of immune-system dysregulation. Therefore, these effects are presumed to improve the morbidity and mortality of COVID-19 patients. As the numbers of COVID-19 cases and deaths continue to rise exponentially without a clear consensus on potential therapeutic agents, urgent conduction of preclinical and clinical studies to prove the efficacy and safety of lithium is reasonable.

scholarly journals Tecnologia, corpo e educação física: entre a formação e a prática docente

2021 ◽  
Vol 5 (2) ◽  
pp. 235-249
Author(s):  
Evandro Antonio Corrêa ◽  
Deivide Telles de Lima
Keyword(s):  
Physical Education ◽  
Social Issues ◽  
Continuous Process ◽  
The Body ◽  
Human Beings ◽  
Cultural Economic ◽  
De Se ◽  
The Face ◽  
The Relationship

ResumoEste ensaio visa refletir as relações entre a formação em Educação Física, o corpo em movimento e as tecnologias na educação escolar. Compreendemos que a Educação Física precisa compreender esse corpo e suas diferentes nuances face as tecnologias, as quais podem contribuir como ferramentas auxiliadoras no processo de emancipação dos seres humanos no sentido de se tornarem mais reflexivos, críticos e criativos. Com os avanços das tecnologias observamos mudanças rápidas na sociedade, e o mesmo com o corpo. Torna-se necessário o debate sobre as inter-relações que ocorrem na sociedade entre a tecnologia, corpo e educação como um processo histórico e contínuo de transformações que envolvem questões culturais, econômicas, políticas, sociais que tem (re)configurado a atuação do professor de Educação Física com “novos” saberes e competências no âmbito escolar.Palavras-chave: Educação Física. Corpo. Tecnologia. Educação. Technology, body and physical education: between training and teaching practiceAbstractThis essay aims to reflect the relationship between training in Physical Education, the body in movement and technologies in school education. We understand that Physical Education needs to understand this body and its different nuances in the face of technologies, which can contribute as auxiliary tools in the emancipation process of human beings in order to become more reflective, critical and creative. With advances in technologies, we observe rapid changes in society, and the same with the body. It is necessary to debate the interrelationships that occur in society between technology, body and education as a historical and continuous process of transformations involving cultural, economic, political, social issues that have (re)configured the role of the Physical Education teacher with “new” knowledge and skills in the school environment.Keywords: Physical Education. Body. Technology. Education. Tecnología, cuerpo y educación física: entre la formación y la práctica docenteResumenEste ensayo tiene como objetivo reflejar las relaciones entre la formación en Educación Física, el móvil y las tecnologías en la educación escolar. Entendemos que la Educación Física necesita comprender este cuerpo y sus diferentes matices de cara a las tecnologías, que pueden contribuir como herramientas auxiliares en el proceso de emancipación del ser humano para volverse más reflexivo, crítico y creativo. Con los avances de la tecnología observamos cambios rápidos en la sociedad, y lo mismo ocurre con el cuerpo. Es necesario debatir las interrelaciones que se dan en la sociedad entre tecnología, cuerpo y educación como un proceso histórico y continuo de transformaciones que involucran cuestiones culturales, económicas, políticas, sociales que han (re) configurado el rol del docente de Educación Física con “nuevos” saberes, competencias en el entorno escolar.Palabras clave: Educación Física. Cuerpo. Tecnología. Educación.

scholarly journals ROLE OF JALUKAVACHARAN AND MAHAMANJISHTADI KWATH IN THE MANAGEMENT OF MUKHADUSHIKA W.S.R TO ACNE VULGARIS- A CASE STUDY

2018 ◽  
Vol 6 (8) ◽  
pp. 25-32
Author(s):  
Dhalpe Suchita Jayant ◽  
Vivek S. Chandurkar
Keyword(s):  
Acne Vulgaris ◽  
Burning Sensation ◽  
Inflammatory Lesions ◽  
The Face ◽  
Sebum Production ◽  
Major Factors

Acne vulgaris is a disease of the pilosebaceous follicle characterized by noninflammatory (open and closed comedowns) and inflammatory lesions (papules, pustules, and nodules). There are four major factors involved in the disease production viz. increased sebum production, cornification of pilosebaceous ducts, microbial involvement and inflammation. This condition is found commonly in puberty. In Ayurveda, it is termed as Mukhadushika In Ayurveda Mukhadushika is described under the heading of Kshudrarogas. The Shalmali thorn like eruption on the face due to vitiation of Kapha, Vata and Rakta which are found on the face of adolescent are called as Mukhadushika or YuvanPidika. Although vata, kapha and rakta are mentioned as dosha-duṣya involved in the pathogenesis of the disease, pittaja symptoms are also found in the disease like daha and paka.  Patient was suffering from Acne over face (Pidika), Burning sensation over face (Daha), Itching over face (Kandu), and Discolouration of skin (Vaivarnya) since 6 months. Patient was treated with jalukavacharan and mahamanjishtadi kwath.

scholarly journals Infantile acne is a medical problem that calls for therapy

2022 ◽  
pp. 49
Author(s):  
◽  
◽  
◽  
Keyword(s):  
Acne Vulgaris ◽  
Case Series ◽  
Medical Problem ◽  
Response To Treatment ◽  
Therapeutic Trial ◽  
Hormonal Changes ◽  
Female Ratio ◽  
Uncommon Disease ◽  
The Face ◽  
Clinical Scoring

Background: Acne vulgaris of infants is a well-recognized medical and cosmetic problem as it may cause severe scarring of the face. Hence medical treatment is essentially needed. Objective: To record all patients with infantile acne vulgaris and to do full demographic and clinical evaluation. Patients and methods:This is case series clinical descriptive study with interventional therapeutic trial that included all patients with infantile acne vulgaris that were seen during the period from Jan 2021 – September 2021 years. All demographic and clinical features were recorded. The clinical scoring of acne severity was done as follow:mild when the rash was mainly comedones,moderate mainly papules and pustules and severe mainly nodules and scarring. Any triggering factors were recorded including hormonal changes. Therapy was started by giving topical 2% clindamycin twice a day and oral trimethoprim-sulfamethoxazole suspension one teaspoonful twice a day for 1-2 months. Results: This study included 28 patients with infantile acne, with 19(67.86%) males and 9(32.14%) females with male to female ratio;2.1. The age of patients ranged from 1-24 months, with a mean 14.6 ±6.1.The duration of rash was ranged from 4-8 weeks. The commonest sites affected were cheeks in 27(96.4%) cases, followed by forehead in 8 (28.6%), then chin in 6 (23.1%), and nose 6 (23.1%) of the cases. Scoring of severity of acne showed moderate in 13(46.4%), followed by mild in 9 (32.1%), and sever in 6 (21.4%). The response to treatment was complete clearance in 15(53.6%) and partial response in 13(46.4%) of the patients while no adverse effects were observed. Conclusions: Infantile acne is not uncommon disease among infants where medical therapy is essentially needed especially in severe cases as to prevent facial scarring. Early diagnosis and treatment with oral trimethoprim-sulfamethoxazole suspension and topical 2% clindamycin lotion is an effective mode of therapy.

scholarly journals Semiotics and education, semioethic perspectives

Semiotica ◽  
2016 ◽  
Vol 2016 (213) ◽  
pp. 247-279 ◽  
Author(s):  
Susan Petrilli
Keyword(s):  
Interdisciplinary Approach ◽  
The Body ◽  
Human Being ◽  
Relational Dynamics ◽  
Physical Organic ◽  
The Face

Abstract“Semioethics” is a neologism coined in the early 1980s to highlight the relation between signs and values, identity and otherness. It keeps account of Victoria Welby’s concept of “significs” and of Sebeok’s “global semiotics” with its critique of glottocentric and anthropocentric tendencies. Together both sources, significs and global semiotics, provide the context for contributions from semioethics to education. Semioethics recovers the ancient vocation of semiotics, originally “semeiotics,” for life and its wellbeing. It elicits the importance of applying an interdisciplinary approach and a “detotalizing method” in education by contrast to the totalizing approaches of grand narratives. The human being is endowed with a “primary modeling device,” also called “language,” and with it “syntactics.” Semioethics considers the role of these special characteristics that specify the human being as a human being, a “semiotic animal,” and addresses the human propensity for creativity, critique, and responsibility for health over the globe, both in terms of physical-organic materiality, the body, and of semiotic materiality, signs and values. These characteristics can be developed and enhanced through a specifically “linguistic education” with a particular emphasis on otherness, dialogue, and listening. Practicing semioethics becomes more pressing in the face of the relational dynamics between the historical-social and biological spheres, between culture and nature, between semiosphere and biosphere, and between semiotics, biosemiotics, and education.

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