Mucormycosis its Pathogenesis and Treatment

Research Journal of Science and Technology ◽

10.52711/2349-2988.2021.00031 ◽

2021 ◽

pp. 205-207

Author(s):

Devkar Aniket ◽

Jadhav Sudha

Keyword(s):

Infectious Disease ◽

Antifungal Therapy ◽

Environmental Contamination ◽

Adjunctive Therapy ◽

Fungal Spore ◽

Iron Sequestration ◽

Medical Approach

Mucormycosis is an ailment that originates from a saprophyte. Mucorales are a group of a growing number of members who have mucormycosis. The environmental contamination with fungal spore and now in COVID-19 the high use of steroid, which increases the occasion of mucor. It is a worldwide infectious disease as well as there is no vaccine to treat mucormycosis. Therapies for mucormycosis involve a coordinated surgical and medical approach. Antifungal therapy, iron sequestration, and adjunctive therapy are the various therapies to treat mucormycosis that will discuss in the article. Also the pathogenesis, identification of mucormycosis will review here.

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Do we know enough to find an adjunctive therapy for cerebral malaria in African children?

F1000Research ◽

10.12688/f1000research.12401.1 ◽

2017 ◽

Vol 6 ◽

pp. 2039 ◽

Cited By ~ 7

Author(s):

Brittany A. Riggle ◽

Louis H. Miller ◽

Susan K. Pierce

Keyword(s):

Infectious Disease ◽

Cerebral Malaria ◽

Severe Malaria ◽

Adjunctive Therapy ◽

Severe Disease ◽

Disease Mechanism ◽

Cerebral Disease ◽

African Children

Cerebral malaria is the deadliest complication of malaria, a febrile infectious disease caused by Plasmodium parasite. Any of the five human Plasmodium species can cause disease, but, for unknown reasons, in approximately 2 million cases each year P. falciparum progresses to severe disease, ultimately resulting in half a million deaths. The majority of these deaths are in children under the age of five. Currently, there is no way to predict which child will progress to severe disease and there are no adjunctive therapies to halt the symptoms after onset. Herein, we discuss what is known about the disease mechanism of one form of severe malaria, cerebral malaria, and how we might exploit this understanding to rescue children in the throes of cerebral disease.

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Treatment of Severe Recalcitrant Fungal Keratitis Using Subconjunctival Fluconazole as an Adjunctive Therapy

Pakistan Journal of Ophthalmology ◽

10.36351/pjo.v37i2.1081 ◽

2021 ◽

Vol 37 (2) ◽

Author(s):

Ambreen Gull ◽

Fuad Ahmad Khan Niazi ◽

Ali Raza

Keyword(s):

Key Words ◽

Study Design ◽

Antifungal Therapy ◽

Adjunctive Therapy ◽

Case Series ◽

Fungal Keratitis ◽

Systemic Toxicity ◽

Adjunctive Treatment ◽

Subconjunctival Injection ◽

Medical University

Purpose: To evaluate the safety and effectiveness of 2% subconjunctival injection of Fluconazole as an adjunctive treatment in severe recalcitrant fungal keratitis. Study Design: Interventional case series. Place and Duration of Study: Ophthalmology department of Holy family hospital, Rawalpindi medical university, from January 2019 to August 2019. Methods: The study included 18 eyes of 18 patients with severe resistant fungal corneal ulcer.We excluded those cases who had known hypersensitivities to Fluconazole. These ulcers were refractory toprimary conventional antifungal therapy with topical Natamycin, topical and systemic Fluconazole. Sample for culture was taken with sterile cotton bud and scraping was taken with kimura spatula. All resistant cases were given1.0 ml of 2% subconjunctival Fluconazole injection once a day for at least one week. After that depending upon the condition, the injections were givenonalternate days for 2 weeks. Results: Average age of the patients was 35.22 years (SD ± 10.42). Among total 18 patients, six (33.33%) were females and 12 (66.67%) were males. Thirteen (72.22%) cases showed absolute response after one week and 5 (27.77%) cases needed more injections. Four (22.22%) of these 5 cases partiallyimproved andone case failed to show improvement. Final vision varied in different cases according to the position of the residual scar. Five cases ended up in keratoplasty. Local or systemic toxicity was not seen in any case. Conclusion: Subconjunctival injection of 2% Fluconazole can be used as an adjunctive therapy for severe fungal keratitis without any toxic complications. Key Words: Keratomycosis, Evisceration, Keratoplasty.

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Critical influenza and prophylactic antifungal therapy for aspergillosis: a nuanced approach to a pertinent infectious disease

Intensive Care Medicine ◽

10.1007/s00134-021-06532-w ◽

2021 ◽

Author(s):

Lore Vanderbeke ◽

Katrien Lagrou ◽

Paul E. Verweij ◽

Joost Wauters

Keyword(s):

Infectious Disease ◽

Antifungal Therapy

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Tissue section lifting for electron microscopy

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100081292 ◽

1978 ◽

Vol 36 (2) ◽

pp. 86-87

Author(s):

Adrian F. van Dellen

Keyword(s):

Infectious Disease ◽

Electron Microscopy ◽

Tissue Culture ◽

Organ System ◽

Surrounding Tissue ◽

Paraffin Sections ◽

Surface Areas ◽

Specific Determination ◽

High Degree ◽

Accuracy And Repeatability

The morphologic pathologist may require information on the ultrastructure of a non-specific lesion seen under the light microscope before he can make a specific determination. Such lesions, when caused by infectious disease agents, may be sparsely distributed in any organ system. Tissue culture systems, too, may only have widely dispersed foci suitable for ultrastructural study. In these situations, when only a few, small foci in large tissue areas are useful for electron microscopy, it is advantageous to employ a methodology which rapidly selects a single tissue focus that is expected to yield beneficial ultrastructural data from amongst the surrounding tissue. This is in essence what "LIFTING" accomplishes. We have developed LIFTING to a high degree of accuracy and repeatability utilizing the Microlift (Fig 1), and have successfully applied it to tissue culture monolayers, histologic paraffin sections, and tissue blocks with large surface areas that had been initially fixed for either light or electron microscopy.

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