Cognitive functions of young Novosibirsk residents and metabolic syndrome

The aim of the study was to provide a population assessment of cognitive impairment patterns in a representative sample of 25–44-year-old men and women living in Western Siberia with metabolic syndrome (MS). Material and methods. A cross-sectional population survey of a random representative sample of 25–44-year-olds of both sexes (1503 people) permanently residing in Western Siberia (Novosibirsk) was performed. The study of cognitive functions was conducted in 1009 people: 463 men (45.9 %) and 546 women (54.1 %). A 10-word memorization test was performed according to the methodology proposed by A.R. Luria (unified for screening purposes), with subsequent reproduction after interfering tasks (recall), a proof-reading test (a letter modification of the Bourdon test used for screening purposes), as well as the exclusion of concepts (a verbal version of the test). The MS criteria (VNOK, 2009) were used: FROM > 80 cm in women and > 94 cm in men and 2 of the following criteria: blood pressure ≥ 130/85 mmHg, TG content ≥ 1.7 mmol/L, HDL-C < 1.0 mmol/L in men and < 1.2 mmol/L in women, LDL-C > 3.0 mmol/L, plasma hyperglycemia > 6.1 mmol/L. Results. In the surveyed sample of residents of In Novosibirsk, 25–44 years old, MS occurred in every fourth person tested for cognitive functions (26.06 %): 148 men (31.96 %) and 115 women (21.06 %), MS occurred more often in women than in men. With age, there is an increase in the frequency of MS in both sexes (p < 0.05). For MS, statistically significant associations are shown with direct memorization (1st memorization experience, p = 0.025), the number of directly memorized words (p = 0.015) and with delayed reproduction of words after an interfering task (p = 0.015) in the 10-word memorization test by A.R. Luria. The average rank, as well as the average values of these cognitive tests, were higher in individuals without MS compared to those with MS diagnosed. There were no links between MS and the indicators of the proofreading test. There were also no statistically significant associations of MS with the number of animals named in 1 min in the speech activity test when studying semantically mediated associations. Conclusion. In a population study of young people (25–44 years old) for the first time in Russia/A statistically significant deterioration of cognitive memory patterns in individuals with MS components has been proven in Siberia (Novosibirsk). This confirms the importance of the «cerebrovascular continuum» in the genesis of cognitive impairment at a young age.

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Evaluación Cognitiva Montreal y consumo de alcohol: Un diagnóstico descriptivo del deterioro cognitivo en estudiantes universitarios de Durango, México

Revista de Técnicas de Enfermería y Salud ◽

10.35429/jnt.2019.7.3.28.38 ◽

2019 ◽

pp. 28-38

Author(s):

Karla Liliana Pérez-Sosa ◽

Edgar Felipe Lares-Bayona

Keyword(s):

Cognitive Impairment ◽

Alcohol Consumption ◽

Cognitive Functions ◽

Toxic Substance ◽

Female Gender ◽

Diagnostic Tools ◽

Cross Sectional ◽

Probabilistic Study ◽

The Central Nervous System ◽

The Relationship

Alcohol is a toxic substance associated with acute and chronic disorders affecting the Central Nervous System and significantly altering brain function. Objective: To determine the relationship between cognitive impairment and alcohol consumption in university students of the Juárez University of the State of Durango. Methodology: It is a cross-sectional, descriptive, comparative, non-probabilistic study, for convenience. A database was designed on the results obtained in a clinical interview on alcohol consumption and the application of the Montreal Cognitive Assessment (MoCA) test. Contribution: The evaluation of cognitive functions show similar results, the male sex presented a better score in Attention and the female one in Orientation. More involvement was identified in the Deferred Memory functions in both groups. In relation to alcohol consumption, the cognitive functions evaluated show lower levels. The female gender was more evident cognitive impairment in relation to alcohol consumption being statistically significant (p <0.025). Alcohol consumption is a risky behavior that deserves to be recognized by the main actors about neurocognitive effects. Alcohol consumption prevention programs and cognitive diagnostic tools are appropriate strategies to reduce risk behaviors in mental health.

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COVID-19 and Cognitive Impairment: A Cross-Sectional Clinic Based Study

10.21203/rs.3.rs-1178928/v1 ◽

2021 ◽

Author(s):

Amira Siddig ◽

Khabab Abbasher Hussien Mohamed Ahmed ◽

Ahmed Abdelrahman ◽

AlHussien Abbasher ◽

Abubaker Alsedig Abbasher ◽

...

Keyword(s):

Cognitive Impairment ◽

Cognitive Functions ◽

Age Distribution ◽

Clinical Manifestations ◽

Cross Sectional Study ◽

Cross Sectional ◽

Senior Consultant ◽

Presenting Symptoms ◽

Phonemic Fluency ◽

History Of

Abstract Background: Patients with dementia are more prone to acquire COVID-19 infection. Patients with COVID-19 showed a tendency to develop cognitive impairment. Objectives: We aimed to study the clinical manifestations of COVID-19 infection among adult Sudanese demented patients and the prevalence of cognitive impairment among adult Sudanese non demented patients. Methodology: This is a descriptive cross-sectional study which took place in Sudan, Khartoum state in the period (September-December 2021) in a private neurology/psychiatry clinic. 135 adult Sudanese patients were included in this study and were divided into two groups. The first group consists of 100 patients with a known history of dementia that got infected recently with COVID-19, while the second group consists of 35 patients who developed some sort of cognitive impairment after recovering from COVID-19 infection. Regarding the second group, cognitive functions were assessed by senior consultant neurologist and senior consultant psychiatrist using a well validated neuropsychological measure. Results: Out of 100 patients in the first group, females were 60 and males were 40. Age distribution is between 63 -98. The common presenting symptoms of COVID-19 among this group were: Cough and fever (90 patients), diarrhea and vomiting (5 patients), breathlessness (4 patients), coughing of blood (5 patients), convulsions (1 patient), paraplegia (1 patient) and hemiplegia (1 patient). Regarding the second group, Age distribution varied from 30 to 80 years. Cognitive functions impairment was noticed as follows: Memory recall (22%), memory recognition (23%), memory encoding (24%), processing speed (16%), executive functioning (19%), phonemic fluency (17%) and category fluency (17%). Conclusion: Patients with dementia are more susceptible to develop COVID-19 infection. Patients with COVID-19 Infection are at risk of developing some sort of cognitive impairment after recovery.

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Burden and correlates of cognitive impairment among hypertensive patients in Tanzania: A cross-sectional study

10.21203/rs.3.rs-627006/v1 ◽

2021 ◽

Author(s):

Pedro Pallangyo ◽

Zabella S Mkojera ◽

Makrina Komba ◽

Lucy R. Mgopa ◽

Smita Bhalia ◽

...

Keyword(s):

Blood Pressure ◽

Logistic Regression ◽

Cognitive Impairment ◽

Renal Dysfunction ◽

Cognitive Functions ◽

Cross Sectional Study ◽

Systemic Hypertension ◽

Sectional Study ◽

Cross Sectional ◽

Hypertensive Patients

Abstract Background: The evolution of cognitive impairment of vascular origin is increasingly becoming a prominent health threat particularly in this era where hypertension is the leading contributor of global disease burden and overall health loss. Hypertension is associated with the alteration of the cerebral microcirculation coupled by unfavorable vascular remodeling with consequential slowing of mental processing speed, reduced abstract reasoning, loss of linguistic abilities, and attention and memory deficits. Owing to the rapidly rising burden of hypertension in Tanzania, we sought to assess the prevalence and correlates of cognitive impairment among hypertensive patients attending a tertiary cardiovascular hospital in Tanzania.Methodology: A hospital-based cross-sectional study was conducted at Jakaya Kikwete Cardiac Institute, a tertiary care public teaching hospital in Dar es Salaam, Tanzania between March 2020 and February 2021. A consecutive sampling method was utilized to recruit consented hypertensive outpatients during their scheduled clinic visit. General Practitioner Assessment of Cognition (GPCOG) Score was utilized in the assessment of cognitive functions. All statistical analyses utilized STATA v11.0 software. Pearson Chi square and Student’s T-test were used to compare categorical and continuous variables respectively. Logistic regression analyses were used to assess for factors associated with cognitive impairment. Odd ratios with 95% confidence intervals and p-values are reported. All tests were 2-sided and p<0.05 was used to denote a statistical significance. Results: A total of 1201 hypertensive patients were enrolled in this study. The mean age was 58.1 years and females constituted nearly two-thirds of the study population. About three quarters had excess body weight, 16.6% had diabetes, 7.7% had history of stroke, 5.7% had heart failure, 16.7% had renal dysfunction, 53.7% had anemia, 27.7% had hypertriglyceridemia, 38.5% had elevated LDL, and 2.4% were HIV-infected. Nearly two-thirds of participants had uncontrolled blood pressure and 8.7% had orthostatic hypotension. Overall, 524 (43.6%) of participants had cognitive impairment. During bivariate analysis in a logistic regression model of 16 characteristics, 14 parameters showed association with cognitive functions. However, after controlling for confounders, multivariate analysis revealed ≤primary education (OR 3.5, 95%CI 2.4-5.2, p<0.001), unemployed state (OR 1.7, 95%CI 1.2-2.6, p<0.01), rural habitation (OR 1.8, 95%CI 1.1-2.9, p=0.01) and renal dysfunction (OR 1.7, 95%CI 1.0-2.7, p= 0.04) to have independent association with cognitive impairment. Conclusion: This present study underscore that cognitive decline is highly prevalent among individuals with systemic hypertension. Moreover, our observation suggests that low education, rural life, unemployment status and renal dysfunction interactions with elevated blood pressure has the potential to predict cognitive performance over time. As the effective disease-modifying treatments for cognitive impairment are lacking, these findings imply that several modifiable risk factors including hypertension represents a potentially vital mechanism for prevention or delay of cognitive impairment.

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Associations of Serum Lipids with Risk of Cognitive Impairment in Chinese Centenarians

10.21203/rs.3.rs-274807/v1 ◽

2021 ◽

Author(s):

Yujian Chen ◽

Ya Huang ◽

ChaoXue Ning ◽

Qiao Zhu ◽

Yao Yao ◽

...

Keyword(s):

Cognitive Impairment ◽

Cognitive Functions ◽

Serum Lipids ◽

Low Density Lipoprotein ◽

Multiple Logistic Regression Analysis ◽

Density Lipoprotein ◽

Lipoprotein Cholesterol ◽

Inverse Association ◽

Cross Sectional ◽

Low Hdl

Abstract Background Dyslipidaemia and cognitive impairment are common in old adults and risks of both of them increase with increasing age. However, the relationship between lipids and cognitive impairment in longevous people is still unclear. This study aimed to assess the association between serum lipids and cognitive impairment in Chinese centenarians. Methods In a cross-sectional study, total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were biochemically measured in 924 centenarians and cognitive functions were evaluated. Multiple logistic regression analysis was used to examine the associations of lipids with cognitive impairment and the risks for cognitive impairment associated with quartile of serum lipid concentrations. Results The results demonstrated HDL-C was an independent beneficial factor for cognitive impairment after controlling for the potential covariates (Odds ratio, OR = 0.350, 95% Confidence interval, CI = 0.159–0.774; P = 0.009). An inverse association of HDL-C with cognitive impairment was found (P for trend = 0.001) and the association remained significant after adjusting for possible cofounders (P for trend = 0.012). The OR of cognitive impairment for the lowest versus highest quartiles of HDL-C was 1.96 (95%CI, 1.09–3.45). Conclusions The results indicated that low HDL-C is likely to be harmful for cognitive functions in centenarians. The cognitive function of longevous persons with low HDL-C concentrations deserves more attention.

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Burden and Correlates of Cognitive Impairment Among Hypertensive Patients in Tanzania: A Cross-Sectional Study

10.21203/rs.3.rs-627006/v2 ◽

2021 ◽

Author(s):

Pedro Pallangyo ◽

Zabella S Mkojera ◽

Makrina Komba ◽

Lucy R. Mgopa ◽

Smita Bhalia ◽

...

Keyword(s):

Blood Pressure ◽

Logistic Regression ◽

Cognitive Impairment ◽

Renal Dysfunction ◽

Cognitive Functions ◽

Cross Sectional Study ◽

Systemic Hypertension ◽

Sectional Study ◽

Cross Sectional ◽

Hypertensive Patients

Abstract Background The evolution of cognitive impairment of vascular origin is increasingly becoming a prominent health threat particularly in this era where hypertension is the leading contributor of global disease burden and overall health loss. Hypertension is associated with the alteration of the cerebral microcirculation coupled by unfavorable vascular remodeling with consequential slowing of mental processing speed, reduced abstract reasoning, loss of linguistic abilities, and attention and memory deficits. Owing to the rapidly rising burden of hypertension in Tanzania, we sought to assess the prevalence and correlates of cognitive impairment among hypertensive patients attending a tertiary cardiovascular hospital in Tanzania. Methodology: A hospital-based cross-sectional study was conducted at Jakaya Kikwete Cardiac Institute, a tertiary care public teaching hospital in Dar es Salaam, Tanzania between March 2020 and February 2021. A consecutive sampling method was utilized to recruit consented hypertensive outpatients during their scheduled clinic visit. General Practitioner Assessment of Cognition (GPCOG) Score was utilized in the assessment of cognitive functions. All statistical analyses utilized STATA v11.0 software. Pearson Chi square and Student’s T-test were used to compare categorical and continuous variables respectively. Logistic regression analyses were used to assess for factors associated with cognitive impairment. Odd ratios with 95% confidence intervals and p-values are reported. All tests were 2-sided and p < 0.05 was used to denote a statistical significance. Results A total of 1201 hypertensive patients were enrolled in this study. The mean age was 58.1 years and females constituted nearly two-thirds of the study population. About three quarters had excess body weight, 16.6% had diabetes, 7.7% had history of stroke, 5.7% had heart failure, 16.7% had renal dysfunction, 53.7% had anemia, 27.7% had hypertriglyceridemia, 38.5% had elevated LDL, and 2.4% were HIV-infected. Nearly two-thirds of participants had uncontrolled blood pressure and 8.7% had orthostatic hypotension. Overall, 524 (43.6%) of participants had cognitive impairment. During bivariate analysis in a logistic regression model of 16 characteristics, 14 parameters showed association with cognitive functions. However, after controlling for confounders, multivariate analysis revealed ≤ primary education (OR 3.5, 95%CI 2.4–5.2, p < 0.001), unemployed state (OR 1.7, 95%CI 1.2–2.6, p < 0.01), rural habitation (OR 1.8, 95%CI 1.1–2.9, p = 0.01) and renal dysfunction (OR 1.7, 95%CI 1.0-2.7, p = 0.04) to have independent association with cognitive impairment. Conclusion This present study underscore that cognitive decline is highly prevalent among individuals with systemic hypertension. Moreover, our observation suggests that low education, rural life, unemployment status and renal dysfunction interactions with elevated blood pressure has the potential to predict cognitive performance over time. As the effective disease-modifying treatments for cognitive impairment are lacking, these findings imply that several modifiable risk factors including hypertension represents a potentially vital mechanism for prevention or delay of cognitive impairment.

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Associations of Serum Lipids With Risk of Cognitive Impairment in Chinese Centenarians

10.21203/rs.3.rs-145816/v1 ◽

2021 ◽

Author(s):

Yujian Chen ◽

Ya Huang ◽

ChaoXue Ning ◽

Qiao Zhu ◽

Yao Yao ◽

...

Keyword(s):

Cognitive Impairment ◽

Cognitive Functions ◽

Serum Lipids ◽

Low Density Lipoprotein ◽

Multiple Logistic Regression Analysis ◽

Density Lipoprotein ◽

Lipoprotein Cholesterol ◽

Inverse Association ◽

Cross Sectional ◽

Low Hdl

Abstract Background: Dyslipidaemia and cognitive impairment are common in old adults and risks of both of them increase with increasing age. However, the relationship between lipids and cognitive impairment in longevous people is still unclear. This study aimed to assess the association between serum lipids and cognitive impairment in Chinese centenarians.Methods: In a cross-sectional study , total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were biochemically measured in 924 centenarians and cognitive functions were evaluated. Multiple logistic regression analysis was used to examine the associations of lipids with cognitive impairment and the risks for cognitive impairment associated with quartile of serum lipid concentrations.Results: The results demonstrated HDL-C was an independent beneficial factor for cognitive impairment after controlling for the potential covariates (Odds ratio, OR=0.350, 95% Confidence interval, CI=0.159–0.774; P=0.009). An inverse association of HDL-C with cognitive impairment was found (P for trend=0.001) and the association remained significant after adjusting for possible cofounders (P for trend =0.012). The OR of cognitive impairment for the lowest versus highest quartiles of HDL-C was 1.96 (95%CI, 1.09–3.45).Conclusions: The results indicated that low HDL-C is likely to be harmful for cognitive functions in centenarians. The cognitive function of longevous persons with low HDL-C concentrations deserves more attention.

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Insulin Sensitivity and Hemostatic Factors in Clinically Healthy 58-year-old Men

Thrombosis and Haemostasis ◽

10.1055/s-0037-1614069 ◽

2000 ◽

Vol 84 (10) ◽

pp. 571-575 ◽

Cited By ~ 13

Author(s):

Lena Bokemark ◽

John Wikstrand ◽

Anders Lindahl ◽

Björn Fagerberg ◽

Stefan Agewall

Keyword(s):

Metabolic Syndrome ◽

Insulin Sensitivity ◽

Protein C ◽

Plasma Concentrations ◽

Protein S ◽

Cross Sectional ◽

The Metabolic Syndrome ◽

Old Men ◽

Pai 1 ◽

Coagulation And Fibrinolysis

SummaryThe objective of this cross-sectional study was to investigate the relationship between factors of the coagulation- and fibrinolysis systems and insulin sensitivity in 104 clinically healthy, 58-years-old men. Insulin sensitivity (hyperinsulinemic euglycemic clamp) adjusted for lean body mass, the metabolic syndrome according to a suggested definition, and different factors in the coagulation- and fibrinolysis system were determined. Subjects with the metabolic syndrome were characterised by increases in PAI-1 activity, tPA antigen, protein C and protein S and low concentrations of tPA activity. Insulin sensitivity was independently and reversibly associated with PAI-1 (p = 0.014) and directly with tPA activity (p = 0.001). Insulin sensitivity was also significantly negatively associated with protein S and protein C and several components in the metabolic syndrome, however not remaining significant in multivariate analyses. Protein C and protein S were significantly associated with PAI-1 activity, tPA activity (negatively), tPA antigen and antithrombin III. In conclusion, the data indicated that insulin resistance and several of the clustering components in the metabolic syndrome are accompanied by increased plasma concentrations of the anticoagulatory proteins C and S which may represent a mechanism which counteracts the concomitantly occurring hypofibrinolysis.

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