PROSPECTS FOR THE CREATION OF MEDICINES BASED ON A NATURAL ADAPTOGEN IN THE COMPLEX THERAPY OF VIRAL INFECTIONS

2022 ◽  
pp. 21-28
Author(s):  
А.М. ОМАРИ ◽  
Т.А. АРЫСТАНОВА
Keyword(s):  
Glycyrrhizic Acid ◽  
Viral Infections ◽  
Licorice Root ◽  
Root Extract ◽  
Current State ◽  
Complex Therapy ◽  
Prevention And Treatment ◽  
The Creation ◽  
Licorice Root Extract

В статье описано современное состояние распространения, переработки и использования солодки в Казахстане. Представлены литературные данные использования компонентов корня солодки в создании лекарственных средств для профилактики и лечения иммунодефицитного состояния при вирусных инфекциях. Обобщены литературные данные о комбинированных препаратах, содержащих экстракт корня солодки, глицирризиновую кислоту. The article describes the current state of distribution, processing and use of licorice in Kazakhstan. The literature data on the use of licorice root components in the creation of medicines for the prevention and treatment of immunodeficiency in viral infections are presented. The literature data on combined preparations containing licorice root extract and glycyrrhizic acid are summarized.

UV SPECTROPHOTOMETRY IN THE ANALYSIS OF A COMBINED MEDICINAL PRODUCT BASED ON DRY LICORICE ROOT EXTRACT

2022 ◽  
pp. 35-38
Author(s):  
А.М. ОМАРИ ◽  
Т.А. АРЫСТАНОВА
Keyword(s):  
Ascorbic Acid ◽  
Quantitative Determination ◽  
Viral Infections ◽  
Licorice Root ◽  
Root Extract ◽  
Uv Spectrophotometry ◽  
Prevention And Treatment ◽  
Licorice Extract ◽  
Licorice Root Extract

Работа посвящена разработке методики количественного определения глицирризина и аскорбиновой кислоты при их совместном присутствии в комбинированном лекарственном препарате в виде саше методом УФ-спектрофотометрии. This paper represents a developed technique for the quantitative determination of a new medicinal composition based on dry licorice extract and ascorbic acid for the prevention and treatment of immunode ciency in viral infections by UV spectrophotometry

Obtaining Glycyrrhizic Acid and Its Practically Useful Salts from a Commercial Licorice Root Extract

2005 ◽  
Vol 39 (2) ◽  
pp. 84-88 ◽  
Author(s):  
R. M. Kondratenko ◽  
L. A. Baltina ◽  
L. R. Mikhailova ◽  
V. T. Danilov ◽  
T. M. Gabbasov ◽  
...  
Keyword(s):  
Glycyrrhizic Acid ◽  
Licorice Root ◽  
Root Extract ◽  
Licorice Root Extract

Jet-spray apparatus for drying licorice root extract

1969 ◽  
Vol 3 (11) ◽  
pp. 665-667
Author(s):  
V. V. Davituliani ◽  
V. I. Ganuchukov
Keyword(s):  
Licorice Root ◽  
Root Extract ◽  
Licorice Root Extract

scholarly journals Glycyrrhizin effectively neutralizes SARS-CoV-2 in vitro by inhibiting the viral main protease

2020 ◽  
Author(s):  
L. van de Sand ◽  
M. Bormann ◽  
M. Alt ◽  
L. Schipper ◽  
C.S. Heilingloh ◽  
...  
Keyword(s):  
Licorice Root ◽  
Viral Diseases ◽  
Root Extract ◽  
Traditional Herbal Medicine ◽  
Complementary Treatment ◽  
Antiviral Compound ◽  
Viral Neutralization ◽  
Main Protease ◽  
Licorice Root Extract

AbstractThe newly emerged coronavirus, which was designated as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the COVID-19 disease. High effective and well-tolerated medication for hospitalized and non-hospitalized patients is urgently needed. Traditional herbal medicine substances were discussed as promising candidates for the complementary treatment of viral diseases and recently suggested for the treatment of COVID-19. In the present study, we investigated aqueous licorice root extract for its neutralizing activity against SARS-CoV-2 in vitro, identified the active compound glycyrrhizin and uncovered the respective mechanism of viral neutralization. We demonstrated that glycyrrhizin, the primary active ingredient of the licorice root, potently neutralizes SARS-CoV-2 by inhibiting the viral main protease. Our experiments highlight glycyrrhizin as a potential antiviral compound that should be further investigated for the treatment of COVID-19.

Glycyrrhizic acid derivatives as new antiviral and immune modulate agents

2020 ◽  
Vol 16 ◽  
Author(s):  
Lidia Baltina ◽  
Rimma Kondratenko
Keyword(s):  
Influenza A ◽  
Glycyrrhizic Acid ◽  
Viral Infections ◽  
Biologically Active ◽  
New Drugs ◽  
Licorice Root ◽  
Primary Immune Response ◽  
Amino Sugars ◽  
Biological Studies ◽  
Influenza A H1n1

: A search of new drugs for the treatment of viral infections and immune deficiencies of various etiologies is still one of the most important tasks of medicinal chemistry, pharmacy and medicine due to the wide spread of a number socially dangerous viral infections. This review is devoted to the chemical modification of Glycyrrhizic acid, the main component of licorice root, which is currently a leading natural glycoside promising as a basis for creation of new antiviral agents. The review presents the results of studies conducted over the past 15 years to obtain a library of Glycyrrhizic acid derivatives for biological studies and search of lead compounds. The synthesis of new biologically active derivatives and analogues (conjugates with amino acids and dipeptides, amino sugars, licorice triterpene acids conjugates with amino sugars, saponins and mono glycosides, heterocyclic amides) was carried out , and their antiviral and immune modulate properties were studied. Potent inhibitors of HIV, SARS CoV, Epstein-Barr, influenza A/H1N1 viruses and stimulators of primary immune response were found among GL derivatives and analogues produced.

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