Formulate gastroretentive  floating  bioadhesive  drug  delivery  system  of  nizatidine  by direct compression technique

The objective of the present study was formulation and evaluation of pulsatile release tablets of Atenolol. A tablet system consisting of cores which was coated with layers of swelling and rupturable coatings. Cores containing Atenolol as model drug were prepared by direct compression with appropriate ratios of lactose and microcrystalline cellulose and then coated sequentially with different ratios of an inner swelling layer containing HPMC and an outer rupturable layer of Ethyl Cellulose. The effect of level of swelling layer and rupturable coating was investigated. The different formulation press coated by using different weight ratios of Hydroxy Propyl Methyl Cellulose (HPMC) / Ethyl Cellulose (EC) / both HPMC and EC. The optimum result was achieved in formulation containing HPMC: EC weight ratios. The F3 batch achieved a highest burst release after the lag time which is applicable pulsatile drug delivery system of Atenolol.

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Chronomodulated Delivery of Pantoprazole for Nocturnal Hyperacidity

International Journal of Pharmaceutical Sciences and Nanotechnology ◽

10.37285/ijpsn.2015.8.4.7 ◽

2015 ◽

Vol 8 (4) ◽

pp. 3038-3044

Author(s):

Mahalakshmi P ◽

Suriyaprakash T N K ◽

S. Lakshmana Prabu

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Drug Delivery Systems ◽

Lag Time ◽

Delivery Systems ◽

Burst Release ◽

Dependent Manner ◽

Compression Technique ◽

Pulsatile Drug Delivery

The objective of this work was to design and evaluate an oral site-specific, pulsatile drug delivery system containing Pantoprazole sodium which can be targeted to colon in a pH and time dependent manner, to modulate the drug level in synchrony with the circadian rhythm of nocturnal hyperacidity. Five different composition of Core tablets were prepared by direct compression technique. Based on the release studies of core tablets, nine different compositions of press coated tablets were prepared and analyzed. The press coated tablet further coated by using five different proportions of Eudragit RS PO for providing consistent, reproducible chronomodulated release profile. Formulation FPC3 is more suitable among the formulations to design pulsatile release formulations of pantoprazole sodium for 6 hours lag time. After this lag time burst release was observed which exhibited sigmodial release pattern and that was considered to be an ideal for the pulsatile drug delivery system. The chronomodulated drug delivery systems for pantoprazole sodium for the treatment of hyperacidity was successfully developed and the release of the drug was sharp and complete after the lag time which is necessary for any pulsatile drug delivery systems.

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DESIGN AND CHARACTERIZATION OF CHLORZOXAZONE FLOATING BIOADHESIVE DRUG DELIVERY SYSTEM

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2018.v11i11.27693 ◽

2018 ◽

Vol 11 (11) ◽

pp. 222

Author(s):

Manish Kumar Pal ◽

Ganesh Deshmukh

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Drug Delivery System ◽

Delivery System ◽

The Other ◽

Direct Compression ◽

Total Dosage ◽

Carbopol 934P

Objective: The objective of the work is to formulate chlorzoxazone floating bioadhesive tablets which will significantly improve the bioavailability of drugs under the condition of prolonged use of drugs and reduce the total dosage of administered drug and reduce the side effect.Methods: Floating bioadhesive tablet was prepared by direct compression of polymer such as HPMCK4M and Carbopol934p in combination.Result: After analysis of different evaluation parameter and drug release, F9 batch was selected as promising formulation for delivery of chlorzoxazone floating bioadhesive tablets with 92.1% drug release at 12th h.Conclusion: It was observed that the combination of polymers in 22.5% (HPMCK4M) and 12.5% (Carbopol 934p) give the best drug release and sustain the drug release for 12 h. Among the other batches, F9 batch was selected as an optimized batch because the pre- and post-compression parameters results are satisfactory.

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FORMULATION AND EVALUATION OF GASTRORETENTIVE FLOATING TABLETS OF CANDESARTAN CELEXETIL BY DIRECT COMPRESSION

INDIAN DRUGS ◽

10.53879/id.54.03.10744 ◽

2017 ◽

Vol 54 (03) ◽

pp. 23-27

Author(s):

Y Dange ◽

D Randive ◽

S Bhinge ◽

M. Bhutkar ◽

G. Wadkar ◽

...

Keyword(s):

Drug Delivery ◽

Sustained Release ◽

Drug Delivery System ◽

Delivery System ◽

Magnesium Stearate ◽

Direct Compression ◽

Floating Tablets ◽

Weight Variation ◽

Floating Drug Delivery ◽

Floating Drug Delivery System

The objective was to develop optimized gastric floating drug delivery system (GFDDS) of candesartan celexetil floating tablets by using various polymers like Eudragit and MCC. In the present work, attempts have been made to prepare candesartan celexetil by direct compression method by using Citric acid, NaHCO3, Magnesium stearate, Eudragit and MCC. Formulations (F1 to F4) of floating tablets of candesartan celexetil were prepared using variable concentrations of Eudragit and MCC. The prepared formulations were evaluated for thickness, hardness, weight variation, friability, drug content and uniformity. The buoyancy lag time and the total floating time was studied for all the formulations. Formulation F4 of sustained release tablet of Candesartan celexetil containing a combination of both polymers was found to be the optimized formulation for 13 hours release as it fulfilled all the requirement of floating drug delivery system of sustained release dosage form.

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