scholarly journals Medical nutrition therapeutic approach of non-alcoholic fatty liver: diet, nutraceuticals, phytotherapy and probiotics

2021 ◽  
Vol 14 (4) ◽  
Author(s):  
Cristian Oprea ◽  
Durval Ribas Filho
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Positive Impact ◽  
Low Cost ◽  
Life Quality ◽  
Pharmacological Therapy ◽  
Public Health Issue ◽  
Alcoholic Fatty Liver ◽  
Important Approach ◽  
Medical Nutrition

Although the genetic and pharmacological research of the non-alcoholic fatty liver disease (NAFLD), the commonest liver disease in the world, affecting more than a quarter of the population, shows a promising future, the non-pharmacological therapy continues to be an important approach of this concerning public health issue. The present study focused on the therapeutical potential of the diet and mainly the phytotherapy, nutraceuticals, and probiotics use, employing the literature review methodology by a selection of recent (last 5-10 years) national and international articles from the PubMed and Google Scholar databases. The conclusion was that the non-pharmacological medical nutrition approach could be considered as a first-line therapeutical option for NAFLD due to its low cost, few adverse effects, and a mainly positive impact on an individual's health and life quality.

scholarly journals Assessment of non-alcoholic fatty liver disease (NAFLD) severity with novel serum-based markers: A pilot study

PLoS ONE ◽  
2021 ◽  
Vol 16 (11) ◽  
pp. e0260313
Author(s):  
Atul Goyale ◽  
Anjly Jain ◽  
Colette Smith ◽  
Margarita Papatheodoridi ◽  
Marta Guerrero Misas ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Positive Likelihood Ratio ◽  
Public Health Issue ◽  
Enzyme Linked Immunosorbent Assay ◽  
Roc Curve Analysis ◽  
Cross Sectional ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

Background/Aims Non-alcoholic fatty liver disease (NAFLD) represents a significant public health issue. Identifying patients with simple steatosis from those with non-alcoholic steatohepatitis (NASH) is crucial since NASH is correlated with increased morbidity and mortality. Serum-based markers, including adipokines and cytokines, are important in the pathogenesis and progression of NAFLD. Here we assessed the usefulness of such markers in patients with NAFLD. Methods This prospective, cross-sectional study included 105 adult patients with varying severity of NAFLD. Twelve serum-based markers were measured by 3 biochip platforms and 2 enzyme-linked immunosorbent assay (ELISA) methods. We also developed a NAFLD individual fibrosis index (NIFI) using the serum-based markers mostly correlated with fibrosis severity. Results Sixty-one out of 105 patients were male (58.1%) with mean age was 53.5 years. Higher Interleukin-6 (IL-6) increased (p = 0.0321) and lower Matrix Metalloproteinase-9 (MMP-9) serum levels (p = 0.0031) were associated with higher fibrosis as measured by Fibroscan® in multivariable regression analysis. Using receiver-operating characteristic (ROC) curve analysis for the NIFI, area under the curve for predicting Fibroscan values ≥ 7.2 kPa was 0.77 (95%CI: 0.67, 0.88, p<0.001), with sensitivity of 89.3%, specificity of 57.9% and a positive likelihood ratio of 2.8. Conclusions Increasing fibrosis severity in NAFLD is associated with differential expression of IL-6 and MMP-9. NIFI could be valuable for the prediction of advanced NAFLD fibrosis and potentially help avoid unnecessary interventions such as liver biopsy in low-risk patients.

A Potential Treatment of Non-Alcoholic Fatty Liver Disease with SIRT1 Activators

2014 ◽  
Vol 23 (3) ◽  
pp. 311-319 ◽  
Author(s):  
Yasar Colak ◽  
Atakan Yesil ◽  
Hasan Huseyin Mutlu ◽  
Ozge Telci Caklili ◽  
Celal Ulasoglu ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Therapeutic Potential ◽  
Positive Impact ◽  
Current Approach ◽  
Protective Effects ◽  
Alcoholic Fatty Liver ◽  
Pathophysiological Mechanisms ◽  
Life Style Changes

Sirtuins (SIRTs) are members of the silent information regulator-2 family and act as nicotinamide adenine dinucleotide (NAD+)-dependent histone/protein deacetylases. The de-acetylation of proteins and histones results in an up- or down-regulation of gene transcription and protein function. In recent years, the regulatory action of the deacetylation activity of SIRT1 has been shown to have a positive impact on the pathophysiological mechanisms of nonalcoholic fatty liver disease (NAFLD). Among the effects of SIRT1 are: its healing activity on insulin sensitivity, thereby ameliorating glycemic regulation; its mimetic activity on calorie restriction; its antihyperlipidemic activity on lipid homeostasis via the liver, adipose tissues and skeletal muscles; its antiinflammatory activities; its protective effects against cardiovascular events and endothelial dysfunction; its positive influence on autophagy, apoptosis and cancer; and finally, its anti-aging activity. The current approach for the treatment of NAFLD involves the treatment of etiological factors and recommendation of life-style changes including more physical activity and a low-calorie diet. However, there are no specific medical treatments for NAFLD. The therapeutic potential of SIRT1 activity in the treatment of NAFLD discovered in humans has been presented in this article. In this review, the potential effects of SIRT1 activation on NAFLD-related pathophysiological mechanisms and on the treatment of NAFLD are discussed.

scholarly journals Curcumin and Biochemical Parameters in Metabolic-Associated Fatty Liver Disease (MAFLD)—A Review

Nutrients ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 2654
Author(s):  
Gracjan Różański ◽  
Sławomir Kujawski ◽  
Julia L. Newton ◽  
Paweł Zalewski ◽  
Joanna Słomko
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Biochemical Parameters ◽  
Public Health Problem ◽  
Pharmacological Therapy ◽  
Alcoholic Fatty Liver ◽  
Significant Public Health ◽  
Health Promoting ◽  
The Individual

Metabolic-associated fatty liver disease (MAFLD), formerly non-alcoholic fatty liver disease (NAFLD), is characterized by excessive fat accumulation in hepatocytes. It is the most common chronic liver disease worldwide and is a significant public health problem. In the absence of pharmacological therapy, other treatments such as diet, physical activity, or supplementation are sought. Non-pharmacological therapies may include curcumin supplementation, which has been shown to have many health-promoting properties, including antioxidant, anti-inflammatory, and anti-cancer effects. For this reason, we reviewed available databases to analyze publications describing the effect of curcumin supplementation on biochemical parameters in MAFLD. Nine studies (eight RCTs and one CT) based solely on supplementation of patients with curcumin were included in this review. The results from the individual trials were varied and did not allow clear conclusions. Although they suggest that curcumin shows some potential in the treatment of MAFLD, further research is needed.

scholarly journals Prevalence of non-alcoholic fatty liver disease among obese children in North Kerala, India

2017 ◽  
Vol 4 (3) ◽  
pp. 1051
Author(s):  
Reetha G. ◽  
Mahesh P.
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Local Population ◽  
Tertiary Care ◽  
Public Health Issue ◽  
Obese Children ◽  
Alcoholic Fatty Liver ◽  
Alanine Amino Transferase ◽  
Alcoholic Fatty Liver Disease

Background: Obesity and related co-morbidities are increasing at an alarming pace all over the world. Non-alcoholic fatty liver disease (NAFLD) is the asymptomatic involvement of the liver mainly seen in obese individuals. NAFLD can progress to chronic liver disease and has to be identified early. The aims of our study were to determine the prevalence of nonalcoholic fatty liver disease among obese children in our local population. To determine the prevalence of abnormal liver enzymes in obese children.Methods: Cross sectional descriptive study in a tertiary care center among children aged 5-18 years for a 1 year period. NAFLD was diagnosed based on ultrasonography. Alanine amino transferase more than 40IU/l was taken as abnormal.Results: A total of 65 patients were enrolled in the study. The prevalence of NAFLD in the study group was 60%. 20% had elevated alanine amino transferase levels.Conclusions: The prevalence of fatty liver in Kerala is comparable to that in the West. Since this is a public health issue more population based studies are needed on a larger group to find out the exact magnitude of the problem.

scholarly journals Pharmacological Therapy of Non-Alcoholic Fatty Liver Disease: What Drugs Are Available Now and Future Perspectives

2019 ◽  
Vol 16 (22) ◽  
pp. 4334 ◽  
Author(s):  
Grazia Pennisi ◽  
Ciro Celsa ◽  
Federica Spatola ◽  
Marcello Dallio ◽  
Alessandro Federico ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Pharmacological Therapy ◽  
Panoramic View ◽  
Alcoholic Fatty Liver ◽  
Current Review ◽  
Liver Decompensation ◽  
Enormous Amount ◽  
Alcoholic Fatty Liver Disease

The non-alcoholic fatty liver disease (NAFLD) is rapidly becoming the most common cause of chronic liver disease as well as the first cause of liver transplantation. NAFLD is commonly associated with metabolic syndrome (MetS), and this is the most important reason why it is extremely difficult to treat this disease bearing in mind the enormous amount of interrelationships between the liver and other systems in maintaining the metabolic health. The treatment of NAFLD is a key point to prevent NASH progression to advanced fibrosis, to prevent cirrhosis and to prevent the development of its hepatic complications (such as liver decompensation and HCC) and even extrahepatic one. A part of the well-known healthy effect of diet and physical exercise in this setting it is important to design the correct pharmaceutical strategy in order to antagonize the progression of the disease. In this regard, the current review has the scope to give a panoramic view on the possible pharmacological treatment strategy in NAFLD patients.

scholarly journals Dietary Polyphenols and Non-Alcoholic Fatty Liver Disease

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 494
Author(s):  
Ludovico Abenavoli ◽  
Tiziana Larussa ◽  
Alessandro Corea ◽  
Anna Caterina Procopio ◽  
Luigi Boccuto ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Science Studies ◽  
Wide Spectrum ◽  
Antioxidant Properties ◽  
Public Health Issue ◽  
Alcoholic Fatty Liver ◽  
Dietary Polyphenols ◽  
Alcoholic Fatty Liver Disease

Non-alcoholic fatty liver disease (NAFLD), which is emerging as a major public health issue worldwide, is characterized by a wide spectrum of liver disorders, ranging from simple fat accumulation in hepatocytes, also known as steatosis, to non-alcoholic steatohepatitis (NASH) and cirrhosis. At present, the pharmacological treatment of NAFLD is still debated and dietary strategies for the prevention and the treatment of this condition are strongly considered. Polyphenols are a group of plant-derived compounds whose anti-inflammatory and antioxidant properties are associated with a low prevalence of metabolic diseases, including obesity, hypertension, and insulin resistance. Since inflammation and oxidative stress are the main risk factors involved in the pathogenesis of NAFLD, recent studies suggest that the consumption of polyphenol-rich diets is involved in the prevention and treatment of NAFLD. However, few clinical trials are available on human subjects with NAFLD. Here, we reviewed the emerging existing evidence on the potential use of polyphenols to treat NAFLD. After introducing the physiopathology of NAFLD, we focused on the most investigated phenolic compounds in the setting of NAFLD and described their potential benefits, starting from basic science studies to animal models and human trials.

scholarly journals Effect of Different Types of Intermittent Fasting on Biochemical and Anthropometric Parameters among Patients with Metabolic-Associated Fatty Liver Disease (MAFLD)—A Systematic Review

Nutrients ◽  
2021 ◽  
Vol 14 (1) ◽  
pp. 91
Author(s):  
Gracjan Różański ◽  
Derek Pheby ◽  
Julia L. Newton ◽  
Modra Murovska ◽  
Paweł Zalewski ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Therapeutic Potential ◽  
Pharmacological Therapy ◽  
Intermittent Fasting ◽  
Anthropometric Parameters ◽  
Alcoholic Fatty Liver ◽  
Different Types ◽  
Dietary Strategy

Metabolic-associated fatty liver disease (MAFLD), previously called non-alcoholic fatty liver disease (NAFLD), is the most common chronic liver disease worldwide. It is characterised by excessive fat accumulation in hepatocytes. Currently, no pharmacological therapy is effective for this disease, so non-pharmacological alternatives such as diet, supplementation or physical activity are being sought. For this reason, we reviewed the available databases to analyse the studies conducted to date using different modifications of intermittent fasting among patients with MAFLD. Eight studies using this dietary strategy were included in this review. The results obtained in the different trials are varied and do not allow a clear determination of the effect of the different types of intermittent fasting on anthropometric and biochemical parameters among patients with MAFLD. However, this type of diet seems to show some therapeutic potential, but further studies are needed.

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