Re-Evaluating the Efficacy of the Aqueous Leaf Extract of Bridelia ferrugenia and its Potential Combination with Metformin in the Management of Diabetes Mellitus

Background: Chrysobalanus orbicularis is commonly used as food, the seeds as a spice for the popular pepper soup, and the leaves are traditionally utilized for managing Type II Diabetes Mellitus (T2DM) in the Niger Delta area of Nigeria. Due to the limited scientific evidence on C. orbicularis, this study investigated its antioxidant and inhibitory properties against major enzymes linked to T2DM. Methods: The antioxidant activity was measured via methods for possible scavenging potentials. The α-amylase and α-glucosidase inhibitory activities were examined using a standard model. Results: The C. orbicularis aqueous leaf extract compared well with the standard compounds, revealing the high antioxidant and inhibitory properties against α-amylase and α- glucosidase. Conclusion: The findings validate the conventional application of C. orbicularis in the treatment of patients with type II diabetes mellitus and other oxidative stress-related disorders.

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Cytoprotective and antiadhesive effects of aqueous leaf extract from Orthosiphon aristatus against uropathogenic E. coli

Planta Medica ◽

10.1055/s-0036-1596551 ◽

2016 ◽

Vol 81 (S 01) ◽

pp. S1-S381 ◽

Cited By ~ 1

Author(s):

S Sarshar ◽

MR Asadi Karam ◽

M Habibi ◽

S Bouzari ◽

X Qin ◽

...

Keyword(s):

Leaf Extract ◽

E Coli ◽

Aqueous Leaf Extract

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Insecticidal Activities of the Leaf Extract of the Invasive Alien Plant, Chromolaena odorata (L.) (Asteraceae) Against Macrotermes species (Termites)

Nigeria Journal of Entomology ◽

10.36108/nje/9102/53.01.31 ◽

2019 ◽

Vol 35 (1) ◽

pp. 145-153

Author(s):

O. Uyi, ◽

I.G. Amolo ◽

A.D. Adetimehin

Keyword(s):

Leaf Extract ◽

Insect Pests ◽

Chromolaena Odorata ◽

Leaf Extracts ◽

Alien Plant ◽

Biological Efficacy ◽

Invasive Alien Plant ◽

Impregnation Technique ◽

Aqueous Leaf Extract ◽

Worker Caste

Several studies have demonstrated the biological efficacy of leaf, stem and root powders or extracts of Chromolaena odorata (L.) King and Robinson against insect pests but those that are focused on the biological efficacy of aqueous leaf extracts against Macrotermes species are scanty. Current management of termites with synthetic insecticides is being discouraged due to human and environmental hazards. Therefore, the insecticidal effectiveness of aqueous leaf extract C. odorata against Macrotermes species was investigated. Five concentrations (0, 2.5, 5.0, 7.5 and 10.0% (w/v)) of the aqueous extract of C. odorata plant were evaluated for repellency and toxicity on the worker caste of Macrotermes species following standard procedures. The filter paper impregnation technique was used for the bioassay. Percentage repellency was monitored for 30 minutes and mortality recorded at 12, 24 and 36 hours post exposure. The leaf extract of C. odorata significantly repelled 95% of Macrotermes species at the highest concentration of 10% (w/v) after 30 minutes post treatment exposure. Mortality of Macrotermes species was independent of treatment concentration, but dependent on duration of exposure. All treatment concentrations of aqueous leaf extract of C. odorata caused significant mortality against Macrotermes species ranging between 94% and 98% compared to the control; indicating very great potential for adoption and use in the management of Macrotermes species.

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Green Synthesis of Silver Nanoparticles by Allamanda cathartica L. Leaf Extract and Evaluation for Antimicrobial Activity

International Journal of Pharmaceutical Sciences and Nanotechnology ◽

10.37285/ijpsn.2013.6.4.9 ◽

2013 ◽

Vol 6 (4) ◽

pp. 2260-2268

Author(s):

M. Linga Rao ◽

Bhumi G ◽

Savithramma N

Keyword(s):

Antimicrobial Activity ◽

Silver Nanoparticles ◽

Leaf Extract ◽

Fusarium Species ◽

Inhibition Zone ◽

Fungal Species ◽

Green Technology ◽

Metallic Silver ◽

Synthesis Of Nanoparticles ◽

Aqueous Leaf Extract

Silver nanoparticles (SNPs) exhibit tremendous applications in medicine as antimicrobial agent. The use of different parts of plants for the synthesis of nanoparticles is considered as a green technology as it does not involve any harmful chemicals. In the present study, we report a rapid biosynthesis of silver nanoparticles from aqueous leaf extract of medicinal plant Allamanda cathartica. The active phytochemicals present in the plant were responsible for the quick reduction of silver ion to metallic silver nanoparticles. The reduced silver nanoparticles were characterized by using UV-Vis spectrophotometry, Scanning Electron Microscope (SEM), Energy Dispersive Analysis of X-ray (EDAX) and Atomic Force Microscopy (AFM). The spherical shaped silver nanoparticles were observed and it was found to 19-40 nm range of size. These phytosynthesized SNPs were tested for their antimicrobial activity and it analyzed by measuring the inhibitory zone. A. cathartica aqueous leaf extract of SNPs showed highest toxicity to Pseudomonas followed by Klebsiella, Bacillus and E. coli and lowest toxicity towards Proteus. In fungal species, highest inhibition zone was noted against Rhizopus followed by Curvularia, Aspergillus flavus and Aspergillus niger and minimum inhibition zone was observed against Fusarium species. These results suggest a promising potential of Indian plant-based green chemistry for production of SNPs for biomedical and nanotechnology applications.

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