Synergistic antimicrobial activity of honey combined with silver nanoparticles topically applied in experimentally infected wounds in Wistar albino rats

Author(s):  
Neeraja Guruvu ◽  
Venkatanarayana Narapogu ◽  
D Lalitha ◽  
Bandaru Bandaru ◽  
Sai Goothy ◽  
...  
2020 ◽  
Vol 8 (32) ◽  
pp. 7197-7212 ◽  
Author(s):  
Zhiyong Qian ◽  
Yating Bai ◽  
Jin Zhou ◽  
Linhao Li ◽  
Jing Na ◽  
...  

The CTS-SF/SA/Ag-Exo dressing possessed multifunctional properties including broad-spectrum antimicrobial activity, promoting wound healing, retaining moisture and maintaining electrolyte balance.


2014 ◽  
Vol 2 (3) ◽  
pp. 235-239 ◽  
Author(s):  
MohamedA. Abd-Elhakeem ◽  
Ingy Badawy ◽  
MohamedA. Hamzawy ◽  
Amira Raafat ◽  
AhmedM. Elsayed ◽  
...  

2017 ◽  
Vol 100 ◽  
pp. 187-196 ◽  
Author(s):  
Balashanmugam Pannerselvam ◽  
Mukesh Kumar Dharmalingam Jothinathan ◽  
Murugan Rajenderan ◽  
Palani Perumal ◽  
Kalaichelvan Pudupalayam Thangavelu ◽  
...  

2017 ◽  
Vol 1 ◽  
pp. 42
Author(s):  
Omodamiro Olorunshola Dave ◽  
Ajah Obinna

The purpose of the present study was to evaluate the laxative and antimicrobial activities of ethanol extracts of leaf and root of Amaranthus viridis L. The laxative activity of ethanolic leaf extract of A. viridis was studied using six groups of wistar albino rats; Group I which served as the negative control received 0.5ml/kg of normal saline, Group II received 10mg/kg of Dulcolax and the rest of the groups (III-VI) received 400, 200, 100 and 50mg/kg of the extract respectively. The laxative activity of the ethanolic leaf extract was expressed as the mean of total weight of faecal output in each group. A significant (p<0.05) dose dependent increase in the faecal output was observed at the 200mg/kg (3.00 ±1.41gm) and 400mg/kg (3.50 ±2.12gm) doses compared with the negative control. The antimicrobial activity was expressed as the diameter of the zone of inhibition hence the minimum inhibitory concentrations were determined. The antimicrobial activity of the A. viridis leaf and root extracts had dose dependent increases in all the tested organisms from their various minimum inhibitory concentrations (MIC). The result confirmed that the leaves and root of A. viridis possess laxative and antimicrobial activity. 


2021 ◽  
Vol 13 (1) ◽  
pp. 343-351
Author(s):  
S. IruthayaKalai Selvam ◽  
S. Marian Bara Joicesky ◽  
A. Amolorpava Dashli ◽  
A. Vinothini ◽  
K. Premkumar

Silver nanoparticles synthesized from plant material have superior bioactivities. The purpose of this current study was to synthesis, characterize and to explore the bioactive efficacy of silver nanoparticles (Ag-NPs) using aqueous leaf extract of Tageteserecta. The biosynthesized Ag-NPs were characterized using ultraviolet-visible spectroscopy, Fourier transform infrared spectroscopy (FTIR), X-ray diffraction and Scanning electron microscopy. Ag-NPs were studied for in-vivo anti-inflammatory and wound healing activities performed in female Wistar albino rats. UV –Vis absorption spectrum of the T.erecta leaves extract was obtained at 428nm due to excitation of surface plasmon vibration in nanoparticles and confirms the synthesis of silver nanoparticles. The FTIR analysis showed the presence of sulfate, alkene and alcohol in the AgNP of T.erectaleaves. The average crystallite size of AgNP synthesized was found to be 27.2 nm. The spherical silver grain of 15.5 nm average size has been depicted with high-resolution scanning electron microscopy. Maximum activity (15mm) of T.erecta leaves silver nanoparticles was observed against Salmonella typhi (15mm) followed by Escherichia coli (12mm). Ag-NPs exhibited significant wound healing activity and anti-inflammatory activity in carrageenan-induced paw volume tests performed in female Wistar albino rats. Colloidal Ag-NPs can be synthesized by simple, nonhazardous methods, and biosynthesized Ag-NPs using T.erectaleaves extract have significant therapeutic properties.This work evidently confirmed that silver nanoparticles mediated T.erecta could be considered as a potential source for anti-inflammatory and wound healing drug.


Author(s):  
M. Linga Rao ◽  
Bhumi G ◽  
Savithramma N

Silver nanoparticles (SNPs) exhibit tremendous applications in medicine as antimicrobial agent.  The use of different parts of plants for the synthesis of nanoparticles is considered as a green technology as it does not involve any harmful chemicals.  In the present study, we report a rapid biosynthesis of silver nanoparticles from aqueous leaf extract of medicinal plant Allamanda cathartica.  The active phytochemicals present in the plant were responsible for the quick reduction of silver ion to metallic silver nanoparticles. The reduced silver nanoparticles were characterized by using UV-Vis spectrophotometry, Scanning Electron Microscope (SEM), Energy Dispersive Analysis of X-ray (EDAX) and Atomic Force Microscopy (AFM).  The spherical shaped silver nanoparticles were observed and it was found to 19-40 nm range of size.  These phytosynthesized SNPs were tested for their antimicrobial activity and it analyzed by measuring the inhibitory zone. A. cathartica aqueous leaf extract of SNPs showed highest toxicity to Pseudomonas followed by Klebsiella, Bacillus and E. coli and lowest toxicity towards Proteus. In fungal species, highest inhibition zone was noted against Rhizopus followed by Curvularia, Aspergillus flavus and Aspergillus niger and minimum inhibition zone was observed against Fusarium species.  These results suggest a promising potential of Indian plant-based green chemistry for production of SNPs for biomedical and nanotechnology applications.


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