Role of tumour- associated neutrophils in tissue material and systemic neutrophil inflammation in colorectal cancer patients

2021 ◽  
Vol 11 (2) ◽  
pp. 85-98
Author(s):  
K. Jakubowska ◽  
M. Koda ◽  
W. Kisielewski ◽  
K. Lomperta ◽  
M. Grudzińska ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Immune Response ◽  
Tumor Growth ◽  
Cancer Patients ◽  
Distant Metastases ◽  
Colorectal Cancer Patients ◽  
Cancer Tissues ◽  
Tumor Associated Neutrophils ◽  
Tissue Material

Colorectal cancer (CRC) is one of the most common malignant cancers worldwide. Immune response is appear to be inseparable component of each part of tumorigenesis. Moreover, several studies have shown that some populations of neutrophils, called tumor-associated neutrophils (TANs) can be also actively involved in the tumor growth, anggenesis and development of the distant metastases in various cancer tissues.

scholarly journals Adamalysines as Biomarkers and a Potential Target of Therapy in Colorectal Cancer Patients: Preliminary Results

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Katarzyna Walkiewicz ◽  
Joanna Strzelczyk ◽  
Dariusz Waniczek ◽  
Krzysztof Biernacki ◽  
Małgorzata Muc-Wierzgoń ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Patients ◽  
Distant Metastases ◽  
Serum Levels ◽  
Control Group ◽  
Colorectal Cancer Patients ◽  
And Control ◽  
The Relationship ◽  
Increased Activity

Colorectal cancer is one of the most common cancers in the world. Due to its still undetermined pathogenesis, we are searching for signaling pathways that are important in the development of colorectal cancer. In this article, we present results of study on the role of ADAM proteins in colorectal cancer. The study included 85 adult colorectal cancer patients (48 men, 37 women) and 25 patients in the control group (after diagnostic colonoscopy—without cancer). During hospitalization, a serum sample (3 cm3) was collected from the study and control group, anthropometric measurements were conducted and others clinical data were analyzed. In the serum ADAM10, 12, 17, and 28, protein concentrations were determined and, in the next step, examined the relationship between ADAMs concentrations and selected clinical parameters in both groups. The analysis showed that serum levels of ADAM10 and ADAM28 are significantly higher in patients with colorectal cancer and correlate with histopathological grading and with presence of distant metastases. Moreover, noticed the trend to correlate concentrations of adamalysines with higher BMI score. One of the functions of adamalysines is the activation of growth factors involved in cancer, including IGF and TNFα. The increased activity of adamalysines in patients may play a role in the pathogenesis of colorectal cancer. Our study highlights the prevalence of metabolic disorders in the group of patients with diagnosed CRC, and this cancer seems to be a further complication of obesity.

472 Addressing the Quality of Hospital Care of Colorectal Cancer Patients Undergoing Surgery: What Did We Learn from the National Bowel Cancer Audit?

2021 ◽  
Vol 108 (Supplement_2) ◽  
Author(s):  
C Li ◽  
S Z Y Ooi ◽  
T Woo ◽  
P H M Chan
Keyword(s):  
Colorectal Cancer ◽  
Cancer Patients ◽  
External Validation ◽  
Distant Metastases ◽  
Management Plan ◽  
Bowel Cancer ◽  
Clinical Factors ◽  
Quality Outcomes ◽  
Colorectal Cancer Patients

Abstract Aim To identify the most relevant clinical factors in the National Bowel Cancer Audit (NBOCA) that contribute to the variation in the quality of care provided in different hospitals for colorectal cancer patients undergoing surgery. Method Data from 36,116 patients with colorectal cancer who had undergone surgery were retrospectively collected from the NBOCA and analysed from 145 and 146 hospitals over two years. A validated multiple linear regression was performed to compare the identified clinical factors with various quality outcomes. The quality outcomes defined in this study were the length of hospitalisation, 2-year mortality, readmission rate, 90-day mortality, and 18-month stoma rate. Results Four clinical factors (laparoscopy rate, abdominal-perineal-resection-of-rectum (APER), pre-operative radiotherapy and patients with distant metastases) were shown to have a significant (p < 0.05) impact on the length of hospitalisation and 18-month stoma rate. 18-month stoma rate was also significantly associated with 2-year mortality. External validation of the regression model demonstrated the Root-Mean-Square-Error of 0.811 and 4.62 for 18-month stoma rate and 2-year mortality respectively. Conclusions Hospitals should monitor the four clinical factors for patients with colorectal cancer during perioperative care. Clinicians should consider these factors along with the individual patients’ history when formulating a management plan for patients with colorectal cancer.

High Expression of sLex Associated with Poor Survival in Argentinian Colorectal Cancer Patients

2014 ◽  
Vol 29 (1) ◽  
pp. e30-e39 ◽  
Author(s):  
Ariel Zwenger ◽  
Martin Rabassa ◽  
Sandra Demichelis ◽  
Gabriel Grossman ◽  
Amada Segal-Eiras ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lymph Nodes ◽  
Cancer Patients ◽  
Normal Mucosa ◽  
Poor Survival ◽  
Primary Tumors ◽  
Metastatic Lymph Nodes ◽  
Metastatic Lymph ◽  
Colorectal Cancer Patients

Aim Colorectal cancer (CRC) is one of the most prevalent malignancies in Argentina with 11,043 new cases and 6,596 deaths estimated to have occurred in 2008. The present study was developed to clarify the differential expression of MUC1, MUC2, sLex, and sLea in colorectal cancer patients and their relationship with survival and clinical and histological features. Methods Ninety primary tumor samples and 43 metastatic lymph nodes from CRC patients were studied; follow-up was documented. Twenty-six adenoma and 68 histological normal mucosa specimens were analyzed. An immunohistochemical approach was applied and statistical analysis was performed. Results In tumor samples, MUC1, sLea, and sLex were highly expressed (94%, 67%, and 91%, respectively); also, we found a significantly increased expression of the 3 antigens in primary tumors and metastatic lymph nodes compared with normal mucosa and adenomas. MUC2 was expressed in 52% of both normal mucosa and CRC samples; this reactivity significantly decreased in metastatic lymph nodes (p<0.05). A multiple comparison analysis showed that MUC1 and sLex discriminated among 3 groups: normal, adenoma, and CRC tissues. The increase of sLex expression showed an association with recurrence, and survival analysis showed that a high sLex staining was significantly associated with a poor survival. By multivariate analysis MUC1 inmunoreactivity correlated positively and significantly with tumor size, while MUC2 expression showed the opposite correlation. Conclusions The correlation of sLex overexpression in primary tumors and metastatic lymph nodes, the discrimination among the normal, adenoma, and CRC groups based on sLex expression, as well as its association with recurrence and survival, all suggest a prognostic role of sLex in Argentinian CRC patients.

scholarly journals Role of different toxicity profile on outcome for colorectal cancer patients receiving Regorafenib monotherapy

2015 ◽  
Vol 26 ◽  
pp. vi51
Author(s):  
R. Giampieri ◽  
M. Del Prete ◽  
L. Faloppi ◽  
M. Bianconi ◽  
K. Andrikou ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Patients ◽  
Toxicity Profile ◽  
Colorectal Cancer Patients

scholarly journals TCR sequencing analysis of cancer tissues and tumor draining lymph nodes in colorectal cancer patients

2019 ◽  
Vol 8 (6) ◽  
pp. e1588085 ◽  
Author(s):  
Tatsuo Matsuda ◽  
Eisaku Miyauchi ◽  
Yu-Wen Hsu ◽  
Satoshi Nagayama ◽  
Kazuma Kiyotani ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lymph Nodes ◽  
Cancer Patients ◽  
Sequencing Analysis ◽  
Colorectal Cancer Patients ◽  
Cancer Tissues ◽  
Draining Lymph Nodes
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