scholarly journals Adenocarcinoma in situ of the cervix detected after long term follow up. A case report.

1998 ◽  
Vol 37 (2) ◽  
pp. 244-249
Author(s):  
Minoru AKIYAMA ◽  
Masaya HIROSE ◽  
Takako OKUBO ◽  
Hidetoshi OKABE ◽  
Kenji TAKAKURA ◽  
...  
Cancers ◽  
2021 ◽  
Vol 13 (15) ◽  
pp. 3864
Author(s):  
Maximilian Gassenmaier ◽  
Matthias Hahn ◽  
Gisela Metzler ◽  
Jürgen Bauer ◽  
Amir Sadegh Yazdi ◽  
...  

Background: PReferentially expressed Antigen in MElanoma (PRAME) immunohistochemistry is increasingly used as diagnostic adjunct in the evaluation of melanocytic tumors. The expression and prognostic significance of PRAME in melanomas ≤1.0 mm and its diagnostic utility in the distinction from severely dysplastic compound nevi (SDN) have not been studied. Methods: We investigated and compared the immunohistochemical PRAME expression in 70 matched thin metastasizing and non-metastasizing melanomas and 45 nevi from patients with long-term follow-up (35 SDN and 10 unequivocally benign compound nevi). Results: Diffuse PRAME staining in >75% of lesional epidermal and dermal melanocytes identified 58.6% of thin melanomas but did not distinguish metastasizing from non-metastasizing melanomas (p = 0.81). A superficial atypical melanocytic proliferation of uncertain significance, in which the final diagnostic interpretation favored a SDN was the only nevus with diffuse PRAME expression (1/45). Melanomas and SDN with PRAME immunoreactivity exhibited different staining patterns. Most melanomas (67.6%) showed uniform PRAME expression in the in situ and invasive component, whereas most SDN (81.0%) showed a decreasing gradient with depth. Conclusion: Diffuse intraepidermal and dermal PRAME staining is highly specific for melanomas in the distinction from SDN. PRAME expression is not a prognostic biomarker in melanomas ≤1.0 mm.


Author(s):  
Eduardo Anitua ◽  
Beatriz Anitua ◽  
Mohammad Hamdan Alkhraisat ◽  
Laura Piñas ◽  
Asier Eguia

2015 ◽  
Vol 10 (4) ◽  
pp. 2465-2467 ◽  
Author(s):  
YU-BAO GONG ◽  
LI-MEI QU ◽  
XIN QI ◽  
JIAN-GUO LIU

2017 ◽  
Vol 23 (4) ◽  
pp. e9-e13
Author(s):  
S.A. Lalé ◽  
E.B. Burger ◽  
J.H.J.M. Bessems ◽  
V. Pollet ◽  
C.A. van Nieuwenhoven

2014 ◽  
Vol 44 (6) ◽  
pp. 863-868 ◽  
Author(s):  
Vlajković Marina ◽  
Rajić Milena ◽  
Petronijević Vesna ◽  
Petrović Slađana ◽  
Artiko Vera

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