scholarly journals Medicinal Importance of Ajuga Species in Iran: Ethnobotanical and Traditional Applications, Phytochemical, and Pharmacological Studies

2022 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Aysan Rahiminiya ◽  
Hamideh Herizchi Ghadim ◽  
Nargess Sadati Lamardi ◽  
Mohsen Haghir Ebrahimabadi ◽  
Seyyed Mohammadbagher Fazljou ◽  
...  
Keyword(s):  
Joint Pain ◽  
Biological Activities ◽  
Natural Antioxidants ◽  
Therapeutic Effects ◽  
Exclusion Criteria ◽  
Ajuga Reptans ◽  
Study Results ◽  
Clerodane Diterpenes ◽  
Pharmacological Studies ◽  
The Common

Context: Five species of the genus Ajuga (Lamiaceae) having the common name of "bugle" are found in Iran. In Persian medicine (PM), the genus Ajuga (Kamaphytus) is used for treating jaundice, joint pain, gout, amenorrhea, sciatica, and wound healing. This study aimed to review the ethnobotanical, phytochemical, and biological activities of Ajuga species that grow in Iran to determine their therapeutic potentials and suggest further studies on the healing properties of this genus in Iran. Evidence Acquisition: Electronic databases such as PubMed, Scopus, and Google Scholar were comprehensively searched for studies on Ajuga species in Iran, including "Ajuga austro-iranica," "Ajuga chamaecistus," "Ajuga comata" (Syn.: "Ajuga Chia," "Ajuga chamaepitys subsp. Chia"), "Ajuga orientalis," and "Ajuga reptans." The search period was from 1966 to February 2021. The related articles were selected according to the inclusion and exclusion criteria of the current study. Results: Several ethnobotanical and pharmacologic reports have verified the traditional uses of the genus Ajuga for anti-inflammatory, hypoglycemic, hypolipidemic, analgesic, anabolic, anti-arthritis, antipyretic, and hepatoprotective activities. Numerous phytochemicals have been identified from Ajuga species involving phytoecdysteroids, neo-clerodane-diterpenes, iridoids, flavonoids, withanolides, phenylethyl glycoside, and essential oils. Conclusions: Due to the beneficial therapeutic effects of Ajuga genus, it can be considered in future clinical studies as a source of natural antioxidants, dietary supplements in the pharmaceutical industry, and stabilizing food against oxidative deterioration.

Structure-Bioactivity Relationship Study of Xanthene Derivatives: A Brief Review

2020 ◽  
Vol 16 (8) ◽  
pp. 1071-1077
Author(s):  
Aref G. Ghahsare ◽  
Zahra S. Nazifi ◽  
Seyed M.R. Nazifi
Keyword(s):  
Biological Activities ◽  
Cyclic Compound ◽  
Research Field ◽  
Pharmaceutical Chemistry ◽  
Therapeutic Effects ◽  
Main Research ◽  
Research Fields ◽  
Xanthene Derivatives ◽  
Anti Cancer ◽  
Heterocyclic Derivatives

: Over the last decades, several heterocyclic derivatives compounds have been synthesized or extracted from natural resources and have been tested for their pharmaceutical activities. Xanthene is one of these heterocyclic derivatives. These compounds consist of an oxygen-containing central heterocyclic structure with two more cyclic structures fused to the central cyclic compound. It has been shown that xanthane derivatives are bioactive compounds with diverse activities such as anti-bacterial, anti-fungal, anti-cancer, and anti-inflammatory as well as therapeutic effects on diabetes and Alzheimer. The anti-cancer activity of such compounds has been one of the main research fields in pharmaceutical chemistry. Due to this diverse biological activity, xanthene core derivatives are still an attractive research field for both academia and industry. This review addresses the current finding on the biological activities of xanthene derivatives and discussed in detail some aspects of their structure-activity relationship (SAR).

scholarly journals Phenolic Composition and Antioxidant Activity of Plants Belonging to the Cephalaria (Caprifoliaceae) Genus

Plants ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 952
Author(s):  
Małgorzata Chrząszcz ◽  
Barbara Krzemińska ◽  
Rafał Celiński ◽  
Katarzyna Szewczyk
Keyword(s):  
Antioxidant Activity ◽  
Lung Diseases ◽  
Antioxidative Activity ◽  
Biological Activities ◽  
Natural Antioxidants ◽  
Antioxidant Effect ◽  
In Vivo Studies ◽  
Phenolic Composition

The genus Cephalaria, belonging to the Caprifoliaceae family, is a rich source of interesting secondary metabolites, including mainly saponins which display a variety of biological activities, such as immunomodulatory, antimicrobial and hemolytic effects. Besides these compounds, flavonoids and phenolic acids were identified in Cephalaria species. Cephalaria is employed in traditional medicine e.g., to cure cardiac and lung diseases, rheumatism, and regulate menstruation. In this review we focus on the phenolic compound composition and antioxidative activity of Cephalaria species. The antioxidant effect can be explained by flavonoids present in all parts of these plants. However, future efforts should concentrate more on in vitro and in vivo studies and also on clinical trials in order to confirm the possibility of using these plants as natural antioxidants for the pharmacology, food or cosmetic industries.

scholarly journals Melatonin in Cancer Treatment: Current Knowledge and Future Opportunities

Molecules ◽  
2021 ◽  
Vol 26 (9) ◽  
pp. 2506
Author(s):  
Wamidh H. Talib ◽  
Ahmad Riyad Alsayed ◽  
Alaa Abuawad ◽  
Safa Daoud ◽  
Asma Ismail Mahmod
Keyword(s):  
Clinical Trials ◽  
Current Knowledge ◽  
Biological Activities ◽  
Experimental Studies ◽  
Therapeutic Effects ◽  
Cell Proliferation Inhibition ◽  
Different Types ◽  
Solid Foundation

Melatonin is a pleotropic molecule with numerous biological activities. Epidemiological and experimental studies have documented that melatonin could inhibit different types of cancer in vitro and in vivo. Results showed the involvement of melatonin in different anticancer mechanisms including apoptosis induction, cell proliferation inhibition, reduction in tumor growth and metastases, reduction in the side effects associated with chemotherapy and radiotherapy, decreasing drug resistance in cancer therapy, and augmentation of the therapeutic effects of conventional anticancer therapies. Clinical trials revealed that melatonin is an effective adjuvant drug to all conventional therapies. This review summarized melatonin biosynthesis, availability from natural sources, metabolism, bioavailability, anticancer mechanisms of melatonin, its use in clinical trials, and pharmaceutical formulation. Studies discussed in this review will provide a solid foundation for researchers and physicians to design and develop new therapies to treat and prevent cancer using melatonin.

scholarly journals Common Diseases and Some Demographic Characteristics among Saudi Women

2015 ◽  
Vol 8 (12) ◽  
pp. 94 ◽  
Author(s):  
Ahmed Abdulrahman Al-Haramlah ◽  
Fawziah Al-Bakr ◽  
Haniah Merza
Keyword(s):  
Physical Activity ◽  
Health Centers ◽  
Saudi Women ◽  
Number Of Children ◽  
Common Diseases ◽  
The Social ◽  
Study Results ◽  
The Common ◽  
Obesity Hypertension

<p class="apa">This study aimed to detect the common diseases among Saudi women and their relationship with the level of physical activity and some variables. This study was applied to 1233 Saudi woman in different regions of the Kingdom, and adopted to explore the common diseases: obesity, hypertension, diabetes, cholesterol and asthma.</p><p class="apa">The study results showed the existence of a statistically significant relationship between the common diseases among Saudi women and the variables of educational level, the nature of the profession, the social status, the justification of the practice of physical activity, the rate of participation in physical activity per week, the practice of physical activity in relation to asthma and the number of children with regard to obesity.</p><p class="apa">The study provided a number of recommendations including: the need to strengthen the role of culture in promoting physical activity by women, through health education via the health centers in the Kingdom.</p>

THE ESSENCE AND CHARACTERISTICS OF THE DETERMINANTS OF SELF-COMMUNICATION DISCOURSE AS AN INTERNAL DIALOGUE

2021 ◽  
pp. 73-81
Author(s):  
I. A. Shapoval ◽  
Keyword(s):  
Differentiation Of Self ◽  
Mental Content ◽  
Self Concept ◽  
Self Organization ◽  
Common Goal ◽  
The Core ◽  
Self Confidence ◽  
Internal Dialogue ◽  
Study Results ◽  
The Common

The paper presents the interdisciplinary analysis of the determinants of the system of self-communication discourse and internal dialogue as the forms of objectivation of human mental content focused on some actions for meeting some objectives. The author describes discourse as integration of communication and language processes in self-understanding and personal identity. Contextually determined and dynamic self-communication discourse, as a way of acquirement of new senses and confirmation of old ones, verbalizes current personal values. The study results reveal the characteristics and relations of the internal dialogue discourse determinants within the human objectivity–subjectivity continuum. Discourse determinants prescribe its context and rules and include the prototype place and agents with their motives and objectives. Self-positions manifested in Self and Non-Self (Other Self) binary self-predications form the core pair of agents. The modality of a person’s attitude to own Self-positions makes their communications a dialogue or a monologue on the boundary of their sub-territories as a discourse prototype place. The degree of discourse agency, its closeness within the prototype place, or transgression openness depends on the complexity and differentiation of Self-concept and ego boundaries functionality. The frustration of meta-necessity to keep self-confidence and self-acceptance by reassessment and reformation of interrelations of Self-positions determines the motives and objectives of self-communication. The common goal of self-organization is implemented through the internal dialogue in the form of institutionalization, verification, and integration of their Self-predications. Status-role characteristics of agents and functionality of discourse prototype place determine the specificity of its motives and objectives according to the systemic effects of Self-organization.

scholarly journals Common Sports Injuries among Physical Activities Practitioners at the Physical Fitness Centers in Jordan (Comparative Study)

2016 ◽  
Vol 12 (5) ◽  
pp. 24
Author(s):  
Majed F. Mujalli ◽  
Maen Z. Zakarneh ◽  
Ala’a Kh. Abu Aloyoun
Keyword(s):  
Physical Fitness ◽  
Sports Injuries ◽  
Physical Activities ◽  
The Body ◽  
Fitness Centers ◽  
Warm Up ◽  
Medical Checkup ◽  
Study Results ◽  
Lumbar Area ◽  
The Common

<p>The aim of the study was to investigate the common sports injuries among physical activities practitioners at the physical fitness centers in Jordan. Study sample consisted of (272) volunteered male (n=221) and female (n=51) (age 30±3). Researchers used a special form used to evaluate athletic injuries. After collecting and analyzing the data. Results showed that the most common sports injuries among sample of the study was muscular tears 27.7%, muscle spasm 20.7%, and tears ligament 20.2%. And the most exposed parts of the body to injury is the lumbar area 26.8%, elbows 16.9%, followed by shoulders 8.9%. Also the study results revealed that the most cusses of injuries was over training 24.14%. Poor warm-up 22.1% and bad technic 11.3%. Bodies-building was the most type of activities subjects to injury with 18.8%. Physical Fitness 6.6% and weight loss 27.7. Results also showed that physical therapy was the most means of treating injuries 54.14%, drugs therapy 33.3% and surgical intervention 4.2%. Also the study shows that males are more exposed to injuries than females.</p><p>Conclusions: These finding indicate that sports injures is part of physical</p><p>Activities participations, preventive measures should be taken by participant's the researchers recommended the need for physical and medical checkup before participation in physical activity at the physical fitness centers.</p>

scholarly journals Pharmacology and Phytochemistry of Ecuadorian Medicinal Plants: An Update and Perspectives

2021 ◽  
Vol 14 (11) ◽  
pp. 1145
Author(s):  
Chabaco Armijos ◽  
Jorge Ramírez ◽  
Melissa Salinas ◽  
Giovanni Vidari ◽  
Alírica I. Suárez
Keyword(s):  
Chemical Composition ◽  
Medicinal Plants ◽  
Secondary Metabolites ◽  
Essential Oils ◽  
Volatile Compounds ◽  
Biological Activities ◽  
Indigenous Communities ◽  
Therapeutic Agents ◽  
Practical Applications ◽  
Pharmacological Studies

The use of plants as therapeutic agents is part of the traditional medicine that is practiced by many indigenous communities in Ecuador. The aim of this study was to update a review published in 2016 by including the studies that were carried out in the period 2016–July 2021 on about 120 Ecuadorian medicinal plants. Relevant data on raw extracts and isolated secondary metabolites were retrieved from different databases, resulting in 104 references. They included phytochemical and pharmacological studies on several non-volatile compounds, as well as the chemical composition of essential oils (EOs). The tested biological activities are also reported. The potential of Ecuadorian plants as sources of products for practical applications in different fields, as well the perspectives of future investigations, are discussed in the last part of the review.

scholarly journals In Vitro study for hesperidin nanoparticles effect on phagocytic activity against Staphylococcus aureus

2018 ◽  
Vol 12 (2) ◽  
pp. 36-39
Author(s):  
Saja Ali ◽  
Ghassan Sulaiman ◽  
Mohammed M. Al-Halbosiy
Keyword(s):  
Biological Activities ◽  
In Vitro Study ◽  
Particle Size Analysis ◽  
Poloxamer 407 ◽  
Size Analysis ◽  
Therapeutic Effects ◽  
X Ray Diffraction ◽  
Setup Cost ◽  
Phagocytosis Index

       Hesperidin is one of the flavonoids from citrus peels and it recognized to possess various biological activities such as, anti-inflammatory, anti-carcinogenic, antioxidant and antimicrobial potentials. The present investigation studies the immunological adjuvant influence of hesperidin nanoparticles. Hesperidin nanoparticles were prepared by nano-precipitation technique by using Poly (D, L-lactic-co-glycolic acid) (PLGA) polymer and Poloxamer 407 was used as a stabilizer. This method was used because of their advantage of low setup cost and simplicity. Hesperidin nanoparticles were characterized by fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X-ray diffraction (XRD) and particle size analysis (PSA) analytical methods. The effect of hesperidin nanoparticles was higher than the effect of pure hesperidin, and there was an obvious increase in phagocytosis index (PI 82%) of hesperidin nanoparticles when compared with pure hesperidin (PI 56%) and in comparison with the control samples (PI 22%). In conclusion we need further studies about if nano-hesperidin has therapeutic effects.

scholarly journals The Electrical Activity of the Orbicularis Oris Muscle in Children with Down Syndrome—A Preliminary Study

2021 ◽  
Vol 10 (23) ◽  
pp. 5611
Author(s):  
Liliana Szyszka-Sommerfeld ◽  
Magdalena Sycińska-Dziarnowska ◽  
Krzysztof Woźniak ◽  
Monika Machoy ◽  
Sławomir Wilczyński ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Electrical Activity ◽  
Healthy Children ◽  
Exclusion Criteria ◽  
Children With Down Syndrome ◽  
Electrical Potentials ◽  
Study Results ◽  
Orbicularis Oris Muscle ◽  
Preliminary Study ◽  
Muscular Effort

The aim of this study was to assess the electrical activity of the superior (SOO) and inferior (IOO) orbicularis oris muscles in children with Down syndrome (DS) and in children without DS. After applying the inclusion and exclusion criteria, 30 subjects were eligible to participate in the later stages of the research—15 subjects with DS (mean age 10.1 ± 1.1) and 15 healthy controls (mean age 9.8 ± 1.0). The electrical potentials of the SOO and IOO muscles were recorded using a DAB-Bluetooth electromyography machine (Zebris Medical GmbH, Germany) during the following tasks: At clinical rest, saliva swallowing, lip protrusion, lip compression, and production of the syllable/pa/. The Mann–Whitney U test was conducted to compare the study results between the groups. An analysis of the electromyographical (EMG) recordings showed that the electrical activity of the orbicularis oris muscle in children with DS and lip incompetence was significantly higher compared to healthy children during saliva swallowing, lip compression, and when producing the syllable/pa/, and this may suggest greater muscular effort due to the need to seal the lips during these functional conditions.

scholarly journals A Review of the Phytochemistry, Traditional Uses and Antibacterial Potential of Psidium guajava

2021 ◽  
Vol 10 (3) ◽  
pp. 2506-2514
Keyword(s):  
Biological Activities ◽  
Psidium Guajava ◽  
New Drugs ◽  
Bioactive Constituents ◽  
Traditional Uses ◽  
The Family ◽  
Pharmacological Studies ◽  
Reliable Knowledge ◽  
Important Drug ◽  
Antibacterial Potential

Psidium guajava is a tropical evergreen tree. It belongs to the family Myrtaceae that consists of about 133 genera and approximately 3800 species worldwide. This plant is mainly found in South Africa, North Africa, South America, and Southeast Asia. Psidium guajava is mainly a nutritional plant, but it also shows various biological activities. An array of bioactive constituents, viz; glycosides, terpenoids, tannins, alkaloids, steroids, saponins, amino acids, anthraquinones, proteins, flavonoids, and phenols, etc. have been isolated from Psidium guajava. These phytochemicals are well known for their biological activities, including antibacterial, antioxidant, antifungal, etc. The present work has been performed to gather data about the traditional uses, important phytochemicals, and antibacterial efficiency of Psidium guajava. Many pharmacological studies have demonstrated its antibacterial potential against various important drug resistive pathogens. We invite researchers' attention to carry out detailed antibacterial studies on this valuable plant species to provide reliable knowledge to the patients and discover more novel compounds for the development of new drugs with fewer side effects compared to conventional medicines.

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