Benign Myoepithelioma of the Lung

2001 ◽  
Vol 125 (11) ◽  
pp. 1494-1496
Author(s):  
Ravindra Veeramachaneni ◽  
Janis Gulick ◽  
Ari O. Halldorsson ◽  
Thanh T. Van ◽  
Ping L. Zhang ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Smooth Muscle ◽  
Smooth Muscle Actin ◽  
Emission Tomography ◽  
Muscle Actin ◽  
Computed Tomographic ◽  
Spindle Cells ◽  
Positron Emission ◽  
Computed Tomographic Scan ◽  
Wedge Biopsy

Abstract This report describes a benign myoepithelioma of the lung that occurred in a 60-year-old woman. The patient had experienced hoarseness for 6 weeks, and a computed tomographic scan showed a nodule of approximately 2 cm in diameter at the peripheral portion of her right upper lung. Positron emission tomography showed no uptake of F-18 fluorodeoxyglucose in the nodule. Wedge biopsy of the lesion showed benign spindle cells arranged in a whorled pattern. The cells were positive for both cytokeratin and smooth muscle actin, which corresponded to the presence of tonofilaments and myofilaments that were identified ultrastructurally. The features of the present case of benign myoepithelioma that differ from features of previously reported benign and malignant cases of myoepithelioma in the lung are discussed in the report.

Glomangiomyoma (Glomus Tumor) of the Kidney

2005 ◽  
Vol 129 (9) ◽  
pp. 1172-1174 ◽  
Author(s):  
Noman H. Siddiqui ◽  
Agnieszka Rogalska ◽  
Indu S. Basil
Keyword(s):  
Electron Microscopy ◽  
Smooth Muscle ◽  
Glomus Tumor ◽  
Smooth Muscle Actin ◽  
Muscle Actin ◽  
Thin Filaments ◽  
Glomus Tumors ◽  
Computed Tomographic ◽  
Dense Bodies ◽  
Computed Tomographic Scan

Abstract We report herein a case of glomus tumor arising in the kidney of a 55-year-old woman, which was found incidentally on a computed tomographic scan. Partial nephrectomy revealed a 2-cm encapsulated mass that was architecturally similar to glomus tumor. Immunohistochemistry showed positivity of tumor cells for vimentin and smooth muscle actin. On electron microscopy, cytoplasmic thin filaments and dense bodies were seen, confirming the smooth muscle nature of the tumor. Glomus tumors arising in visceral organs are rare, and those arising in kidney are exceedingly rare.

scholarly journals Glucagon-like peptide-1 receptor expression after myocardial infarction: Imaging study using 68Ga-NODAGA-exendin-4 positron emission tomography

2018 ◽  
Vol 27 (6) ◽  
pp. 2386-2397 ◽  
Author(s):  
Mia Ståhle ◽  
Ville Kytö ◽  
Max Kiugel ◽  
Heidi Liljenbäck ◽  
Olli Metsälä ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Positron Emission Tomography ◽  
Smooth Muscle Actin ◽  
Receptor Expression ◽  
Emission Tomography ◽  
Sham Operation ◽  
Alpha Smooth Muscle Actin ◽  
Positron Emission ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

Abstract Background Activation of glucagon-like peptide-1 receptor (GLP-1R) signaling protects against cardiac dysfunction and remodeling after myocardial infarction (MI). The aim of the study was to evaluate 68Ga-NODAGA-exendin-4 positron emission tomography (PET) for assessment of GLP-1R expression after MI in rats. Methods and Results Rats were studied at 3 days, 1 and 12 weeks after permanent coronary ligation or a sham-operation. Rats were injected with 68Ga-NODAGA-exendin-4 and scanned with PET and contrast-enhanced computed tomography (CT) followed by digital autoradiography and histology of left ventricle tissue sections. 68Ga-NODAGA-exendin-4 PET/CT showed focally increased tracer uptake in the infarcted regions peaking at 3 days and continuing at 1 week after MI. Pre-treatment with an unlabeled exendin-4 peptide significantly reduced 68Ga-NODAGA-exendin-4 uptake. By autoradiography, 68Ga-NODAGA-exendin-4 uptake was 8.6-fold higher in the infarcted region and slightly increased also in the remote, non-infarcted myocardium at 1 week and 12 weeks post-MI compared with sham. Uptake of 68Ga-NODAGA-exendin-4 correlated with the amount of CD68-positive macrophages in the infarcted area and alpha-smooth muscle actin staining in the remote myocardium. Conclusions 68Ga-NODAGA-exendin-4 PET detects up-regulation of cardiac GLP-1R expression during healing of MI in rats and may provide information on the activated repair mechanisms after ischemic myocardial injury.

scholarly journals Recurrent leiomyoma of the vulva mimicking peripheral nerve sheath tumour

2019 ◽  
Vol 12 (12) ◽  
pp. e232065
Author(s):  
Keerthana Kothandaraman ◽  
Gowri Dorairajan ◽  
Murali Subbaiah ◽  
LN Dorairajan ◽  
Bhawana A Badhe ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Postmenopausal Woman ◽  
Peripheral Nerve ◽  
Smooth Muscle Actin ◽  
Muscle Actin ◽  
Soft Tissue Tumours ◽  
Nerve Sheath Tumour ◽  
Nerve Sheath ◽  
Wedge Biopsy ◽  
Peripheral Nerve Sheath Tumour

Leiomyoma, a benign monoclonal tumour, is very rarely found in extrauterine sites, especially in the vulval region. Histopathology of the soft tissue tumours affecting this region is similar and immunohistochemistry (IHC) may be essential to confirm the diagnosis. We report a case of a 63-year-old postmenopausal woman who presented with a recurrent vulval mass involving the clitoris and left labia majora with suspected urethral involvement. Although the wedge biopsy was reported as peripheral nerve sheath tumour, staining with smooth muscle actin clinched the diagnosis of leiomyoma, highlighting the importance of IHC for diagnosis.

Leiomyomatous hamartoma of the incisive papilla

2002 ◽  
Vol 25 (2) ◽  
pp. 157-159 ◽  
Author(s):  
Luciana Corrêa ◽  
Mônica Lotufo ◽  
Marília Trierveiler Martins ◽  
Norberto Sugaya ◽  
Suzana Cantanhede Orsini Machado de Sousa
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Immunohistochemical Staining ◽  
Smooth Muscle Actin ◽  
Muscle Cells ◽  
Histological Diagnosis ◽  
Muscle Actin ◽  
Histological Findings ◽  
Spindle Cells ◽  
Congenital Epulis

A case of unusual hamartoma in a six-year-old otherwise healthy Brazilian girl is reported, with emphasis on histological and immunohistochemical features. A mass observed in the incisive papilla was detected whose appearance was similar to congenital epulis or fibroma. Histological findings showed interlacing fascicles of large spindle cells resembling smooth muscle cells. Immunohistochemical staining for desmin and for smooth-muscle actin was positive. The histological diagnosis was leiomyomatous hamartoma, based on clinical and microscopic observations.

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