The effects of transoral surgery for the recurrent hypopharyngeal cancer after radiation therapy with cetuximab

Toukeibu Gan ◽  
2017 ◽  
Vol 43 (1) ◽  
pp. 28-32
Author(s):  
Fuminori Nomura ◽  
Taro Sugimoto ◽  
Kenro Kawada ◽  
Takuro Sumi ◽  
Yousuke Ariizumi ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Hypopharyngeal Cancer ◽  
Transoral Surgery

Phase II Randomized Trial of Transoral Surgery and Low-Dose Intensity Modulated Radiation Therapy in Resectable p16+ Locally Advanced Oropharynx Cancer: An ECOG-ACRIN Cancer Research Group Trial (E3311)

2021 ◽  
Author(s):  
Robert L. Ferris ◽  
Yael Flamand ◽  
Gregory S. Weinstein ◽  
Shuli Li ◽  
Harry Quon ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Cancer Therapy ◽  
Randomized Trial ◽  
Functional Assessment ◽  
Oncologic Outcome ◽  
Progression Free Survival ◽  
Transoral Surgery ◽  
Intermediate Risk ◽  
Free Survival ◽  
Oropharynx Cancer

PURPOSE Definitive or postoperative chemoradiation (CRT) is curative for human papillomavirus–associated (HPV+) oropharynx cancer (OPC) but induces significant toxicity. As a deintensification strategy, we studied primary transoral surgery (TOS) and reduced postoperative radiation therapy (RT) in intermediate-risk HPV+ OPC. METHODS E3311 is a phase II randomized trial of reduced- or standard-dose postoperative RT for resected stage III-IVa (American Joint Committee on Cancer-seventh edition) HPV+ OPC, determined by pathologic parameters. Primary goals were feasibility of prospective multi-institutional study of TOS for HPV+ OPC, and oncologic efficacy (2-year progression-free survival) of TOS and adjuvant therapy in intermediate-risk patients after resection. TOS plus 50 Gy was considered promising if the lower limit of the exact 90% binomial confidence intervals exceeded 85%. Quality of life and swallowing were measured by functional assessment of cancer therapy-head and neck and MD Anderson Dysphagia Index. RESULTS Credentialed surgeons performed TOS for 495 patients. Eligible and treated patients were assigned as follows: arm A (low risk, n = 38) enrolled 11%, intermediate risk arms B (50 Gy, n = 100) or C (60 Gy, n = 108) randomly allocated 58%, and arm D (high risk, n = 113) enrolled 31%. With a median 35.2-month follow-up for 359 evaluable (eligible and treated) patients, 2-year progression-free survival Kaplan-Meier estimate is 96.9% (90% CI, 91.9 to 100) for arm A (observation), 94.9% (90% CI, 91.3 to 98.6]) for arm B (50 Gy), 96.0% (90% CI, 92.8 to 99.3) for arm C (60 Gy), and 90.7% (90% CI, 86.2 to 95.4) for arm D (66 Gy plus weekly cisplatin). Treatment arm distribution and oncologic outcome for ineligible or step 2 untreated patients (n = 136) mirrored the 359 evaluable patients. Exploratory comparison of functional assessment of cancer therapy-head and neck total scores between arms B and C is presented. CONCLUSION Primary TOS and reduced postoperative RT result in outstanding oncologic outcome and favorable functional outcomes in intermediate-risk HPV+ OPC.

scholarly journals Factors predicting suitability of organ preservation with radiation therapy in laryngeal and hypopharyngeal cancer

2014 ◽  
Vol 4 (4) ◽  
Author(s):  
Parul Barry ◽  
Adrianna L. Henson ◽  
Nicole E. Goodwin ◽  
Elizabeth Cash ◽  
Megan A. Mezera ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Organ Preservation ◽  
Hypopharyngeal Cancer

scholarly journals A prospective clinical trial of the second‐look procedure for transoral surgery in patients with T1 and T2 laryngeal, oropharyngeal, and hypopharyngeal cancer

2019 ◽  
Vol 8 (17) ◽  
pp. 7197-7206 ◽  
Author(s):  
Goshi Nishimura ◽  
Daisuke Sano ◽  
Yasuhiro Arai ◽  
Takashi Hatano ◽  
Hideaki Takahashi ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Hypopharyngeal Cancer ◽  
Prospective Clinical Trial ◽  
Transoral Surgery ◽  
Second Look ◽  
T1 And T2

Radiation Therapy for Early Hypopharyngeal Cancer

2007 ◽  
Vol 69 (3) ◽  
pp. S447-S448
Author(s):  
H. Nishimura ◽  
R. Sasaki ◽  
Y. Okamoto ◽  
Y. Ota ◽  
K. Yoshida ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Hypopharyngeal Cancer

scholarly journals Oncological and Functional Evaluation of Open Conservation Surgery for Hypopharyngeal Cancer with/without Reconstruction

2018 ◽  
Vol 2018 ◽  
pp. 1-6
Author(s):  
Tsutomu Nomura ◽  
Daisuke Maki ◽  
Sadahiro Kishishita ◽  
Fumihiko Matsumoto ◽  
Seiichi Yoshimoto
Keyword(s):  
Survival Rates ◽  
Oral Intake ◽  
Functional Results ◽  
Hypopharyngeal Cancer ◽  
Transoral Surgery ◽  
Functional Evaluation ◽  
Kaplan Meier ◽  
Conservation Surgery ◽  
Group A ◽  
Group B

Objectives. Oncological and functional results of open conservation surgery for hypopharyngeal cancer have been desired. Methods. We performed a chart review of 33 patients with hypopharyngeal cancer who underwent open conservation surgery. Oncological and functional results were evaluated in surgery with primary closure (Group A) and surgery with reconstruction (Group B). Postoperative functions were evaluated by interval to resumption of oral intake, Functional Outcome Swallowing Scale (FOSS) and Communication Scale (CS). Results. Five-year disease-specific and overall cumulative survival rates by Kaplan-Meier method for all cases were 95.7% and 82.3%, respectively. Duration from surgery to full oral intake was 12 days in Group A and 14 days in Group B. FOSS rates were 83.3 in Group A and 95.5 in Group B. CS was 0 in both groups. Conclusion. Oncological and functional results of open conservation surgery were comparable to those with transoral surgery and chemo/radiotherapy. Our technique represents a reliable treatment for hypopharyngeal cancer.

Retrospective analysis of platinum-based concurrent chemoradiotherapy using 3D conformal radiation therapy for hypopharyngeal cancer

Toukeibu Gan ◽  
2018 ◽  
Vol 44 (1) ◽  
pp. 32-38
Author(s):  
Itsuko Serizawa ◽  
Takashi Toshiyasu ◽  
Yasuko Kumai ◽  
Kenji Nakano ◽  
Akira Seto ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Retrospective Analysis ◽  
Concurrent Chemoradiotherapy ◽  
Hypopharyngeal Cancer ◽  
Conformal Radiation Therapy ◽  
3D Conformal Radiation Therapy
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