scholarly journals Biomarkers of endometriosis: How far have we come and where are we going?

2021 ◽  
pp. 1-10
Author(s):  
Vid Janša ◽  
Joško Osredkar ◽  
Eda Vrtačnik Bokal ◽  
Tea Lanišnik Rižner ◽  
Helena Ban Frangež
Keyword(s):  
Quality Of Life ◽  
Biomarker Discovery ◽  
Uterine Cavity ◽  
Final Diagnosis ◽  
Non Invasive ◽  
Research Priority ◽  
Diagnostic Characteristics ◽  
Diagnostic Approaches ◽  
Gynaecological Disease

Endometriosis is a common gynaecological disease that is characterized by endometrium-like tissue outside the uterine cavity. Endometriosis significantly compromises the quality of life of women and is a major cause of infertility. The gold standard for diagnosis of endometriosis is visual inspection by laparoscopy, which significantly prolongs the time to final diagnosis. This lack of non-invasive diagnostic approaches is why the discovery of biomarkers for endometriosis has been defined as a research priority. In this report, we describe hypothesis-driven and hypothesis-generating approaches for biomarker discovery, along with some important potential biomarkers of endometriosis and their diagnostic characteristics, sensitivities, and specificities. Finally, we present our perspective on the discovery of biomarkers for endometriosis, and discuss some results from our previous and more recent studies. Future studies must focus on improving patient quality of life rather than on discovering significant differences, and therefore close collaboration between clinicians and pre-clinical researchers is essential.

scholarly journals FEATURES OF BRONCHIAL ASTHMA CONTROL AND COURSE IN CHILDREN WITH AN ALTERNATIVE ONSET OF THE DISEASE

2020 ◽  
Vol 8 (4) ◽  
pp. 383-392
Author(s):  
О.К. Koloskova ◽  
Т.М. Bilous ◽  
N.O. Shevchenko ◽  
V.V. Bilous
Keyword(s):  
Quality Of Life ◽  
Respiratory Tract ◽  
Medical Care ◽  
Asthma Control ◽  
Bronchial Asthma ◽  
Diagnostic Procedures ◽  
Individualized Treatment ◽  
Economic Losses ◽  
Non Invasive

Despite the large number of studies on the diagnosis and treatment of asthma and the constant updating of recommendations for the provision of medical care to patients with asthma, this disease still has a significant impact on the quality of life of patients and their families and significant economic losses. However, the peculiarities of bronchial asthma and the diagnosis of certain phenotypes of the disease in children, depending on biomarkers of inflammatory activity in the airways, require greater use of non-invasive diagnostic procedures and optimization of individualized treatment depending on the nature and intensity of inflammation in the respiratory tract.

scholarly journals Assessment of Myocardial Viability: A Review of Current Non Invasive Imaging Techniques

2015 ◽  
Vol 1 (3) ◽  
pp. 113 ◽  
Author(s):  
Ahmed Talib
Keyword(s):  
Quality Of Life ◽  
Coronary Artery Disease ◽  
Ventricular Dysfunction ◽  
Imaging Techniques ◽  
Left Ventricular ◽  
Common Cause ◽  
Non Invasive ◽  
Artery Disease ◽  
Impaired Quality

Coronary artery disease (CAD) is the most prevalent and<br />single most common cause of morbidity and mortality1 with<br />the resulting left ventricular dysfunction (LVD) an important<br />complication2. Worldwide, CAD accounts for 5.7 million new<br />cases per year, of these 1.3 million in Europe alone3. In addition,<br />it imposes a substantial share of health service resources and<br />expenses, an impaired quality of life, disability and high social<br />cost3,4. Furthermore, LVD itself has been shown to be a powerful<br />determinant of survival2, 5.

scholarly journals Features of Measuring the Subjective Quality of Life in Different Diagnostic Approaches

2020 ◽  
Vol 13 (3) ◽  
pp. 169-179
Author(s):  
G.M. Golovina ◽  
T.N. Savchenko
Keyword(s):  
Quality Of Life ◽  
Physical Health ◽  
Personal Growth ◽  
Theoretical Basis ◽  
Subjective Quality ◽  
Cognitive Factor ◽  
Subjective Quality Of Life ◽  
Valid Instrument ◽  
Diagnostic Approaches

In this paper, the measurements of the subjective quality of life were correlated in different diagnostic approaches, for which the correspondence of the subjective quality of life was measured by means of the SQL scale methodology (Savchenko, Golovina, 2007) and the SCLL questionnaire (Eksakusto, Zaichenko, 2012). The study of the correlation of concepts and scales of two methods having a common theoretical basis, but a different kind of presentation of the points of the techniques, is carried out. It turned out that the similarly or identically named scales and concepts (values) in the two questionnaires significantly correlated. A comparison of the reconstructed factor structures showed the correspondence between the factors of the SQL and the SQL. Both methods allowed to speak about the factor of “emotional and physical health”, the cognitive factor or the factor of “personal growth” and the factor of “famely”, which indicates the compliance of measuring the subjective quality of life and satisfaction with it in both methods, and accordingly, the possibility of using a compact questionnaire as a valid instrument.

PERSONIFIED MONITORING OF ACUTE CORONARY SYNDROME AND ITS OUTCOMES IN ELDERLY PATIENTS. ANGINA. HEART FAILURE (OVERVIEW)

2020 ◽  
pp. 92-98
Author(s):  
А. С. Пушкин
Keyword(s):  
Quality Of Life ◽  
Heart Failure ◽  
Acute Coronary Syndrome ◽  
Risk Stratification ◽  
Diagnostic Tests ◽  
Diagnostic Process ◽  
Coronary Syndrome ◽  
Non Invasive ◽  
Patients With Heart Failure

В обзорной статье собраны современные представления об особенностях диагностики и мониторинга пациентов пожилого и старческого возраста с сердечной недостаточностью и стенокардией. Особое внимание уделено проблеме коморбидности пациентов старше 65 лет, что требует корректирующих действий при стратификации риска и прогнозировании клинических исходов. Отмечена приоритетность неинвазивных диагностических тестов. Рекомендована оценка хрупкости как неотъемлемой части диагностического процесса пациентов с сердечной недостаточностью и стенокардией ввиду чёткой связи с худшим прогнозом с точки зрения качества жизни, госпитализации и смертности. Review is about current information on the features of heart failure and angina diagnosis and monitoring in elderly and senile patients. One of the main problem in patients over 65 years is comorbidity, which requires corrective action in the risk stratification and prediction of clinical outcomes. The priority of non-invasive diagnostic tests is noted. Authors of the article recommend frailty as an obligatory part of diagnostic process in patients with heart failure and angina due to a clear connection with the worst prognosis in terms of quality of life, hospitalization and mortality.

Detailed needs assessment

2018 ◽  
Author(s):  
Traolach S. Brugha
Keyword(s):  
Quality Of Life ◽  
Risk Management ◽  
Multidisciplinary Approach ◽  
Management Plan ◽  
Language Therapy ◽  
Speech And Language Therapy ◽  
Randomized Controlled ◽  
Controlled Treatment ◽  
Diagnostic Approaches

Patients with more complex presentations that include autism may require more detailed assessments involving a multidisciplinary approach. This chapter covers a range of measures that are used in clinical practice and in randomized controlled treatment trials in adults, which add more detailed information. These may be helpful in planning for the interventions described in subsequent chapters. Advanced diagnostic approaches will be considered, which call upon neuropsychology, speech and language therapy, social work, occupational therapy, and the use of quality of life approaches. More detailed assessments should consider an assessment of risk to self and others sufficient to develop a risk management plan where appropriate.

scholarly journals Refractory angina is a growing challenge for palliative medicine: a systematic review of non-invasive interventions

2020 ◽  
pp. bmjspcare-2020-002202
Author(s):  
Iain Murphy ◽  
Akshara Sivashankar ◽  
Amy Gadoud
Keyword(s):  
Quality Of Life ◽  
Adverse Effects ◽  
Literature Search ◽  
Grey Literature ◽  
Refractory Angina ◽  
Positive Effects ◽  
Non Invasive ◽  
European Society Of Cardiology ◽  
Current Guidelines

BackgroundRefractory angina can have a significant effect on quality of life. Non-invasive interventions have been suggested but there are few guidelines on management. Our aim was to systematically review all studies that reported non-invasive interventions for refractory angina and report on their effectiveness and safety.MethodsWe performed a literature search of six databases and a grey literature search. Treatments considered first line or second line according to the European Society of Cardiology were excluded, as were interventions that had undergone review within the last 3 years. Design, setting and outcomes were extracted and quality was assessed. A narrative synthesis was undertaken, including an analysis of adverse effects.Results4476 studies were screened, 14 studies were included in our analysis. Interventions were specialist multidisciplinary programmes, transcutaneous electrical nerve stimulation (TENS), perhexiline, medical optimisation, morphine and intranasal alfentanil. The effects of specialist programmes and perhexiline treatment were mixed. Positive effects were reported with TENS, opioids and medical optimisation, with improvements in symptoms, exercise capacity and quality of life. No major adverse effects were noted in any of the treatments.ConclusionThere are non-invasive treatments for refractory angina that are overlooked by current guidelines. While the quality of these studies varies, positive changes have been reported in symptoms, exercise tolerance and quality of life with few adverse effects. There is a need for further research into these treatments which could be useful within the contexts of cardiology and palliative care.

Non-invasive vagus nerve stimulation significantly improves quality of life in patients with persistent postural-perceptual dizziness

2018 ◽  
Vol 265 (S1) ◽  
pp. 63-69 ◽  
Author(s):  
Ozan E. Eren ◽  
Filipp Filippopulos ◽  
Kristina Sönmez ◽  
Ken Möhwald ◽  
Andreas Straube ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Non Invasive
Sign in / Sign up

Export Citation Format

Share Document