scholarly journals Does early acne intervention provide more than just a reduction in the incidence of scars? A review of the literature

2021 ◽  
Vol 12 (4) ◽  
pp. 402-405
Author(s):  
Ayesha Vos
Keyword(s):  
Early Intervention ◽  
Cost Benefit ◽  
Cochrane Library ◽  
Published Data ◽  
Review Of The Literature ◽  
Primary Research ◽  
Acne Scars ◽  
Acne Treatment ◽  
The Cochrane Library ◽  
Relapse Rates

Background: It is well established that early intervention in acne treatment reduces the incidence of scars. The purpose of this paper was to identify if early intervention in acne management also provides a cost benefit to the patient, reduces relapse rates or lessens the requirement for the treatment of acne scars. Method: A systematic search of The Cochrane Library, MEDLINE and Cumulative Index to Nursing and Allied Health Literature (CINAHL) was performed independently by one reviewer using predefined criteria. Results: Seven articles were identified from the literature – one systematic review, one review article and five expert opinion articles. Although data supports early intervention in acne management, no articles identified whether a cost benefit was also provided, if there was a reduction in the relapse rates or if there was a decreased requirement for the treatment of acne scars. Conclusions: This review identifies an overall lack of published data regarding multiple outcomes for early intervention in acne and allows for the possible identification of areas where primary research would be beneficial.

scholarly journals Better survival of patients with oligo- compared with polymetastatic cancers:  a systematic review and meta-analysis of 173 studies

F1000Research ◽  
2021 ◽  
Vol 10 ◽  
pp. 423
Author(s):  
Fausto Petrelli ◽  
Antonio Ghidini ◽  
Michele Ghidini ◽  
Roberta Bukovec ◽  
Francesca Trevisan ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Stage Iv ◽  
Progression Free Survival ◽  
Hazard Ratio ◽  
Modern Concept ◽  
Cochrane Library ◽  
Published Data ◽  
Risk Of Death ◽  
Personalized Approach ◽  
The Cochrane Library

Background: The modern concept of oligometastatic (OM) state has been initially developed to describe patients with a low burden of disease and with a potential for cure with local ablative treatments. We systematically assessed the risk of death and relapse of oligometastatic (OM) cancers compared to cancers with more diffuse metastatic spread, through a meta-analysis of published data.  Methods: PubMed, the Cochrane Library, and EMBASE were searched for studies reporting prognosis of patients with OM solid tumors. Risk of death and relapse were extracted and pooled to provide an adjusted hazard ratio with a 95% confidence interval (HR 95%CI).  The primary outcome of the study refers to overall mortality in OM vs. polymetastatic (PM) patients.  Results. Mortality and relapse associated with OM state in patients with cancer were evaluated among 104,234 participants (n=173 studies). Progression-free survival was better in patients with OM disease (hazard ratio [HR] = 0.62, 95% CI 0.57–0.68; P <.001; n=69 studies). Also, OM cancers were associated with a better overall survival (OS) (HR = 0.65, 95% CI 0.62-0.68; P<.01; n=161 studies). In colorectal (CRC), breast, non-small cell lung cancer (NSCLC) and renal cell carcinoma (RCC) the reduction in the risk of death for OM patients were 35, 38, 30 and 42%, respectively. Biliary tract and cervical cancer do not significantly better in OM stage likely for paucity of data. Conclusions. Patients with OM cancers have a significantly better prognosis than those with more widespread stage IV tumors. In OM cancer patients a personalized approach should be pursued.

scholarly journals A Systematic Review of the Literature on Early Vocalizations and Babbling Patterns in Young Children

2018 ◽  
Vol 40 (1) ◽  
pp. 3-14 ◽  
Author(s):  
Lydia Morgan ◽  
Yvonne E. Wren
Keyword(s):  
Systematic Review ◽  
Case Series ◽  
Speech Development ◽  
Cochrane Library ◽  
Bibliographic Databases ◽  
Review Of The Literature ◽  
Phonological Acquisition ◽  
Future Studies ◽  
The Cochrane Library ◽  
Children's Speech

Children’s speech development begins in infancy. The pattern of this development has been explored in studies over a number of years using a range of research methodology and approaches to investigation. A systematic review of the existing literature was carried out to determine the collective contribution of this literature to our understanding of early vocalizations and babbling through the period 9 to 18 months. Eight bibliographic databases were searched as well as the Cochrane library. Thirteen studies were identified for inclusion, which were mostly longitudinal observational case series. The review identified progressive increases in the complexity and volume of infants’ early vocalizations through the period. It also found a broad order of phonological acquisition. Although the studies in this review demonstrated marked individual variation, the review provides indicative patterns of development which can be used as a basis to explore relationships with later speech development in future studies.

A Systematic Review: Dexmedetomidine Versus Placebo to Decrease the Incidence of Emergence Delirium/Emergence Agitation (ED/EA) in Pediatric Patients

2008 ◽  
Vol 1 (2) ◽  
pp. 89-94
Author(s):  
William M. Enlow ◽  
Laura L. Ardizzone
Keyword(s):  
Systematic Review ◽  
Hospital Costs ◽  
Cost Benefit ◽  
Cochrane Library ◽  
Primary Study ◽  
Emergence Agitation ◽  
Emergence Delirium ◽  
Comprehensive Search ◽  
Randomized Control ◽  
The Cochrane Library

Background: Emergence delirium/emergence agitation (ED/EA) has a reported incidence of up to 73% after general anesthesia (GA) in children. The implications of ED/EA are broad and include patient complications, increased nursing care intensity, and increased hospital costs. Objective: The objective of this systematic review is to appraise available randomized control trials (RCTs) comparing intravenous dexmedetomidine to placebo in decreasing the incidence of ED/EA among children after GA. Method: We conducted a comprehensive search of the literature using Medline from 1950 through September 2007 and CINHAL from 1982 through September 2007, as well as PubMed and The Cochrane Library. Four RCTs were included in the review and were appraised for methodological quality by each author. Results: Evaluation of the primary study outcomes showed an overall decreased incidence of ED/EA in those groups that received dexmedetomidine versus placebo. Conclusion: Though these RCTs demonstrate statistically significant reduction of ED/EA after GA among children who receive dexmedetomidine, the clinical significance of this pharmacologic intervention is not clear. Further research is necessary to determine cost–benefit of dexmedetomidine to prevent ED/EA in children after GA and the effect of dexmedetomidine on ED/EA compared to other agents.

scholarly journals The effectiveness of surgical procedures to prevent post-hysterectomy pelvic organ prolapse: a systematic review of the literature

2020 ◽  
Author(s):  
Greta Lisa Carlin ◽  
Barbara Bodner-Adler ◽  
Heinrich Husslein ◽  
Magdalena Ritter ◽  
Wolfgang Umek
Keyword(s):  
Systematic Review ◽  
Pelvic Organ Prolapse ◽  
Surgical Procedures ◽  
Surgical Procedure ◽  
De Novo ◽  
Pelvic Organ ◽  
Complete Analysis ◽  
Cochrane Library ◽  
Published Data ◽  
Review Of The Literature

Abstract Introduction and hypothesis Hysterectomy is one of the most commonly performed gynecological surgical procedures. One of the long-term risks associated with hysterectomy is the occurrence of pelvic organ prolapse (POP). To prevent post-hysterectomy POP, several suspension procedures are routinely performed at the time of hysterectomy. We performed a systematic review of published data in order to define the most effective surgical procedures for the prevention of post-hysterectomy POP. Methods We performed a systematic review of the literature by searching PubMed, the Cochrane Library, EMBASE, Ovid MEDLINE, and clinicaltrials.gov up to 24 May 2020. The search strategy included the keywords hysterectomy, post-hysterectomy, prolapse, colposuspension, culdoplasty, McCall, and combinations thereof. The inclusion criterion was a surgical procedure at the time of hysterectomy to prevent de novo POP. The outcome was incidence of post-hysterectomy POP. Results Six out of 553 retrieved studies met the methodological criteria for complete analysis. In this review, 719 women aged over 18 years were included. Only 2 studies were designed as prospective trials; however, only 1 compared women undergoing a procedure at the time of hysterectomy with controls. The prevalence of post-hysterectomy prolapse varied from 0% to 39%. Conclusion A systematic review of published literature suggests that performing variations of McCall culdoplasty at the time of hysterectomy might be the most effective prophylactic surgical procedure for preventing post-hysterectomy pelvic organ prolapse.

scholarly journals The Best Anticoagulation Strategy for Cirrhotic Patients who Underwent Splenectomy: A Network Meta-Analysis

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Cheng Gong ◽  
Xian Qin ◽  
Jian Yang ◽  
Tao Guo
Keyword(s):  
Antithrombin Iii ◽  
Meta Analysis ◽  
Therapeutic Strategies ◽  
Cochrane Library ◽  
Cumulative Probability ◽  
Review Of The Literature ◽  
Good Convergence ◽  
First Choice ◽  
Cirrhotic Patients ◽  
The Cochrane Library

Objective. To determine the best anticoagulation strategy for the patients who underwent splenectomy with cirrhosis through network meta-analysis. Methods. We conducted a systematic review of the literature in PubMed, Embase, and the Cochrane Library database. We extracted data on incidence of Portal vein system thrombosis (PVST) from studies that compared various anticoagulation strategies for use with patients who underwent splenectomy with cirrhosis. Network meta-analysis was conducted in ADDIS by evaluating the different incidence of PVST. Consistency and inconsistency models were developed to identify differences among the therapeutic strategies. Cumulative probability was utilized to rank the strategies under examination. Results. A total of 11 studies containing 1153 patients were included in the network meta-analysis. The results revealed that the application of Antithrombin III was the best anticoagulation option for patients who underwent splenectomy with cirrhosis (P=0.59). The data of consistency and inconsistency models exhibited basically consistent and showed good convergence. Conclusions. Application of Antithrombin III seemed to be the best anticoagulation strategy for cirrhotic patients who underwent splenectomy and should be considered a first-choice clinical reference.

scholarly journals Chemotherapy-induced peripheral neuropathies: an integrative review of the literature

2015 ◽  
Vol 49 (2) ◽  
pp. 0335-0345 ◽  
Author(s):  
Talita Cassanta Costa ◽  
Miriam Lopes ◽  
Anna Cláudia Yokoyama dos Anjos ◽  
Marcia Maria Fontão Zago
Keyword(s):  
Latin American ◽  
Health Sciences ◽  
Integrative Review ◽  
Cochrane Library ◽  
Peripheral Neuropathies ◽  
Review Of The Literature ◽  
Electronic Library ◽  
The Cochrane Library ◽  
Chemotherapy Agents ◽  
Positive Results

OBJECTIVE: To identify scientific studies and to deepen the knowledge of peripheral neuropathies induced by chemotherapy antineoplastic, seeking evidence for assistance to cancer patients. METHOD: Integrative review of the literature conducted in the databases Latin American and Caribbean Health Sciences (LILACS), Scientific Electronic Library Online (SciELO), Medical Literature Analysis (PubMed/MEDLINE), the Cochrane Library and the Spanish Bibliographic Index Health Sciences (IBECS). RESULTS: The sample consisted of 15 studies published between 2005-2014 that met the inclusion criteria. Studies showed aspects related to advanced age, main symptoms of neuropathy and chemotherapy agents as important adverse effect of neuropathy. CONCLUSION: We identified a small number of studies that addressed the topic, as well as low production of evidence related to interventions with positive results. It is considered important to develop new studies proposed for the prevention and/or treatment, enabling adjustment of the patient's cancer chemotherapy and consequently better service.

scholarly journals Better survival of patients with oligo- compared with polymetastatic cancers:  a systematic review and meta-analysis of 173 studies

F1000Research ◽  
2021 ◽  
Vol 10 ◽  
pp. 423
Author(s):  
Fausto Petrelli ◽  
Antonio Ghidini ◽  
Michele Ghidini ◽  
Roberta Bukovec ◽  
Francesca Trevisan ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Stage Iv ◽  
Progression Free Survival ◽  
Hazard Ratio ◽  
Modern Concept ◽  
Cochrane Library ◽  
Published Data ◽  
Risk Of Death ◽  
Personalized Approach ◽  
The Cochrane Library

Background: The modern concept of oligometastatic (OM) state has been initially developed to describe patients with a low burden of disease and with a potential for cure with local ablative treatments. We systematically assessed the risk of death and relapse of oligometastatic (OM) cancers compared to cancers with more diffuse metastatic spread, through a meta-analysis of published data.  Methods: PubMed, the Cochrane Library, and EMBASE were searched for studies reporting prognosis of patients with OM solid tumors. Risk of death and relapse were extracted and pooled to provide an adjusted hazard ratio with a 95% confidence interval (HR 95%CI).  The primary outcome of the study refers to overall mortality in OM vs. polymetastatic (PM) patients.  Results. Mortality and relapse associated with OM state in patients with cancer were evaluated among 104,234 participants (n=173 studies). Progression-free survival was better in patients with OM disease (hazard ratio [HR] = 0.62, 95% CI 0.57–0.68; P <.001; n=69 studies). Also, OM cancers were associated with a better overall survival (OS) (HR = 0.65, 95% CI 0.62-0.68; P<.01; n=161 studies). In colorectal (CRC), breast, non-small cell lung cancer (NSCLC) and renal cell carcinoma (RCC) the reduction in the risk of death for OM patients were 35, 38, 30 and 42%, respectively. Biliary tract and cervical cancer do not significantly better in OM stage likely for paucity of data. Conclusions. Patients with oligometastases have a significantly better prognosis than those with more widespread stage IV tumors. In OM cancer patients a personalized approach should be pursued.

scholarly journals Real-time Inferential Analytics Based on Online Databases of Trends: A Breakthrough Within the Discipline of Digital Epidemiology of Dentistry and Oral-Maxillofacial Surgery

2019 ◽  
Vol 13 (2) ◽  
pp. 81 ◽  
Author(s):  
Ahmed Al-Imam ◽  
Usama Khalid ◽  
Nawfal Al-Hadithi ◽  
Dawoude Kaouche
Keyword(s):  
Statistical Analysis ◽  
Statistical Inference ◽  
Real Time ◽  
Machine Learning Algorithms ◽  
Google Trends ◽  
Cochrane Library ◽  
Review Of The Literature ◽  
Dental Anatomy ◽  
Digital Epidemiology ◽  
The Cochrane Library

Background: Epidemiological sciences have been evolving at an exponential rate paralleled only by the comparable growth within the discipline of data science. Digital epidemiological studies are playing a vital role in medical science analytics for the past few decades. To date, there are no published attempts at deploying the use of real-time analytics in connection with the disciplines of Dentistry or Medicine. Aims and Objectives: We deployed a real-time statistical analysis in connection with topics in Dental Anatomy and Dental Pathology represented by the maxillary sinus, posterior maxillary teeth, related oral pathology. The purpose is to infer the digital epidemiology based on a continuous stream of raw data retrieved from Google Trends database. Materials and Methods: Statistical analysis was carried out via Microsoft Excel 2016 and SPSS version 24. Google Trends database was used to retrieve data for digital epidemiology. Real-time analysis and the statistical inference were based on encoding a programming script using Python high-level programming language. A systematic review of the literature was carried out via PubMed-NCBI, the Cochrane Library, and Elsevier databases. Results: The comprehensive review of the literature, based on specific keywords search, yielded 491813 published studies. These were distributed as 488884 (PubMed-NCBI), 1611 (the Cochrane Library), and 1318 (Elsevier). However, there was no single study attempting real-time analytics. Nevertheless, we succeeded in achieving an automated real-time stream of data accompanied by a statistical inference based on data extrapolated from Google Trends. Conclusion: Real-time analytics are of considerable impact when implemented in biological and life sciences as they will tremendously reduce the required resources for research. Predictive analytics, based on artificial neural networks and machine learning algorithms, can be the next step to be deployed in continuation of the real-time systems to prognosticate changes in the temporal trends and the digital epidemiology of phenomena of interest.

scholarly journals Better survival of patients with oligo- compared with polymetastatic cancers:  a systematic review and meta-analysis of 173 studies

F1000Research ◽  
2021 ◽  
Vol 10 ◽  
pp. 423
Author(s):  
Fausto Petrelli ◽  
Antonio Ghidini ◽  
Michele Ghidini ◽  
Roberta Bukovec ◽  
Francesca Trevisan ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Stage Iv ◽  
Progression Free Survival ◽  
Hazard Ratio ◽  
Modern Concept ◽  
Cochrane Library ◽  
Published Data ◽  
Patients With Cancer ◽  
Risk Of Death ◽  
The Cochrane Library

Background: The modern concept of oligometastatic (OM) state has been initially developed to describe patients with a low burden of disease and with a potential for cure with local ablative treatments. We systematically assessed the risk of death and relapse of oligometastatic (OM) cancers compared to cancers with more diffuse metastatic spread, through a meta-analysis of published data.  Methods: PubMed, the Cochrane Library, and EMBASE were searched for studies reporting prognosis of patients with OM solid tumors. Risk of death and relapse were extracted and pooled to provide an adjusted hazard ratio with a 95% confidence interval (HR 95%CI).  The primary outcome of the study refers to overall mortality in OM vs. polymetastatic (PM) patients.  Results. Mortality and relapse associated with OM state in patients with cancer were evaluated among 104,234 participants (n=173 studies). Progression-free survival was better in patients with OM disease (hazard ratio [HR] = 0.62, 95% CI 0.57–0.68; P <.001; n=69 studies). Also, OM cancers were associated with a better OS (HR = 0.65, 95% CI 0.62-0.68; P<.01; n=161 studies). In colorectal (CRC), breast, non-small cell lung cancer (NSCLC) and renal cell carcinoma (RCC) the reduction in the risk of death for OM patients were 35, 38, 30 and 42%, respectively.  Conclusions. Patients with oligometastases have a significantly better prognosis than those with more widespread stage IV tumors. We suggest that a treatment strategy that involves bot the primary and the metastases should be identified at the time of diagnosis.

Infantile hemangioma: current classification, clinical picture and effective methods of therapy

2016 ◽  
Vol 19 (3) ◽  
pp. 178-183
Author(s):  
Oleg V. Sheptiy ◽  
L. S Kruglova
Keyword(s):  
Topical Therapy ◽  
Infantile Hemangioma ◽  
Cochrane Library ◽  
Functional Disorders ◽  
Review Of The Literature ◽  
Current Classification ◽  
Phases Of Development ◽  
Spontaneous Involution ◽  
Β Blockers ◽  
The Cochrane Library

Review of the literature devoted to one of the most common tumors of childhood - hemangioma is presented. Literature search was performed using the NCBI, including PubMed, PubMed Health, and The Cochrane Library databases. Infantile hemangioma is a neoplastic proliferation of endothelial cells, which is characterized by different phases of development: proliferation and spontaneous involution. The types of infantile hemangiomas, variants of the course and possible complications such as ulceration, functional disorders, and the formation of cosmetic defects are described. Incidence associated with infantile hemangioma syndrome is presented. The current views on the pathogenesis of infantile hemangiomas are described. Information about the best methods of diagnostic imaging, as well as medical and surgical therapies, including systemic and topical therapy with β-blockers, corticosteroids and use of lasers are described.

Sign in / Sign up

Export Citation Format

Share Document