scholarly journals Commercial utilities and future perspective of nanomedicines

PeerJ ◽  
2021 ◽  
Vol 9 ◽  
pp. e12392
Author(s):  
Rishabha Malviya ◽  
Shivkanya Fuloria ◽  
Swati Verma ◽  
Vetriselvan Subramaniyan ◽  
Kathiresan V. Sathasivam ◽  
...  
Keyword(s):  
Health Care Professionals ◽  
Market Value ◽  
Aqueous Solubility ◽  
Future Perspective ◽  
Therapeutic Effects ◽  
Future Perspectives ◽  
High Importance ◽  
Standards And Guidelines ◽  
Pharmaceutical Production ◽  
Factual Data

The present review aims to describe the commercial utilities and future perspectives of nanomedicines. Nanomedicines are intended to increase precision medicine and decrease the adverse effects on the patient. Nanomedicines are produced, engineered, and industrialized at the cellular, chemical, and macromolecular levels. This study describes the various aspects of nanomedicine such as governing outlooks over high use of nanomedicine, regulatory advancements for nanomedicines, standards, and guidelines for nanomedicines as per Therapeutic Goods Administration (TGA). This review also focuses on the patents and clinical trials based on nanoformulation, along with nanomedicines utilization as drug therapy and their market value. The present study concludes that nanomedicines are of high importance in biomedical and pharmaceutical production and offer better therapeutic effects especially in the case of drugs that possess low aqueous solubility. The factual data presented in this study will assist the researchers and health care professionals in understanding the applications of nanomedicine for better diagnosis and effective treatment of a disease.

scholarly journals Therapeutic Role of Tocilizumab in SARS-CoV-2-Induced Cytokine Storm: Rationale and Current Evidence

2021 ◽  
Vol 22 (6) ◽  
pp. 3059
Author(s):  
Corrado Pelaia ◽  
Cecilia Calabrese ◽  
Eugenio Garofalo ◽  
Andrea Bruni ◽  
Alessandro Vatrella ◽  
...  
Keyword(s):  
Review Article ◽  
Lung Damage ◽  
Current Evidence ◽  
Therapeutic Effects ◽  
Cytokine Storm ◽  
Future Perspectives ◽  
Pathogenic Role ◽  
Refractory Rheumatoid Arthritis ◽  
Life Threatening

Among patients suffering from coronavirus disease 2019 (COVID-19) syndrome, one of the worst possible scenarios is represented by the critical lung damage caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-induced cytokine storm, responsible for a potentially very dangerous hyperinflammatory condition. Within such a context, interleukin-6 (IL-6) plays a key pathogenic role, thus being a suitable therapeutic target. Indeed, the IL-6-receptor antagonist tocilizumab, already approved for treatment of refractory rheumatoid arthritis, is often used to treat patients with severe COVID-19 symptoms and lung involvement. Therefore, the aim of this review article is to focus on the rationale of tocilizumab utilization in the SARS-CoV-2-triggered cytokine storm, as well as to discuss current evidence and future perspectives, especially with regard to ongoing trials referring to the evaluation of tocilizumab’s therapeutic effects in patients with life-threatening SARS-CoV-2 infection.

scholarly journals Migraine: Experimental Models and Novel Therapeutic Approaches

2019 ◽  
Vol 20 (12) ◽  
pp. 2932 ◽  
Author(s):  
Giuseppe Tardiolo ◽  
Placido Bramanti ◽  
Emanuela Mazzon
Keyword(s):  
Experimental Models ◽  
Brain Targeting ◽  
Future Perspective ◽  
Therapeutic Effects ◽  
Therapeutic Approaches ◽  
Pharmacological Targets ◽  
Genetic Modifications ◽  
Inflammatory Soup ◽  
Calcitonin Gene

Migraine is a disorder affecting an increasing number of subjects. Currently, this disorder is not entirely understood, and limited therapeutic solutions are available. Migraine manifests as a debilitating headache associated with an altered sensory perception that may compromise the quality of life. Animal models have been developed using chemical, physical or genetic modifications, to evoke migraine-like hallmarks for the identification of novel molecules for the treatment of migraine. In this context, experimental models based on the use of chemicals as nitroglycerin or inflammatory soup were extensively used to mimic the acute state and the chronicity of the disorder. This manuscript is aimed to provide an overview of murine models used to investigate migraine pathophysiology. Pharmacological targets as 5-HT and calcitonin gene-related peptide (CGRP) receptors were evaluated for their relevance in the development of migraine therapeutics. Drug delivery systems using nanoparticles may be helpful for the enhancement of the brain targeting and bioavailability of anti-migraine drugs as triptans. In conclusion, the progresses in migraine management have been reached with the development of emerging agonists of 5-HT receptors and novel antagonists of CGRP receptors. The nanoformulations may represent a future perspective in which already known anti-migraine drugs showed to better exert their therapeutic effects.

scholarly journals Drug Repositioning for the Treatment of Glioma: Current State and Future Perspective

2020 ◽  
Author(s):  
Sho Tamai ◽  
Nozomi Hirai ◽  
Shabierjiang Jiapaer ◽  
Takuya Furuta ◽  
Mitsutoshi Nakada
Keyword(s):  
Clinical Trials ◽  
Brain Tumors ◽  
Standard Therapy ◽  
Drug Repositioning ◽  
Chemotherapeutic Agents ◽  
Future Perspective ◽  
Future Perspectives ◽  
Current Standard ◽  
Therapeutic Drugs ◽  
Current State

Gliomas are the most common primary brain tumors. Among them, glioblastoma (GBM) possesses the most malignant phenotype. Despite the current standard therapy using an alkylating anticancer agent, temozolomide, most patients with GBM die within 2 years. Novel chemotherapeutic agents are urgently needed to improve the prognosis of GBM. One of the solutions, drug repositioning, which broadens the indications of existing drugs, has gained attention. Herein, we categorize candidate agents, which are newly identified as therapeutic drugs for malignant glioma into 10 classifications based on these original identifications. Some drugs are in clinical trials with hope. Additionally, the obstacles, which should be overcome in order to accomplish drug repositioning as an application for GBM and the future perspectives, have been discussed.

scholarly journals Probiotic-based cultivation of Clarias batrachus: importance and future perspective

2019 ◽  
Vol 62 (2) ◽  
pp. 158-168
Author(s):  
Arindam Ganguly ◽  
Amrita Banerjee ◽  
Asish Mandal ◽  
Pradeep K. Das Mohapatra
Keyword(s):  
Large Scale ◽  
Clarias Gariepinus ◽  
Clarias Batrachus ◽  
Future Perspective ◽  
Future Perspectives ◽  
Potential Threat ◽  
Natural Habitats ◽  
Economic Significance ◽  
The World ◽  
Large Scale Cultivation

Clarias batrachus (Linn.) is widely recognized in Indian sub-continent for its nutritional and economic significance. At present, it remains at a merely vulnerable state. Pathogenic infections, diminution of natural habitats and introduction of allied exotic fishes are the causes of productivity constraint, particularly in Southern Asia. Conversely, African cat fish Clarias gariepinus has been significantly identified as a potential threat to biodiversity, despite being its large scale cultivation across the world. Thus emphasis on indigenous C. batrachus farming is becoming inevitable. Currently, screening of autochthonous probiotic organisms for the cultivation of C. batrachus in semi-intensive manner is getting importance. At the same time, molecular omics-based technologies are also gaining considerable attention to identify potential probiotic markers. This review provides an overall concept of probiotics, its application and future perspectives in relation to the cultivation of C. batrachus.

scholarly journals Impact of herbal drugs and its clinical application

2019 ◽  
Vol 10 (2) ◽  
pp. 1340-1345
Author(s):  
Vetriselvan Subramaniyan ◽  
Saminathan Kayarohanam ◽  
Ashok Kumar J ◽  
Vinoth Kumarasamy
Keyword(s):  
Health Care Professionals ◽  
Herbal Medicines ◽  
Drug Formulation ◽  
Therapeutic Effects ◽  
Clinical Use ◽  
Herbal Drugs ◽  
Herbal Drug ◽  
Alternative Medicines ◽  
Ancient Times ◽  
The Impact

Since ancient times until now exploring the importance of herbal medicines to treat the variety of diseases. Currently the herbal medicines searching for health, wellness and aim to achieve effective treatment without much side effect. Recent days the impact of herbal medicines well established even herbal treatment is one of the alternative medicines for most of the diseases such as hyperlipidemia, diabetes mellitus etc. Medicinal plants always have been rich sources of bioactive compounds, and that will be very helpful to human health. The reasons for herbal medicines attracted by the health care professionals and common individuals, including concern about confidence and safety of drugs. Allopathic medicines have many side effects and sometimes failing to treat and most of the herbal drugs proven better therapeutic effects without any major adverse effects. With the demand for phytomedicine user, this review highlights modern herbal drug formulation and its clinical use.

scholarly journals Metal Oxide Nanoparticles as Biomedical Materials

Biomimetics ◽  
2020 ◽  
Vol 5 (2) ◽  
pp. 27 ◽  
Author(s):  
Maria P. Nikolova ◽  
Murthy S. Chavali
Keyword(s):  
Metal Oxide ◽  
Metal Oxide Nanoparticles ◽  
Market Value ◽  
Diagnostic Tools ◽  
Oxide Nanoparticles ◽  
Therapeutic Effects ◽  
Biomedical Materials ◽  
Tissue Therapy ◽  
Application Potential ◽  
Low Toxicity

The development of new nanomaterials with high biomedical performance and low toxicity is essential to obtain more efficient therapy and precise diagnostic tools and devices. Recently, scientists often face issues of balancing between positive therapeutic effects of metal oxide nanoparticles and their toxic side effects. In this review, considering metal oxide nanoparticles as important technological and biomedical materials, the authors provide a comprehensive review of researches on metal oxide nanoparticles, their nanoscale physicochemical properties, defining specific applications in the various fields of nanomedicine. Authors discuss the recent development of metal oxide nanoparticles that were employed as biomedical materials in tissue therapy, immunotherapy, diagnosis, dentistry, regenerative medicine, wound healing and biosensing platforms. Besides, their antimicrobial, antifungal, antiviral properties along with biotoxicology were debated in detail. The significant breakthroughs in the field of nanobiomedicine have emerged in areas and numbers predicting tremendous application potential and enormous market value for metal oxide nanoparticles.

scholarly journals Energy and Nutrients’ Recovery in Anaerobic Digestion of Agricultural Biomass: An Italian Perspective for Future Applications

Energies ◽  
2019 ◽  
Vol 12 (17) ◽  
pp. 3287 ◽  
Author(s):  
Battista ◽  
Frison ◽  
Bolzonella
Keyword(s):  
Anaerobic Digestion ◽  
Electricity Production ◽  
Future Perspective ◽  
Incentive Scheme ◽  
Future Perspectives ◽  
Future Scenario ◽  
Agricultural Biomass ◽  
The Future ◽  
Biomethane Production ◽  
Power To Gas

Anaerobic digestion (AD) is the most adopted biotechnology for the valorization of agricultural biomass into valuable products like biogas and digestate, a renewable fertilizer. This paper illustrates in the first part the actual situation of the anaerobic digestion sector in Italy, including the number of plants, their geographical distribution, the installed power and the typical feedstock used. In the second part, a future perspective, independent of the actual incentive scheme, is presented. It emerged that Italy is the second European country for the number of anaerobic digestion plants with more than 1500 units for a total electricity production of about 1400 MWel. More than 60% of them are in the range of 200 kW–1 MW installed power. Almost 70% of the plants are located in the northern part of the Country where intensive agriculture and husbandry are applied. Most of the plants are now using energy crops in the feedstock. The future perspectives of the biogas sector in Italy will necessarily consider a shift from power generation to biomethane production, and an enlargement of the portfolio of possible feedstocks, the recovery of nutrients from digestate in a concentrated form, and the expansion of the AD sector to southern regions. Power to gas and biobased products will complete the future scenario.

Current Strategies and Future Perspective for the Effective Treatment of Diabetic Retinopathy

2020 ◽  
Vol 15 (4) ◽  
pp. 299-311
Author(s):  
Deep Shikha Sharma ◽  
Sachin Kumar Singh ◽  
Divya Thakur ◽  
Arya K.R ◽  
Rubiya Khursheed ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Side Effects ◽  
Combination Therapy ◽  
Future Perspective ◽  
Therapeutic Effects ◽  
Herbal Drugs ◽  
Laser Technology ◽  
Treatment And Prevention ◽  
Retinal Capillaries ◽  
Main Strategy

: Diabetes Retinopathy (DR) is one of the main complications due to diabetes. DR will damage the retinal capillaries and block them, which causes the loss of vision. Different drugs and therapies are used for the treatment and prevention of the DR. The most commonly used treatment is laser technology and combination therapy, along with some drugs. But these drugs possess side effects in the form of cataract, glaucoma, and complete blindness of the eye. The main strategy to overcome In DR, medicines with minimum side effects or maximum therapeutic effects are used. This article emphasizes the current strategy used for the treatment of DR with allopathic as well as herbal drugs.

Future perspectives on progressive farming with adoption of virtual reality technology for sustainable quality in agriculture

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Sneha Kumari ◽  
P. Raghuram ◽  
V.G. Venkatesh ◽  
Yangyan Shi
Keyword(s):  
Virtual Reality ◽  
Technology Adoption ◽  
Theoretical Framework ◽  
Emerging Economy ◽  
Partial Least Square ◽  
Policy Implications ◽  
Future Perspective ◽  
Future Perspectives ◽  
Content Type ◽  
The Future

PurposeThe paper aims to evaluate how progressive stakeholders view the adoption of contemporary techniques such as virtual technology in driving sustainable quality in an emerging economy context.Design/methodology/approachThe authors adopted a systematic literature review to develop the theoretical framework for virtual reality (VR) technology adoption in sustaining quality in agriculture production. The framework was refined after discussion with a panel of academic experts. The refined theoretical framework was further empirically validated using Partial Least Square Structure Equation Modelling.FindingsThe study focuses on the future perspective of the perception for progressive farming with the adoption of VR technology in an emerging economy. The data were collected from the stakeholders (farmers, collectives, cooperative, etc.), for their future perspectives for the adoption of VR technology and sustainable quality agriculture production. The study may help build up VR technology in emerging economies which may take years to be established.Research limitations/implicationsThe perception of the future perspective of VR technology study conducted has limitations. The findings are well established on technology adoption; however, the technology used will take many extra years to find its application in the agriculture sector. The study offers insightful theoretical, managerial and policy implications for sustainable quality in agriculture production through the adoption of virtual reality (VR) technology. The authors found very few works that focused on VR technology adoption.Originality/valueThe study discusses VR, which has an impact on sustaining the quality of agriculture production. The study has notable managerial and policy implications that suggest the future perspective for VR technology in agriculture production. The study is an unexplored area that needs research to capture future perspectives.

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