scholarly journals Comparative Evaluation of Nasopharyngeal and Oropharyngeal Swab Based Rapid SARS-CoV-2 Antigen Detection and Real-Time RT-PCR for Diagnosis of COVID-19 in Tertiary Care Hospital

Cureus ◽  
2021 ◽  
Author(s):  
Arpana Singh ◽  
Pratima Gupta ◽  
Yogendra P Mathuria ◽  
Deepjyoti Kalita ◽  
Amber Prasad ◽  
...  
Keyword(s):  
Real Time ◽  
Comparative Evaluation ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Antigen Detection ◽  
Care Hospital ◽  
Rt Pcr ◽  
Oropharyngeal Swab

scholarly journals A comparative study: Results of rapid antigen detection assay and real time RT-PCR for diagnosis of COVID-19 in a tertiary care hospital

2020 ◽  
Vol 8 (S1) ◽  
pp. 33-40
Author(s):  
Banerjee J ◽  
Reddy SG ◽  
Darapuneni RC ◽  
Bilolikar AK
Keyword(s):  
Real Time ◽  
Tertiary Care ◽  
Antigen Detection ◽  
Diagnostic Tools ◽  
Nasopharyngeal Swab ◽  
Care Hospital ◽  
Rt Pcr ◽  
Rapid Antigen Detection Test ◽  
Detection Assay ◽  
Study Results

Introduction: December 2019, witnessed the emergence of a novel coronavirus in human population. Later named as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has since spread across the globe and results into coronavirus disease 2019 (COVID-19) pandemic. Objective: The objective of this study was to evaluate COVID-19 infection positivity rate, its age and gender wise prevalence and to compare the results of rapid antigen detection test with gold standard real time RT-PCR for early detection of SARS-CoV-2 virus. Methods: An observational study was conducted in the Department of Microbiology and Molecular Biology of Krishna Institute of Medical Sciences, Secunderabad, Telangana. Results: A total of 208 patients’ specimens (nasopharyngeal swab) were compared within a period of one and half month. Infection positivity rate was observed as 26.92% (n=56). Our study revealed that among all 56 COVID-19 positive patients, 60.71% (n=34) were symptomatic whereas 39.2% (n=22) were asymptomatic. Conclusion: We conclude that after comparing with real time RT-PCR, antigen detection assay is not as sensitive as molecular test especially during the early stages of infection but this has potential to become an important tool for mass screening for COVID-19 and can be considered as fast and economic diagnostic tools in the remote areas where the laboratory facilities for molecular tests are not accessible. Keywords: COVID-19; pandemic; nasopharyngeal swab; rapid antigen detection assay; real time RT-PCR

scholarly journals A Comparative study of RT-PCR and TRUENAT BETA-CoV TEST in a tertiary care hospital

2021 ◽  
Vol 39 ◽  
pp. S57
Author(s):  
Sandhya rani Pagidirai ◽  
A. Renuka Devi ◽  
A. Surekha ◽  
Shanthi Reddy
Keyword(s):  
Comparative Study ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital ◽  
Rt Pcr

scholarly journals Vertical transmission and clinical outcome of the neonates born to SARS-CoV-2-positive mothers: a tertiary care hospital-based observational study

2021 ◽  
Vol 5 (1) ◽  
pp. e001193
Author(s):  
Pradeep Kumar ◽  
Fadila ◽  
Arun Prasad ◽  
Ambrin Akhtar ◽  
Bhabesh Kant Chaudhary ◽  
...  
Keyword(s):  
Clinical Outcome ◽  
Observational Study ◽  
Vertical Transmission ◽  
Prospective Observational Study ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Stable Condition ◽  
Nasopharyngeal Swab ◽  
Care Hospital ◽  
Rt Pcr

BackgroundNeonatal transmission of SARS-CoV-2 from positive mothers to their babies has been a real concern, opening the arena of research in this area.ObjectiveTo detect the possibility of vertical transmission of SARS-CoV-2 from COVID-19-positive mothers to their neonates and the clinicopathological outcome in them.DesignA single-centre, prospective, observational study involving 47 COVID-19-positive mothers and their neonates.SettingA tertiary care hospital in Eastern India.ParticipantsNeonates born to SARS-CoV-2-infected mothers.Main outcome measuresWe investigated the SARS-CoV-2 positivity rate by real-time reverse transcriptase-PCR (RT-PCR) done twice (on admission and after 24 hours of admission) in neonates born to SARS-CoV-2-positive mothers, who tested RT-PCR positive for this virus in their nasopharyngeal swab. Clinical outcome was also assessed in these neonates during their hospital stay.ResultsOut of 47 neonates born to SARS-CoV-2-positive mothers, four were SARS-CoV-2 positive by RT-PCR. All the neonates in our study were discharged home in stable condition after management of acute complications. None of them required readmission.ConclusionVertical transmission occurs in neonates born to COVID-19-positive mothers; however, the risk is small. Majority of the neonates remain asymptomatic with good clinical outcome.

CORRELATION BETWEEN CT CHEST SEVERITY SCORE AND CLINICAL PARAMETERS AND BIOCHEMICAL MARKERS IN COVID 19 PATIENTS

2021 ◽  
pp. 25-28
Author(s):  
Pramodh Kumar ◽  
Konduru Aneesha ◽  
Ch. Radhika ◽  
Elaya Kumar ◽  
R. Srinivasan
Keyword(s):  
Severity Score ◽  
Biochemical Markers ◽  
Tamil Nadu ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Clinical Parameters ◽  
Care Hospital ◽  
Rt Pcr ◽  
The Relationship ◽  
D Dimer

AIM: To correlate between CT chest severity score in COVID 19 patients with Clinical [SpO2, RR, PaO2/FiO2] and Biochemical parameters [NLR ratio, CRP, D- Dimer values]. METHODS: A Retrospective, observational study was conducted in a tertiary care hospital in Kanchipuram, Tamil Nadu. 110 patients were admitted to the hospital with COVID 19 [RT PCR swab for COVID 19 positive and radiologically positive] between March 2021 to June 2021. The patient was clinically, radiologically, and biochemically evaluated. CT chest severity score was used to differentiate the patients into mild, moderate, and severe groups. The relationship between CT Severity score and Clinical parameters such as SpO2, RR, PaO2/FiO2 and Biochemical markers [ NLR ratio, CRP, D-Dimer] were studied. RESULTS: CT chest severity score was found to be positively correlated with decreased SpO2 levels, decreased PaO2/ FiO2, increased RR and elevated NLR ratio, D Dimer and CRP levels(P < 0.001). CONCLUSION: The 25 CT Severity score scores well with the Clinical parameters and biochemical markers. Our data suggest that CT Chest Severity Score correlates well with clinical parameters and biochemical markers.

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