scholarly journals Streptococcus equi subspecies zooepidemicus Meningitis, Septicemia, and Brain Infarcts in a Costa Rican Infant

Cureus ◽  
2021 ◽  
Author(s):  
Fabricio Sevilla-Acosta ◽  
Angela Ballestero-Pernudi ◽  
Elisandro Jiménez-Cruz ◽  
Hazel Álvarez-Cabalceta ◽  
Gabriela Naranjo-Zuñiga
Planta Medica ◽  
2015 ◽  
Vol 81 (11) ◽  
Author(s):  
JJ Araya ◽  
M Chavarría ◽  
A Pinto-Tomás ◽  
C Murillo ◽  
L Uribe ◽  
...  

2010 ◽  
Vol 30 (S 01) ◽  
pp. S150-S152
Author(s):  
G. Jiménez-Cruz ◽  
M. Mendez ◽  
P. Chaverri ◽  
P. Alvarado ◽  
W. Schröder ◽  
...  

SummaryHaemophilia A (HA) is X-chromosome linked bleeding disorders caused by deficiency of the coagulation factor VIII (FVIII). It is caused by FVIII gene intron 22 inversion (Inv22) in approximately 45% and by intron 1 inversion (Inv1) in 5% of the patients. Both inversions occur as a result of intrachromosomal recombination between homologous regions, in intron 1 or 22 and their extragenic copy located telomeric to the FVIII gene. The aim of this study was to analyze the presence of these mutations in 25 HA Costa Rican families. Patients, methods: We studied 34 HA patients and 110 unrelated obligate members and possible carriers for the presence of Inv22or Inv1. Standard analyses of the factor VIII gene were used incl. Southern blot and long-range polymerase chain reaction for inversion analysis. Results: We found altered Inv22 restriction profiles in 21 patients and 37 carriers. It was found type 1 and type 2 of the inversion of Inv22. During the screening for Inv1 among the HA patient, who were Inv22 negative, we did not found this mutation. Discussion: Our data highlight the importance of the analysis of Inv22 for their association with development of inhibitors in the HA patients and we are continuous searching of Inv1 mutation. This knowledge represents a step for genetic counseling and prevention of the inhibitor development.


Author(s):  
Jennifer M. Piscopo

Jennifer M. Piscopo examines how the crisis of representation in Costa Rica has placed a ceiling on gender equality in representation. The restructuring of the Costa Rican party system and party fragmentation has made electing multiple candidates from any one ballot more difficult. Top spots have become even more prestigious and more likely to be allocated to men, which reduces women’s electoral chances. Corruption scandals, party breakdown, citizen frustration, and economic problems tainted the administration of the nation’s first female president, Laura Chinchilla. Female legislators have often worked to promote women’s issues and feminist policies, but Chinchilla eschewed feminism, even though several of her policies did benefit women. Overall, her failed presidency may create difficulties for other women seeking top political offices and could have negative consequences for views of women in politics. These challenges notwithstanding, Piscopo concludes that Costa Rica remains at the vanguard of women’s political representation in Latin America.


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