scholarly journals Variety of Cardiac Events in Hospitalized Chronic Kidney Disease Patients

Cureus ◽  
2021 ◽  
Author(s):  
Asfia Jabbar ◽  
Ruqaya Qureshi ◽  
Murtaza Dhrolia ◽  
Kiran Nasir ◽  
Aasim Ahmad
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Cardiac Events

Abstract 1691: Stages of Chronic Kidney Disease Correlate with Major Adverse Cardiac Events as well as Late Lumen Loss Following the Sirolimus Eluting Coronary Stent

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Yota Kawamura ◽  
Yoshihiro Morino ◽  
Masakazu Nagaoka ◽  
Takashi Matsukage ◽  
Naoki Masuda ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Stent Implantation ◽  
Major Adverse Cardiac Events ◽  
Drug Eluting Stent ◽  
Maximum Pressure ◽  
Cardiac Events ◽  
Late Lumen Loss ◽  
Adverse Cardiac Events

Background: Chronic Kidney Disease (CKD) is considered as a risk factor for development of cardiovascular disease. However, it is unclear whether CKD has association with prognosis following the drug eluting stent implantation. Methods and Results : The Cypher coronary stents were implanted to 302 lesions in 249 patients who underwent elective PCI between January 2005 and April 2006. Average age was 66.3 ± 9.7 and male gender was 80.3%. Diabetes was found in 47% of the patients including 16% of insulin treatment. Stages of CKD are shown in the table 1 and 2 . AHA/ACC lesion type B2/C was 62%. Cypher stents were implanted at maximum pressure at 17.3 ± 3.0 atm. Intravascular ultrasound was used in 92% of the procedure. Clinical follow-up data were available in 89.9 % at 1 year although angiographic follow-up was performed in 73.1% at 8 months. Major adverse cardiac events were frequently observed in association with stages of CKD as shown in the table 1 . Stages of CKD have correlation with late lumen loss at 8 months (Table 2 ). Furthermore, in-stent late lumen loss inversely correlated with glomerular filtration rate (GFR) (R = −0.18, p = 0.0097). Conclusion : Stages of CKD have correlation with major adverse cardiac events as well as late lumen loss following the sirolimus eluting stent implantation. Clinical follow-up at 1 year of study stratified by stages of CKD Angiographic data of study stratified by stages of CKD

scholarly journals Copeptin, myeloperoxidase and pro-adrenomedullin for acute coronary syndrome in patients with chronic kidney disease

2019 ◽  
Vol 28 (3) ◽  
pp. 173-183
Author(s):  
Jen Heng Pek ◽  
Stephanie Man Chung Fook-Chong ◽  
Jason Chon Jun Choo ◽  
Carol Hui Chen Tan ◽  
Ziwei Lin ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Acute Coronary Syndrome ◽  
Kidney Disease ◽  
Poor Performance ◽  
Cardiac Events ◽  
Cardiac Marker ◽  
Routine Testing ◽  
Coronary Syndrome ◽  
Diagnosis And Prognosis ◽  
Adverse Cardiac Events

Objectives:Copeptin, myeloperoxidase and pro-adrenomedullin have emerged as potential biomarkers for diagnosis and prognosis of acute coronary syndrome (ACS). However, their applicability in patients with chronic kidney disease (CKD) remains unknown as these patients were excluded from previous studies. Our objective was to determine the superior novel cardiac marker to predict 30-day and six-month adverse cardiac events (ACEs) defined as cardiac-related death, myocardial infarction and ventricular fibrillation.Methods:A prospective observational study was carried out. Patients were included if they presented to the emergency department with symptoms suggestive of ACS and had CKD as defined as a serum creatinine of more than 130 µmol/l. Copeptin, myeloperoxidase and pro-adrenomedulin assays were performed. Occurrence of ACE was traced from review of the patients’ case records and the registry of deaths.Results:A total of 724 patients were recruited: 60.6% were male and 68.6% were Chinese. The median age was 67 years. Among those recruited, 88.3% had CKD stages 4 and 5, with 33.5% on dialysis. The rates of ACE at 30 days and six months were 15.1% and 21.7%, respectively. All readings of the three biomarkers were not significantly different in patients with ACE compared with those without both at 30 days and six months. The areas under the curve for copeptin, myeloperoxidase and pro-adrenomedullin were 0.53, 0.50 and 0.45, respectively ( p > 0.05).Conclusions:The poor performance of the biomarkers may be attributable to lack of specificity for ACS, as elevated levels could be from other causes in CKD patients. Routine testing cannot be recommended.

scholarly journals The impact of chronic kidney disease as a predictor of major cardiac events in patients with no evidence of coronary artery disease

2010 ◽  
Vol 55 (3) ◽  
pp. 328-336 ◽  
Author(s):  
Tatsuhiko Furuhashi ◽  
Masao Moroi ◽  
Nobuhiko Joki ◽  
Hiroki Hase ◽  
Hirofumi Masai ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Chronic Kidney Disease ◽  
Coronary Artery ◽  
Kidney Disease ◽  
Cardiac Events ◽  
Artery Disease ◽  
The Impact

Extended Mortality and Chronic Kidney Disease After Septic Acute Kidney Injury

2018 ◽  
Vol 35 (6) ◽  
pp. 527-535 ◽  
Author(s):  
Horng-Ruey Chua ◽  
Weng-Kin Wong ◽  
Venetia Huiling Ong ◽  
Dipika Agrawal ◽  
Anantharaman Vathsala ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Acute Kidney Injury ◽  
Kidney Disease ◽  
Kidney Injury ◽  
Simplified Acute Physiology Score ◽  
Cardiac Events ◽  
Ckd Progression ◽  
Septic Acute Kidney Injury ◽  
Adverse Cardiac Events ◽  
Kidney Disease Progression

Purpose: To evaluate 1-year mortality in patients with septic acute kidney injury (AKI) and to determine association between initial AKI recovery patterns ( reversal within 5 days, beyond 5 days but recovery, or nonrecovery) and chronic kidney disease (CKD) progression. Methods: Prospective observational study, with retrospective evaluation of initial nonconsenters, of critically ill patients with septic AKI. Results: We studied 207 patients (age, mean [SD]: 64 [16] years, 39% males), of which 56 (27%), 18 (9%), and 9 (4%) died in intensive care unit (ICU), post-ICU in hospital, and posthospitalization, respectively. Infections (including pneumonia) and major adverse cardiac events accounted for 64% and 12% of deaths, respectively. Factors independently associated with 1-year mortality include older age, ischemic heart disease, higher Simplified Acute Physiology Score II, central nervous system or musculoskeletal primary infections, higher daily fluid balance (FB), and frusemide administration during ICU stay (all P < .05). Among 63 patients receiving renal replacement therapy (RRT), hospital mortality was higher with cumulative median FB >8 L versus ≤8 L at RRT initiation (57% vs 24%; P = .009); there was trend for less ICU- and RRT-free days at day 28 in patients with higher FB pre-RRT ( P = NS). Chronic kidney disease progression over 1 year developed in 21%, 30%, and 79% of 105 initial survivors with AKI reversal, recovery, and nonrecovery, respectively ( P < .001). Acute kidney injury nonrecovery during hospitalization independently predicted CKD progression ( P = .001). Conclusions: Patients with septic AKI had 40% 1-year mortality, mainly associated with infections. High FB and frusemide administration were modifiable risk factors. Risk of CKD progression is high especially with initial AKI nonrecovery.

scholarly journals Chronic kidney disease impairs prognosis in electrical storm

2021 ◽  
Author(s):  
Kathrin Weidner ◽  
Michael Behnes ◽  
Tobias Schupp ◽  
Jorge Hoppner ◽  
Uzair Ansari ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Heart Rhythm ◽  
Electrical Storm ◽  
Prognostic Impact ◽  
Cardiac Events ◽  
All Cause Mortality ◽  
Life Threatening ◽  
Long Term Mortality

Abstract Background The study sought to assess the prognostic impact of chronic kidney disease (CKD) in patients with electrical storm (ES). ES represents a life-threatening heart rhythm disorder. In particular, CKD patients are at risk of suffering from ES. However, data regarding the prognostic impact of CKD on long-term mortality in ES patients is limited. Methods All consecutive ES patients with an implantable cardioverter–defibrillator (ICD) were included retrospectively from 2002 to 2016. Patients with CKD (MDRD-GFR < 60 ml/min/1.73 m2) were compared to patients without CKD. The primary endpoint was all-cause mortality at 3 years. Secondary endpoints were in-hospital mortality, cardiac rehospitalization, recurrences of electrical storm (ES-R), and major adverse cardiac events (MACE) at 3 years. Results A total of 70 consecutive ES patients were included. CKD was present in 43% of ES patients with a median glomerular filtration rate (GFR) of 43.3 ml/min/1.73 m2. CKD was associated with increased all-cause mortality at 3 years (63% vs. 20%; p = 0.001; HR = 4.293; 95% CI 1.874–9.836; p = 0.001) and MACE (57% vs. 30%; p = 0.025; HR = 3.597; 95% CI 1.679–7.708; p = 0.001). In contrast, first cardiac rehospitalization (43% vs. 45%; log-rank p = 0.889) and ES-R (30% vs. 20%; log-rank p = 0.334) were not affected by CKD. Even after multivariable adjustment, CKD was still associated with increased long-term mortality (HR = 2.397; 95% CI 1.012–5.697; p = 0.047), as well as with the secondary endpoint MACE (HR = 2.520; 95% CI 1.109–5.727; p = 0.027). Conclusions In patients with ES, the presence of CKD was associated with increased long-term mortality and MACE.

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