scholarly journals A NARRATIVE REVIEW ON TRANSFERSOMES: VESICULAR TRANSDERMAL DELIVERY SYSTEM FOR ENHANCED DRUG PERMEATION

2021 ◽  
Vol 12 (2) ◽  
pp. 1-4
Author(s):  
Syeda Jabeen Unnisa ◽  
Swarupa Arvapalli ◽  
B Karunakar ◽  
PS Rishika Reddy ◽  
A Vaishnavi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Transdermal Delivery ◽  
Drug Transport ◽  
Vascular System ◽  
The Body ◽  
Transdermal Drug Delivery System ◽  
Transdermal Delivery System ◽  
Pass Through

Transdermal administration of drug is generally limited by the barrier function of the skin vascular system are one of the most controversial method for transdermal delivery of active substance. transdermal drug delivery system is designed to deliver biological active agents through the skin, principally by diffusion for local internal if not systemic effects. The transdermal delivery system was relaunched after the discovery of elastic vesicles like transfersome, ethosome, cubosome, phytosome etc. Transfersomes are a form of elastic or deformable vesicle, which were introduced in the early 1990s. Elasticity is generated by incorporation of edge activator in lipid bilayer structure. Drug absorbed and distributed into organs and tissue and eliminated from the body it must pass through one or more biological membranes at various locations such movement of drug across the membrane is called as drug transport for the drug delivery to cross the body it should pass through the membrane barrier. This concept of drug delivery system was designed in attempt to concentrate the amount of drug in the remaining drug; therefore, the phospholipid-based carrier system is of considerable interest in the era.

scholarly journals EXTRACTION, MODIFICATION, AND CHARACTERIZATION OF NATURAL POLYMERS USED IN TRANSDERMAL DRUG DELIVERY SYSTEM: AN UPDATED REVIEW

2020 ◽  
pp. 10-20
Author(s):  
DIPJYOTI BISWAS ◽  
SUDIP DAS ◽  
SOURAV MOHANTO ◽  
SHUBHRAJIT MANTRY
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Transdermal Drug Delivery ◽  
Biomedical Application ◽  
The Body ◽  
Fixed Dose ◽  
Natural Polymers ◽  
Transdermal Drug Delivery System

The modified/regulated drug delivery system helps to sustain the delivery of the drug for a prolonged period. The modified drug delivery system is primarily aimed at ensuring protection, the effectiveness of the drug, and patient compliance. The transdermal drug delivery system (TDDS) falls within the modified drug delivery system, in which the goal is to deliver the drug at a fixed dose and regulated rate through the skin. Polymers are the backbone of the framework for providing transdermal systems. The polymer should be stable, non-toxic, economical, and provide a sustainable release of the drug. In general, natural polymers used in the TDDS as rate-controlling agents, protective, and stabilizing agents and also used to minimize the frequency of dosing and improve the drug’s effectiveness by localizing at the site of action. Nowadays, manufacturers are likely to use natural polymers due to many issues associated with drug release and side effects with synthetic polymers. Drug release processes from natural polymers include oxidation, diffusion, and swelling. Natural polymers may be used as the basis to achieve predetermined drug distribution throughout the body. The use of natural materials for traditional and modern types of dosage forms are gums, mucilages, resins, and plant waste etc. Thus, the main objective of this review article is to give a brief knowledge about the extraction, modification, characterization, and biomedical application of conventional natural polymers used in the transdermal drug delivery system and their future prospective.

scholarly journals An updated review on transdermal drug delivery systems

2015 ◽  
Vol 1 (6) ◽  
pp. 244 ◽  
Author(s):  
Audumbar Digambar Mali ◽  
Ritesh Bathe ◽  
Manojkumar Patil
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Transdermal Delivery ◽  
Transdermal Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Transdermal Drug Delivery System ◽  
Transdermal Drug Delivery Systems ◽  
Novel Drug

Transdermal drug delivery systems (TDDS), also known as patches, are dosage forms designed to deliver a therapeutically effective amount of drug across a patients skin. In order to deliver therapeutic agents through the human skin for systemic effects, the comprehensive morphological, biophysical and physicochemical properties of the skin are to be considered. Transdermal delivery provides a leading edge over injectables and oral routes by increasing patient compliance and avoiding first pass metabolism respectively. Transdermal delivery not only provides controlled, constant administration of the drug, but also allows continuous input of drugs with short biological half-lives and eliminates pulsed entry into systemic circulation, which often causes undesirable side effects. The TDDS review articles provide valuable information regarding the transdermal drug delivery systems and its evaluation process details as a ready reference for the research scientist who is involved in TDDS. With the advancement in technology Pharma industries have trendified all its resources. Earlier we use convectional dosage form but now we use novel drug delivery system. One of greatest innovation of novel drug delivery is transdermal patch. The advantage of transdermal drug delivery system is that it is painless technique of administration of drugs.

scholarly journals Drug Penetration Enhancement Techniques in Transdermal Drug Delivery System: A Review

2021 ◽  
pp. 46-61
Author(s):  
Joshi Hrushikesh Anantrao ◽  
Pandye Aaditya Nath ◽  
Patil Rajendra Nivrutti
Keyword(s):  
Drug Delivery ◽  
Stratum Corneum ◽  
Drug Delivery System ◽  
Drug Administration ◽  
Delivery System ◽  
Transdermal Delivery ◽  
Transdermal Drug Delivery ◽  
Hormone Replacement ◽  
Transdermal Drug Delivery System ◽  
Penetration Enhancement

Transdermal Drug Delivery System (TDDS) is described as a self-contained or discrete dosage form that is applied to the intact skin. This rout of drug administration of drugs through the skin for therapeutic use is an alternative approach to oral, intravascular, subcutaneous, and transmucosal routes. The delivery of drugs through the skin to the systemic circulation provides a convenient route of administration for a variety of clinical indications. Transdermal Drug Delivery System allows continuous drug administration, use of drugs with short biological half lives, avoids increases hepatic first pass elimination and rapid termination of medication by removing the transdermal drug delivery system from the skin.  Various transdermal technologies may be applied for different categories of pharmaceuticals used for the treatment of disorders of the skin or for systemic effects to treat diseases of other organs. Several transdermal products and applications include hormone replacement therapy, contraception, pain management, angina pectoris, smoking cessation, and neurological disorders such as Parkinson's disease. The most commonly used transdermal system is the skin patch using various types of technologies. Stratum corneum is the outermost layer of the skin and it is the main barrier layer for permeation of drug in transdermal delivery of drugs. So, to circumvent the barrier properties of stratum corneum and to increase the flux of drug through skin membrane various penetration enhancement techniques are used in transdermal drug delivery system. The review presents different physical and chemical methods in penetration enhancement approaches and to optimize the transdermal delivery system.

Identifying underlying issues related to the inactive excipients of transfersomes based drug delivery system

2020 ◽  
Vol 26 ◽  
Author(s):  
Drashti Patel ◽  
Bappaditya Chatterjee
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Transdermal Delivery ◽  
Systemic Availability ◽  
Drug Penetration ◽  
Skin Damage ◽  
Variable Effect ◽  
Practical Factors ◽  
Edge Activator

: Transfersomes are bilayer vesicles composed of phospholipid and edge-activators, which are mostly surfactant. Transfersomes based drug delivery system has gained a lot of interest of the pharmaceutical researchers for their ability to improve drug penetration and permeation through the skin. Transdermal drug delivery via transfersomes has the potential to overcome the challenge of low systemic availability. However, this complex vesicular system has different issues to consider for developing a successful transdermal delivery system. One of the major ingredients, phospholipid has versatile sources and variable effect on the vesicle size and drug entrapment in transfersomes. The other one termed as edge-activator or surfactant has some crucial consideration of skin damage and toxicity depending upon its type and concentration. A complex interaction between type and concentration of phospholipid and surfactant was observed, which affect the physicochemical properties of transfersomes. This review focuses on the practical factors related to these two major ingredients such as phospholipid and surfactant. The origin, purity, desired concentration, the susceptibility of degradation, etc. are the important factors for selecting phospholipid. Regarding surfactants, the major aspects are type and desired concentration. A successful development of transfersomes based drug delivery system depends on the proper considerations of these factors and practical aspects.

Wetting transition in nanochannels for biomimetic free-blocking on-demand drug transport

2018 ◽  
Vol 6 (39) ◽  
pp. 6269-6277 ◽  
Author(s):  
Yaya Cheng ◽  
Xiangyu Jiao ◽  
Liang Zhao ◽  
Yang Liu ◽  
Fang Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Transport ◽  
Mesoporous Silica Nanoparticles ◽  
Wetting Transition ◽  
On Demand ◽  
Inner Surface

Inspired by aquaporins in nature, herein, a biomimetic free-blocking on-demand drug delivery system is proposed, which is constructed by controlling the wettability of the inner surface of nanochannels on mesoporous silica nanoparticles (MSNs).

Recent Applications of Nanoemulsion Based Drug Delivery System: A Review

2021 ◽  
pp. 2852-2858
Author(s):  
Asif Eqbal ◽  
Vaseem Ahamad Ansari ◽  
Abdul Hafeez ◽  
Farogh Ahsan ◽  
Mohd Imran ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Transdermal Drug Delivery ◽  
Therapeutic Agents ◽  
Topical Drug Delivery ◽  
Transdermal Drug Delivery System ◽  
Small Droplet ◽  
Pharmaceutical Application ◽  
System A

Nanoemulsions are drug transporters for the delivery of therapeutic agents. They possess the small droplet size having the range of 20×10-9-200×10-9m. The main purpose of using Nanoemulsion is to enhance the drug bio- availability of transdermal drug delivery system. With the help of phase diagram, we can select the components of nanoemulsion depending upon formulas ratio of oil phase, surfactant/co-surfactant and water phase. Nanoemulsion directly used as a topical drug delivery in skin organs. The most useable pharmaceutical application has been developed till date to provide systemic effects to penetrating the full thickness of skin organ layer nanoemulsions can be administered through variety of routes such as percutaneous, perioral, topical, transdermal, ocular and parental administration of medicaments. Nanoemulsions are transparent and slightly opalescent. Nanoemulsion can be prepared through various methods. Nanoemulsions are transparent and slightly opalescent. Factor affecting nanoemulsions are surfactant, viscosity, lipophilic, drug content, pH, concentration of each component, and methodology of formulation. It is unfeasible to test all factors at the various levels. Design of formulation when it comes to experimental design it gives an excellent approach through reducing the time and money.

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