scholarly journals DEVELOPMENT SODIUM ALGINATE SODIUM BICARBONATE CALCIUM CARBONATE ORAL SUSPENSION USING TURBISCAN TOWER AND ZETA POTENTIAL

2021 ◽  
Vol 12 (8) ◽  
pp. 32-40
Author(s):  
Canberk Yılmaz ◽  
Cüneyt Toprak ◽  
Gökay Gün
Keyword(s):  
Calcium Carbonate ◽  
Pilot Study ◽  
Zeta Potential ◽  
Sodium Bicarbonate ◽  
Sodium Alginate ◽  
Stress Conditions ◽  
Homogeneous Mixture ◽  
Oral Suspension ◽  
Combination Formulation

Sodium Alginate Sodium Bicarbonate Calcium Carbonate combination reduces heartburn, heartburn or stomach complaints caused by reflux. The aim of this study is to create sodium alginate sodium bicarbonate calcium carbonate combination formulation using pre-development devices such as Turbiscan Tower and Zeta Potential. In order to obtain a homogeneous mixture during production and pilot study using two different boiler 5 trial production, samples will be pre-feasibility devices (Turbiscan Tower and Zeta Potential) stress conditions using physical behaviors have been observed.

scholarly journals Formulation, Development and Evaluation of Chewable Bi-layered Tablets for Treating Gastro Esophageal Reflux Disease

2020 ◽  
Vol 10 (4-s) ◽  
pp. 92-99
Author(s):  
Ankur Vasoya ◽  
Sunil Kumar Shah ◽  
C K Tyagi ◽  
Prabhakar Budholiya ◽  
Harish Pandey
Keyword(s):  
Calcium Carbonate ◽  
Drug Release ◽  
Sodium Bicarbonate ◽  
Sodium Alginate ◽  
Acid Neutralization ◽  
In Vitro Drug Release ◽  
Neutralization Capacity ◽  
Acid Neutralization Capacity ◽  
Bilayer Tablets

The purpose of this research work was to formulate raft-forming chewable bilayer tablets of sodium alginate using a raft-forming agent along with gas-generating agents. Tablets were prepared by wet granulation and evaluated for raft strength, acid neutralization capacity, weight variation, % drug content, thickness, hardness, friability and in vitro drug release. Various raft-forming agents were used in preliminary screening. The amount of sodium alginate, amount of calcium carbonate and amount sodium bicarbonate were selected as variables. Raft strength, acid neutralization capacity and drug release at 30 min were selected as responses.Tablets containing sodium alginate were having maximum raft strength as compared with other raft-forming agents. Acid neutralization capacity and in vitro drug release of all factorial batches were found to be satisfactory. Prepared tablets were found to be pharmaceutically equivalent to the marketed product. It was concluded that raft-forming chewable bilayer tablets prepared using an optimum amount of sodium alginate, calcium carbonate and sodium bicarbonate could be an efficient dosage form in the treatment of gastro oesophageal reflux diseases. Keywords: Chewable bilayer tablet, Sodium alginate, Raft forming agent, Acid Neutralizing capacity

Investigation of the Role of the Alkalizing Agent in Sodium Alginate Liquid Anti-reflux Suspension

2020 ◽  
Vol 15 (1) ◽  
pp. 53-60
Author(s):  
Sangmesh Torne ◽  
A. Sheela ◽  
N.C. Sarada
Keyword(s):  
Calcium Carbonate ◽  
Sodium Bicarbonate ◽  
Sodium Alginate ◽  
Reflux Disease ◽  
Oesophageal Reflux ◽  
Acid Neutralization ◽  
Neutralization Capacity ◽  
Acid Neutralization Capacity ◽  
Oesophageal Reflux Disease

Background: Anti-reflux formulation is one of the popular formulations across the globe in the pharmaceutical industry used specifically for the management of gastro-oesophageal reflux disease. But, this formulation is less explored with respect to research. Anti-reflux formulation has challenges to show its antacid functionality, which could have synergies in the management of refluxes in gastro-oesophageal reflux disease. Alkalizing agents act as antacid and improve the acid neutralization capacity in the anti-reflux formulation, and can be used appropriately as they affect raft strength beyond certain (optimum) limits. Objective: The objective of this work is to investigate the significance of alkalizing agent in sodium alginate based on oral liquid anti-reflux suspension for the management of Gastro-oesophageal Reflux Disease (GERD). Methods: In the present study, the formulation was prepared using sodium alginate along with different alkalizing agents like calcium carbonate and sodium bicarbonate at different levels. The formulation was further studied for in-vitro characterization like pH, viscosity, Acid Neutralization Capacity (ANC), thickness, formation speed, flotation, and raft strength. Results: The formulation with a higher level of calcium carbonate as the alkalizing agent showed a positive effect on the acid neutralization capacity (20.83mEq) and raft strength (16.95g) as well. Whereas, the formulation with a higher level of sodium bi-carbonate (4.01%) showed improved acid neutralization (22.31mEq) but showed a negative effect on raft strengths (10.08g). Conclusion: Based on the study, the optimum levels include 5% sodium alginate, 1.6% calcium carbonate and 2.67% sodium bicarbonate to achieve good liquid suspension formulation possessing good acid neutralization capacity as well as raft strength.

scholarly journals FORMULATION AND CHARACTERIZATION OF TIMOLOL MALEATE-LOADED NANOPARTICLES GEL BY IONIC GELATION METHOD USING CHITOSAN AND SODIUM ALGINATE

2019 ◽  
pp. 48-54 ◽  
Author(s):  
RISA AHDYANI ◽  
LARAS NOVITASARI ◽  
RONNY MARTIEN
Keyword(s):  
Particle Size ◽  
Zeta Potential ◽  
Sodium Alginate ◽  
Release Kinetics ◽  
In Vitro Release ◽  
Entrapment Efficiency ◽  
Polydispersity Index ◽  
Ionic Gelation ◽  
Timolol Maleate ◽  
Optimum Formula

Objective: The objectives of this study were to formulate and characterize nanoparticles gel of timolol maleate (TM) by ionic gelation method using chitosan (CS) and sodium alginate (SA). Methods: Optimization was carried out by factorial design using Design Expert®10.0.1 software to obtain the concentration of CS, SA, and calcium chloride (CaCl2) to produce the optimum formula of TM nanoparticles. The optimum formula was characterized for particle size, polydispersity index, entrapment efficiency, Zeta potential, and molecular structure. Hydroxy Propyl Methyl Cellulose (HPMC) K15 was incorporated into optimum formula to form nanoparticles gel of TM and carried out in vivo release study using the Franz Diffusion Cell. Results: TM nanoparticles was successfully prepared with concentration of CS, SA, and CaCl2 of 0.01 % (w/v), 0.1 % (w/v), and 0.25 % (w/v), respectively. The particle size, polydispersity index, entrapment efficiency, and Zeta potential were found to be 200.47±4.20 nm, 0.27±0.0154, 35.23±4.55 %, and-5.68±1.80 mV, respectively. The result of FTIR spectra indicated TM-loaded in the nanoparticles system. In vitro release profile of TM-loaded nanoparticles gel showed controlled release and the Korsmeyer-Peppas model was found to be the best fit for drug release kinetics. Conclusion: TM-loaded CS/SA nanoparticles gel was successfully prepared and could be considered as a promising candidate for controlled TM delivery of infantile hemangioma treatment.

Reliability and Effect of Sodium Bicarbonate: Buffering and 2000-m Rowing Performance

2012 ◽  
Vol 7 (2) ◽  
pp. 152-160 ◽  
Author(s):  
Amelia J. Carr ◽  
Gary J. Slater ◽  
Christopher J. Gore ◽  
Brian Dawson ◽  
Louise M. Burke
Keyword(s):  
Calcium Carbonate ◽  
Confidence Interval ◽  
Sodium Bicarbonate ◽  
Pairwise Comparisons ◽  
Bicarbonate Concentration ◽  
Mean Power ◽  
Typical Error ◽  
Rowing Performance ◽  
Rowing Ergometer ◽  
Double Blinded

Purpose:The aim of this study was to determine the effect and reliability of acute and chronic sodium bicarbonate ingestion for 2000-m rowing ergometer performance (watts) and blood bicarbonate concentration [HCO3−].Methods:In a crossover study, 7 well-trained rowers performed paired 2000-m rowing ergometer trials under 3 double-blinded conditions: (1) 0.3 grams per kilogram of body mass (g/kg BM) acute bicarbonate; (2) 0.5 g/kg BM daily chronic bicarbonate for 3 d; and (3) calcium carbonate placebo, in semi-counterbalanced order. For 2000-m performance and [HCO3−], we examined differences in effects between conditions via pairwise comparisons, with differences interpreted in relation to the likelihood of exceeding smallest worthwhile change thresholds for each variable. We also calculated the within-subject variation (percent typical error).Results:There were only trivial differences in 2000-m performance between placebo (277 ± 60 W), acute bicarbonate (280 ± 65 W) and chronic bicarbonate (282 ± 65 W); however, [HCO3−] was substantially greater after acute bicarbonate, than with chronic loading and placebo. Typical error for 2000-m mean power was 2.1% (90% confidence interval 1.4 to 4.0%) for acute bicarbonate, 3.6% (2.5 to 7.0%) for chronic bicarbonate, and 1.6% (1.1 to 3.0%) for placebo. Postsupplementation [HCO3−] typical error was 7.3% (5.0 to 14.5%) for acute bicarbonate, 2.9% (2.0 to 5.7%) for chronic bicarbonate and 6.0% (1.4 to 11.9%) for placebo.Conclusion:Performance in 2000-m rowing ergometer trials may not substantially improve after acute or chronic bicarbonate loading. However, performances will be reliable with both acute and chronic bicarbonate loading protocols.

scholarly journals Preparation of Injectable Composite Hydrogels by Blending Poloxamers with Calcium Carbonate‐Crosslinked Sodium Alginate

ChemistryOpen ◽  
2020 ◽  
Vol 9 (4) ◽  
pp. 451-458
Author(s):  
Ningxia Xu ◽  
Jing Xu ◽  
Xiaoyan Zheng ◽  
Junfeng Hui
Keyword(s):  
Calcium Carbonate ◽  
Sodium Alginate ◽  
Composite Hydrogels
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