A REVIEW ON THE APPLICATION OF SOLID LIPID NANOPARTICLES IN TRANSDERMAL PATCH DRUG DELIVERY

The transdermal patches are used to deliver medication through the skin to treat the entire ailment. These depend on a unique size property of skins to encoded drugs solid lipid nanoparticles (SLNs) current a chance to create upon novel therapeutic properties used for drugs transmission SLN targeting holds great potential for target achieving, a penalty area, Many aspects of the loaded of SLN sin transdermal patches for increasing mechanism of penetration, formulation, characterization parameters, future advantages, limitations of SLNs, had better biocompatibility, low harmfulness, SLNs is physically stable, and better delivery for Lipophilic drugs are discussed here. SLNs are a hybrid of liposomes and polymer-based carriers that could be used to encapsulate both lipid and water-soluble medicines. SLN is a low-cost product that can be scaled up. They also have a long-life span and could be customized by using different lipids. Because of their multiple significant qualities, SLNs also started to emerge when effective drug delivery carriers, as well as the prospect with liposome delivery of drugs, depends heavily on them. Many patents relating to SLNs have already been submitted, there are more invented SLN-based delivery systems on the way soon.

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Solid Lipid Nanoparticle for the Delivery of Docetaxel: A Review

Journal of Drug Delivery and Therapeutics ◽

10.22270/jddt.v10i5-s.4441 ◽

2020 ◽

Vol 10 (5-s) ◽

pp. 224-228

Author(s):

Pranav Agrawal ◽

Amol Tatode ◽

Milind Umekar

Keyword(s):

Drug Delivery ◽

Solid Lipid Nanoparticles ◽

Clinical Medicine ◽

Lipid Nanoparticles ◽

Water Soluble ◽

Pharmacokinetic Parameters ◽

Poorly Water Soluble Drugs ◽

Solid Lipid ◽

Water Soluble Drugs ◽

Poorly Water Soluble

Solid lipid nanoparticles are the forefront of the rapidly developing field of nanotechnology with several potential applications in drug delivery, clinical medicine and research. Due to its solid state it has greater stability than other nanocarrier systems. There are several other advantages like sustained release, improves bioavaibility and delivery of poorly water soluble drugs, helps in control of several pharmacokinetic parameters of drugs due to which use of SLN is increasing day by day. Various techniques can be used for the formulation of SLN i.e. solvent evaporation, microemulsification technique, high pressure homogenization and supercritical fluid method. It has several applications likes it is use in gene transfer therapy, also use in different drug delivery systmer like oral and pulmonary drug delivery system. Due to several advantages SLNs are widely used in chemotherapy for the treatment of the cancer. The use of SLN for the delivery of Docetaxel to tumor site have several benefits likes site specific delivery, less toxic effect, more cell cytotoxicity and more bioavaibility which leads to decrease in the dosing frequency. Docetaxel is an anticancer agent extracted from plant Taxus Baccata which is widely used in chemotherapy to treat cancer. This article contains the detail information of about the advantages, disadvantages, different method of preparation and several SLN loaded with Docetaxel. Keywords: Solid lipid nanoparticles, drug delivery, clinical medicine, poorly water soluble drugs

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A concise review on preparation methods used for the development of solid lipid nanoparticles

Journal of Drug Delivery and Therapeutics ◽

10.22270/jddt.v11i1-s.4687 ◽

2021 ◽

Vol 11 (1-s) ◽

pp. 162-169

Author(s):

Vasu Deva Reddy Matta

Keyword(s):

Drug Delivery ◽

Targeted Delivery ◽

Solid Lipid Nanoparticles ◽

Oral Drug Delivery ◽

Lipid Nanoparticles ◽

Water Soluble ◽

Oral Drug ◽

Preparation Methods ◽

Hydrophilic Drugs ◽

Solid Lipid

Solid lipid nanoparticles (SLNs) are in submicron size range nanoparticles and are made of biocompatible and biodegradable materials (mainly composed of lipids and surfactants) capable of incorporating both lipophilic and hydrophilic drugs. SLNs are also considered as substitute to other colloidal drug systems, also used as controlled systems and targeted delivery. SLNs can be considered as an alternative for oral drug delivery vehicle to improve the oral bioavailability of drugs, associated reduction of drug toxicity and stability of drug in both GIT and plasma. There are different techniques used for the preparation of SLNs. Generally, the preparation of SLNs and any other nanoparticle system necessitates a dispersed system as precursor; otherwise particles are produced through the use of a particular instrumentation. This review provides the summary on the techniques or methods used for the development of SLNs of poorly water soluble drugs for improved drug delivery. Keywords: Solid lipid nanoparticles, controlled delivery, precursor, techniques.

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Solid Lipid Nanoparticles for Oral Drug Delivery: A Review

Current Nanomedicine ◽

10.2174/2468187310666200221105315 ◽

2020 ◽

Vol 10 (3) ◽

pp. 208-224

Author(s):

Manish Gautam ◽

Madhu Verma ◽

Iti Chauhan ◽

Mohd. Yasir ◽

Alok Pratap Singh ◽

...

Keyword(s):

Drug Delivery ◽

Solid Lipid Nanoparticles ◽

Oral Drug Delivery ◽

Lipid Nanoparticles ◽

Delivery Systems ◽

Water Soluble ◽

Oral Drug ◽

Pharmacokinetic Studies ◽

Future Prospects ◽

Solid Lipid

Background: The high molecular weight and increasing lipophilicity of drug face many problems starting from the drug development to formulation and conduction of pharmacological, toxicological and pharmacokinetic studies to its biological application. To overcome this problem, nano-sized formulations are in trend recently. The use of Solid lipid nanoparticles (SLNs) offers new insight into the formulation of the poor soluble and low bioavailable drug. Objective: The study aimed to investigate the literature concerning the development of SLNs for oral drug delivery of poorly soluble drugs, with a view survey the various methods of manufacturing and evaluation of formulation of SLNs and future prospects of SLNs and application of SLNs in oral delivery systems. Conclusion: Oral drug delivery is looking ahead progressively into newer directions due to the realization of various poor performance limiting factors such as reduced drug solubility or absorption, rapid metabolism, high actuation in plasma level of drug and variability caused due to food effect. These play a vital role in disappointing in vivo results, which leads in the failure of the conventional delivery system. Since the last decade, oral drug delivery has taken a new dimension with the increasing application of SLNs as a carrier for the delivery of poorly water-soluble or lipophilic drugs. The site-specific and sustained release effect of the drug is better achieved by using SLNs. This review highlights the various pros and cons, manufacturing techniques, characterization, and future prospects of SLNs in oral drug delivery systems.

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Development of Solid Lipid Nanoparticles of Lamivudine for Brain Targeting

International Journal of Drug Delivery Technology ◽

10.25258/ijddt.v1i1.8837 ◽

2009 ◽

Vol 1 (1) ◽

Cited By ~ 1

Author(s):

Pravin Patil ◽

Anil Sharma ◽

Subhash Dadarwal ◽

Vijay Sharma

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Solid Lipid Nanoparticles ◽

Rotation Speed ◽

Lipid Nanoparticles ◽

Brain Targeting ◽

Brain Penetration ◽

Solid Lipid ◽

Diffusion Technique

The objective of present investigation was to enhance brain penetration of Lamivudine, one of the most widely used drugs for the treatment of AIDS. This was achieved through incorporating the drug into solid lipid nanoparticles (SLN) prepared by using emulsion solvent diffusion technique. The formulations were characterized for surface morphology, size and size distribution, percent drug entrapment and drug release. The optimum rotation speed, resulting into better drug entrapment and percent yield, was in the range of 1000-1250 r/min. In vitro cumulative % drug release from optimized SLN formulation was found 40-50 % in PBS (pH-7.4) and SGF (pH-1.2) respectively for 10 h. After 24 h more than 65 % of the drug was released from all formulations in both mediums meeting the requirement for drug delivery for prolong period of time.

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Solid Lipid Nanoparticles: A Promising Drug Delivery Technology

International Journal of Pharmaceutical Sciences and Nanotechnology ◽

10.37285/ijpsn.2009.2.2.3 ◽

2009 ◽

Vol 2 (2) ◽

pp. 509-516

Author(s):

S. Pragati ◽

S. Kuldeep ◽

S. Ashok ◽

M. Satheesh

Keyword(s):

Drug Delivery ◽

Solid Lipid Nanoparticles ◽

Large Scale ◽

Colloidal Particles ◽

Scale Up ◽

Lipid Nanoparticles ◽

Scale Production ◽

Research Activity ◽

New Approach ◽

Solid Lipid

One of the situations in the treatment of disease is the delivery of efficacious medication of appropriate concentration to the site of action in a controlled and continual manner. Nanoparticle represents an important particulate carrier system, developed accordingly. Nanoparticles are solid colloidal particles ranging in size from 1 to 1000 nm and composed of macromolecular material. Nanoparticles could be polymeric or lipidic (SLNs). Industry estimates suggest that approximately 40% of lipophilic drug candidates fail due to solubility and formulation stability issues, prompting significant research activity in advanced lipophile delivery technologies. Solid lipid nanoparticle technology represents a promising new approach to lipophile drug delivery. Solid lipid nanoparticles (SLNs) are important advancement in this area. The bioacceptable and biodegradable nature of SLNs makes them less toxic as compared to polymeric nanoparticles. Supplemented with small size which prolongs the circulation time in blood, feasible scale up for large scale production and absence of burst effect makes them interesting candidates for study. In this present review this new approach is discussed in terms of their preparation, advantages, characterization and special features.

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Development of Gel-Core Solid Lipid Nanoparticles as Drug Delivery Systems for Hydrophilic Molecules

Current Nanoscience ◽

10.2174/1573413712999160803145919 ◽

2016 ◽

Vol 12 (5) ◽

pp. 598-604 ◽

Cited By ~ 2

Author(s):

Tatiana N. Pashirova ◽

Tatiana Andreani ◽

Ana S. Macedo ◽

Eliana B. Souto ◽

Lucia Ya. Zakharova

Keyword(s):

Drug Delivery ◽

Solid Lipid Nanoparticles ◽

Drug Delivery Systems ◽

Lipid Nanoparticles ◽

Delivery Systems ◽

Solid Lipid

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Solid Lipid Nanoparticles: Special Feature, Bioavailability Enhancement and Recent Advances in the Oral Drug Delivery

Recent Patents on Nanomedicine ◽

10.2174/1877912305666150616222015 ◽

2015 ◽

Vol 05 (999) ◽

pp. 1-1

Author(s):

Syed Sarim Imam ◽

Mohammad Aqil ◽

Yasmin Sultana

Keyword(s):

Drug Delivery ◽

Solid Lipid Nanoparticles ◽

Oral Drug Delivery ◽

Lipid Nanoparticles ◽

Oral Drug ◽

Bioavailability Enhancement ◽

Solid Lipid ◽

Recent Advances

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Optimization of Solid Lipid Nanoparticles of Ezetimibe in Combination with Simvastatin Using Quality by Design (QbD)

Nanoscience &Nanotechnology-Asia ◽

10.2174/2210681209666190218143736 ◽

2020 ◽

Vol 10 (4) ◽

pp. 404-418

Author(s):

Kruti Borderwala ◽

Ganesh Swain ◽

Namrata Mange ◽

Jaimini Gandhi ◽

Manisha Lalan ◽

...

Keyword(s):

Particle Size ◽

Solid Lipid Nanoparticles ◽

High Speed ◽

Entrapment Efficiency ◽

Lipid Nanoparticles ◽

Water Soluble ◽

Lipid Matrix ◽

Solid Lipid ◽

32 Factorial Design ◽

Full Factorial Experimental Design

Background: The objective of this study was to develop solid lipid nanoparticles (SLNs) of poorly water soluble anti-hyperlipidemic drugs-Ezetimibe in combination with Simvastatin. Methods: This study describes a 32 full factorial experimental design to optimize the formulation of drug loaded lipid nanoparticles (SLN) by the high speed homogenization technique. The independent variables amount of lipid (GMS) and amount of surfactant (Poloxamer 188) were studied at three levels and arranged in a 32 factorial design to study the influence on the response variables- particle size, % entrapment efficiency (%EE) and cumulative drug release (% CDR) at 24 h. Results: The particle size, % EE and % CDR at 24 h for the 9 batches (B1 to B9) showed a wide variation of 104.6-496.6 nm, 47.80-82.05% (Simvastatin); 48.60-84.23% (Ezetimibe) and 54.64-92.27% (Simvastatin); 43.8-97.1% (Ezetimibe), respectively. The responses of the design were analysed using Design Expert 10.0.2. (Stat-Ease, Inc, USA), and the analytical tools of software were used to draw response surface plots. From the statistical analysis of data, polynomial equations were generated. Optimized formulation showed particle size of 169.5 nm, % EE of 75.43% (Simvastatin); 79.10% (Ezetimibe) and 74.13% (Simvastatin); 77.11% (Ezetimibe) %CDR after 24 h. Thermal analysis of prepared solid lipid nanoparticles gave indication of solubilisation of drugs within lipid matrix. Conclusion: Fourier Transformation Infrared Spectroscopy (FTIR) showed the absence of new bands for loaded solid lipid nanoparticles indicating no interaction between drugs and lipid matrix and being only dissolved in it. Electron microscope of transmission techniques indicated sphere form of prepared solid lipid nanoparticles with smooth surface with size approximately around 100 nm.

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